Gene Gene information from NCBI Gene database.
Entrez ID 389015
Gene name Solute carrier family 9 member A4
Gene symbol SLC9A4
Synonyms (NCBI Gene)
NHE4
Chromosome 2
Chromosome location 2q12.1
miRNA miRNA information provided by mirtarbase database.
717
miRTarBase ID miRNA Experiments Reference
MIRT531082 hsa-miR-548a-5p PAR-CLIP 21572407
MIRT531081 hsa-miR-548ab PAR-CLIP 21572407
MIRT531080 hsa-miR-548ad-5p PAR-CLIP 21572407
MIRT531079 hsa-miR-548ae-5p PAR-CLIP 21572407
MIRT531078 hsa-miR-548ak PAR-CLIP 21572407
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
29
GO ID Ontology Definition Evidence Reference
GO:0001696 Process Gastric acid secretion IEA
GO:0002068 Process Glandular epithelial cell development IEA
GO:0005886 Component Plasma membrane IBA
GO:0005886 Component Plasma membrane IEA
GO:0005886 Component Plasma membrane TAS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
600531 11077 ENSG00000180251
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q6AI14
Protein name Sodium/hydrogen exchanger 4 (Na(+)/H(+) exchanger 4) (NHE-4) (Solute carrier family 9 member 4)
Protein function Electroneutral antiporter that exchanges sodium for protons or ammonium ions at the basolateral membrane of epithelia to regulate cell volume and intracellular pH upon hypertonic conditions (By similarity). As part of transcellular ammonia trans
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00999 Na_H_Exchanger 73 477 Sodium/hydrogen exchanger family Family
PF16644 NEXCaM_BD 566 675 Regulatory region of Na+/H+ exchanger NHE binds to calmodulin Domain
Sequence
Sequence length 798
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Gastric acid secretion   Sodium/Proton exchangers
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
4
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Ascending aortic dissection association rs1468788, rs11692304, rs4851608, rs4241211 RCV001543144
RCV001543146
RCV001543141
RCV001543142
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Asthma Associate 35524249
Celiac Disease Associate 27836013
Death Associate 31455667
Diabetes Mellitus Type 2 Inhibit 34134627
Graft vs Host Disease Associate 31455667
Infections Associate 31455667
Inflammation Associate 34134627
Obesity Associate 35524249