KRT18 (keratin 18)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3875
Gene name Gene Name - the full gene name approved by the HGNC.
Keratin 18
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
KRT18
Synonyms (NCBI Gene) Gene synonyms aliases
CK-18, CYK18, K18
Chromosome Chromosome number
12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
12q13.13
Summary Summary of gene provided in NCBI Entrez Gene.
KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(21)
miRTarBase ID miRNA Experiments Reference
MIRT023274 hsa-miR-122-5p Proteomics 17612493
MIRT029677 hsa-miR-26b-5p Microarray 19088304
MIRT1101167 hsa-miR-1976 CLIP-seq
MIRT1101168 hsa-miR-370 CLIP-seq
MIRT1101169 hsa-miR-4757-5p CLIP-seq
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(3)
Transcription factor Regulation Reference
BRCA1 Unknown 15831101
CTBP1 Unknown 15831101
SP1 Unknown 10094831;7537848
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(36)
GO ID Ontology Definition Evidence Reference
GO:0003723 Function RNA binding HDA 22658674
GO:0005198 Function Structural molecule activity IEA
GO:0005515 Function Protein binding IPI 10852826, 10954706, 11684708, 14710194, 14756564, 15671067, 15731013, 15846844, 16189514, 16367866, 19549727, 20035625, 20936779, 21988832, 23112296, 24940650, 25416956, 25910212, 26769854, 26871637, 30021884, 31515488, 32296183, 32814053, 35271311, 36931259
GO:0005634 Component Nucleus IEA
GO:0005730 Component Nucleolus IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
148070 6430 ENSG00000111057
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P05783
Protein name Keratin, type I cytoskeletal 18 (Cell proliferation-inducing gene 46 protein) (Cytokeratin-18) (CK-18) (Keratin-18) (K18)
Protein function Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is inv
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00038 Filament 79 → 391 Intermediate filament protein Coiled-coil
Tissue specificity TISSUE SPECIFICITY: Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma. {ECO:0000269|PubMed:17213200, ECO:0000269|PubMed:2422083, ECO:0000269|PubMed:2434380, ECO:0000269|PubMe
Sequence
Sequence length 430
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Estrogen signaling pathway
Staphylococcus aureus infection 		  Keratinization
Formation of the cornified envelope
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (3)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Cirrhosis cirrhosis, familial N/A N/A GenCC
Cleft Lip With Or Without Cleft Palate Cleft lip with or without cleft palate N/A N/A GWAS
Prostate cancer Prostate cancer N/A N/A GWAS
Show/Hide Text Mining Associations (123)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma Associate 11923318, 1690512, 29949537, 33588765, 35328735
Adenocarcinoma of Lung Associate 2414994, 35102706
Alzheimer Disease Associate 32833429
Arrest of spermatogenesis Associate 12009342
Ascites Associate 8946143
Asthma Associate 16891808
Atypical Squamous Cells of the Cervix Associate 19309563
Biliary Atresia Associate 12724528, 35029214
Breast Neoplasms Associate 14556659, 19050795, 20103682, 21425134, 28634007, 29884220, 33588765, 34801010, 8946143, 9786916
Cancer Pain Associate 21425134