KRTAP10-8 (keratin associated protein 10-8)

Gene

• Entrez ID: 386681
• Gene name: Keratin associated protein 10-8
• Gene symbol: KRTAP10-8
• Synonyms (NCBI Gene): KAP10.8, KRTAP18-8, KRTAP18.8
• Chromosome: 21
• Chromosome location: 21q22.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT2027731	hsa-miR-1207-3p	CLIP-seq
MIRT2027732	hsa-miR-3176	CLIP-seq
MIRT2027733	hsa-miR-378	CLIP-seq
MIRT2027734	hsa-miR-378b	CLIP-seq
MIRT2027735	hsa-miR-378c	CLIP-seq
MIRT2027736	hsa-miR-378d	CLIP-seq
MIRT2027737	hsa-miR-378e	CLIP-seq
MIRT2027738	hsa-miR-378f	CLIP-seq
MIRT2027739	hsa-miR-378h	CLIP-seq
MIRT2027740	hsa-miR-378i	CLIP-seq
MIRT2027741	hsa-miR-3922-3p	CLIP-seq
MIRT2027742	hsa-miR-422a	CLIP-seq
MIRT2027743	hsa-miR-4468	CLIP-seq
MIRT2027744	hsa-miR-646	CLIP-seq
MIRT2027732	hsa-miR-3176	CLIP-seq
MIRT2027733	hsa-miR-378	CLIP-seq
MIRT2027734	hsa-miR-378b	CLIP-seq
MIRT2027735	hsa-miR-378c	CLIP-seq
MIRT2027736	hsa-miR-378d	CLIP-seq
MIRT2027737	hsa-miR-378e	CLIP-seq
MIRT2027738	hsa-miR-378f	CLIP-seq
MIRT2027739	hsa-miR-378h	CLIP-seq
MIRT2027740	hsa-miR-378i	CLIP-seq
MIRT2027741	hsa-miR-3922-3p	CLIP-seq
MIRT2027742	hsa-miR-422a	CLIP-seq
MIRT2027743	hsa-miR-4468	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 25910212, 26871637, 29892012, 31515488, 32296183
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005882	Component	Intermediate filament	IEA
GO:0042802	Function	Identical protein binding	IPI	25416956, 32296183
GO:0045095	Component	Keratin filament	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: P60410
• Protein name: Keratin-associated protein 10-8 (High sulfur keratin-associated protein 10.8) (Keratin-associated protein 10.8) (Keratin-associated protein 18-8) (Keratin-associated protein 18.8)
• Protein function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their e
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF05287	PMG	2 → 91	PMG protein	Family
  PF13885	Keratin_B2_2	140 → 186	Keratin, high sulfur B2 protein	Family
  PF13885	Keratin_B2_2	178 → 216	Keratin, high sulfur B2 protein	Family

• Tissue specificity: TISSUE SPECIFICITY: Restricted to a narrow region of the hair fiber cuticle, lying approximately 20 cell layers above the apex of the dermal papilla of the hair root; not detected in any other tissues. {ECO:0000269|PubMed:14962103, ECO:0000269|PubMed:1502
• Sequence:

  MADACCTRTYVIAASTMSVCSSDVGHVSRVSSPSTCTGSSWQVDNCQESCCEPRSCASSC
  CTPSCCAPAPCLALVCAPVSCEPSPCQSGCTDSCTPSCCQQSSCQPACCTSSPCQQACCV
  PVCCKSNCCKPVCCVSICSGASSPCCQQSSCQSACCTFSPCQQACCVPICCKPICCVPVC
  SGASSLCCQKSSCQPACCTTSCCRPSSSVSLLCRPVCRPACCVPVPSCCVPASSCQPSCC
  HPASCLSFLCRPACSRLAC

• Sequence length: 259

Pathways

Reactome:

Keratinization