Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	3887
Gene name Gene Name - the full gene name approved by the HGNC.	Keratin 81
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	KRT81
Synonyms (NCBI Gene) Gene synonyms aliases	HB1, Hb-1, K81, KRTHB1, MLN137, MNLIX2, ghHkb1, hHAKB2-1
Chromosome Chromosome number	12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	12q13.13
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome

Show/Hide all(138)

miRTarBase ID	miRNA	Experiments
MIRT1101780	hsa-miR-1207-5p	CLIP-seq
MIRT1101781	hsa-miR-1254	CLIP-seq
MIRT1101782	hsa-miR-2861	CLIP-seq
MIRT1101783	hsa-miR-3116	CLIP-seq
MIRT1101784	hsa-miR-3199	CLIP-seq
MIRT1101785	hsa-miR-3714	CLIP-seq
MIRT1101786	hsa-miR-4436b-3p	CLIP-seq
MIRT1101787	hsa-miR-4708-3p	CLIP-seq
MIRT1101788	hsa-miR-4763-3p	CLIP-seq
MIRT1101789	hsa-miR-661	CLIP-seq
MIRT1101790	hsa-miR-940	CLIP-seq
MIRT1920071	hsa-miR-1193	CLIP-seq
MIRT1101780	hsa-miR-1207-5p	CLIP-seq
MIRT1920072	hsa-miR-1243	CLIP-seq
MIRT1101781	hsa-miR-1254	CLIP-seq
MIRT1920073	hsa-miR-1269	CLIP-seq
MIRT1920074	hsa-miR-1269b	CLIP-seq
MIRT1920075	hsa-miR-1288	CLIP-seq
MIRT1101783	hsa-miR-3116	CLIP-seq
MIRT1920076	hsa-miR-3690	CLIP-seq
MIRT1101785	hsa-miR-3714	CLIP-seq
MIRT1920077	hsa-miR-378	CLIP-seq
MIRT1920078	hsa-miR-378b	CLIP-seq
MIRT1920079	hsa-miR-378c	CLIP-seq
MIRT1920080	hsa-miR-378d	CLIP-seq
MIRT1920081	hsa-miR-378e	CLIP-seq
MIRT1920082	hsa-miR-378f	CLIP-seq
MIRT1920083	hsa-miR-378h	CLIP-seq
MIRT1920084	hsa-miR-378i	CLIP-seq
MIRT1920085	hsa-miR-422a	CLIP-seq
MIRT1101786	hsa-miR-4436b-3p	CLIP-seq
MIRT1920086	hsa-miR-4515	CLIP-seq
MIRT1920087	hsa-miR-4640-5p	CLIP-seq
MIRT1920088	hsa-miR-4645-5p	CLIP-seq
MIRT1920089	hsa-miR-4673	CLIP-seq
MIRT1101787	hsa-miR-4708-3p	CLIP-seq
MIRT1920090	hsa-miR-4726-5p	CLIP-seq
MIRT1920091	hsa-miR-4740-5p	CLIP-seq
MIRT1101788	hsa-miR-4763-3p	CLIP-seq
MIRT1920092	hsa-miR-566	CLIP-seq
MIRT1101790	hsa-miR-940	CLIP-seq
MIRT1920071	hsa-miR-1193	CLIP-seq
MIRT1920072	hsa-miR-1243	CLIP-seq
MIRT1101781	hsa-miR-1254	CLIP-seq
MIRT1920073	hsa-miR-1269	CLIP-seq
MIRT1920074	hsa-miR-1269b	CLIP-seq
MIRT1920075	hsa-miR-1288	CLIP-seq
MIRT1101783	hsa-miR-3116	CLIP-seq
MIRT1920076	hsa-miR-3690	CLIP-seq
MIRT1101785	hsa-miR-3714	CLIP-seq
MIRT1920077	hsa-miR-378	CLIP-seq
MIRT1920078	hsa-miR-378b	CLIP-seq
MIRT1920079	hsa-miR-378c	CLIP-seq
MIRT1920080	hsa-miR-378d	CLIP-seq
MIRT1920081	hsa-miR-378e	CLIP-seq
MIRT1920082	hsa-miR-378f	CLIP-seq
MIRT1920083	hsa-miR-378h	CLIP-seq
MIRT1920084	hsa-miR-378i	CLIP-seq
MIRT1920085	hsa-miR-422a	CLIP-seq
MIRT1920086	hsa-miR-4515	CLIP-seq
MIRT1920087	hsa-miR-4640-5p	CLIP-seq
MIRT1920088	hsa-miR-4645-5p	CLIP-seq
MIRT1920089	hsa-miR-4673	CLIP-seq
MIRT1101787	hsa-miR-4708-3p	CLIP-seq
MIRT1920090	hsa-miR-4726-5p	CLIP-seq
MIRT1920091	hsa-miR-4740-5p	CLIP-seq
MIRT1920092	hsa-miR-566	CLIP-seq
MIRT1101790	hsa-miR-940	CLIP-seq
MIRT1920071	hsa-miR-1193	CLIP-seq
MIRT1101780	hsa-miR-1207-5p	CLIP-seq
MIRT1920072	hsa-miR-1243	CLIP-seq
MIRT1101781	hsa-miR-1254	CLIP-seq
MIRT1920073	hsa-miR-1269	CLIP-seq
MIRT1920074	hsa-miR-1269b	CLIP-seq
MIRT1920075	hsa-miR-1288	CLIP-seq
MIRT1101783	hsa-miR-3116	CLIP-seq
MIRT1920076	hsa-miR-3690	CLIP-seq
MIRT1101785	hsa-miR-3714	CLIP-seq
MIRT1920077	hsa-miR-378	CLIP-seq
MIRT1920078	hsa-miR-378b	CLIP-seq
MIRT1920079	hsa-miR-378c	CLIP-seq
MIRT1920080	hsa-miR-378d	CLIP-seq
MIRT1920081	hsa-miR-378e	CLIP-seq
MIRT1920082	hsa-miR-378f	CLIP-seq
MIRT1920083	hsa-miR-378h	CLIP-seq
MIRT1920084	hsa-miR-378i	CLIP-seq
MIRT1920085	hsa-miR-422a	CLIP-seq
MIRT1101786	hsa-miR-4436b-3p	CLIP-seq
MIRT1920086	hsa-miR-4515	CLIP-seq
MIRT1920087	hsa-miR-4640-5p	CLIP-seq
MIRT1920088	hsa-miR-4645-5p	CLIP-seq
MIRT1920089	hsa-miR-4673	CLIP-seq
MIRT1101787	hsa-miR-4708-3p	CLIP-seq
MIRT1920090	hsa-miR-4726-5p	CLIP-seq
MIRT1920091	hsa-miR-4740-5p	CLIP-seq
MIRT1101788	hsa-miR-4763-3p	CLIP-seq
MIRT1920092	hsa-miR-566	CLIP-seq
MIRT1101790	hsa-miR-940	CLIP-seq
MIRT2027645	hsa-miR-106a	CLIP-seq
MIRT2027646	hsa-miR-106b	CLIP-seq
MIRT2027647	hsa-miR-1200	CLIP-seq
MIRT2027648	hsa-miR-1202	CLIP-seq
MIRT2027649	hsa-miR-1286	CLIP-seq
MIRT2027650	hsa-miR-1291	CLIP-seq
MIRT2027651	hsa-miR-17	CLIP-seq
MIRT2027652	hsa-miR-20a	CLIP-seq
MIRT2027653	hsa-miR-20b	CLIP-seq
MIRT2027654	hsa-miR-3074-5p	CLIP-seq
MIRT2027655	hsa-miR-3115	CLIP-seq
MIRT2027656	hsa-miR-3127-3p	CLIP-seq
MIRT2027657	hsa-miR-3194-5p	CLIP-seq
MIRT2027658	hsa-miR-328	CLIP-seq
MIRT2027659	hsa-miR-337-3p	CLIP-seq
MIRT2027660	hsa-miR-3663-3p	CLIP-seq
MIRT2027661	hsa-miR-3667-3p	CLIP-seq
MIRT2027662	hsa-miR-370	CLIP-seq
MIRT2027663	hsa-miR-3972	CLIP-seq
MIRT2027664	hsa-miR-4268	CLIP-seq
MIRT2027665	hsa-miR-4324	CLIP-seq
MIRT2027666	hsa-miR-4434	CLIP-seq
MIRT2027667	hsa-miR-4448	CLIP-seq
MIRT2027668	hsa-miR-4516	CLIP-seq
MIRT2027669	hsa-miR-4649-3p	CLIP-seq
MIRT2027670	hsa-miR-4663	CLIP-seq
MIRT2027671	hsa-miR-4722-5p	CLIP-seq
MIRT2027672	hsa-miR-4768-3p	CLIP-seq
MIRT2027673	hsa-miR-519a	CLIP-seq
MIRT2027674	hsa-miR-519b-3p	CLIP-seq
MIRT2027675	hsa-miR-519c-3p	CLIP-seq
MIRT2027676	hsa-miR-519d	CLIP-seq
MIRT2027677	hsa-miR-544b	CLIP-seq
MIRT2027678	hsa-miR-562	CLIP-seq
MIRT2027679	hsa-miR-93	CLIP-seq
MIRT2259005	hsa-miR-1294	CLIP-seq
MIRT2259006	hsa-miR-377	CLIP-seq
MIRT2259007	hsa-miR-3919	CLIP-seq
MIRT2259008	hsa-miR-4316	CLIP-seq
MIRT2259009	hsa-miR-539	CLIP-seq

Show/Hide all(10)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16189514, 23088713, 25416956, 29892012, 32296183, 32814053
GO:0005615	Component	Extracellular space	HDA	23580065
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005882	Component	Intermediate filament	IEA
GO:0030280	Function	Structural constituent of skin epidermis	IBA
GO:0031424	Process	Keratinization	IBA
GO:0045095	Component	Keratin filament	IBA
GO:0045095	Component	Keratin filament	IEA
GO:0045109	Process	Intermediate filament organization	IBA

MIM	HGNC	e!Ensembl
602153	6458	ENSG00000205426

Protein

UniProt ID

Q14533

Protein name

Keratin, type II cuticular Hb1 (Hair keratin K2.9) (Keratin, hair, basic, 1) (Keratin-81) (K81) (Metastatic lymph node 137 gene protein) (MLN 137) (Type II hair keratin Hb1) (Type-II keratin Kb21) (ghHKb1) (ghHb1)

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF16208	Keratin_2_head	1 → 102	Keratin type II head	Family
PF00038	Filament	105 → 416	Intermediate filament protein	Coiled-coil

Tissue specificity

TISSUE SPECIFICITY: Abundantly expressed in the differentiating cortex of growing (anagen) hair. Expression is restricted to the keratinocytes of the hair cortex and is absent from inner root sheath and medulla. Expressed in malignant lymph node tissue in

Sequence

MTCGSGFGGRAFSCISACGPRPGRCCITAAPYRGISCYRGLTGGFGSHSVCGGFRAGSCG
RSFGYRSGGVCGPSPPCITTVSVNESLLTPLNLEIDPNAQCVKQEEKEQIKSLNSRFAAF
IDKVRFLEQQNKLLETKLQFYQNRECCQSNLEPLFEGYIETLRREAECVEADSGRLASEL
NHVQEVLEGYKKKYEEEVSLRATAENEFVALKKDVDCAYLRKSDLEANVEALIQEIDFLR
RLYEEEILILQSHISDTSVVVKLDNSRDLNMDCIIAEIKAQYDDIVTRSRAEAESWYRSK
CEEMKATVIRHGETLRRTKEEINELNRMIQRLTAEVENAKCQNSKLEAAVAQSEQQGEAA
LSDARCKLAELEGALQKAKQDMACLIREYQEVMNSKLGLDIEIATYRRLLEGEEQRLCEG
IGAVNVCVSSSRGGVVCGDLCVSGSRPVTGSVCSAPCNGNVAVSTGLCAPCGQLNTTCGG
GSCGVGSCGISSLGVGSCGSSCRKC

Sequence length

505

Interactions

View interactions

	Reactome
			Keratinization Formation of the cornified envelope

KRT81 (keratin 81)