KRT18 (keratin 18)

Gene Gene information from NCBI Gene database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 3875
Gene name Keratin 18
Gene symbol KRT18
Synonyms (NCBI Gene)
CK-18CYK18K18
Chromosome 12
Chromosome location 12q13.13
Summary KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial
miRNA miRNA information provided by mirtarbase database.
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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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miRTarBase ID miRNA Experiments Reference
MIRT023274 hsa-miR-122-5p Proteomics 17612493
MIRT029677 hsa-miR-26b-5p Microarray 19088304
MIRT1101167 hsa-miR-1976 CLIP-seq
MIRT1101168 hsa-miR-370 CLIP-seq
MIRT1101169 hsa-miR-4757-5p CLIP-seq
Transcription factors Transcription factors information provided by TRRUST V2 database.
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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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Transcription factor Regulation Reference
BRCA1 Unknown 15831101
CTBP1 Unknown 15831101
SP1 Unknown 10094831;7537848
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0003723 Function RNA binding HDA 22658674
GO:0005198 Function Structural molecule activity IEA
GO:0005515 Function Protein binding IPI 10852826, 10954706, 11684708, 14710194, 14756564, 15671067, 15731013, 15846844, 16189514, 16367866, 19549727, 20035625, 20936779, 21988832, 23112296, 24940650, 25416956, 25910212, 26769854, 26871637, 30021884, 31515488, 32296183, 32814053, 35271311, 36931259
GO:0005634 Component Nucleus IEA
GO:0005730 Component Nucleolus IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
148070 6430 ENSG00000111057
Protein Protein information from UniProt database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P05783
Protein name Keratin, type I cytoskeletal 18 (Cell proliferation-inducing gene 46 protein) (Cytokeratin-18) (CK-18) (Keratin-18) (K18)
Protein function Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is inv
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00038 Filament 79 → 391 Intermediate filament protein Coiled-coil
Tissue specificity TISSUE SPECIFICITY: Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma. {ECO:0000269|PubMed:17213200, ECO:0000269|PubMed:2422083, ECO:0000269|PubMed:2434380, ECO:0000269|PubMe
Sequence
Sequence length 430
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  Reactome
  Estrogen signaling pathway
Staphylococcus aureus infection 		  Keratinization
Formation of the cornified envelope
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (2)
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Cirrhosis, cryptogenic Pathogenic rs57758506 RCV000015686
Cirrhosis, noncryptogenic, susceptibility to Pathogenic rs57758506 RCV000015687
Show/Hide Unknown Diseases (2)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Cirrhosis, familial Uncertain significance rs532875586, rs1942470902, rs146788536 RCV001331079
RCV001331080
RCV003985250
Hepatitis C virus, susceptibility to not provided rs386834225, rs200221269 RCV000049576
RCV000049578
Show/Hide Text Mining Associations (123)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma Associate 11923318, 1690512, 29949537, 33588765, 35328735
Adenocarcinoma of Lung Associate 2414994, 35102706
Alzheimer Disease Associate 32833429
Arrest of spermatogenesis Associate 12009342
Ascites Associate 8946143
Asthma Associate 16891808
Atypical Squamous Cells of the Cervix Associate 19309563
Biliary Atresia Associate 12724528, 35029214
Breast Neoplasms Associate 14556659, 19050795, 20103682, 21425134, 28634007, 29884220, 33588765, 34801010, 8946143, 9786916
Cancer Pain Associate 21425134