IL31 (interleukin 31)

Gene
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
386653
Gene name Gene Name - the full gene name approved by the HGNC.
Interleukin 31
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
IL31
Synonyms (NCBI Gene) Gene synonyms aliases
IL-31
Chromosome Chromosome number
12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
12q24.31
Summary Summary of gene provided in NCBI Entrez Gene.
IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting of IL31RA (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed on epithelial cells and keratinocytes. IL31 may be involved in
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(8)
GO ID Ontology Definition Evidence Reference
GO:0002376 Process Immune system process IEA
GO:0005125 Function Cytokine activity IBA 21873635
GO:0005126 Function Cytokine receptor binding IBA 21873635
GO:0005515 Function Protein binding IPI 32296183
GO:0005576 Component Extracellular region TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
609509 19372 ENSG00000204671
Protein
Gene Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q6EBC2
Protein name Interleukin-31 (IL-31)
Protein function Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR (PubMed:15184896). May function in skin immunity (PubMed:15184896). Enhances myeloid progenitor cell survival in vitro (By similarit
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF15209 IL31 24 → 154 Interleukin 31 Family
Tissue specificity TISSUE SPECIFICITY: Detected at low levels in testis, bone marrow, skeletal muscle, kidney, colon, thymus, small intestine and trachea. {ECO:0000269|PubMed:15184896}.
Sequence
Sequence length 164
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Cytokine-cytokine receptor interaction
JAK-STAT signaling pathway 		  IL-6-type cytokine receptor ligand interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Dermatitis Dermatitis, Atopic rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174 18249437
Show/Hide Text Mining Associations (45)
Associations from Text Mining
Disease Name Relationship Type References
Acute On Chronic Liver Failure Stimulate 25716231
Adenocarcinoma Associate 35800186
Arthritis Psoriatic Stimulate 29317264
Arthritis Psoriatic Associate 32138573
Asthma Stimulate 26956917
Asthma Associate 37274898
Bronchiolitis Associate 36137923
Carcinoma Ovarian Epithelial Associate 29484036
Cardiomyopathy Dilated Associate 28572699
Chronic Urticaria Inhibit 37795408