Gene Gene information from NCBI Gene database.
Entrez ID 389
Gene name Ras homolog family member C
Gene symbol RHOC
Synonyms (NCBI Gene)
ARH9ARHCH9RHOH9
Chromosome 1
Chromosome location 1p13.2
Summary This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskel
miRNA miRNA information provided by mirtarbase database.
505
miRTarBase ID miRNA Experiments Reference
MIRT000495 hsa-miR-138-5p qRT-PCRLuciferase reporter assayWestern blot 20232393
MIRT005932 hsa-miR-372-3p ImmunocytochemistryLuciferase reporter assayMicroarrayqRT-PCRWestern blot 21490602
MIRT005932 hsa-miR-372-3p ImmunocytochemistryLuciferase reporter assayMicroarrayqRT-PCRWestern blot 21490602
MIRT005933 hsa-miR-302b-3p ImmunocytochemistryLuciferase reporter assayMicroarrayqRT-PCRWestern blot 21490602
MIRT005933 hsa-miR-302b-3p ImmunocytochemistryLuciferase reporter assayMicroarrayqRT-PCRWestern blot 21490602
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
ETS1 Activation 21732343
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
40
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0000281 Process Mitotic cytokinesis IBA
GO:0000281 Process Mitotic cytokinesis IDA 16236794
GO:0000281 Process Mitotic cytokinesis IEA
GO:0003924 Function GTPase activity IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
165380 669 ENSG00000155366
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P08134
Protein name Rho-related GTP-binding protein RhoC (Rho cDNA clone 9) (h9)
Protein function Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell
PDB 1Z2C , 2GCN , 2GCO , 2GCP
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00071 Ras 7 180 Ras family Domain
Sequence
Sequence length 193
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Rho GTPase cycle
G alpha (12/13) signalling events
Sema4D induced cell migration and growth-cone collapse
RHO GTPases activate PKNs
RHO GTPases activate CIT
RHO GTPases Activate ROCKs
RHO GTPases Activate Formins
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
HYPERTENSION GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
MYOCARDIAL ISCHEMIA CTD, Disgenet
CTD, Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Adenocarcinoma Associate 23200924
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of Lung Associate 27748883
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Associate 16187229, 20843787, 22992742, 24096540, 25123151
★☆☆☆☆
Found in Text Mining only
Calcinosis Cutis Associate 12970882, 31324164
★☆☆☆☆
Found in Text Mining only
Calcinosis Cutis Stimulate 18415097, 9459160
★☆☆☆☆
Found in Text Mining only
Carcinogenesis Associate 18614849, 19374769, 20503409
★☆☆☆☆
Found in Text Mining only
Carcinoma Adenoid Cystic Associate 39610069
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Associate 12970882, 15534908, 25472720, 26165487, 30779947, 31324164
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Inhibit 15150600
★☆☆☆☆
Found in Text Mining only
Carcinoma Intraductal Noninfiltrating Associate 16187229
★☆☆☆☆
Found in Text Mining only