ARHGEF37 (Rho guanine nucleotide exchange factor 37)

Gene

• Entrez ID: 389337
• Gene name: Rho guanine nucleotide exchange factor 37
• Gene symbol: ARHGEF37
• Synonyms (NCBI Gene): -
• Chromosome: 5
• Chromosome location: 5q32

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017866	hsa-miR-335-5p	Microarray	18185580
MIRT718286	hsa-miR-6734-3p	HITS-CLIP	19536157
MIRT718285	hsa-miR-6880-3p	HITS-CLIP	19536157
MIRT718284	hsa-miR-4297	HITS-CLIP	19536157
MIRT718283	hsa-miR-5581-5p	HITS-CLIP	19536157
MIRT718282	hsa-miR-7977	HITS-CLIP	19536157
MIRT718281	hsa-miR-7111-3p	HITS-CLIP	19536157
MIRT718280	hsa-miR-6780a-3p	HITS-CLIP	19536157
MIRT718279	hsa-miR-6881-3p	HITS-CLIP	19536157
MIRT718278	hsa-miR-670-3p	HITS-CLIP	19536157
MIRT718277	hsa-miR-1238-3p	HITS-CLIP	19536157
MIRT718286	hsa-miR-6734-3p	HITS-CLIP	19536157
MIRT718285	hsa-miR-6880-3p	HITS-CLIP	19536157
MIRT718284	hsa-miR-4297	HITS-CLIP	19536157
MIRT718283	hsa-miR-5581-5p	HITS-CLIP	19536157
MIRT718282	hsa-miR-7977	HITS-CLIP	19536157
MIRT718281	hsa-miR-7111-3p	HITS-CLIP	19536157
MIRT718280	hsa-miR-6780a-3p	HITS-CLIP	19536157
MIRT718279	hsa-miR-6881-3p	HITS-CLIP	19536157
MIRT718278	hsa-miR-670-3p	HITS-CLIP	19536157
MIRT718277	hsa-miR-1238-3p	HITS-CLIP	19536157
MIRT795830	hsa-miR-1253	CLIP-seq
MIRT795831	hsa-miR-1288	CLIP-seq
MIRT795832	hsa-miR-1910	CLIP-seq
MIRT795833	hsa-miR-3064-5p	CLIP-seq
MIRT795834	hsa-miR-3074-5p	CLIP-seq
MIRT795835	hsa-miR-3128	CLIP-seq
MIRT795836	hsa-miR-3130-3p	CLIP-seq
MIRT795837	hsa-miR-3135b	CLIP-seq
MIRT795838	hsa-miR-3149	CLIP-seq
MIRT795839	hsa-miR-3187-3p	CLIP-seq
MIRT795840	hsa-miR-3199	CLIP-seq
MIRT739613	hsa-miR-3200-5p	CLIP-seq
MIRT795841	hsa-miR-326	CLIP-seq
MIRT795842	hsa-miR-330-5p	CLIP-seq
MIRT739614	hsa-miR-361-5p	CLIP-seq
MIRT795843	hsa-miR-3652	CLIP-seq
MIRT795844	hsa-miR-3691-3p	CLIP-seq
MIRT795845	hsa-miR-3943	CLIP-seq
MIRT795846	hsa-miR-4274	CLIP-seq
MIRT739615	hsa-miR-4303	CLIP-seq
MIRT795847	hsa-miR-4430	CLIP-seq
MIRT795848	hsa-miR-4461	CLIP-seq
MIRT739612	hsa-miR-4468	CLIP-seq
MIRT795849	hsa-miR-4505	CLIP-seq
MIRT795850	hsa-miR-4529-5p	CLIP-seq
MIRT795851	hsa-miR-4720-5p	CLIP-seq
MIRT795852	hsa-miR-4729	CLIP-seq
MIRT795853	hsa-miR-4733-3p	CLIP-seq
MIRT795854	hsa-miR-4772-3p	CLIP-seq
MIRT795855	hsa-miR-4793-3p	CLIP-seq
MIRT795856	hsa-miR-4799-3p	CLIP-seq
MIRT795857	hsa-miR-516a-3p	CLIP-seq
MIRT795858	hsa-miR-580	CLIP-seq
MIRT795859	hsa-miR-604	CLIP-seq
MIRT795860	hsa-miR-616	CLIP-seq
MIRT795861	hsa-miR-626	CLIP-seq
MIRT795862	hsa-miR-647	CLIP-seq
MIRT795863	hsa-miR-659	CLIP-seq
MIRT795864	hsa-miR-671-5p	CLIP-seq
MIRT1935048	hsa-miR-1229	CLIP-seq
MIRT1935049	hsa-miR-1245b-5p	CLIP-seq
MIRT1935050	hsa-miR-128	CLIP-seq
MIRT1935051	hsa-miR-1299	CLIP-seq
MIRT1935052	hsa-miR-188-3p	CLIP-seq
MIRT795833	hsa-miR-3064-5p	CLIP-seq
MIRT1935053	hsa-miR-3142	CLIP-seq
MIRT1935054	hsa-miR-3156-3p	CLIP-seq
MIRT1935055	hsa-miR-331-5p	CLIP-seq
MIRT1935056	hsa-miR-3658	CLIP-seq
MIRT1935057	hsa-miR-3940-5p	CLIP-seq
MIRT1935058	hsa-miR-409-5p	CLIP-seq
MIRT1935059	hsa-miR-4276	CLIP-seq
MIRT1935060	hsa-miR-4301	CLIP-seq
MIRT1935061	hsa-miR-4446-5p	CLIP-seq
MIRT1935062	hsa-miR-4507	CLIP-seq
MIRT1935063	hsa-miR-4678	CLIP-seq
MIRT1935064	hsa-miR-4691-5p	CLIP-seq
MIRT1935065	hsa-miR-4782-5p	CLIP-seq
MIRT1935066	hsa-miR-4798-5p	CLIP-seq
MIRT1935067	hsa-miR-483-3p	CLIP-seq
MIRT1935068	hsa-miR-513a-5p	CLIP-seq
MIRT1935069	hsa-miR-516b	CLIP-seq
MIRT1935070	hsa-miR-520d-5p	CLIP-seq
MIRT1935071	hsa-miR-524-5p	CLIP-seq
MIRT1935072	hsa-miR-586	CLIP-seq
MIRT2174936	hsa-miR-10a	CLIP-seq
MIRT2174937	hsa-miR-10b	CLIP-seq
MIRT2174938	hsa-miR-1200	CLIP-seq
MIRT1935049	hsa-miR-1245b-5p	CLIP-seq
MIRT2174939	hsa-miR-125a-3p	CLIP-seq
MIRT1935050	hsa-miR-128	CLIP-seq
MIRT795831	hsa-miR-1288	CLIP-seq
MIRT2174940	hsa-miR-1294	CLIP-seq
MIRT1935051	hsa-miR-1299	CLIP-seq
MIRT2174941	hsa-miR-130a	CLIP-seq
MIRT2174942	hsa-miR-130b	CLIP-seq
MIRT2174943	hsa-miR-149	CLIP-seq
MIRT795832	hsa-miR-1910	CLIP-seq
MIRT2174944	hsa-miR-1915	CLIP-seq
MIRT2174945	hsa-miR-204	CLIP-seq
MIRT2174946	hsa-miR-2053	CLIP-seq
MIRT2174947	hsa-miR-21	CLIP-seq
MIRT2174948	hsa-miR-211	CLIP-seq
MIRT2174949	hsa-miR-223	CLIP-seq
MIRT2174950	hsa-miR-23a	CLIP-seq
MIRT2174951	hsa-miR-23b	CLIP-seq
MIRT2174952	hsa-miR-23c	CLIP-seq
MIRT2174953	hsa-miR-2467-3p	CLIP-seq
MIRT2174954	hsa-miR-27a	CLIP-seq
MIRT2174955	hsa-miR-27b	CLIP-seq
MIRT2174956	hsa-miR-301a	CLIP-seq
MIRT2174957	hsa-miR-301b	CLIP-seq
MIRT795833	hsa-miR-3064-5p	CLIP-seq
MIRT795836	hsa-miR-3130-3p	CLIP-seq
MIRT1935053	hsa-miR-3142	CLIP-seq
MIRT2174958	hsa-miR-3151	CLIP-seq
MIRT2174959	hsa-miR-3156-5p	CLIP-seq
MIRT2174960	hsa-miR-3182	CLIP-seq
MIRT2174961	hsa-miR-3194-3p	CLIP-seq
MIRT795840	hsa-miR-3199	CLIP-seq
MIRT1935055	hsa-miR-331-5p	CLIP-seq
MIRT2174962	hsa-miR-335	CLIP-seq
MIRT2174963	hsa-miR-3612	CLIP-seq
MIRT2174964	hsa-miR-3614-5p	CLIP-seq
MIRT2174965	hsa-miR-3666	CLIP-seq
MIRT2174966	hsa-miR-3670	CLIP-seq
MIRT2174967	hsa-miR-3678-3p	CLIP-seq
MIRT2174968	hsa-miR-376c	CLIP-seq
MIRT2174969	hsa-miR-377	CLIP-seq
MIRT2174970	hsa-miR-3934	CLIP-seq
MIRT2174971	hsa-miR-3938	CLIP-seq
MIRT1935057	hsa-miR-3940-5p	CLIP-seq
MIRT795845	hsa-miR-3943	CLIP-seq
MIRT2174972	hsa-miR-4270	CLIP-seq
MIRT795846	hsa-miR-4274	CLIP-seq
MIRT2174973	hsa-miR-4295	CLIP-seq
MIRT2174974	hsa-miR-4300	CLIP-seq
MIRT2174975	hsa-miR-4317	CLIP-seq
MIRT2174976	hsa-miR-4323	CLIP-seq
MIRT2174977	hsa-miR-4324	CLIP-seq
MIRT2174978	hsa-miR-4441	CLIP-seq
MIRT739612	hsa-miR-4468	CLIP-seq
MIRT1935062	hsa-miR-4507	CLIP-seq
MIRT2174979	hsa-miR-4530	CLIP-seq
MIRT2174980	hsa-miR-454	CLIP-seq
MIRT2174981	hsa-miR-4641	CLIP-seq
MIRT2174982	hsa-miR-4671-3p	CLIP-seq
MIRT2174983	hsa-miR-4677-3p	CLIP-seq
MIRT1935063	hsa-miR-4678	CLIP-seq
MIRT2174984	hsa-miR-4695-5p	CLIP-seq
MIRT2174985	hsa-miR-4697-3p	CLIP-seq
MIRT2174986	hsa-miR-4726-3p	CLIP-seq
MIRT2174987	hsa-miR-4747-3p	CLIP-seq
MIRT2174988	hsa-miR-4758-3p	CLIP-seq
MIRT2174989	hsa-miR-4765	CLIP-seq
MIRT2174990	hsa-miR-4769-3p	CLIP-seq
MIRT1935065	hsa-miR-4782-5p	CLIP-seq
MIRT795855	hsa-miR-4793-3p	CLIP-seq
MIRT2174991	hsa-miR-4794	CLIP-seq
MIRT1935066	hsa-miR-4798-5p	CLIP-seq
MIRT2174992	hsa-miR-486-3p	CLIP-seq
MIRT2174993	hsa-miR-5095	CLIP-seq
MIRT1935068	hsa-miR-513a-5p	CLIP-seq
MIRT2174994	hsa-miR-513c	CLIP-seq
MIRT2174995	hsa-miR-514b-5p	CLIP-seq
MIRT1935069	hsa-miR-516b	CLIP-seq
MIRT2174996	hsa-miR-544b	CLIP-seq
MIRT1935072	hsa-miR-586	CLIP-seq
MIRT2174997	hsa-miR-590-5p	CLIP-seq
MIRT2174998	hsa-miR-598	CLIP-seq
MIRT2174999	hsa-miR-600	CLIP-seq
MIRT795859	hsa-miR-604	CLIP-seq
MIRT2175000	hsa-miR-642b	CLIP-seq
MIRT795862	hsa-miR-647	CLIP-seq
MIRT2175001	hsa-miR-650	CLIP-seq
MIRT2175002	hsa-miR-662	CLIP-seq
MIRT2175003	hsa-miR-764	CLIP-seq
MIRT2175004	hsa-miR-920	CLIP-seq
MIRT2175005	hsa-miR-935	CLIP-seq
MIRT2175006	hsa-miR-942	CLIP-seq
MIRT1935049	hsa-miR-1245b-5p	CLIP-seq
MIRT1935053	hsa-miR-3142	CLIP-seq
MIRT1935055	hsa-miR-331-5p	CLIP-seq
MIRT1935063	hsa-miR-4678	CLIP-seq
MIRT1935066	hsa-miR-4798-5p	CLIP-seq
MIRT2478208	hsa-miR-1266	CLIP-seq
MIRT2478209	hsa-miR-4518	CLIP-seq
MIRT795852	hsa-miR-4729	CLIP-seq
MIRT2478210	hsa-miR-4740-3p	CLIP-seq
MIRT795860	hsa-miR-616	CLIP-seq
MIRT795861	hsa-miR-626	CLIP-seq
MIRT2478211	hsa-miR-665	CLIP-seq
MIRT2478208	hsa-miR-1266	CLIP-seq
MIRT795832	hsa-miR-1910	CLIP-seq
MIRT2174945	hsa-miR-204	CLIP-seq
MIRT2174948	hsa-miR-211	CLIP-seq
MIRT2675323	hsa-miR-214	CLIP-seq
MIRT2675324	hsa-miR-3189-5p	CLIP-seq
MIRT2675325	hsa-miR-3619-5p	CLIP-seq
MIRT2675326	hsa-miR-3663-5p	CLIP-seq
MIRT2478209	hsa-miR-4518	CLIP-seq
MIRT2174979	hsa-miR-4530	CLIP-seq
MIRT2675327	hsa-miR-455-3p	CLIP-seq
MIRT795852	hsa-miR-4729	CLIP-seq
MIRT2478210	hsa-miR-4740-3p	CLIP-seq
MIRT2675328	hsa-miR-4755-5p	CLIP-seq
MIRT2174988	hsa-miR-4758-3p	CLIP-seq
MIRT795860	hsa-miR-616	CLIP-seq
MIRT2675329	hsa-miR-623	CLIP-seq
MIRT795861	hsa-miR-626	CLIP-seq
MIRT2478211	hsa-miR-665	CLIP-seq
MIRT2675330	hsa-miR-761	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IBA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA

Other IDs

• MIM: 620664
• HGNC: 34430
• e!Ensembl: ENSG00000183111

Protein

• UniProt ID: A1IGU5
• Protein name: Rho guanine nucleotide exchange factor 37
• Protein function: May act as a guanine nucleotide exchange factor (GEF).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00621	RhoGEF	34 → 211	RhoGEF domain	Domain
  PF07653	SH3_2	510 → 566	Variant SH3 domain	Domain
  PF00018	SH3_1	608 → 657	SH3 domain	Domain

• Sequence:

  MAKHGADEPSSRSGSPDREGRASEDRSLLHQRLAVRELIDTEVSYLHMLQLCASDIRSRL
  QQLPQGDLDVLFSNIDDIIKVNSRFLHDLQETASKEEEQVQLVGNIFLEFQEELEQVYKV
  YCASYDQALLLVDTYRKEPELQRHIQGIVEAVVPQAGSSGLSFLLVIPLQRITRYPLLLQ
  KILENTVPDASAYPVLQRAVSALQDVNTNINEYKMRKEVASKYTKVEQLTLRERLARINT
  HTLSKKTTRLSQLLKQEAGLIPRTEDKEFDDLEERFQWVSLCVTELKNNVAAYLDNLQAF
  LYFRPHEYNLDIPEGPAVQYCNLARDLHLEAFLKFKQRLEGLVWQPLCSLAKALLGPQNL
  IKKRLDKLLDFERVEEKLLEVGSVTYQEEAARHTYQALNSLLVAELPQFNQLVMQWLGQI
  MCTFVTLQRDLAKQVLQRAEGSMAQLPHHHVPEPAFRKLVEDALGRTSNQLRSFQETFEK
  VQPPPTTQPLLPGSERQVQALLSRYGPGKLYQVTSNISGTGTLDLTLPRGQIVAILQNKD
  TKGNSGRWLVDTGGHRGYVPAGKLQLYHVVPSAEELRRQAGLNKDPRCLTPEPSPALVPS
  IPTMNQVIAAYPFVARSSHEVSLQAGQPVTILEAQDKKGNPEWSLVEVNGQRGYVPSGFL
  ARARSPVLWGWSLPS

• Sequence length: 675

Pathways

Reactome:

NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Ovarian serous cystadenocarcinoma	Uncertain significance	rs543805061	RCV005930735