LIN28B (lin-28 RNA binding posttranscriptional regulator B)

Gene

• Entrez ID: 389421
• Gene name: Lin-28 RNA binding posttranscriptional regulator B
• Gene symbol: LIN28B
• Synonyms (NCBI Gene): CSDD2
• Chromosome: 6
• Chromosome location: 6q16.3-q21
• Summary: The protein encoded by this gene belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. This gene is highly expressed in testis, fetal liver, placenta, and in primary human tumor

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT003834	hsa-let-7b-5p	Luciferase reporter assay	16971064
MIRT003834	hsa-let-7b-5p	Luciferase reporter assay	16971064
MIRT003834	hsa-let-7b-5p	Luciferase reporter assay	16971064
MIRT003834	hsa-let-7b-5p	Luciferase reporter assay	16971064
MIRT003834	hsa-let-7b-5p	Luciferase reporter assay	16971064
MIRT003834	hsa-let-7b-5p	Microarray	17699775
MIRT005804	hsa-miR-125b-5p	Luciferase reporter assay, qRT-PCR, Western blot	20827722
MIRT019513	hsa-miR-151a-3p	Sequencing	20371350
MIRT026096	hsa-miR-196a-5p	Sequencing	20371350
MIRT032185	hsa-let-7d-5p	Sequencing	20371350
MIRT048544	hsa-miR-100-5p	CLASH	23622248
MIRT046425	hsa-miR-15b-5p	CLASH	23622248
MIRT045709	hsa-miR-125a-5p	CLASH	23622248
MIRT042267	hsa-miR-484	CLASH	23622248
MIRT054676	hsa-miR-26a-5p	SK-MEL-5 and SK-MEL-28)	24056962
MIRT054676	hsa-miR-26a-5p	SK-MEL-5 and SK-MEL-28)	24056962
MIRT054676	hsa-miR-26a-5p	SK-MEL-5 and SK-MEL-28)	24056962
MIRT566935	hsa-miR-379-5p	PAR-CLIP	20371350
MIRT566934	hsa-miR-3529-5p	PAR-CLIP	20371350
MIRT566933	hsa-miR-3133	PAR-CLIP	20371350
MIRT566932	hsa-miR-651-3p	PAR-CLIP	20371350
MIRT566931	hsa-miR-3927-3p	PAR-CLIP	20371350
MIRT566930	hsa-miR-6831-5p	PAR-CLIP	20371350
MIRT566929	hsa-miR-6076	PAR-CLIP	20371350
MIRT566928	hsa-miR-6797-3p	PAR-CLIP	20371350
MIRT566927	hsa-miR-5011-3p	PAR-CLIP	20371350
MIRT566926	hsa-miR-4666b	PAR-CLIP	20371350
MIRT566925	hsa-miR-450b-5p	PAR-CLIP	20371350
MIRT547589	hsa-miR-576-3p	PAR-CLIP	21572407
MIRT556552	hsa-miR-4453	PAR-CLIP	21572407
MIRT556551	hsa-miR-4538	PAR-CLIP	21572407
MIRT547588	hsa-miR-140-5p	PAR-CLIP	21572407
MIRT547587	hsa-miR-335-5p	PAR-CLIP	21572407
MIRT556550	hsa-miR-323a-5p	PAR-CLIP	21572407
MIRT556549	hsa-miR-876-3p	PAR-CLIP	21572407
MIRT547586	hsa-miR-380-5p	PAR-CLIP	21572407
MIRT547585	hsa-miR-563	PAR-CLIP	21572407
MIRT556548	hsa-miR-4536-5p	PAR-CLIP	21572407
MIRT547584	hsa-miR-1273g-5p	PAR-CLIP	21572407
MIRT547583	hsa-miR-8070	PAR-CLIP	21572407
MIRT443422	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT547609	hsa-miR-3163	PAR-CLIP	21572407
MIRT547608	hsa-miR-369-3p	PAR-CLIP	21572407
MIRT547607	hsa-miR-5692b	PAR-CLIP	21572407
MIRT547606	hsa-miR-5692c	PAR-CLIP	21572407
MIRT547605	hsa-miR-410-3p	PAR-CLIP	21572407
MIRT547604	hsa-miR-205-3p	PAR-CLIP	21572407
MIRT547603	hsa-miR-4795-5p	PAR-CLIP	21572407
MIRT547602	hsa-miR-5681b	PAR-CLIP	21572407
MIRT547601	hsa-miR-374a-5p	PAR-CLIP	21572407
MIRT547600	hsa-miR-374b-5p	PAR-CLIP	21572407
MIRT547599	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT547597	hsa-miR-6083	PAR-CLIP	21572407
MIRT547598	hsa-miR-498	PAR-CLIP	21572407
MIRT547595	hsa-miR-4797-5p	PAR-CLIP	21572407
MIRT547596	hsa-miR-3607-3p	PAR-CLIP	21572407
MIRT547594	hsa-miR-1537-5p	PAR-CLIP	21572407
MIRT547592	hsa-miR-4718	PAR-CLIP	21572407
MIRT547593	hsa-miR-4999-5p	PAR-CLIP	21572407
MIRT547591	hsa-miR-6885-3p	PAR-CLIP	21572407
MIRT547590	hsa-miR-2681-5p	PAR-CLIP	21572407
MIRT547589	hsa-miR-576-3p	PAR-CLIP	21572407
MIRT547588	hsa-miR-140-5p	PAR-CLIP	21572407
MIRT547587	hsa-miR-335-5p	PAR-CLIP	21572407
MIRT547586	hsa-miR-380-5p	PAR-CLIP	21572407
MIRT547585	hsa-miR-563	PAR-CLIP	21572407
MIRT547584	hsa-miR-1273g-5p	PAR-CLIP	21572407
MIRT547583	hsa-miR-8070	PAR-CLIP	21572407
MIRT443422	hsa-miR-1277-5p	PAR-CLIP	22100165
MIRT727310	hsa-miR-30a-5p	HITS-CLIP	22473208
MIRT727309	hsa-miR-30b-5p	HITS-CLIP	22473208
MIRT727308	hsa-miR-30c-5p	HITS-CLIP	22473208
MIRT727307	hsa-miR-30d-5p	HITS-CLIP	22473208
MIRT727306	hsa-miR-30e-5p	HITS-CLIP	22473208
MIRT732354	hsa-miR-203a-3p	Luciferase reporter assay, qRT-PCR, Western blot	28218277
MIRT732354	hsa-miR-203a-3p	Luciferase reporter assay, qRT-PCR, Western blot	28218277
MIRT054676	hsa-miR-26a-5p	Luciferase reporter assay, qRT-PCR, Western blot	26787543
MIRT054676	hsa-miR-26a-5p	Luciferase reporter assay, qRT-PCR, Western blot	26787543
MIRT054676	hsa-miR-26a-5p	Luciferase reporter assay, qRT-PCR, Western blot	26787543
MIRT054676	hsa-miR-26a-5p	Luciferase reporter assay, qRT-PCR, Western blot	26787543
MIRT054676	hsa-miR-26a-5p	Luciferase reporter assay, qRT-PCR, Western blot	26787543
MIRT054676	hsa-miR-26a-5p	Luciferase reporter assay, qRT-PCR, Western blot	26787543
MIRT054676	hsa-miR-26a-5p	Luciferase reporter assay, qRT-PCR, Western blot	26787543
MIRT734887	hsa-let-7a-3p	qRT-PCR, Immunocytochemistry (ICC)	33379329
MIRT736230	hsa-miR-152-3p	Luciferase reporter assay, Western blotting, qRT-PCR	31609010
MIRT734887	hsa-let-7a-3p	Western blotting, Immunohistochemistry (IHC), qRT-PCR	32046465
MIRT566935	hsa-miR-379-5p	Luciferase reporter assay, Western blotting, Immunohistochemistry (IHC), RNA-seq, Immunofluorescence, qRT-PCR, In situ hybridization	31907362
MIRT566935	hsa-miR-379-5p	PAR-CLIP	20371350
MIRT566934	hsa-miR-3529-5p	PAR-CLIP	20371350
MIRT566933	hsa-miR-3133	PAR-CLIP	20371350
MIRT566932	hsa-miR-651-3p	PAR-CLIP	20371350
MIRT566931	hsa-miR-3927-3p	PAR-CLIP	20371350
MIRT566930	hsa-miR-6831-5p	PAR-CLIP	20371350
MIRT566929	hsa-miR-6076	PAR-CLIP	20371350
MIRT566928	hsa-miR-6797-3p	PAR-CLIP	20371350
MIRT566927	hsa-miR-5011-3p	PAR-CLIP	20371350
MIRT566926	hsa-miR-4666b	PAR-CLIP	20371350
MIRT566925	hsa-miR-450b-5p	PAR-CLIP	20371350
MIRT547589	hsa-miR-576-3p	PAR-CLIP	21572407
MIRT556552	hsa-miR-4453	PAR-CLIP	21572407
MIRT556551	hsa-miR-4538	PAR-CLIP	21572407
MIRT547588	hsa-miR-140-5p	PAR-CLIP	21572407
MIRT547587	hsa-miR-335-5p	PAR-CLIP	21572407
MIRT556550	hsa-miR-323a-5p	PAR-CLIP	21572407
MIRT556549	hsa-miR-876-3p	PAR-CLIP	21572407
MIRT547586	hsa-miR-380-5p	PAR-CLIP	21572407
MIRT547585	hsa-miR-563	PAR-CLIP	21572407
MIRT556548	hsa-miR-4536-5p	PAR-CLIP	21572407
MIRT547584	hsa-miR-1273g-5p	PAR-CLIP	21572407
MIRT547583	hsa-miR-8070	PAR-CLIP	21572407
MIRT443422	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT547609	hsa-miR-3163	PAR-CLIP	21572407
MIRT547608	hsa-miR-369-3p	PAR-CLIP	21572407
MIRT547607	hsa-miR-5692b	PAR-CLIP	21572407
MIRT547606	hsa-miR-5692c	PAR-CLIP	21572407
MIRT547605	hsa-miR-410-3p	PAR-CLIP	21572407
MIRT547604	hsa-miR-205-3p	PAR-CLIP	21572407
MIRT547603	hsa-miR-4795-5p	PAR-CLIP	21572407
MIRT547602	hsa-miR-5681b	PAR-CLIP	21572407
MIRT547601	hsa-miR-374a-5p	PAR-CLIP	21572407
MIRT547600	hsa-miR-374b-5p	PAR-CLIP	21572407
MIRT547599	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT547597	hsa-miR-6083	PAR-CLIP	21572407
MIRT547598	hsa-miR-498	PAR-CLIP	21572407
MIRT547595	hsa-miR-4797-5p	PAR-CLIP	21572407
MIRT547596	hsa-miR-3607-3p	PAR-CLIP	21572407
MIRT547594	hsa-miR-1537-5p	PAR-CLIP	21572407
MIRT547592	hsa-miR-4718	PAR-CLIP	21572407
MIRT547593	hsa-miR-4999-5p	PAR-CLIP	21572407
MIRT547591	hsa-miR-6885-3p	PAR-CLIP	21572407
MIRT547590	hsa-miR-2681-5p	PAR-CLIP	21572407
MIRT547589	hsa-miR-576-3p	PAR-CLIP	21572407
MIRT547588	hsa-miR-140-5p	PAR-CLIP	21572407
MIRT547587	hsa-miR-335-5p	PAR-CLIP	21572407
MIRT547586	hsa-miR-380-5p	PAR-CLIP	21572407
MIRT547585	hsa-miR-563	PAR-CLIP	21572407
MIRT547584	hsa-miR-1273g-5p	PAR-CLIP	21572407
MIRT547583	hsa-miR-8070	PAR-CLIP	21572407
MIRT443422	hsa-miR-1277-5p	PAR-CLIP	22100165
MIRT756034	hsa-miR-99b-5p	Luciferase reporter assay, Western blotting, qRT-PCR, Immunohistochemistry (IHC), RNA-seq	34998954
MIRT1110149	hsa-miR-101	CLIP-seq
MIRT1110150	hsa-miR-1229	CLIP-seq
MIRT1110151	hsa-miR-1253	CLIP-seq
MIRT1110152	hsa-miR-128	CLIP-seq
MIRT1110153	hsa-miR-1297	CLIP-seq
MIRT1110154	hsa-miR-1305	CLIP-seq
MIRT1110155	hsa-miR-144	CLIP-seq
MIRT1110156	hsa-miR-1827	CLIP-seq
MIRT1110157	hsa-miR-199a-3p	CLIP-seq
MIRT1110158	hsa-miR-199b-3p	CLIP-seq
MIRT1110159	hsa-miR-200b	CLIP-seq
MIRT1110160	hsa-miR-200c	CLIP-seq
MIRT1110161	hsa-miR-205	CLIP-seq
MIRT1110162	hsa-miR-218	CLIP-seq
MIRT1110163	hsa-miR-219-1-3p	CLIP-seq
MIRT1110164	hsa-miR-23a	CLIP-seq
MIRT1110165	hsa-miR-23b	CLIP-seq
MIRT1110166	hsa-miR-23c	CLIP-seq
MIRT1110167	hsa-miR-26a	CLIP-seq
MIRT1110168	hsa-miR-26b	CLIP-seq
MIRT1110169	hsa-miR-27a	CLIP-seq
MIRT1110170	hsa-miR-27b	CLIP-seq
MIRT1110171	hsa-miR-3127-3p	CLIP-seq
MIRT1110172	hsa-miR-3129-5p	CLIP-seq
MIRT1110173	hsa-miR-3145-3p	CLIP-seq
MIRT1110174	hsa-miR-3145-5p	CLIP-seq
MIRT1110175	hsa-miR-3155	CLIP-seq
MIRT1110176	hsa-miR-3155b	CLIP-seq
MIRT1110177	hsa-miR-3173-3p	CLIP-seq
MIRT1110178	hsa-miR-329	CLIP-seq
MIRT1110179	hsa-miR-342-3p	CLIP-seq
MIRT1110180	hsa-miR-3617	CLIP-seq
MIRT1110181	hsa-miR-362-3p	CLIP-seq
MIRT1110182	hsa-miR-3650	CLIP-seq
MIRT1110183	hsa-miR-3682-5p	CLIP-seq
MIRT1110184	hsa-miR-3689a-5p	CLIP-seq
MIRT1110185	hsa-miR-3689b	CLIP-seq
MIRT1110186	hsa-miR-3689e	CLIP-seq
MIRT1110187	hsa-miR-3689f	CLIP-seq
MIRT1110188	hsa-miR-3941	CLIP-seq
MIRT1110189	hsa-miR-3977	CLIP-seq
MIRT1110190	hsa-miR-4276	CLIP-seq
MIRT1110191	hsa-miR-4287	CLIP-seq
MIRT1110192	hsa-miR-429	CLIP-seq
MIRT1110193	hsa-miR-4292	CLIP-seq
MIRT1110194	hsa-miR-4308	CLIP-seq
MIRT1110195	hsa-miR-4428	CLIP-seq
MIRT1110196	hsa-miR-4455	CLIP-seq
MIRT1110197	hsa-miR-4465	CLIP-seq
MIRT1110198	hsa-miR-4469	CLIP-seq
MIRT1110199	hsa-miR-4649-3p	CLIP-seq
MIRT1110200	hsa-miR-4685-3p	CLIP-seq
MIRT1110201	hsa-miR-4699-5p	CLIP-seq
MIRT1110202	hsa-miR-4712-3p	CLIP-seq
MIRT1110203	hsa-miR-4713-5p	CLIP-seq
MIRT1110204	hsa-miR-4717-3p	CLIP-seq
MIRT1110205	hsa-miR-4753-3p	CLIP-seq
MIRT1110206	hsa-miR-4756-3p	CLIP-seq
MIRT1110207	hsa-miR-4768-5p	CLIP-seq
MIRT1110208	hsa-miR-4775	CLIP-seq
MIRT1110209	hsa-miR-4779	CLIP-seq
MIRT1110210	hsa-miR-501-3p	CLIP-seq
MIRT1110211	hsa-miR-502-3p	CLIP-seq
MIRT1110212	hsa-miR-508-5p	CLIP-seq
MIRT1110213	hsa-miR-510	CLIP-seq
MIRT1110214	hsa-miR-511	CLIP-seq
MIRT1110215	hsa-miR-520a-5p	CLIP-seq
MIRT1110216	hsa-miR-525-5p	CLIP-seq
MIRT1110217	hsa-miR-544b	CLIP-seq
MIRT1110218	hsa-miR-548ac	CLIP-seq
MIRT1110219	hsa-miR-548ae	CLIP-seq
MIRT1110220	hsa-miR-548aj	CLIP-seq
MIRT1110221	hsa-miR-548am	CLIP-seq
MIRT1110222	hsa-miR-548d-3p	CLIP-seq
MIRT1110223	hsa-miR-548x	CLIP-seq
MIRT1110224	hsa-miR-548z	CLIP-seq
MIRT1110225	hsa-miR-579	CLIP-seq
MIRT1110226	hsa-miR-582-5p	CLIP-seq
MIRT1110227	hsa-miR-583	CLIP-seq
MIRT1110228	hsa-miR-587	CLIP-seq
MIRT1110229	hsa-miR-590-3p	CLIP-seq
MIRT1110230	hsa-miR-603	CLIP-seq
MIRT1110231	hsa-miR-629	CLIP-seq
MIRT1110232	hsa-miR-636	CLIP-seq
MIRT1110233	hsa-miR-641	CLIP-seq
MIRT1110234	hsa-miR-936	CLIP-seq
MIRT1922218	hsa-miR-1206	CLIP-seq
MIRT1922219	hsa-miR-4793-5p	CLIP-seq
MIRT1922220	hsa-miR-486-5p	CLIP-seq
MIRT2030679	hsa-let-7a	CLIP-seq
MIRT2030680	hsa-let-7b	CLIP-seq
MIRT2030681	hsa-let-7c	CLIP-seq
MIRT2030682	hsa-let-7d	CLIP-seq
MIRT2030683	hsa-let-7e	CLIP-seq
MIRT2030684	hsa-let-7f	CLIP-seq
MIRT2030685	hsa-let-7g	CLIP-seq
MIRT2030686	hsa-let-7i	CLIP-seq
MIRT1110150	hsa-miR-1229	CLIP-seq
MIRT2030687	hsa-miR-1303	CLIP-seq
MIRT1110164	hsa-miR-23a	CLIP-seq
MIRT1110165	hsa-miR-23b	CLIP-seq
MIRT1110166	hsa-miR-23c	CLIP-seq
MIRT2030688	hsa-miR-3125	CLIP-seq
MIRT2030689	hsa-miR-3591-3p	CLIP-seq
MIRT2030690	hsa-miR-3609	CLIP-seq
MIRT2030691	hsa-miR-377	CLIP-seq
MIRT2030692	hsa-miR-3916	CLIP-seq
MIRT1110189	hsa-miR-3977	CLIP-seq
MIRT2030693	hsa-miR-4458	CLIP-seq
MIRT2030694	hsa-miR-4500	CLIP-seq
MIRT2030695	hsa-miR-4639-3p	CLIP-seq
MIRT1110204	hsa-miR-4717-3p	CLIP-seq
MIRT2030696	hsa-miR-5096	CLIP-seq
MIRT2030697	hsa-miR-518a-5p	CLIP-seq
MIRT2030698	hsa-miR-520g	CLIP-seq
MIRT2030699	hsa-miR-520h	CLIP-seq
MIRT2030700	hsa-miR-527	CLIP-seq
MIRT1110218	hsa-miR-548ac	CLIP-seq
MIRT1110219	hsa-miR-548ae	CLIP-seq
MIRT2030701	hsa-miR-548ag	CLIP-seq
MIRT2030702	hsa-miR-548ah	CLIP-seq
MIRT2030703	hsa-miR-548ai	CLIP-seq
MIRT1110220	hsa-miR-548aj	CLIP-seq
MIRT1110221	hsa-miR-548am	CLIP-seq
MIRT1110222	hsa-miR-548d-3p	CLIP-seq
MIRT2030704	hsa-miR-548m	CLIP-seq
MIRT1110223	hsa-miR-548x	CLIP-seq
MIRT1110224	hsa-miR-548z	CLIP-seq
MIRT2030705	hsa-miR-659	CLIP-seq
MIRT2030706	hsa-miR-877	CLIP-seq
MIRT2030707	hsa-miR-9	CLIP-seq
MIRT2030708	hsa-miR-98	CLIP-seq
MIRT2030679	hsa-let-7a	CLIP-seq
MIRT2030680	hsa-let-7b	CLIP-seq
MIRT2030681	hsa-let-7c	CLIP-seq
MIRT2030682	hsa-let-7d	CLIP-seq
MIRT2030683	hsa-let-7e	CLIP-seq
MIRT2030684	hsa-let-7f	CLIP-seq
MIRT2030685	hsa-let-7g	CLIP-seq
MIRT2030686	hsa-let-7i	CLIP-seq
MIRT1922218	hsa-miR-1206	CLIP-seq
MIRT2030687	hsa-miR-1303	CLIP-seq
MIRT1110154	hsa-miR-1305	CLIP-seq
MIRT2261384	hsa-miR-202	CLIP-seq
MIRT1110164	hsa-miR-23a	CLIP-seq
MIRT1110165	hsa-miR-23b	CLIP-seq
MIRT1110166	hsa-miR-23c	CLIP-seq
MIRT2261385	hsa-miR-30a	CLIP-seq
MIRT2261386	hsa-miR-30b	CLIP-seq
MIRT2261387	hsa-miR-30c	CLIP-seq
MIRT2261388	hsa-miR-30d	CLIP-seq
MIRT2261389	hsa-miR-30e	CLIP-seq
MIRT2261390	hsa-miR-3123	CLIP-seq
MIRT2261391	hsa-miR-3529	CLIP-seq
MIRT2030690	hsa-miR-3609	CLIP-seq
MIRT2261392	hsa-miR-3613-3p	CLIP-seq
MIRT2261393	hsa-miR-379	CLIP-seq
MIRT2261394	hsa-miR-3925-5p	CLIP-seq
MIRT2261395	hsa-miR-3927	CLIP-seq
MIRT1110189	hsa-miR-3977	CLIP-seq
MIRT2030693	hsa-miR-4458	CLIP-seq
MIRT2030694	hsa-miR-4500	CLIP-seq
MIRT1110204	hsa-miR-4717-3p	CLIP-seq
MIRT2261396	hsa-miR-4733-5p	CLIP-seq
MIRT2261397	hsa-miR-494	CLIP-seq
MIRT2030698	hsa-miR-520g	CLIP-seq
MIRT2030699	hsa-miR-520h	CLIP-seq
MIRT2030702	hsa-miR-548ah	CLIP-seq
MIRT2261398	hsa-miR-570	CLIP-seq
MIRT2261399	hsa-miR-577	CLIP-seq
MIRT2030708	hsa-miR-98	CLIP-seq
MIRT2390157	hsa-miR-320e	CLIP-seq
MIRT1110179	hsa-miR-342-3p	CLIP-seq
MIRT2390158	hsa-miR-380	CLIP-seq
MIRT2390159	hsa-miR-4457	CLIP-seq
MIRT2390160	hsa-miR-4490	CLIP-seq
MIRT2390161	hsa-miR-4495	CLIP-seq
MIRT2390162	hsa-miR-513b	CLIP-seq
MIRT2390163	hsa-miR-618	CLIP-seq
MIRT1110154	hsa-miR-1305	CLIP-seq
MIRT2453063	hsa-miR-3164	CLIP-seq
MIRT2030690	hsa-miR-3609	CLIP-seq
MIRT2453064	hsa-miR-3973	CLIP-seq
MIRT2453065	hsa-miR-4452	CLIP-seq
MIRT2030698	hsa-miR-520g	CLIP-seq
MIRT2030699	hsa-miR-520h	CLIP-seq
MIRT2030702	hsa-miR-548ah	CLIP-seq
MIRT2453066	hsa-miR-607	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
TBP	Activation	23494474

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	HDA	22681889
GO:0003723	Function	RNA binding	IDA	19703396
GO:0003723	Function	RNA binding	IEA
GO:0003729	Function	MRNA binding	IBA
GO:0005515	Function	Protein binding	IPI	19703396
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005730	Component	Nucleolus	IDA
GO:0005730	Component	Nucleolus	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0008270	Function	Zinc ion binding	IEA
GO:0010587	Process	MiRNA catabolic process	IEA
GO:0010587	Process	MiRNA catabolic process	IMP	19703396
GO:0010608	Process	Post-transcriptional regulation of gene expression	IEA
GO:0031047	Process	Regulatory ncRNA-mediated gene silencing	IEA
GO:0031054	Process	Pre-miRNA processing	IBA
GO:0031054	Process	Pre-miRNA processing	IEA
GO:0031054	Process	Pre-miRNA processing	IMP	19703396
GO:0031123	Process	RNA 3'-end processing	IEA
GO:0031123	Process	RNA 3'-end processing	IMP	19703396
GO:0046872	Function	Metal ion binding	IEA
GO:0050779	Process	RNA destabilization	IDA	18951094
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536
GO:2000627	Process	Positive regulation of miRNA catabolic process	IMP	18951094
GO:2000632	Process	Negative regulation of pre-miRNA processing	IDA	18951094
GO:2000632	Process	Negative regulation of pre-miRNA processing	IEA
GO:2000635	Process	Negative regulation of primary miRNA processing	IDA	18951094

Other IDs

• MIM: 611044
• HGNC: 32207
• e!Ensembl: ENSG00000187772

Protein

• UniProt ID: Q6ZN17
• Protein name: Protein lin-28 homolog B (Lin-28B)
• Protein function: Suppressor of microRNA (miRNA) biogenesis, including that of let-7 and possibly of miR107, miR-143 and miR-200c. Binds primary let-7 transcripts (pri-let-7), including pri-let-7g and pri-let-7a-1, and sequester them in the nucleolus, away from t
• PDB: 4A4I
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00313	CSD	30 → 102		Domain
  PF00098	zf-CCHC	127 → 144	Zinc knuckle	Domain
  PF00098	zf-CCHC	149 → 166	Zinc knuckle	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed at high levels in the placenta and, at mucher lower, in testis and fetal liver (PubMed:16971064). Isoform 1 is only detected in placenta and in moderately and poorly differentiated hepatocellular carcinoma cells (at protein l
• Sequence:

  MAEGGASKGGGEEPGKLPEPAEEESQVLRGTGHCKWFNVRMGFGFISMINREGSPLDIPV
  DVFVHQSKLFMEGFRSLKEGEPVEFTFKKSSKGLESIRVTGPGGSPCLGSERRPKGKTLQ
  KRKPKGDRCYNCGGLDHHAKECSLPPQPKKCHYCQSIMHMVANCPHKNVAQPPASSQGRQ
  EAESQPCTSTLPREVGGGHGCTSPPFPQEARAEISERSGRSPQEASSTKSSIAPEEQSKK
  GPSVQKRKKT

• Sequence length: 250