NUGGC (nuclear GTPase, germinal center associated)

Gene

• Entrez ID: 389643
• Gene name: Nuclear GTPase, germinal center associated
• Gene symbol: NUGGC
• Synonyms (NCBI Gene): C8orf80, HMFN0672, SLIP-GC, SLIPGC
• Chromosome: 8
• Chromosome location: 8p21.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT691095	hsa-miR-106a-5p	HITS-CLIP	23313552
MIRT691094	hsa-miR-106b-5p	HITS-CLIP	23313552
MIRT691093	hsa-miR-17-5p	HITS-CLIP	23313552
MIRT691092	hsa-miR-20a-5p	HITS-CLIP	23313552
MIRT691091	hsa-miR-20b-5p	HITS-CLIP	23313552
MIRT691090	hsa-miR-519d-3p	HITS-CLIP	23313552
MIRT691089	hsa-miR-526b-3p	HITS-CLIP	23313552
MIRT691088	hsa-miR-93-5p	HITS-CLIP	23313552
MIRT691087	hsa-miR-302a-3p	HITS-CLIP	23313552
MIRT691086	hsa-miR-302b-3p	HITS-CLIP	23313552
MIRT691085	hsa-miR-302c-3p	HITS-CLIP	23313552
MIRT691084	hsa-miR-302d-3p	HITS-CLIP	23313552
MIRT691083	hsa-miR-302e	HITS-CLIP	23313552
MIRT691082	hsa-miR-372-3p	HITS-CLIP	23313552
MIRT691081	hsa-miR-373-3p	HITS-CLIP	23313552
MIRT691080	hsa-miR-520a-3p	HITS-CLIP	23313552
MIRT691079	hsa-miR-520b	HITS-CLIP	23313552
MIRT691078	hsa-miR-520c-3p	HITS-CLIP	23313552
MIRT691077	hsa-miR-520d-3p	HITS-CLIP	23313552
MIRT691076	hsa-miR-520e	HITS-CLIP	23313552
MIRT691075	hsa-miR-4681	HITS-CLIP	23313552
MIRT691074	hsa-miR-512-3p	HITS-CLIP	23313552
MIRT691073	hsa-miR-520g-3p	HITS-CLIP	23313552
MIRT691072	hsa-miR-520h	HITS-CLIP	23313552
MIRT691071	hsa-miR-186-3p	HITS-CLIP	23313552
MIRT691070	hsa-miR-150-5p	HITS-CLIP	23313552
MIRT691069	hsa-miR-619-5p	HITS-CLIP	23313552
MIRT691068	hsa-miR-6506-5p	HITS-CLIP	23313552
MIRT691067	hsa-miR-4707-3p	HITS-CLIP	23313552
MIRT691066	hsa-miR-4731-5p	HITS-CLIP	23313552
MIRT691065	hsa-miR-5589-5p	HITS-CLIP	23313552
MIRT691064	hsa-miR-5089-5p	HITS-CLIP	23313552
MIRT691095	hsa-miR-106a-5p	HITS-CLIP	23313552
MIRT691094	hsa-miR-106b-5p	HITS-CLIP	23313552
MIRT691093	hsa-miR-17-5p	HITS-CLIP	23313552
MIRT691092	hsa-miR-20a-5p	HITS-CLIP	23313552
MIRT691091	hsa-miR-20b-5p	HITS-CLIP	23313552
MIRT691090	hsa-miR-519d-3p	HITS-CLIP	23313552
MIRT691089	hsa-miR-526b-3p	HITS-CLIP	23313552
MIRT691088	hsa-miR-93-5p	HITS-CLIP	23313552
MIRT691087	hsa-miR-302a-3p	HITS-CLIP	23313552
MIRT691086	hsa-miR-302b-3p	HITS-CLIP	23313552
MIRT691085	hsa-miR-302c-3p	HITS-CLIP	23313552
MIRT691084	hsa-miR-302d-3p	HITS-CLIP	23313552
MIRT691083	hsa-miR-302e	HITS-CLIP	23313552
MIRT691082	hsa-miR-372-3p	HITS-CLIP	23313552
MIRT691081	hsa-miR-373-3p	HITS-CLIP	23313552
MIRT691080	hsa-miR-520a-3p	HITS-CLIP	23313552
MIRT691079	hsa-miR-520b	HITS-CLIP	23313552
MIRT691078	hsa-miR-520c-3p	HITS-CLIP	23313552
MIRT691077	hsa-miR-520d-3p	HITS-CLIP	23313552
MIRT691076	hsa-miR-520e	HITS-CLIP	23313552
MIRT691075	hsa-miR-4681	HITS-CLIP	23313552
MIRT691074	hsa-miR-512-3p	HITS-CLIP	23313552
MIRT691073	hsa-miR-520g-3p	HITS-CLIP	23313552
MIRT691072	hsa-miR-520h	HITS-CLIP	23313552
MIRT691071	hsa-miR-186-3p	HITS-CLIP	23313552
MIRT691070	hsa-miR-150-5p	HITS-CLIP	23313552
MIRT691069	hsa-miR-619-5p	HITS-CLIP	23313552
MIRT691068	hsa-miR-6506-5p	HITS-CLIP	23313552
MIRT691067	hsa-miR-4707-3p	HITS-CLIP	23313552
MIRT691066	hsa-miR-4731-5p	HITS-CLIP	23313552
MIRT691065	hsa-miR-5589-5p	HITS-CLIP	23313552
MIRT691064	hsa-miR-5089-5p	HITS-CLIP	23313552

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0003924	Function	GTPase activity	IBA
GO:0003924	Function	GTPase activity	IDA	19734146
GO:0005525	Function	GTP binding	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005829	Component	Cytosol	IDA
GO:0016607	Component	Nuclear speck	IDA
GO:0016607	Component	Nuclear speck	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0033262	Process	Regulation of nuclear cell cycle DNA replication	IMP	19734146
GO:0043066	Process	Negative regulation of apoptotic process	IMP	19734146
GO:0071222	Process	Cellular response to lipopolysaccharide	IDA	19734146

Other IDs

• MIM: 619088
• HGNC: 33550
• e!Ensembl: ENSG00000189233

Protein

• UniProt ID: Q68CJ6
• Protein name: Nuclear GTPase SLIP-GC (EC 3.6.1.-) (Speckled-like pattern in the germinal center)
• Protein function: Nuclear GTPase found in germinal center B-cells, where it may inhibit function of the activation-induced cytidine deaminase AICDA (PubMed:19734146). Reduces somatic hypermutation in B-cells which may enhance genome stability (By similarity). {EC
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00350	Dynamin_N	103 → 356	Dynamin family	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in germinal center B-cell and in lymphomas derived from germinal center B-cell. {ECO:0000269|PubMed:19734146}.
• Sequence:

  MAETKDVFGQEPHPVEDDLYKERTRKRRKSDRDQRFRAFPSMEQSALKEYEKLESRTRRV
  LSNTYQKLIQSVFLDDSIPNGVKYLINRLLALIEKPTVDPIYIALFGSTGAGKSSLINAI
  IQQAMFLPVSGESICTSCIVQVSSGCCVQYEAKIHLLSDQEWREELKNLTKLLHRTEELS
  REEADAWNRDEAVEEATWKLQMIYGNGAESKNYEELLRAKPKRKIPTSRVITLKAEEAEE
  LSIKLDPYIRTQRRDWDGEAAEMRIWPLIKHVEVTLPKSDLIPEGVVLVDIPGTGDFNSK
  RDEMWKKTIDKCSVIWVISDIERVSGGQAHEDLLNESIKACQRGFCRDVALVVTKMDKLH
  LPEYLRERKAGNQAIQSQREAVLERNEMIKLQRTRILKEKLKRKLPADFKVLEASDLVYT
  VSAQEYWQQALLTEEETEIPKLREYIRKSLLDKKKRTVTKYVTEAFGLLLLTDSFNSTQN
  LPNEHLHMSVLRRFAEEKVELLEKAIAQCFACMEQPLQEGVRTARTSYRCILRACLVRSK
  GNQGFHQTLKAVCLKNGIYASRTLARIDLNEALTQPVYDQIDPVFGSIFRTGKPTGSALM
  PHIDAFKQSLQEKMTEIGIRSGWKYDSCKKNFLIQEISAILGGLEDHILRRKRRIYESLT
  ASVQSDLKLCYEEAAQITGKKACERMKDAIRRGVDRQVAEGMFERAQERMQHQFQQLKTG
  IVEKVKGSITTMLALASSQGDGLYKELADVGSEYKEMEKLHRSLREVAENARLRKGMQEF
  LLRASPSKAGPPGTSL

• Sequence length: 796