Gene Gene information from NCBI Gene database.
Entrez ID 388
Gene name Ras homolog family member B
Gene symbol RHOB
Synonyms (NCBI Gene)
ARH6ARHBMST081MSTP081RHOH6
Chromosome 2
Chromosome location 2p24.1
miRNA miRNA information provided by mirtarbase database.
1296
miRTarBase ID miRNA Experiments Reference
MIRT001109 hsa-miR-223-3p Luciferase reporter assayWestern blot 19850724
MIRT001109 hsa-miR-223-3p Luciferase reporter assay 19850724
MIRT003317 hsa-miR-21-5p Luciferase reporter assayqRT-PCRWestern blot 20460403
MIRT003317 hsa-miR-21-5p Luciferase reporter assayqRT-PCRWestern blot 20460403
MIRT003317 hsa-miR-21-5p Luciferase reporter assayqRT-PCRWestern blot 20460403
Transcription factors Transcription factors information provided by TRRUST V2 database.
2
Transcription factor Regulation Reference
HDAC1 Repression 13679859
JUN Activation 21565167
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
60
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0000281 Process Mitotic cytokinesis IEA
GO:0000281 Process Mitotic cytokinesis IMP 16236794
GO:0001525 Process Angiogenesis IEA
GO:0003924 Function GTPase activity IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
165370 668 ENSG00000143878
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P62745
Protein name Rho-related GTP-binding protein RhoB (Rho cDNA clone 6) (h6)
Protein function Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor fo
PDB 2FV8 , 6HXU , 6SGE
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00071 Ras 7 180 Ras family Domain
Sequence
Sequence length 196
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Salmonella infection   GPVI-mediated activation cascade
Rho GTPase cycle
G alpha (12/13) signalling events
Sema4D induced cell migration and growth-cone collapse
RHO GTPases activate PKNs
RHO GTPases activate CIT
RHO GTPases Activate ROCKs
RHO GTPases Activate Formins
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
6
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
"See Cases" Conflicting classifications of pathogenicity ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Recurrent pancreatitis Conflicting classifications of pathogenicity ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
RHOB-related disorder Conflicting classifications of pathogenicity ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
SCLERODERMA, SYSTEMIC CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Arrest of spermatogenesis Associate 19997872
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Associate 16984733, 21373644, 23339407, 23420497, 32671953, 33162807, 36329030, 38041032
★☆☆☆☆
Found in Text Mining only
Calcinosis Cutis Associate 20460403
★☆☆☆☆
Found in Text Mining only
Capillary Leak Syndrome Associate 29097442
★☆☆☆☆
Found in Text Mining only
Carcinogenesis Associate 24223801, 25249323, 25540389
★☆☆☆☆
Found in Text Mining only
Carcinoma Basal Cell Associate 33162807
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Associate 25540389
★☆☆☆☆
Found in Text Mining only
Carcinoma Non Small Cell Lung Associate 28131418, 37453674
★☆☆☆☆
Found in Text Mining only
Carcinoma Pancreatic Ductal Associate 27832197
★☆☆☆☆
Found in Text Mining only
Carcinoma Renal Cell Inhibit 27384222, 29474434
★☆☆☆☆
Found in Text Mining only