Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
388336
Gene name Gene Name - the full gene name approved by the HGNC.
Shisa family member 6
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SHISA6
Synonyms (NCBI Gene) Gene synonyms aliases
-
Chromosome Chromosome number
17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17p12
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT625318 hsa-miR-6887-3p HITS-CLIP 23824327
MIRT625317 hsa-miR-6795-3p HITS-CLIP 23824327
MIRT625310 hsa-miR-205-5p HITS-CLIP 23824327
MIRT653846 hsa-miR-6841-3p HITS-CLIP 23824327
MIRT653845 hsa-miR-1915-5p HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 32296183
GO:0007283 Process Spermatogenesis ISS
GO:0014069 Component Postsynaptic density IBA 21873635
GO:0014069 Component Postsynaptic density ISS
GO:0016055 Process Wnt signaling pathway IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
617327 34491 ENSG00000188803
Protein
UniProt ID Q6ZSJ9
Protein name Protein shisa-6
Protein function Involved in maintenance of high-frequency synaptic transmission at hippocampal CA3-CA1 synapses. Regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13908 Shisa 91 282 Wnt and FGF inhibitory regulator Family
Tissue specificity TISSUE SPECIFICITY: Expressed in the developing ventral mesencephalon. {ECO:0000269|PubMed:16473350}.
Sequence
MALRRLLLLLLLSLESLDLLPSVHGARGRAANRTLSAGGAAVGGRRAGGALARGGRELNG
TARAPGIPEAGSRRGQPAAAVAAAASAAVTYETCWGYYDVSGQYDKEFECNNSESGYLYC
CGTCYYRFCCKKRHEKLDQRQCTNYQSPVWVQTPSTKVVSPGPENKYDPEKDKTNFTVYI
TCGVIAFVIVAGVFAKVSYDKAHRPPREMNIHRALADILRQQGPIPIAHCERETISAIDT
SPKENTPVRSSSKNHYTPVRTAKQTPEKPRMNNILTSATEPY
DLSFSRSFQNLAHLPPSY
ESAVKTNPSKYSSLKRLTDKEADEYYMRRRHLPDLAARGTLPLNVIQMSQQKPLPRERPR
RPIRAMSQDRVLSPDRGLPDEFSMPYDRILSDEQLLSTERLHSQDPLLSPERTAFPEQSL
SRAISHTDVFVSTPVLDRYRMSKMHSHPSASNNSYATLGQSQTAAKRHAFASRRHNTVEQ
LHYIPGHHTCYTASKTEVTV
Sequence length 500
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Leukemia Leukemia, Myelocytic, Acute rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297 27903959
Myopia Myopia rs387907109, rs146936371, rs587776903, rs786205127, rs398122836, rs199624584, rs587777625, rs786205216, rs758872875, rs764211125, rs1135402746, rs765658563, rs1555941129, rs1555941116, rs199923805
View all (6 more)
27182965
Unknown
Disease term Disease name Evidence References Source
Schizophrenia Schizophrenia GWAS
Ischemic Stroke Ischemic Stroke GWAS
Hyperopia Hyperopia GWAS
Alzheimer disease Alzheimer disease GWAS
Associations from Text Mining
Disease Name Relationship Type References
Endometriosis Associate 39408909
Hypertension Associate 37181702
Myopia Associate 37181702
Obesity Associate 37181702