CENPW (centromere protein W)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
387103
Gene name Gene Name - the full gene name approved by the HGNC.
Centromere protein W
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CENPW
Synonyms (NCBI Gene) Gene synonyms aliases
C6orf173, CENP-W, CUG2
Chromosome Chromosome number
6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6q22.32
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(1)
miRTarBase ID miRNA Experiments Reference
MIRT885458 hsa-miR-498 CLIP-seq
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(1)
Transcription factor Regulation Reference
SP1 Unknown 20180024
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0000278 Process Mitotic cell cycle IBA
GO:0000278 Process Mitotic cell cycle IEA
GO:0000278 Process Mitotic cell cycle IMP 21695110
GO:0000775 Component Chromosome, centromeric region IDA 19533040
GO:0000775 Component Chromosome, centromeric region IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
611264 21488 ENSG00000203760
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q5EE01
Protein name Centromere protein W (CENP-W) (Cancer-up-regulated gene 2 protein)
Protein function Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). The CENPA-NAC complex recruits the CENPA-CAD (nu
PDB 7QOO , 7R5S , 7XHN , 7XHO , 7YWX
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF15510 CENP-W 1 → 88 CENP-W protein Domain
Tissue specificity TISSUE SPECIFICITY: Highly expressed in ovary, liver, lung and pancreas and to a lower extent in breast and gastrointestinal tract cancers; such as those of the colon, rectum and stomach. Overexpressed in high grade breast invasive tumors. Expressed in ma
Sequence
Sequence length 88
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Deposition of new CENPA-containing nucleosomes at the centromere
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (7)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Carcinoma Basal cell carcinoma N/A N/A GWAS
Coronary artery disease Coronary artery disease N/A N/A GWAS
Diabetes Body fat percentage and type 2 diabetes (pairwise), Type 2 diabetes with ophthalmic manifestations (PheCode 250.23), Type 2 diabetes mellitus adjusted for BMI or coronary artery disease (pleiotropy), Type 2 diabetes mellitus or coronary artery disease (pleiotropy), Diabetes, Type 2 diabetes N/A N/A GWAS
Diabetes Type 1 diabetes N/A N/A GWAS
Show/Hide Text Mining Associations (9)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Carcinoma Hepatocellular Associate 32635817
Carcinoma Hepatocellular Stimulate 33973496
Cholangiocarcinoma Associate 33725402
Colorectal Neoplasms Stimulate 25107436
Diabetes Mellitus Type 1 Associate 21270831, 31455420
Lung Neoplasms Associate 27974707, 30226605, 35000669
Neoplasms Associate 30226605, 35363173
Neoplasms Stimulate 35000669
Obesity Associate 34872017