KTN1 (kinectin 1)

Gene

• Entrez ID: 3895
• Gene name: Kinectin 1
• Gene symbol: KTN1
• Synonyms (NCBI Gene): CG1, KNT, MU-RMS-40.19
• Chromosome: 14
• Chromosome location: 14q22.3
• Summary: This gene encodes an integral membrane protein that is a member of the kinectin protein family. The encoded protein is primarily localized to the endoplasmic reticulum membrane. This protein binds kinesin and may be involved in intracellular organelle mot

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT025459	hsa-miR-34a-5p	Proteomics	21566225
MIRT740003	hsa-miR-139-5p	CLIP-seq
MIRT740001	hsa-miR-3618	CLIP-seq
MIRT740006	hsa-miR-4714-5p	CLIP-seq
MIRT740000	hsa-miR-4797-5p	CLIP-seq
MIRT740005	hsa-miR-493	CLIP-seq
MIRT740002	hsa-miR-571	CLIP-seq
MIRT740004	hsa-miR-934	CLIP-seq
MIRT1102440	hsa-miR-1237	CLIP-seq
MIRT1102441	hsa-miR-1248	CLIP-seq
MIRT740003	hsa-miR-139-5p	CLIP-seq
MIRT1102442	hsa-miR-1827	CLIP-seq
MIRT1102443	hsa-miR-199a-3p	CLIP-seq
MIRT1102444	hsa-miR-199b-3p	CLIP-seq
MIRT1102445	hsa-miR-2682	CLIP-seq
MIRT1102446	hsa-miR-3119	CLIP-seq
MIRT1102447	hsa-miR-3129-5p	CLIP-seq
MIRT1102448	hsa-miR-3177-5p	CLIP-seq
MIRT740001	hsa-miR-3618	CLIP-seq
MIRT1102449	hsa-miR-3662	CLIP-seq
MIRT1102450	hsa-miR-3682-5p	CLIP-seq
MIRT1102451	hsa-miR-449c	CLIP-seq
MIRT1102452	hsa-miR-4698	CLIP-seq
MIRT1102453	hsa-miR-4715-5p	CLIP-seq
MIRT740000	hsa-miR-4797-5p	CLIP-seq
MIRT740005	hsa-miR-493	CLIP-seq
MIRT740002	hsa-miR-571	CLIP-seq
MIRT740004	hsa-miR-934	CLIP-seq
MIRT1102454	hsa-miR-935	CLIP-seq
MIRT1102455	hsa-miR-936	CLIP-seq
MIRT2028053	hsa-miR-3182	CLIP-seq
MIRT1102450	hsa-miR-3682-5p	CLIP-seq
MIRT1102452	hsa-miR-4698	CLIP-seq
MIRT2028054	hsa-miR-511	CLIP-seq
MIRT2028055	hsa-miR-548m	CLIP-seq
MIRT1102440	hsa-miR-1237	CLIP-seq
MIRT1102441	hsa-miR-1248	CLIP-seq
MIRT1102442	hsa-miR-1827	CLIP-seq
MIRT1102443	hsa-miR-199a-3p	CLIP-seq
MIRT1102444	hsa-miR-199b-3p	CLIP-seq
MIRT2259201	hsa-miR-219-1-3p	CLIP-seq
MIRT1102445	hsa-miR-2682	CLIP-seq
MIRT1102447	hsa-miR-3129-5p	CLIP-seq
MIRT2259202	hsa-miR-3616-5p	CLIP-seq
MIRT2259203	hsa-miR-3647-5p	CLIP-seq
MIRT1102450	hsa-miR-3682-5p	CLIP-seq
MIRT2259204	hsa-miR-4257	CLIP-seq
MIRT1102451	hsa-miR-449c	CLIP-seq
MIRT2259205	hsa-miR-526b	CLIP-seq
MIRT740002	hsa-miR-571	CLIP-seq
MIRT2259206	hsa-miR-573	CLIP-seq
MIRT1102454	hsa-miR-935	CLIP-seq
MIRT1102455	hsa-miR-936	CLIP-seq
MIRT2559556	hsa-miR-105	CLIP-seq
MIRT2559557	hsa-miR-1271	CLIP-seq
MIRT2559558	hsa-miR-182	CLIP-seq
MIRT2259201	hsa-miR-219-1-3p	CLIP-seq
MIRT2559559	hsa-miR-3065-5p	CLIP-seq
MIRT2559560	hsa-miR-323-3p	CLIP-seq
MIRT2559561	hsa-miR-3613-3p	CLIP-seq
MIRT2259202	hsa-miR-3616-5p	CLIP-seq
MIRT2559562	hsa-miR-3646	CLIP-seq
MIRT2259203	hsa-miR-3647-5p	CLIP-seq
MIRT2559563	hsa-miR-369-3p	CLIP-seq
MIRT2559564	hsa-miR-374a	CLIP-seq
MIRT2559565	hsa-miR-374b	CLIP-seq
MIRT2559566	hsa-miR-374c	CLIP-seq
MIRT2559567	hsa-miR-3973	CLIP-seq
MIRT2559568	hsa-miR-4470	CLIP-seq
MIRT2559569	hsa-miR-4666-3p	CLIP-seq
MIRT2559570	hsa-miR-4766-3p	CLIP-seq
MIRT2559571	hsa-miR-4775	CLIP-seq
MIRT2559572	hsa-miR-4803	CLIP-seq
MIRT2559573	hsa-miR-520d-5p	CLIP-seq
MIRT2559574	hsa-miR-524-5p	CLIP-seq
MIRT2259205	hsa-miR-526b	CLIP-seq
MIRT2559575	hsa-miR-532-5p	CLIP-seq
MIRT2559576	hsa-miR-548ac	CLIP-seq
MIRT2559577	hsa-miR-548d-3p	CLIP-seq
MIRT2559578	hsa-miR-548t	CLIP-seq
MIRT2559579	hsa-miR-548z	CLIP-seq
MIRT2559580	hsa-miR-570	CLIP-seq
MIRT740002	hsa-miR-571	CLIP-seq
MIRT2259206	hsa-miR-573	CLIP-seq
MIRT2559581	hsa-miR-578	CLIP-seq
MIRT2559582	hsa-miR-655	CLIP-seq
MIRT2559583	hsa-miR-885-5p	CLIP-seq
MIRT2559584	hsa-miR-96	CLIP-seq
MIRT2559556	hsa-miR-105	CLIP-seq
MIRT2559557	hsa-miR-1271	CLIP-seq
MIRT2559558	hsa-miR-182	CLIP-seq
MIRT2259201	hsa-miR-219-1-3p	CLIP-seq
MIRT2559559	hsa-miR-3065-5p	CLIP-seq
MIRT2559560	hsa-miR-323-3p	CLIP-seq
MIRT2559561	hsa-miR-3613-3p	CLIP-seq
MIRT2559562	hsa-miR-3646	CLIP-seq
MIRT2559563	hsa-miR-369-3p	CLIP-seq
MIRT2559564	hsa-miR-374a	CLIP-seq
MIRT2559565	hsa-miR-374b	CLIP-seq
MIRT2559566	hsa-miR-374c	CLIP-seq
MIRT2559567	hsa-miR-3973	CLIP-seq
MIRT2559568	hsa-miR-4470	CLIP-seq
MIRT2559569	hsa-miR-4666-3p	CLIP-seq
MIRT2559570	hsa-miR-4766-3p	CLIP-seq
MIRT2559571	hsa-miR-4775	CLIP-seq
MIRT2559572	hsa-miR-4803	CLIP-seq
MIRT2559573	hsa-miR-520d-5p	CLIP-seq
MIRT2559574	hsa-miR-524-5p	CLIP-seq
MIRT2259205	hsa-miR-526b	CLIP-seq
MIRT2559575	hsa-miR-532-5p	CLIP-seq
MIRT2559576	hsa-miR-548ac	CLIP-seq
MIRT2559577	hsa-miR-548d-3p	CLIP-seq
MIRT2559578	hsa-miR-548t	CLIP-seq
MIRT2559579	hsa-miR-548z	CLIP-seq
MIRT2559580	hsa-miR-570	CLIP-seq
MIRT740002	hsa-miR-571	CLIP-seq
MIRT2559581	hsa-miR-578	CLIP-seq
MIRT2559582	hsa-miR-655	CLIP-seq
MIRT2559583	hsa-miR-885-5p	CLIP-seq
MIRT2559584	hsa-miR-96	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	HDA	22658674
GO:0005515	Function	Protein binding	IPI	25416956
GO:0005783	Component	Endoplasmic reticulum	IDA
GO:0005788	Component	Endoplasmic reticulum lumen	TAS
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	TAS	7787243
GO:0007018	Process	Microtubule-based movement	IEA
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016021	Component	Integral component of membrane	TAS	7787244
GO:0019894	Function	Kinesin binding	IEA
GO:0030176	Component	Integral component of endoplasmic reticulum membrane	IEA
GO:0043687	Process	Post-translational protein modification	TAS
GO:0044267	Process	Cellular protein metabolic process	TAS
GO:0045296	Function	Cadherin binding	HDA	25468996

Other IDs

• MIM: 600381
• HGNC: 6467
• e!Ensembl: ENSG00000126777

Protein

• UniProt ID: Q86UP2
• Protein name: Kinectin (CG-1 antigen) (Kinesin receptor)
• Protein function: Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF05104	Rib_recp_KP_reg	29 → 168	Ribosome receptor lysine/proline rich region	Family

• Tissue specificity: TISSUE SPECIFICITY: High levels in peripheral blood lymphocytes, testis and ovary, lower levels in spleen, thymus, prostate, small intestine and colon.
• Sequence:

  MEFYESAYFIVLIPSIVITVIFLFFWLFMKETLYDEVLAKQKREQKLIPTKTDKKKAEKK
  KNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKK
  QKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKK
  VETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNA
  DSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDE
  ALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQ
  EMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIA
  HLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAE
  QAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTL
  VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASV
  LAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANE
  QAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTL
  VSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQ
  DLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKA
  LKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDL
  QEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKT
  QLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKD
  AVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLF
  PKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYK
  SVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIE
  NLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKA
  QLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSE
  KETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE

• Sequence length: 1357

Pathways

Reactome:

Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
RHO GTPases activate KTN1
Post-translational protein phosphorylation

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158, rs80357524, rs80357115, rs80357945, rs80357729, rs80357609, rs80357259, rs80357981, rs80358063, rs80357389, rs80356862, rs80359876, rs80357580, rs80358053, rs80358089, rs80187739, rs397507241, rs80358069, rs80357590, rs80357284, rs80357941, rs80359261, rs80359272, rs80359276, rs276174813, rs80358474, rs80359316, rs1555282969, rs80359388, rs80359499, rs80359505, rs80359520, rs80359526, rs80359533, rs56253082, rs80358824, rs80359554, rs80359636, rs80359651, rs80359659, rs80359011, rs80359012, rs80359013, rs80359718, rs397507410, rs81002812, rs80359730, rs80359152, rs80359159, rs397507419, rs28897759, rs80359211, rs80359775, rs397514577, rs397507584, rs80358435, rs80358456, rs80359340, rs80359343, rs80359365, rs80358579, rs397507670, rs80358593, rs80359406, rs80359444, rs80359454, rs276174853, rs276174854, rs80359483, rs80359537, rs80358815, rs80358843, rs80359558, rs80359560, rs80359594, rs80358893, rs28897743, rs397507900, rs397507906, rs397507918, rs80358971, rs80358981, rs397507941, rs80359030, rs80359035, rs41293511, rs397507396, rs81002806, rs80359112, rs397508006, rs81002893, rs45580035, rs80359760, rs397508051, rs80359772, rs4987049, rs80359777, rs80357770, rs397508867, rs62625303, rs397508874, rs80357506, rs80357287, rs273898674, rs80358042, rs80358083, rs80357058, rs41286296, rs80357960, rs80356945, rs80357223, rs386134270, rs80358116, rs80357856, rs80357424, rs397509050, rs80357485, rs80357966, rs397509067, rs80357310, rs80356866, rs80357260, rs80357437, rs80358023, rs80358086, rs80357133, rs80356993, rs80357997, rs80357239, rs80357227, rs397509243, rs80356969, rs80356959, rs63750617, rs63751319, rs587779315, rs200640585, rs398122546, rs80357543, rs398122687, rs80359328, rs398122779, rs398122783, rs62517194, rs80358029, rs515726060, rs180177103, rs180177111, rs180177133, rs587776527, rs180177135, rs180177136, rs515726117, rs587779813, rs587779909, rs587780024, rs587780100, rs28909982, rs121908698, rs180177100, rs587780210, rs587780240, rs587780639, rs587781269, rs587781353, rs587781471, rs587781658, rs587781697, rs587781730, rs587781894, rs587781948, rs587782005, rs587782011, rs200928781, rs587781558, rs370228071, rs587782245, rs587782401, rs180177110, rs587782504, rs72552322, rs587782531, rs587782620, rs587782680, rs587782774, rs587782818, rs730881411, rs730881389, rs564652222, rs397507768, rs587776419, rs730881868, rs730881940, rs56383036, rs758972589, rs201089102, rs730881348, rs786202608, rs786201886, rs786203318, rs786203775, rs786203714, rs786202033, rs750621215, rs786203884, rs786203650, rs772821016, rs863224521, rs864622223, rs864622655, rs375699023, rs876659572, rs768362387, rs876659535, rs876658957, rs483353072, rs876659435, rs267608041, rs876661113, rs730881369, rs878853535, rs772228129, rs878855122, rs760551339, rs80359596, rs397509222, rs886039630, rs886039683, rs886040828, rs587781799, rs886040374, rs886040649, rs397507967, rs878854957, rs886040043, rs1057517589, rs1060502769, rs866380588, rs863224765, rs1064793243, rs747563556, rs1555074976, rs1064795885, rs753961188, rs1064794708, rs869312772, rs1064793887, rs1131690820, rs1135401928, rs1135401868, rs1135401859, rs1553370324, rs397507630, rs1555283160, rs1555283251, rs1555283262, rs1555283361, rs1555286298, rs1555288462, rs886040950, rs1555289566, rs776323117, rs80357123, rs1555579627, rs1555580697, rs80358054, rs1555593302, rs1328985852, rs763470424, rs1555139694, rs878854697, rs1555461217, rs1555461765, rs774684620, rs766416564, rs1554558613, rs1305740166, rs1555461460, rs1555461407, rs1555461586, rs1555567202, rs1555607022, rs1555069815, rs1442299125, rs1474786480, rs1555084947, rs1555457867, rs141087784, rs1482641121, rs1564830522, rs1565469955, rs1565503137, rs864622613, rs755263466, rs757679199, rs1593903166, rs1597801649, rs1603293306, rs879253880, rs80358754, rs1597062038, rs45494092, rs1603275367, rs887358871, rs1597091518, rs1966967065, rs1064793049, rs2082872908, rs2085078278, rs2072475243

Unknown
Disease term	Disease name	Evidence	References	Source
Parkinson Disease	Parkinson Disease			GWAS
Tremor	Tremor			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Anemia Aplastic	Associate	12947009
Atrophy	Associate	34586830
Attention Deficit Disorder with Hyperactivity	Associate	32190980, 35654767
Carcinoma Squamous Cell	Associate	30683916
Esophageal Neoplasms	Stimulate	36418920
Esophageal Squamous Cell Carcinoma	Associate	36418920
Glioblastoma	Stimulate	36762036
Huntington Disease	Associate	34586830
Lymphatic Metastasis	Stimulate	36418920
Neoplasms	Stimulate	36418920
Neoplasms	Associate	37355145
Squamous Cell Carcinoma of Head and Neck	Stimulate	37355145
Uveal melanoma	Associate	27745836