Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	3895
Gene name	Kinectin 1
Gene symbol	KTN1
Synonyms (NCBI Gene)	CG1KNTMU-RMS-40.19
Chromosome	14
Chromosome location	14q22.3
Summary	This gene encodes an integral membrane protein that is a member of the kinectin protein family. The encoded protein is primarily localized to the endoplasmic reticulum membrane. This protein binds kinesin and may be involved in intracellular organelle mot

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miRTarBase ID	miRNA	Experiments	Reference
MIRT025459	hsa-miR-34a-5p	Proteomics	21566225
MIRT740003	hsa-miR-139-5p	CLIP-seq
MIRT740001	hsa-miR-3618	CLIP-seq
MIRT740006	hsa-miR-4714-5p	CLIP-seq
MIRT740000	hsa-miR-4797-5p	CLIP-seq
MIRT740005	hsa-miR-493	CLIP-seq
MIRT740002	hsa-miR-571	CLIP-seq
MIRT740004	hsa-miR-934	CLIP-seq
MIRT1102440	hsa-miR-1237	CLIP-seq
MIRT1102441	hsa-miR-1248	CLIP-seq
MIRT740003	hsa-miR-139-5p	CLIP-seq
MIRT1102442	hsa-miR-1827	CLIP-seq
MIRT1102443	hsa-miR-199a-3p	CLIP-seq
MIRT1102444	hsa-miR-199b-3p	CLIP-seq
MIRT1102445	hsa-miR-2682	CLIP-seq
MIRT1102446	hsa-miR-3119	CLIP-seq
MIRT1102447	hsa-miR-3129-5p	CLIP-seq
MIRT1102448	hsa-miR-3177-5p	CLIP-seq
MIRT740001	hsa-miR-3618	CLIP-seq
MIRT1102449	hsa-miR-3662	CLIP-seq
MIRT1102450	hsa-miR-3682-5p	CLIP-seq
MIRT1102451	hsa-miR-449c	CLIP-seq
MIRT1102452	hsa-miR-4698	CLIP-seq
MIRT1102453	hsa-miR-4715-5p	CLIP-seq
MIRT740000	hsa-miR-4797-5p	CLIP-seq
MIRT740005	hsa-miR-493	CLIP-seq
MIRT740002	hsa-miR-571	CLIP-seq
MIRT740004	hsa-miR-934	CLIP-seq
MIRT1102454	hsa-miR-935	CLIP-seq
MIRT1102455	hsa-miR-936	CLIP-seq
MIRT2028053	hsa-miR-3182	CLIP-seq
MIRT1102450	hsa-miR-3682-5p	CLIP-seq
MIRT1102452	hsa-miR-4698	CLIP-seq
MIRT2028054	hsa-miR-511	CLIP-seq
MIRT2028055	hsa-miR-548m	CLIP-seq
MIRT1102440	hsa-miR-1237	CLIP-seq
MIRT1102441	hsa-miR-1248	CLIP-seq
MIRT1102442	hsa-miR-1827	CLIP-seq
MIRT1102443	hsa-miR-199a-3p	CLIP-seq
MIRT1102444	hsa-miR-199b-3p	CLIP-seq
MIRT2259201	hsa-miR-219-1-3p	CLIP-seq
MIRT1102445	hsa-miR-2682	CLIP-seq
MIRT1102447	hsa-miR-3129-5p	CLIP-seq
MIRT2259202	hsa-miR-3616-5p	CLIP-seq
MIRT2259203	hsa-miR-3647-5p	CLIP-seq
MIRT1102450	hsa-miR-3682-5p	CLIP-seq
MIRT2259204	hsa-miR-4257	CLIP-seq
MIRT1102451	hsa-miR-449c	CLIP-seq
MIRT2259205	hsa-miR-526b	CLIP-seq
MIRT740002	hsa-miR-571	CLIP-seq
MIRT2259206	hsa-miR-573	CLIP-seq
MIRT1102454	hsa-miR-935	CLIP-seq
MIRT1102455	hsa-miR-936	CLIP-seq
MIRT2559556	hsa-miR-105	CLIP-seq
MIRT2559557	hsa-miR-1271	CLIP-seq
MIRT2559558	hsa-miR-182	CLIP-seq
MIRT2259201	hsa-miR-219-1-3p	CLIP-seq
MIRT2559559	hsa-miR-3065-5p	CLIP-seq
MIRT2559560	hsa-miR-323-3p	CLIP-seq
MIRT2559561	hsa-miR-3613-3p	CLIP-seq
MIRT2259202	hsa-miR-3616-5p	CLIP-seq
MIRT2559562	hsa-miR-3646	CLIP-seq
MIRT2259203	hsa-miR-3647-5p	CLIP-seq
MIRT2559563	hsa-miR-369-3p	CLIP-seq
MIRT2559564	hsa-miR-374a	CLIP-seq
MIRT2559565	hsa-miR-374b	CLIP-seq
MIRT2559566	hsa-miR-374c	CLIP-seq
MIRT2559567	hsa-miR-3973	CLIP-seq
MIRT2559568	hsa-miR-4470	CLIP-seq
MIRT2559569	hsa-miR-4666-3p	CLIP-seq
MIRT2559570	hsa-miR-4766-3p	CLIP-seq
MIRT2559571	hsa-miR-4775	CLIP-seq
MIRT2559572	hsa-miR-4803	CLIP-seq
MIRT2559573	hsa-miR-520d-5p	CLIP-seq
MIRT2559574	hsa-miR-524-5p	CLIP-seq
MIRT2259205	hsa-miR-526b	CLIP-seq
MIRT2559575	hsa-miR-532-5p	CLIP-seq
MIRT2559576	hsa-miR-548ac	CLIP-seq
MIRT2559577	hsa-miR-548d-3p	CLIP-seq
MIRT2559578	hsa-miR-548t	CLIP-seq
MIRT2559579	hsa-miR-548z	CLIP-seq
MIRT2559580	hsa-miR-570	CLIP-seq
MIRT740002	hsa-miR-571	CLIP-seq
MIRT2259206	hsa-miR-573	CLIP-seq
MIRT2559581	hsa-miR-578	CLIP-seq
MIRT2559582	hsa-miR-655	CLIP-seq
MIRT2559583	hsa-miR-885-5p	CLIP-seq
MIRT2559584	hsa-miR-96	CLIP-seq
MIRT2559556	hsa-miR-105	CLIP-seq
MIRT2559557	hsa-miR-1271	CLIP-seq
MIRT2559558	hsa-miR-182	CLIP-seq
MIRT2259201	hsa-miR-219-1-3p	CLIP-seq
MIRT2559559	hsa-miR-3065-5p	CLIP-seq
MIRT2559560	hsa-miR-323-3p	CLIP-seq
MIRT2559561	hsa-miR-3613-3p	CLIP-seq
MIRT2559562	hsa-miR-3646	CLIP-seq
MIRT2559563	hsa-miR-369-3p	CLIP-seq
MIRT2559564	hsa-miR-374a	CLIP-seq
MIRT2559565	hsa-miR-374b	CLIP-seq
MIRT2559566	hsa-miR-374c	CLIP-seq
MIRT2559567	hsa-miR-3973	CLIP-seq
MIRT2559568	hsa-miR-4470	CLIP-seq
MIRT2559569	hsa-miR-4666-3p	CLIP-seq
MIRT2559570	hsa-miR-4766-3p	CLIP-seq
MIRT2559571	hsa-miR-4775	CLIP-seq
MIRT2559572	hsa-miR-4803	CLIP-seq
MIRT2559573	hsa-miR-520d-5p	CLIP-seq
MIRT2559574	hsa-miR-524-5p	CLIP-seq
MIRT2259205	hsa-miR-526b	CLIP-seq
MIRT2559575	hsa-miR-532-5p	CLIP-seq
MIRT2559576	hsa-miR-548ac	CLIP-seq
MIRT2559577	hsa-miR-548d-3p	CLIP-seq
MIRT2559578	hsa-miR-548t	CLIP-seq
MIRT2559579	hsa-miR-548z	CLIP-seq
MIRT2559580	hsa-miR-570	CLIP-seq
MIRT740002	hsa-miR-571	CLIP-seq
MIRT2559581	hsa-miR-578	CLIP-seq
MIRT2559582	hsa-miR-655	CLIP-seq
MIRT2559583	hsa-miR-885-5p	CLIP-seq
MIRT2559584	hsa-miR-96	CLIP-seq

Show/Hide all (16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	HDA	22658674
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005783	Component	Endoplasmic reticulum	IDA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005788	Component	Endoplasmic reticulum lumen	TAS
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	TAS	7787243
GO:0005886	Component	Plasma membrane	TAS	7787243
GO:0007018	Process	Microtubule-based movement	IEA
GO:0007018	Process	Microtubule-based movement	NAS	7787243
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	7787243, 7787244
GO:0019894	Function	Kinesin binding	IEA
GO:0045296	Function	Cadherin binding	HDA	25468996

MIM	HGNC	e!Ensembl
600381	6467	ENSG00000126777

Q86UP2

Protein name

Kinectin (CG-1 antigen) (Kinesin receptor)

Protein function

Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF05104	Rib_recp_KP_reg	29 → 168	Ribosome receptor lysine/proline rich region	Family

Tissue specificity

TISSUE SPECIFICITY: High levels in peripheral blood lymphocytes, testis and ovary, lower levels in spleen, thymus, prostate, small intestine and colon.

Sequence

MEFYESAYFIVLIPSIVITVIFLFFWLFMKETLYDEVLAKQKREQKLIPTKTDKKKAEKK
KNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKK
QKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKK
VETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNA
DSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDE
ALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQ
EMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIA
HLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAE
QAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTL
VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASV
LAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANE
QAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTL
VSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQ
DLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKA
LKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDL
QEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKT
QLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKD
AVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLF
PKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYK
SVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIE
NLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKA
QLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSE
KETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE

Sequence length

1357

Interactions

View interactions

	Reactome
			Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RHO GTPases activate KTN1 Post-translational protein phosphorylation

Show/Hide Unknown Diseases (13)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Acute myeloid leukemia	Benign	rs17128636	RCV005910228
Adrenocortical carcinoma, hereditary	Benign	rs17128636	RCV005910232
Cervical cancer	Benign	rs17128636	RCV005910233
Clear cell carcinoma of kidney	Benign	rs17128636	RCV005910234
Colon adenocarcinoma	Benign	rs17128636	RCV005910227
Gastric cancer	Benign	rs17128636	RCV005910236
Hepatocellular carcinoma	Benign	rs17128636	RCV005910229
Lung cancer	Benign	rs17128636	RCV005910238
Malignant tumor of esophagus	Benign	rs17128636	RCV005910230
Nonpapillary renal cell carcinoma	Benign	rs17128636	RCV005910231
Ovarian serous cystadenocarcinoma	Benign	rs17128636	RCV005910237
Sarcoma	Benign	rs17128636	RCV005910235
Uterine corpus endometrial carcinoma	Benign	rs17128636	RCV005910239

Show/Hide Text Mining Associations (13)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Anemia Aplastic	Associate	12947009
Atrophy	Associate	34586830
Attention Deficit Disorder with Hyperactivity	Associate	32190980, 35654767
Carcinoma Squamous Cell	Associate	30683916
Esophageal Neoplasms	Stimulate	36418920
Esophageal Squamous Cell Carcinoma	Associate	36418920
Glioblastoma	Stimulate	36762036
Huntington Disease	Associate	34586830
Lymphatic Metastasis	Stimulate	36418920
Neoplasms	Stimulate	36418920
Neoplasms	Associate	37355145
Squamous Cell Carcinoma of Head and Neck	Stimulate	37355145
Uveal melanoma	Associate	27745836

KTN1 (kinectin 1)