Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
389015
Gene name Gene Name - the full gene name approved by the HGNC.
Solute carrier family 9 member A4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SLC9A4
Synonyms (NCBI Gene) Gene synonyms aliases
NHE4
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2q12.1
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT531082 hsa-miR-548a-5p PAR-CLIP 21572407
MIRT531081 hsa-miR-548ab PAR-CLIP 21572407
MIRT531080 hsa-miR-548ad-5p PAR-CLIP 21572407
MIRT531079 hsa-miR-548ae-5p PAR-CLIP 21572407
MIRT531078 hsa-miR-548ak PAR-CLIP 21572407
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001696 Process Gastric acid secretion IEA
GO:0002068 Process Glandular epithelial cell development IEA
GO:0005886 Component Plasma membrane IBA
GO:0005886 Component Plasma membrane IEA
GO:0005886 Component Plasma membrane TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
600531 11077 ENSG00000180251
Protein
UniProt ID Q6AI14
Protein name Sodium/hydrogen exchanger 4 (Na(+)/H(+) exchanger 4) (NHE-4) (Solute carrier family 9 member 4)
Protein function Electroneutral antiporter that exchanges sodium for protons or ammonium ions at the basolateral membrane of epithelia to regulate cell volume and intracellular pH upon hypertonic conditions (By similarity). As part of transcellular ammonia trans
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00999 Na_H_Exchanger 73 477 Sodium/hydrogen exchanger family Family
PF16644 NEXCaM_BD 566 675 Regulatory region of Na+/H+ exchanger NHE binds to calmodulin Domain
Sequence
Sequence length 798
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Gastric acid secretion   Sodium/Proton exchangers
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Asthma Nonatopic asthma, Atopic asthma, Asthma (adult onset), Asthma (childhood onset) N/A N/A GWAS
Celiac disease Celiac disease N/A N/A GWAS
Crohn Disease Crohn's disease or Leprosy (opposite effect) N/A N/A GWAS
Dermatitis Atopic dermatitis N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Asthma Associate 35524249
Celiac Disease Associate 27836013
Death Associate 31455667
Diabetes Mellitus Type 2 Inhibit 34134627
Graft vs Host Disease Associate 31455667
Infections Associate 31455667
Inflammation Associate 34134627
Obesity Associate 35524249