IYD (iodotyrosine deiodinase)

Gene

• Entrez ID: 389434
• Gene name: Iodotyrosine deiodinase
• Gene symbol: IYD
• Synonyms (NCBI Gene): C6orf71, DEHAL1, IYD-1, TDH4
• Chromosome: 6
• Chromosome location: 6q25.1
• Summary: This gene encodes an enzyme that catalyzes the oxidative NADPH-dependent deiodination of mono- and diiodotyrosine, which are the halogenated byproducts of thyroid hormone production. The N-terminus of the protein functions as a membrane anchor. Mutations

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs121918138	C>T	Pathogenic	Missense variant, non coding transcript variant, coding sequence variant, synonymous variant
rs121918139	T>C	Pathogenic	Missense variant, non coding transcript variant, intron variant, coding sequence variant
rs121918140	G>A	Pathogenic	Missense variant, non coding transcript variant, coding sequence variant
rs863223276	CAT>-	Pathogenic	Inframe indel, coding sequence variant, intron variant, non coding transcript variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017241	hsa-miR-335-5p	Microarray	18185580
MIRT693866	hsa-miR-4781-3p	HITS-CLIP	23313552
MIRT693865	hsa-miR-4716-5p	HITS-CLIP	23313552
MIRT693864	hsa-miR-3663-5p	HITS-CLIP	23313552
MIRT693863	hsa-miR-4680-5p	HITS-CLIP	23313552
MIRT693862	hsa-miR-4755-3p	HITS-CLIP	23313552
MIRT693861	hsa-miR-6131	HITS-CLIP	23313552
MIRT693860	hsa-miR-197-3p	HITS-CLIP	23313552
MIRT693859	hsa-miR-526b-5p	HITS-CLIP	23313552
MIRT693858	hsa-miR-548s	HITS-CLIP	23313552
MIRT693857	hsa-miR-4701-5p	HITS-CLIP	23313552
MIRT693856	hsa-miR-588	HITS-CLIP	23313552
MIRT693855	hsa-miR-4435	HITS-CLIP	23313552
MIRT693853	hsa-miR-3187-3p	HITS-CLIP	23313552
MIRT693854	hsa-miR-6843-3p	HITS-CLIP	23313552
MIRT693852	hsa-miR-6848-3p	HITS-CLIP	23313552
MIRT693851	hsa-miR-5096	HITS-CLIP	23313552
MIRT663502	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT663501	hsa-miR-1267	HITS-CLIP	23824327
MIRT663500	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT663499	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT663498	hsa-miR-3135b	HITS-CLIP	23824327
MIRT663497	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT663496	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT663495	hsa-miR-3652	HITS-CLIP	23824327
MIRT663494	hsa-miR-4430	HITS-CLIP	23824327
MIRT663492	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT663491	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT663490	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT663489	hsa-miR-4642	HITS-CLIP	23824327
MIRT663488	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT663487	hsa-miR-5698	HITS-CLIP	23824327
MIRT663503	hsa-miR-6812-3p	HITS-CLIP	23824327
MIRT663502	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT663501	hsa-miR-1267	HITS-CLIP	23824327
MIRT663500	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT663499	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT663498	hsa-miR-3135b	HITS-CLIP	23824327
MIRT663497	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT663496	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT663495	hsa-miR-3652	HITS-CLIP	23824327
MIRT663494	hsa-miR-4430	HITS-CLIP	23824327
MIRT663493	hsa-miR-597-3p	HITS-CLIP	23824327
MIRT663492	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT663491	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT663490	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT663489	hsa-miR-4642	HITS-CLIP	23824327
MIRT663488	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT663487	hsa-miR-5698	HITS-CLIP	23824327
MIRT529512	hsa-miR-532-5p	PAR-CLIP	22012620
MIRT529511	hsa-miR-4778-5p	PAR-CLIP	22012620
MIRT529510	hsa-miR-6760-3p	PAR-CLIP	22012620
MIRT529509	hsa-miR-1208	PAR-CLIP	22012620
MIRT529508	hsa-miR-26a-1-3p	PAR-CLIP	22012620
MIRT529507	hsa-miR-26a-2-3p	PAR-CLIP	22012620
MIRT529506	hsa-miR-3920	PAR-CLIP	22012620
MIRT529505	hsa-miR-29a-5p	PAR-CLIP	22012620
MIRT529504	hsa-miR-4633-5p	PAR-CLIP	22012620
MIRT529503	hsa-miR-181b-2-3p	PAR-CLIP	22012620
MIRT529502	hsa-miR-181b-3p	PAR-CLIP	22012620
MIRT529501	hsa-miR-4420	PAR-CLIP	22012620
MIRT529500	hsa-miR-653-3p	PAR-CLIP	22012620
MIRT529499	hsa-miR-3192-3p	PAR-CLIP	22012620
MIRT529498	hsa-miR-676-3p	PAR-CLIP	22012620
MIRT529497	hsa-miR-491-3p	PAR-CLIP	22012620
MIRT529496	hsa-miR-4762-3p	PAR-CLIP	22012620
MIRT693866	hsa-miR-4781-3p	HITS-CLIP	23313552
MIRT693865	hsa-miR-4716-5p	HITS-CLIP	23313552
MIRT693864	hsa-miR-3663-5p	HITS-CLIP	23313552
MIRT693863	hsa-miR-4680-5p	HITS-CLIP	23313552
MIRT693862	hsa-miR-4755-3p	HITS-CLIP	23313552
MIRT693861	hsa-miR-6131	HITS-CLIP	23313552
MIRT693860	hsa-miR-197-3p	HITS-CLIP	23313552
MIRT693859	hsa-miR-526b-5p	HITS-CLIP	23313552
MIRT693858	hsa-miR-548s	HITS-CLIP	23313552
MIRT693857	hsa-miR-4701-5p	HITS-CLIP	23313552
MIRT693856	hsa-miR-588	HITS-CLIP	23313552
MIRT693855	hsa-miR-4435	HITS-CLIP	23313552
MIRT693853	hsa-miR-3187-3p	HITS-CLIP	23313552
MIRT693854	hsa-miR-6843-3p	HITS-CLIP	23313552
MIRT693852	hsa-miR-6848-3p	HITS-CLIP	23313552
MIRT693851	hsa-miR-5096	HITS-CLIP	23313552
MIRT663502	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT663501	hsa-miR-1267	HITS-CLIP	23824327
MIRT663500	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT663499	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT663498	hsa-miR-3135b	HITS-CLIP	23824327
MIRT663497	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT663496	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT663495	hsa-miR-3652	HITS-CLIP	23824327
MIRT663494	hsa-miR-4430	HITS-CLIP	23824327
MIRT663492	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT663491	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT663490	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT663489	hsa-miR-4642	HITS-CLIP	23824327
MIRT663488	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT663487	hsa-miR-5698	HITS-CLIP	23824327
MIRT663503	hsa-miR-6812-3p	HITS-CLIP	23824327
MIRT663502	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT663501	hsa-miR-1267	HITS-CLIP	23824327
MIRT663500	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT663499	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT663498	hsa-miR-3135b	HITS-CLIP	23824327
MIRT663497	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT663496	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT663495	hsa-miR-3652	HITS-CLIP	23824327
MIRT663494	hsa-miR-4430	HITS-CLIP	23824327
MIRT663493	hsa-miR-597-3p	HITS-CLIP	23824327
MIRT663492	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT663491	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT663490	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT663489	hsa-miR-4642	HITS-CLIP	23824327
MIRT663488	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT663487	hsa-miR-5698	HITS-CLIP	23824327
MIRT529512	hsa-miR-532-5p	PAR-CLIP	22012620
MIRT529511	hsa-miR-4778-5p	PAR-CLIP	22012620
MIRT529510	hsa-miR-6760-3p	PAR-CLIP	22012620
MIRT529509	hsa-miR-1208	PAR-CLIP	22012620
MIRT529508	hsa-miR-26a-1-3p	PAR-CLIP	22012620
MIRT529507	hsa-miR-26a-2-3p	PAR-CLIP	22012620
MIRT529506	hsa-miR-3920	PAR-CLIP	22012620
MIRT529505	hsa-miR-29a-5p	PAR-CLIP	22012620
MIRT529504	hsa-miR-4633-5p	PAR-CLIP	22012620
MIRT529503	hsa-miR-181b-2-3p	PAR-CLIP	22012620
MIRT529502	hsa-miR-181b-3p	PAR-CLIP	22012620
MIRT529501	hsa-miR-4420	PAR-CLIP	22012620
MIRT529500	hsa-miR-653-3p	PAR-CLIP	22012620
MIRT529499	hsa-miR-3192-3p	PAR-CLIP	22012620
MIRT529498	hsa-miR-676-3p	PAR-CLIP	22012620
MIRT529497	hsa-miR-491-3p	PAR-CLIP	22012620
MIRT529496	hsa-miR-4762-3p	PAR-CLIP	22012620
MIRT1075723	hsa-miR-1224-5p	CLIP-seq
MIRT1075724	hsa-miR-1305	CLIP-seq
MIRT1075725	hsa-miR-146a	CLIP-seq
MIRT1075726	hsa-miR-146b-5p	CLIP-seq
MIRT1075727	hsa-miR-197	CLIP-seq
MIRT1075728	hsa-miR-2116	CLIP-seq
MIRT1075729	hsa-miR-3144-3p	CLIP-seq
MIRT1075730	hsa-miR-3662	CLIP-seq
MIRT1075731	hsa-miR-3671	CLIP-seq
MIRT1075732	hsa-miR-3675-5p	CLIP-seq
MIRT1075733	hsa-miR-3688-3p	CLIP-seq
MIRT1075734	hsa-miR-4253	CLIP-seq
MIRT1075735	hsa-miR-4495	CLIP-seq
MIRT1075736	hsa-miR-4659a-3p	CLIP-seq
MIRT1075737	hsa-miR-4659b-3p	CLIP-seq
MIRT1075738	hsa-miR-4677-5p	CLIP-seq
MIRT1075739	hsa-miR-4751	CLIP-seq
MIRT1075740	hsa-miR-4762-5p	CLIP-seq
MIRT1075741	hsa-miR-4799-5p	CLIP-seq
MIRT1075742	hsa-miR-486-3p	CLIP-seq
MIRT1075743	hsa-miR-513c	CLIP-seq
MIRT1075744	hsa-miR-514b-5p	CLIP-seq
MIRT1075745	hsa-miR-543	CLIP-seq
MIRT1075746	hsa-miR-548ac	CLIP-seq
MIRT1075747	hsa-miR-548ae	CLIP-seq
MIRT1075748	hsa-miR-548aj	CLIP-seq
MIRT1075749	hsa-miR-548am	CLIP-seq
MIRT1075750	hsa-miR-548d-3p	CLIP-seq
MIRT1075751	hsa-miR-548x	CLIP-seq
MIRT1075752	hsa-miR-548z	CLIP-seq
MIRT1075753	hsa-miR-568	CLIP-seq
MIRT1075754	hsa-miR-578	CLIP-seq
MIRT1075755	hsa-miR-589	CLIP-seq
MIRT1075756	hsa-miR-607	CLIP-seq
MIRT1075757	hsa-miR-643	CLIP-seq
MIRT1075758	hsa-miR-875-5p	CLIP-seq
MIRT1075759	hsa-miR-106a	CLIP-seq
MIRT1075760	hsa-miR-106b	CLIP-seq
MIRT1075761	hsa-miR-1224-3p	CLIP-seq
MIRT1075762	hsa-miR-1234	CLIP-seq
MIRT1075763	hsa-miR-1275	CLIP-seq
MIRT1075764	hsa-miR-1323	CLIP-seq
MIRT1075765	hsa-miR-150	CLIP-seq
MIRT1075766	hsa-miR-17	CLIP-seq
MIRT1075767	hsa-miR-1913	CLIP-seq
MIRT1075768	hsa-miR-20a	CLIP-seq
MIRT1075769	hsa-miR-20b	CLIP-seq
MIRT1075770	hsa-miR-2276	CLIP-seq
MIRT1075771	hsa-miR-302a	CLIP-seq
MIRT1075772	hsa-miR-302b	CLIP-seq
MIRT1075773	hsa-miR-302c	CLIP-seq
MIRT1075774	hsa-miR-302d	CLIP-seq
MIRT1075775	hsa-miR-302e	CLIP-seq
MIRT1075776	hsa-miR-3176	CLIP-seq
MIRT1075777	hsa-miR-324-3p	CLIP-seq
MIRT1075778	hsa-miR-3670	CLIP-seq
MIRT1075779	hsa-miR-372	CLIP-seq
MIRT1075780	hsa-miR-373	CLIP-seq
MIRT1075781	hsa-miR-3908	CLIP-seq
MIRT1075782	hsa-miR-3922-3p	CLIP-seq
MIRT1075783	hsa-miR-409-5p	CLIP-seq
MIRT1075784	hsa-miR-4252	CLIP-seq
MIRT1075785	hsa-miR-4269	CLIP-seq
MIRT1075786	hsa-miR-4272	CLIP-seq
MIRT1075787	hsa-miR-4307	CLIP-seq
MIRT1075788	hsa-miR-4434	CLIP-seq
MIRT1075789	hsa-miR-4438	CLIP-seq
MIRT1075790	hsa-miR-4447	CLIP-seq
MIRT1075791	hsa-miR-4472	CLIP-seq
MIRT1075792	hsa-miR-4514	CLIP-seq
MIRT1075793	hsa-miR-4516	CLIP-seq
MIRT1075794	hsa-miR-4525	CLIP-seq
MIRT1075795	hsa-miR-4529-5p	CLIP-seq
MIRT1075796	hsa-miR-4531	CLIP-seq
MIRT1075797	hsa-miR-4665-5p	CLIP-seq
MIRT1075798	hsa-miR-4692	CLIP-seq
MIRT1075799	hsa-miR-4723-5p	CLIP-seq
MIRT1075800	hsa-miR-4731-5p	CLIP-seq
MIRT1075801	hsa-miR-4742-5p	CLIP-seq
MIRT1075802	hsa-miR-5095	CLIP-seq
MIRT1075803	hsa-miR-512-3p	CLIP-seq
MIRT1075804	hsa-miR-516b	CLIP-seq
MIRT1075805	hsa-miR-519d	CLIP-seq
MIRT1075806	hsa-miR-520a-3p	CLIP-seq
MIRT1075807	hsa-miR-520b	CLIP-seq
MIRT1075808	hsa-miR-520c-3p	CLIP-seq
MIRT1075809	hsa-miR-520d-3p	CLIP-seq
MIRT1075810	hsa-miR-520e	CLIP-seq
MIRT1075811	hsa-miR-520g	CLIP-seq
MIRT1075812	hsa-miR-520h	CLIP-seq
MIRT1075813	hsa-miR-526b	CLIP-seq
MIRT1075814	hsa-miR-548o	CLIP-seq
MIRT1075815	hsa-miR-625	CLIP-seq
MIRT1075816	hsa-miR-651	CLIP-seq
MIRT1075817	hsa-miR-802	CLIP-seq
MIRT1075818	hsa-miR-93	CLIP-seq
MIRT1075819	hsa-miR-1	CLIP-seq
MIRT1075820	hsa-miR-15a	CLIP-seq
MIRT1075821	hsa-miR-15b	CLIP-seq
MIRT1075822	hsa-miR-16	CLIP-seq
MIRT1075823	hsa-miR-184	CLIP-seq
MIRT1075824	hsa-miR-18a	CLIP-seq
MIRT1075825	hsa-miR-18b	CLIP-seq
MIRT1075826	hsa-miR-1910	CLIP-seq
MIRT1075827	hsa-miR-195	CLIP-seq
MIRT1075828	hsa-miR-206	CLIP-seq
MIRT1075829	hsa-miR-218	CLIP-seq
MIRT1075830	hsa-miR-298	CLIP-seq
MIRT1075831	hsa-miR-3121-5p	CLIP-seq
MIRT1075832	hsa-miR-3122	CLIP-seq
MIRT1075833	hsa-miR-3132	CLIP-seq
MIRT1075834	hsa-miR-3136-5p	CLIP-seq
MIRT1075835	hsa-miR-3151	CLIP-seq
MIRT1075836	hsa-miR-3154	CLIP-seq
MIRT1075837	hsa-miR-3160-3p	CLIP-seq
MIRT1075838	hsa-miR-342-5p	CLIP-seq
MIRT1075839	hsa-miR-3591-5p	CLIP-seq
MIRT1075840	hsa-miR-3612	CLIP-seq
MIRT1075841	hsa-miR-3614-5p	CLIP-seq
MIRT1075842	hsa-miR-3657	CLIP-seq
MIRT1075843	hsa-miR-3689a-3p	CLIP-seq
MIRT1075844	hsa-miR-3689c	CLIP-seq
MIRT1075845	hsa-miR-3689d	CLIP-seq
MIRT1075846	hsa-miR-3913-5p	CLIP-seq
MIRT1075847	hsa-miR-3942-3p	CLIP-seq
MIRT1075848	hsa-miR-424	CLIP-seq
MIRT1075849	hsa-miR-4260	CLIP-seq
MIRT1075850	hsa-miR-4439	CLIP-seq
MIRT1075790	hsa-miR-4447	CLIP-seq
MIRT1075851	hsa-miR-4455	CLIP-seq
MIRT1075791	hsa-miR-4472	CLIP-seq
MIRT1075852	hsa-miR-4505	CLIP-seq
MIRT1075853	hsa-miR-4524	CLIP-seq
MIRT1075854	hsa-miR-455-3p	CLIP-seq
MIRT1075855	hsa-miR-4650-3p	CLIP-seq
MIRT1075856	hsa-miR-4651	CLIP-seq
MIRT1075857	hsa-miR-4664-5p	CLIP-seq
MIRT1075858	hsa-miR-4669	CLIP-seq
MIRT1075859	hsa-miR-4675	CLIP-seq
MIRT1075860	hsa-miR-4677-3p	CLIP-seq
MIRT1075861	hsa-miR-4725-5p	CLIP-seq
MIRT1075862	hsa-miR-4728-5p	CLIP-seq
MIRT1075800	hsa-miR-4731-5p	CLIP-seq
MIRT1075863	hsa-miR-4735-3p	CLIP-seq
MIRT1075864	hsa-miR-4741	CLIP-seq
MIRT1075865	hsa-miR-4804-5p	CLIP-seq
MIRT1075742	hsa-miR-486-3p	CLIP-seq
MIRT1075866	hsa-miR-491-5p	CLIP-seq
MIRT1075867	hsa-miR-497	CLIP-seq
MIRT1075868	hsa-miR-503	CLIP-seq
MIRT1075869	hsa-miR-504	CLIP-seq
MIRT1075870	hsa-miR-539	CLIP-seq
MIRT1075871	hsa-miR-587	CLIP-seq
MIRT1075872	hsa-miR-592	CLIP-seq
MIRT1075873	hsa-miR-599	CLIP-seq
MIRT1075874	hsa-miR-608	CLIP-seq
MIRT1075875	hsa-miR-613	CLIP-seq
MIRT1075876	hsa-miR-636	CLIP-seq
MIRT1075877	hsa-miR-637	CLIP-seq
MIRT1075878	hsa-miR-646	CLIP-seq
MIRT1075879	hsa-miR-648	CLIP-seq
MIRT1075880	hsa-miR-650	CLIP-seq
MIRT1075881	hsa-miR-668	CLIP-seq
MIRT1075882	hsa-miR-892a	CLIP-seq
MIRT1075883	hsa-miR-922	CLIP-seq
MIRT1075884	hsa-miR-943	CLIP-seq
MIRT1075840	hsa-miR-3612	CLIP-seq
MIRT1550355	hsa-miR-4443	CLIP-seq
MIRT1550356	hsa-miR-485-5p	CLIP-seq
MIRT1550357	hsa-miR-610	CLIP-seq
MIRT1075880	hsa-miR-650	CLIP-seq
MIRT2018825	hsa-miR-1292	CLIP-seq
MIRT1075832	hsa-miR-3122	CLIP-seq
MIRT2018826	hsa-miR-3145-5p	CLIP-seq
MIRT2018827	hsa-miR-323b-3p	CLIP-seq
MIRT1075846	hsa-miR-3913-5p	CLIP-seq
MIRT2018828	hsa-miR-4471	CLIP-seq
MIRT2018829	hsa-miR-9	CLIP-seq
MIRT1075759	hsa-miR-106a	CLIP-seq
MIRT1075760	hsa-miR-106b	CLIP-seq
MIRT2250707	hsa-miR-1206	CLIP-seq
MIRT1075761	hsa-miR-1224-3p	CLIP-seq
MIRT2250708	hsa-miR-1260	CLIP-seq
MIRT2250709	hsa-miR-1260b	CLIP-seq
MIRT2250710	hsa-miR-1262	CLIP-seq
MIRT2250711	hsa-miR-1269	CLIP-seq
MIRT2250712	hsa-miR-1269b	CLIP-seq
MIRT2250713	hsa-miR-1273f	CLIP-seq
MIRT1075724	hsa-miR-1305	CLIP-seq
MIRT2250714	hsa-miR-1321	CLIP-seq
MIRT2250715	hsa-miR-145	CLIP-seq
MIRT1075766	hsa-miR-17	CLIP-seq
MIRT2250716	hsa-miR-188-3p	CLIP-seq
MIRT1075727	hsa-miR-197	CLIP-seq
MIRT2250717	hsa-miR-2052	CLIP-seq
MIRT1075768	hsa-miR-20a	CLIP-seq
MIRT1075769	hsa-miR-20b	CLIP-seq
MIRT2250718	hsa-miR-2110	CLIP-seq
MIRT1075728	hsa-miR-2116	CLIP-seq
MIRT2250719	hsa-miR-2117	CLIP-seq
MIRT2250720	hsa-miR-217	CLIP-seq
MIRT2250721	hsa-miR-224	CLIP-seq
MIRT2250722	hsa-miR-3140-5p	CLIP-seq
MIRT1075729	hsa-miR-3144-3p	CLIP-seq
MIRT2250723	hsa-miR-3150a-3p	CLIP-seq
MIRT2250724	hsa-miR-3156-3p	CLIP-seq
MIRT2250725	hsa-miR-3170	CLIP-seq
MIRT2250726	hsa-miR-3173-3p	CLIP-seq
MIRT2250727	hsa-miR-3609	CLIP-seq
MIRT1075840	hsa-miR-3612	CLIP-seq
MIRT2250728	hsa-miR-3622a-3p	CLIP-seq
MIRT2250729	hsa-miR-3622b-3p	CLIP-seq
MIRT1075731	hsa-miR-3671	CLIP-seq
MIRT2250730	hsa-miR-377	CLIP-seq
MIRT1075847	hsa-miR-3942-3p	CLIP-seq
MIRT2250731	hsa-miR-411	CLIP-seq
MIRT1075734	hsa-miR-4253	CLIP-seq
MIRT2250732	hsa-miR-4255	CLIP-seq
MIRT1075849	hsa-miR-4260	CLIP-seq
MIRT2250733	hsa-miR-4271	CLIP-seq
MIRT2250734	hsa-miR-4293	CLIP-seq
MIRT1075787	hsa-miR-4307	CLIP-seq
MIRT2250735	hsa-miR-4452	CLIP-seq
MIRT2250736	hsa-miR-451b	CLIP-seq
MIRT2250737	hsa-miR-4529-3p	CLIP-seq
MIRT1075860	hsa-miR-4677-3p	CLIP-seq
MIRT1075738	hsa-miR-4677-5p	CLIP-seq
MIRT2250738	hsa-miR-4701-3p	CLIP-seq
MIRT2250739	hsa-miR-4724-3p	CLIP-seq
MIRT2250740	hsa-miR-4725-3p	CLIP-seq
MIRT1075800	hsa-miR-4731-5p	CLIP-seq
MIRT2250741	hsa-miR-4733-5p	CLIP-seq
MIRT2250742	hsa-miR-4739	CLIP-seq
MIRT2250743	hsa-miR-4756-5p	CLIP-seq
MIRT2250744	hsa-miR-4796-3p	CLIP-seq
MIRT1075805	hsa-miR-519d	CLIP-seq
MIRT1075811	hsa-miR-520g	CLIP-seq
MIRT1075812	hsa-miR-520h	CLIP-seq
MIRT1075870	hsa-miR-539	CLIP-seq
MIRT2250745	hsa-miR-542-3p	CLIP-seq
MIRT2250746	hsa-miR-548ah	CLIP-seq
MIRT1075871	hsa-miR-587	CLIP-seq
MIRT2250747	hsa-miR-596	CLIP-seq
MIRT1075756	hsa-miR-607	CLIP-seq
MIRT2250748	hsa-miR-617	CLIP-seq
MIRT2250749	hsa-miR-619	CLIP-seq
MIRT1075880	hsa-miR-650	CLIP-seq
MIRT2250750	hsa-miR-661	CLIP-seq
MIRT1075758	hsa-miR-875-5p	CLIP-seq
MIRT1075883	hsa-miR-922	CLIP-seq
MIRT1075818	hsa-miR-93	CLIP-seq
MIRT2389534	hsa-miR-2467-5p	CLIP-seq
MIRT2250725	hsa-miR-3170	CLIP-seq
MIRT2389535	hsa-miR-4266	CLIP-seq
MIRT2389536	hsa-miR-4695-5p	CLIP-seq
MIRT2389537	hsa-miR-4779	CLIP-seq
MIRT2389538	hsa-miR-615-5p	CLIP-seq
MIRT2250707	hsa-miR-1206	CLIP-seq
MIRT2452055	hsa-miR-1261	CLIP-seq
MIRT2250713	hsa-miR-1273f	CLIP-seq
MIRT2452056	hsa-miR-129-5p	CLIP-seq
MIRT2452057	hsa-miR-3149	CLIP-seq
MIRT2250725	hsa-miR-3170	CLIP-seq
MIRT2452058	hsa-miR-3681	CLIP-seq
MIRT2250731	hsa-miR-411	CLIP-seq
MIRT2452059	hsa-miR-4735-5p	CLIP-seq
MIRT2452060	hsa-miR-4775	CLIP-seq
MIRT2250744	hsa-miR-4796-3p	CLIP-seq
MIRT2452061	hsa-miR-519a	CLIP-seq
MIRT2452062	hsa-miR-519b-3p	CLIP-seq
MIRT2452063	hsa-miR-519c-3p	CLIP-seq
MIRT1075811	hsa-miR-520g	CLIP-seq
MIRT1075812	hsa-miR-520h	CLIP-seq
MIRT2452064	hsa-miR-586	CLIP-seq
MIRT2452065	hsa-miR-590-3p	CLIP-seq
MIRT2452066	hsa-miR-720	CLIP-seq
MIRT2250707	hsa-miR-1206	CLIP-seq
MIRT2452055	hsa-miR-1261	CLIP-seq
MIRT2250711	hsa-miR-1269	CLIP-seq
MIRT2250712	hsa-miR-1269b	CLIP-seq
MIRT2465499	hsa-miR-3616-3p	CLIP-seq
MIRT2452058	hsa-miR-3681	CLIP-seq
MIRT2250737	hsa-miR-4529-3p	CLIP-seq
MIRT2250744	hsa-miR-4796-3p	CLIP-seq
MIRT1075811	hsa-miR-520g	CLIP-seq
MIRT1075812	hsa-miR-520h	CLIP-seq
MIRT2452064	hsa-miR-586	CLIP-seq
MIRT2250748	hsa-miR-617	CLIP-seq
MIRT1075759	hsa-miR-106a	CLIP-seq
MIRT1075760	hsa-miR-106b	CLIP-seq
MIRT1075762	hsa-miR-1234	CLIP-seq
MIRT2250713	hsa-miR-1273f	CLIP-seq
MIRT2452056	hsa-miR-129-5p	CLIP-seq
MIRT1075765	hsa-miR-150	CLIP-seq
MIRT1075766	hsa-miR-17	CLIP-seq
MIRT1075727	hsa-miR-197	CLIP-seq
MIRT1075768	hsa-miR-20a	CLIP-seq
MIRT1075769	hsa-miR-20b	CLIP-seq
MIRT1075771	hsa-miR-302a	CLIP-seq
MIRT1075772	hsa-miR-302b	CLIP-seq
MIRT1075773	hsa-miR-302c	CLIP-seq
MIRT1075774	hsa-miR-302d	CLIP-seq
MIRT1075775	hsa-miR-302e	CLIP-seq
MIRT2452057	hsa-miR-3149	CLIP-seq
MIRT2250725	hsa-miR-3170	CLIP-seq
MIRT1075779	hsa-miR-372	CLIP-seq
MIRT1075780	hsa-miR-373	CLIP-seq
MIRT2250731	hsa-miR-411	CLIP-seq
MIRT1075800	hsa-miR-4731-5p	CLIP-seq
MIRT2452059	hsa-miR-4735-5p	CLIP-seq
MIRT2452060	hsa-miR-4775	CLIP-seq
MIRT1075802	hsa-miR-5095	CLIP-seq
MIRT1075803	hsa-miR-512-3p	CLIP-seq
MIRT2452061	hsa-miR-519a	CLIP-seq
MIRT2452062	hsa-miR-519b-3p	CLIP-seq
MIRT2452063	hsa-miR-519c-3p	CLIP-seq
MIRT1075805	hsa-miR-519d	CLIP-seq
MIRT1075806	hsa-miR-520a-3p	CLIP-seq
MIRT1075807	hsa-miR-520b	CLIP-seq
MIRT1075808	hsa-miR-520c-3p	CLIP-seq
MIRT1075809	hsa-miR-520d-3p	CLIP-seq
MIRT1075810	hsa-miR-520e	CLIP-seq
MIRT1075811	hsa-miR-520g	CLIP-seq
MIRT1075812	hsa-miR-520h	CLIP-seq
MIRT2452065	hsa-miR-590-3p	CLIP-seq
MIRT1075818	hsa-miR-93	CLIP-seq
MIRT2250713	hsa-miR-1273f	CLIP-seq
MIRT2452056	hsa-miR-129-5p	CLIP-seq
MIRT1075727	hsa-miR-197	CLIP-seq
MIRT2452057	hsa-miR-3149	CLIP-seq
MIRT2250725	hsa-miR-3170	CLIP-seq
MIRT2250731	hsa-miR-411	CLIP-seq
MIRT2452059	hsa-miR-4735-5p	CLIP-seq
MIRT2452060	hsa-miR-4775	CLIP-seq
MIRT2452061	hsa-miR-519a	CLIP-seq
MIRT2452062	hsa-miR-519b-3p	CLIP-seq
MIRT2452063	hsa-miR-519c-3p	CLIP-seq
MIRT2452065	hsa-miR-590-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 25910212
GO:0005654	Component	Nucleoplasm	IDA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	15289438
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006570	Process	Tyrosine metabolic process	IBA
GO:0006570	Process	Tyrosine metabolic process	IDA	25395621, 28157283
GO:0006570	Process	Tyrosine metabolic process	IEA
GO:0010181	Function	FMN binding	IDA	25395621, 28157283
GO:0010181	Function	FMN binding	IEA
GO:0016020	Component	Membrane	IEA
GO:0016491	Function	Oxidoreductase activity	IBA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0030659	Component	Cytoplasmic vesicle membrane	IDA	15289438
GO:0030659	Component	Cytoplasmic vesicle membrane	IEA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0042403	Process	Thyroid hormone metabolic process	IBA
GO:0042403	Process	Thyroid hormone metabolic process	IDA	25395621
GO:0140616	Function	Iodotyrosine deiodinase activity	IDA	15289438, 25395621, 28157283
GO:0140616	Function	Iodotyrosine deiodinase activity	IEA
GO:0140616	Function	Iodotyrosine deiodinase activity	IMP	18434651

Other IDs

• MIM: 612025
• HGNC: 21071
• e!Ensembl: ENSG00000009765

Protein

• UniProt ID: Q6PHW0
• Protein name: Iodotyrosine deiodinase 1 (IYD-1) (EC 1.21.1.1) (Iodotyrosine dehalogenase 1)
• Protein function: Catalyzes the dehalogenation of halotyrosines such as 3-bromo-L-tyrosine, 3-chloro-L-tyrosine, 3-iodo-L-tyrosine and 3,5-diiodo-L-tyrosine (PubMed:15289438, PubMed:18434651, PubMed:25395621, PubMed:28157283). During thyroid hormone biosynthesis,
• PDB: 4TTB, 4TTC, 5YAK
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00881	Nitroreductase	97 → 267	Nitroreductase family	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed at a high level in thyroid gland (at protein level). Expressed at a high level in thyroid gland and at lower level in kidney and trachea. {ECO:0000269|PubMed:15289438}.
• Sequence:

  MYFLTPILVAILCILVVWIFKNADRSMEKKKGEPRTRAEARPWVDEDLKDSSDLHQAEED
  ADEWQESEENVEHIPFSHNHYPEKEMVKRSQEFYELLNKRRSVRFISNEQVPMEVIDNVI
  RTAGTAPSGAHTEPWTFVVVKDPDVKHKIRKIIEEEEEINYMKRMGHRWVTDLKKLRTNW
  IKEYLDTAPILILIFKQVHGFAANGKKKVHYYNEISVSIACGILLAALQNAGLVTVTTTP
  LNCGPRLRVLLGRPAHEKLLMLLPVGYPSKEATVPDLKRKPLDQIMVTV

• Sequence length: 289

Pathways

KEGG:

Thyroid hormone synthesis

Reactome:

Thyroxine biosynthesis

Associated diseases

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Iodotyrosine deiodination defect	Likely pathogenic; Pathogenic	rs121918138, rs121918139, rs121918140, rs1052959039	RCV000000773 RCV000000775 RCV000000776 RCV003324290
IYD-related disorder	Likely pathogenic	rs121918138	RCV003430626

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Clear cell carcinoma of kidney	Benign	rs111758467	RCV005899049
Colon adenocarcinoma	Benign	rs111758467	RCV005899047
Congenital hypothyroidism	Uncertain significance; Likely benign; Benign	rs886061163, rs61597872, rs11268976, rs761967547, rs374913437, rs770486449, rs886061172, rs886061184	RCV000314511 RCV000354435 RCV000348331 RCV000293759 RCV000299544 RCV000326329 RCV000391009 RCV000359774 RCV000308570
Hepatocellular carcinoma	Benign	rs111758467	RCV005899048

Associations from Text Mining
Disease Name	Relationship Type	References
Breast Neoplasms	Associate	39512680
Carcinoma Hepatocellular	Associate	36582227
Cognition Disorders	Associate	18434651
Congenital Hypothyroidism	Associate	18434651, 34200080, 36633921
Hypothyroidism	Associate	18434651, 36633921
Thyroid Dyshormonogenesis 4	Associate	18434651
Urinary Bladder Neoplasms	Associate	30642841