NUGGC (nuclear GTPase, germinal center associated)

Gene
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
389643
Gene name Gene Name - the full gene name approved by the HGNC.
Nuclear GTPase, germinal center associated
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
NUGGC
Synonyms (NCBI Gene) Gene synonyms aliases
C8orf80, HMFN0672, SLIP-GC, SLIPGC
Chromosome Chromosome number
8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
8p21.1
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(64)
miRTarBase ID miRNA Experiments Reference
MIRT691095 hsa-miR-106a-5p HITS-CLIP 23313552
MIRT691094 hsa-miR-106b-5p HITS-CLIP 23313552
MIRT691093 hsa-miR-17-5p HITS-CLIP 23313552
MIRT691092 hsa-miR-20a-5p HITS-CLIP 23313552
MIRT691091 hsa-miR-20b-5p HITS-CLIP 23313552
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(7)
GO ID Ontology Definition Evidence Reference
GO:0003924 Function GTPase activity IBA 21873635
GO:0003924 Function GTPase activity IDA 19734146
GO:0005525 Function GTP binding IEA
GO:0016607 Component Nuclear speck IEA
GO:0033262 Process Regulation of nuclear cell cycle DNA replication IMP 19734146
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
619088 33550 ENSG00000189233
Protein
Gene miRNA Gene ontology Other IDs Protein Associated diseases
UniProt ID Q68CJ6
Protein name Nuclear GTPase SLIP-GC (EC 3.6.1.-) (Speckled-like pattern in the germinal center)
Protein function Nuclear GTPase found in germinal center B-cells, where it may inhibit function of the activation-induced cytidine deaminase AICDA (PubMed:19734146). Reduces somatic hypermutation in B-cells which may enhance genome stability (By similarity). {EC
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00350 Dynamin_N 103 → 356 Dynamin family Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in germinal center B-cell and in lymphomas derived from germinal center B-cell. {ECO:0000269|PubMed:19734146}.
Sequence 
MAETKDVFGQEPHPVEDDLYKERTRKRRKSDRDQRFRAFPSMEQSALKEYEKLESRTRRV
LSNTYQKLIQSVFLDDSIPNGVKYLINRLLALIEKPTVDPIYIALFGSTGAGKSSLINAI
IQQAMFLPVSGESICTSCIVQVSSGCCVQYEAKIHLLSDQEWREELKNLTKLLHRTEELS
REEADAWNRDEAVEEATWKLQMIYGNGAESKNYEELLRAKPKRKIPTSRVITLKAEEAEE
LSIKLDPYIRTQRRDWDGEAAEMRIWPLIKHVEVTLPKSDLIPEGVVLVDIPGTGDFNSK
RDEMWKKTIDKCSVIWVISDIERVSGGQAHEDLLNESIKACQRGFCRDVALVVTKMDKLH
LPEYLRERKAGNQAIQSQREAVLERNEMIKLQRTRILKEKLKRKLPADFKVLEASDLVYT
VSAQEYWQQALLTEEETEIPKLREYIRKSLLDKKKRTVTKYVTEAFGLLLLTDSFNSTQN
LPNEHLHMSVLRRFAEEKVELLEKAIAQCFACMEQPLQEGVRTARTSYRCILRACLVRSK
GNQGFHQTLKAVCLKNGIYASRTLARIDLNEALTQPVYDQIDPVFGSIFRTGKPTGSALM
PHIDAFKQSLQEKMTEIGIRSGWKYDSCKKNFLIQEISAILGGLEDHILRRKRRIYESLT
ASVQSDLKLCYEEAAQITGKKACERMKDAIRRGVDRQVAEGMFERAQERMQHQFQQLKTG
IVEKVKGSITTMLALASSQGDGLYKELADVGSEYKEMEKLHRSLREVAENARLRKGMQEF
LLRASPSKAGPPGTSL
Sequence length 796
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Leukemia Leukemia, Myelocytic, Acute rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297 27903959
Show/Hide Text Mining Associations (1)
Associations from Text Mining
Disease Name Relationship Type References
Venous Thromboembolism Associate 31420334