KRT10 (keratin 10)

Gene

• Entrez ID: 3858
• Gene name: Keratin 10
• Gene symbol: KRT10
• Synonyms (NCBI Gene): BCIE, BIE, CK10, EHK, EHK2, EHK2A, EHK2B, IHL, K10, KPP
• Chromosome: 17
• Chromosome location: 17q21.2
• Summary: This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along wi

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT023292	hsa-miR-122-5p	Proteomics	21750653
MIRT460670	hsa-miR-497-3p	PAR-CLIP	20371350
MIRT077072	hsa-miR-3609	PAR-CLIP	20371350
MIRT077074	hsa-miR-548ah-5p	PAR-CLIP	20371350
MIRT077067	hsa-miR-106a-5p	PAR-CLIP	20371350
MIRT077068	hsa-miR-106b-5p	PAR-CLIP	20371350
MIRT077063	hsa-miR-17-5p	PAR-CLIP	20371350
MIRT077064	hsa-miR-20a-5p	PAR-CLIP	20371350
MIRT077069	hsa-miR-20b-5p	PAR-CLIP	20371350
MIRT077071	hsa-miR-519d-3p	PAR-CLIP	20371350
MIRT077070	hsa-miR-526b-3p	PAR-CLIP	20371350
MIRT077065	hsa-miR-93-5p	PAR-CLIP	20371350
MIRT077079	hsa-miR-4796-3p	PAR-CLIP	20371350
MIRT460669	hsa-miR-4490	PAR-CLIP	20371350
MIRT460668	hsa-miR-4774-5p	PAR-CLIP	20371350
MIRT460670	hsa-miR-497-3p	PAR-CLIP	21572407
MIRT077072	hsa-miR-3609	PAR-CLIP	21572407
MIRT077074	hsa-miR-548ah-5p	PAR-CLIP	21572407
MIRT077067	hsa-miR-106a-5p	PAR-CLIP	21572407
MIRT077068	hsa-miR-106b-5p	PAR-CLIP	21572407
MIRT077063	hsa-miR-17-5p	PAR-CLIP	21572407
MIRT077064	hsa-miR-20a-5p	PAR-CLIP	21572407
MIRT077069	hsa-miR-20b-5p	PAR-CLIP	21572407
MIRT077071	hsa-miR-519d-3p	PAR-CLIP	21572407
MIRT077070	hsa-miR-526b-3p	PAR-CLIP	21572407
MIRT077065	hsa-miR-93-5p	PAR-CLIP	21572407
MIRT077079	hsa-miR-4796-3p	PAR-CLIP	21572407
MIRT460669	hsa-miR-4490	PAR-CLIP	21572407
MIRT460668	hsa-miR-4774-5p	PAR-CLIP	21572407
MIRT460670	hsa-miR-497-3p	PAR-CLIP	21572407
MIRT077072	hsa-miR-3609	PAR-CLIP	21572407
MIRT077074	hsa-miR-548ah-5p	PAR-CLIP	21572407
MIRT077067	hsa-miR-106a-5p	PAR-CLIP	21572407
MIRT077068	hsa-miR-106b-5p	PAR-CLIP	21572407
MIRT077063	hsa-miR-17-5p	PAR-CLIP	21572407
MIRT077064	hsa-miR-20a-5p	PAR-CLIP	21572407
MIRT077069	hsa-miR-20b-5p	PAR-CLIP	21572407
MIRT077071	hsa-miR-519d-3p	PAR-CLIP	21572407
MIRT077070	hsa-miR-526b-3p	PAR-CLIP	21572407
MIRT077065	hsa-miR-93-5p	PAR-CLIP	21572407
MIRT077079	hsa-miR-4796-3p	PAR-CLIP	21572407
MIRT460669	hsa-miR-4490	PAR-CLIP	21572407
MIRT460668	hsa-miR-4774-5p	PAR-CLIP	21572407
MIRT460670	hsa-miR-497-3p	PAR-CLIP	23446348
MIRT077072	hsa-miR-3609	PAR-CLIP	23446348
MIRT077074	hsa-miR-548ah-5p	PAR-CLIP	23446348
MIRT077067	hsa-miR-106a-5p	PAR-CLIP	23446348
MIRT077068	hsa-miR-106b-5p	PAR-CLIP	23446348
MIRT077063	hsa-miR-17-5p	PAR-CLIP	23446348
MIRT077064	hsa-miR-20a-5p	PAR-CLIP	23446348
MIRT077069	hsa-miR-20b-5p	PAR-CLIP	23446348
MIRT077071	hsa-miR-519d-3p	PAR-CLIP	23446348
MIRT077070	hsa-miR-526b-3p	PAR-CLIP	23446348
MIRT077065	hsa-miR-93-5p	PAR-CLIP	23446348
MIRT077079	hsa-miR-4796-3p	PAR-CLIP	23446348
MIRT460669	hsa-miR-4490	PAR-CLIP	23446348
MIRT460668	hsa-miR-4774-5p	PAR-CLIP	23446348
MIRT460670	hsa-miR-497-3p	PAR-CLIP	23446348
MIRT077072	hsa-miR-3609	PAR-CLIP	23446348
MIRT077074	hsa-miR-548ah-5p	PAR-CLIP	23446348
MIRT077067	hsa-miR-106a-5p	PAR-CLIP	23446348
MIRT077068	hsa-miR-106b-5p	PAR-CLIP	23446348
MIRT077063	hsa-miR-17-5p	PAR-CLIP	23446348
MIRT077064	hsa-miR-20a-5p	PAR-CLIP	23446348
MIRT077069	hsa-miR-20b-5p	PAR-CLIP	23446348
MIRT077071	hsa-miR-519d-3p	PAR-CLIP	23446348
MIRT077070	hsa-miR-526b-3p	PAR-CLIP	23446348
MIRT077065	hsa-miR-93-5p	PAR-CLIP	23446348
MIRT077079	hsa-miR-4796-3p	PAR-CLIP	23446348
MIRT460669	hsa-miR-4490	PAR-CLIP	23446348
MIRT460668	hsa-miR-4774-5p	PAR-CLIP	23446348
MIRT460670	hsa-miR-497-3p	PAR-CLIP	23592263
MIRT077072	hsa-miR-3609	PAR-CLIP	23592263
MIRT077074	hsa-miR-548ah-5p	PAR-CLIP	23592263
MIRT077067	hsa-miR-106a-5p	PAR-CLIP	23592263
MIRT077068	hsa-miR-106b-5p	PAR-CLIP	23592263
MIRT077063	hsa-miR-17-5p	PAR-CLIP	23592263
MIRT077064	hsa-miR-20a-5p	PAR-CLIP	23592263
MIRT077069	hsa-miR-20b-5p	PAR-CLIP	23592263
MIRT077071	hsa-miR-519d-3p	PAR-CLIP	23592263
MIRT077070	hsa-miR-526b-3p	PAR-CLIP	23592263
MIRT077065	hsa-miR-93-5p	PAR-CLIP	23592263
MIRT077079	hsa-miR-4796-3p	PAR-CLIP	23592263
MIRT460669	hsa-miR-4490	PAR-CLIP	23592263
MIRT460668	hsa-miR-4774-5p	PAR-CLIP	23592263
MIRT077067	hsa-miR-106a-5p	PAR-CLIP	27292025
MIRT077068	hsa-miR-106b-5p	PAR-CLIP	27292025
MIRT077063	hsa-miR-17-5p	PAR-CLIP	27292025
MIRT077064	hsa-miR-20a-5p	PAR-CLIP	27292025
MIRT077069	hsa-miR-20b-5p	PAR-CLIP	27292025
MIRT077072	hsa-miR-3609	PAR-CLIP	27292025
MIRT460669	hsa-miR-4490	PAR-CLIP	27292025
MIRT460668	hsa-miR-4774-5p	PAR-CLIP	27292025
MIRT077079	hsa-miR-4796-3p	PAR-CLIP	27292025
MIRT460670	hsa-miR-497-3p	PAR-CLIP	27292025
MIRT077071	hsa-miR-519d-3p	PAR-CLIP	27292025
MIRT077070	hsa-miR-526b-3p	PAR-CLIP	27292025
MIRT077074	hsa-miR-548ah-5p	PAR-CLIP	27292025
MIRT077065	hsa-miR-93-5p	PAR-CLIP	27292025
MIRT460670	hsa-miR-497-3p	PAR-CLIP	20371350
MIRT077072	hsa-miR-3609	PAR-CLIP	20371350
MIRT077074	hsa-miR-548ah-5p	PAR-CLIP	20371350
MIRT077067	hsa-miR-106a-5p	PAR-CLIP	20371350
MIRT077068	hsa-miR-106b-5p	PAR-CLIP	20371350
MIRT077063	hsa-miR-17-5p	PAR-CLIP	20371350
MIRT077064	hsa-miR-20a-5p	PAR-CLIP	20371350
MIRT077069	hsa-miR-20b-5p	PAR-CLIP	20371350
MIRT077071	hsa-miR-519d-3p	PAR-CLIP	20371350
MIRT077070	hsa-miR-526b-3p	PAR-CLIP	20371350
MIRT077065	hsa-miR-93-5p	PAR-CLIP	20371350
MIRT077079	hsa-miR-4796-3p	PAR-CLIP	20371350
MIRT460669	hsa-miR-4490	PAR-CLIP	20371350
MIRT460668	hsa-miR-4774-5p	PAR-CLIP	20371350
MIRT460670	hsa-miR-497-3p	PAR-CLIP	21572407
MIRT077072	hsa-miR-3609	PAR-CLIP	21572407
MIRT077074	hsa-miR-548ah-5p	PAR-CLIP	21572407
MIRT077067	hsa-miR-106a-5p	PAR-CLIP	21572407
MIRT077068	hsa-miR-106b-5p	PAR-CLIP	21572407
MIRT077063	hsa-miR-17-5p	PAR-CLIP	21572407
MIRT077064	hsa-miR-20a-5p	PAR-CLIP	21572407
MIRT077069	hsa-miR-20b-5p	PAR-CLIP	21572407
MIRT077071	hsa-miR-519d-3p	PAR-CLIP	21572407
MIRT077070	hsa-miR-526b-3p	PAR-CLIP	21572407
MIRT077065	hsa-miR-93-5p	PAR-CLIP	21572407
MIRT077079	hsa-miR-4796-3p	PAR-CLIP	21572407
MIRT460669	hsa-miR-4490	PAR-CLIP	21572407
MIRT460668	hsa-miR-4774-5p	PAR-CLIP	21572407
MIRT460670	hsa-miR-497-3p	PAR-CLIP	21572407
MIRT077072	hsa-miR-3609	PAR-CLIP	21572407
MIRT077074	hsa-miR-548ah-5p	PAR-CLIP	21572407
MIRT077067	hsa-miR-106a-5p	PAR-CLIP	21572407
MIRT077068	hsa-miR-106b-5p	PAR-CLIP	21572407
MIRT077063	hsa-miR-17-5p	PAR-CLIP	21572407
MIRT077064	hsa-miR-20a-5p	PAR-CLIP	21572407
MIRT077069	hsa-miR-20b-5p	PAR-CLIP	21572407
MIRT077071	hsa-miR-519d-3p	PAR-CLIP	21572407
MIRT077070	hsa-miR-526b-3p	PAR-CLIP	21572407
MIRT077065	hsa-miR-93-5p	PAR-CLIP	21572407
MIRT077079	hsa-miR-4796-3p	PAR-CLIP	21572407
MIRT460669	hsa-miR-4490	PAR-CLIP	21572407
MIRT460668	hsa-miR-4774-5p	PAR-CLIP	21572407
MIRT460670	hsa-miR-497-3p	PAR-CLIP	23446348
MIRT077072	hsa-miR-3609	PAR-CLIP	23446348
MIRT077074	hsa-miR-548ah-5p	PAR-CLIP	23446348
MIRT077067	hsa-miR-106a-5p	PAR-CLIP	23446348
MIRT077068	hsa-miR-106b-5p	PAR-CLIP	23446348
MIRT077063	hsa-miR-17-5p	PAR-CLIP	23446348
MIRT077064	hsa-miR-20a-5p	PAR-CLIP	23446348
MIRT077069	hsa-miR-20b-5p	PAR-CLIP	23446348
MIRT077071	hsa-miR-519d-3p	PAR-CLIP	23446348
MIRT077070	hsa-miR-526b-3p	PAR-CLIP	23446348
MIRT077065	hsa-miR-93-5p	PAR-CLIP	23446348
MIRT077079	hsa-miR-4796-3p	PAR-CLIP	23446348
MIRT460669	hsa-miR-4490	PAR-CLIP	23446348
MIRT460668	hsa-miR-4774-5p	PAR-CLIP	23446348
MIRT460670	hsa-miR-497-3p	PAR-CLIP	23446348
MIRT077072	hsa-miR-3609	PAR-CLIP	23446348
MIRT077074	hsa-miR-548ah-5p	PAR-CLIP	23446348
MIRT077067	hsa-miR-106a-5p	PAR-CLIP	23446348
MIRT077068	hsa-miR-106b-5p	PAR-CLIP	23446348
MIRT077063	hsa-miR-17-5p	PAR-CLIP	23446348
MIRT077064	hsa-miR-20a-5p	PAR-CLIP	23446348
MIRT077069	hsa-miR-20b-5p	PAR-CLIP	23446348
MIRT077071	hsa-miR-519d-3p	PAR-CLIP	23446348
MIRT077070	hsa-miR-526b-3p	PAR-CLIP	23446348
MIRT077065	hsa-miR-93-5p	PAR-CLIP	23446348
MIRT077079	hsa-miR-4796-3p	PAR-CLIP	23446348
MIRT460669	hsa-miR-4490	PAR-CLIP	23446348
MIRT460668	hsa-miR-4774-5p	PAR-CLIP	23446348
MIRT460670	hsa-miR-497-3p	PAR-CLIP	23592263
MIRT077072	hsa-miR-3609	PAR-CLIP	23592263
MIRT077074	hsa-miR-548ah-5p	PAR-CLIP	23592263
MIRT077067	hsa-miR-106a-5p	PAR-CLIP	23592263
MIRT077068	hsa-miR-106b-5p	PAR-CLIP	23592263
MIRT077063	hsa-miR-17-5p	PAR-CLIP	23592263
MIRT077064	hsa-miR-20a-5p	PAR-CLIP	23592263
MIRT077069	hsa-miR-20b-5p	PAR-CLIP	23592263
MIRT077071	hsa-miR-519d-3p	PAR-CLIP	23592263
MIRT077070	hsa-miR-526b-3p	PAR-CLIP	23592263
MIRT077065	hsa-miR-93-5p	PAR-CLIP	23592263
MIRT077079	hsa-miR-4796-3p	PAR-CLIP	23592263
MIRT460669	hsa-miR-4490	PAR-CLIP	23592263
MIRT460668	hsa-miR-4774-5p	PAR-CLIP	23592263
MIRT1101074	hsa-miR-106a	CLIP-seq
MIRT1101075	hsa-miR-106b	CLIP-seq
MIRT1101076	hsa-miR-1238	CLIP-seq
MIRT1101077	hsa-miR-1244	CLIP-seq
MIRT1101078	hsa-miR-1270	CLIP-seq
MIRT1101079	hsa-miR-142-3p	CLIP-seq
MIRT1101080	hsa-miR-146a	CLIP-seq
MIRT1101081	hsa-miR-146b-5p	CLIP-seq
MIRT1101082	hsa-miR-17	CLIP-seq
MIRT1101083	hsa-miR-186	CLIP-seq
MIRT1101084	hsa-miR-20a	CLIP-seq
MIRT1101085	hsa-miR-20b	CLIP-seq
MIRT1101086	hsa-miR-3124-3p	CLIP-seq
MIRT1101087	hsa-miR-3133	CLIP-seq
MIRT1101088	hsa-miR-3179	CLIP-seq
MIRT1101089	hsa-miR-3607-3p	CLIP-seq
MIRT1101090	hsa-miR-3611	CLIP-seq
MIRT1101091	hsa-miR-3686	CLIP-seq
MIRT1101092	hsa-miR-382	CLIP-seq
MIRT1101093	hsa-miR-3920	CLIP-seq
MIRT1101094	hsa-miR-4255	CLIP-seq
MIRT1101095	hsa-miR-4272	CLIP-seq
MIRT1101096	hsa-miR-432	CLIP-seq
MIRT1101097	hsa-miR-4527	CLIP-seq
MIRT1101098	hsa-miR-4531	CLIP-seq
MIRT1101099	hsa-miR-4762-3p	CLIP-seq
MIRT1101100	hsa-miR-4773	CLIP-seq
MIRT1101101	hsa-miR-519d	CLIP-seq
MIRT1101102	hsa-miR-548ah	CLIP-seq
MIRT1101103	hsa-miR-578	CLIP-seq
MIRT1101104	hsa-miR-587	CLIP-seq
MIRT1101105	hsa-miR-589	CLIP-seq
MIRT1101106	hsa-miR-620	CLIP-seq
MIRT1101107	hsa-miR-633	CLIP-seq
MIRT1101108	hsa-miR-885-5p	CLIP-seq
MIRT1101109	hsa-miR-93	CLIP-seq
MIRT1101076	hsa-miR-1238	CLIP-seq
MIRT1101077	hsa-miR-1244	CLIP-seq
MIRT1101079	hsa-miR-142-3p	CLIP-seq
MIRT1101080	hsa-miR-146a	CLIP-seq
MIRT1101081	hsa-miR-146b-5p	CLIP-seq
MIRT1101086	hsa-miR-3124-3p	CLIP-seq
MIRT1101087	hsa-miR-3133	CLIP-seq
MIRT1101088	hsa-miR-3179	CLIP-seq
MIRT1101089	hsa-miR-3607-3p	CLIP-seq
MIRT1101090	hsa-miR-3611	CLIP-seq
MIRT2027539	hsa-miR-3674	CLIP-seq
MIRT1101091	hsa-miR-3686	CLIP-seq
MIRT1101093	hsa-miR-3920	CLIP-seq
MIRT1101094	hsa-miR-4255	CLIP-seq
MIRT1101095	hsa-miR-4272	CLIP-seq
MIRT2027540	hsa-miR-431	CLIP-seq
MIRT2027541	hsa-miR-4511	CLIP-seq
MIRT1101097	hsa-miR-4527	CLIP-seq
MIRT2027542	hsa-miR-4680-5p	CLIP-seq
MIRT2027543	hsa-miR-4750	CLIP-seq
MIRT1101099	hsa-miR-4762-3p	CLIP-seq
MIRT2027544	hsa-miR-511	CLIP-seq
MIRT1101103	hsa-miR-578	CLIP-seq
MIRT1101104	hsa-miR-587	CLIP-seq
MIRT1101105	hsa-miR-589	CLIP-seq
MIRT2027545	hsa-miR-618	CLIP-seq
MIRT1101107	hsa-miR-633	CLIP-seq
MIRT1101074	hsa-miR-106a	CLIP-seq
MIRT1101075	hsa-miR-106b	CLIP-seq
MIRT1101076	hsa-miR-1238	CLIP-seq
MIRT1101077	hsa-miR-1244	CLIP-seq
MIRT1101079	hsa-miR-142-3p	CLIP-seq
MIRT1101082	hsa-miR-17	CLIP-seq
MIRT1101083	hsa-miR-186	CLIP-seq
MIRT1101084	hsa-miR-20a	CLIP-seq
MIRT1101085	hsa-miR-20b	CLIP-seq
MIRT1101086	hsa-miR-3124-3p	CLIP-seq
MIRT1101087	hsa-miR-3133	CLIP-seq
MIRT1101089	hsa-miR-3607-3p	CLIP-seq
MIRT1101091	hsa-miR-3686	CLIP-seq
MIRT1101093	hsa-miR-3920	CLIP-seq
MIRT1101094	hsa-miR-4255	CLIP-seq
MIRT1101095	hsa-miR-4272	CLIP-seq
MIRT2027540	hsa-miR-431	CLIP-seq
MIRT2027541	hsa-miR-4511	CLIP-seq
MIRT1101097	hsa-miR-4527	CLIP-seq
MIRT2027542	hsa-miR-4680-5p	CLIP-seq
MIRT2027543	hsa-miR-4750	CLIP-seq
MIRT1101099	hsa-miR-4762-3p	CLIP-seq
MIRT2027544	hsa-miR-511	CLIP-seq
MIRT1101101	hsa-miR-519d	CLIP-seq
MIRT1101102	hsa-miR-548ah	CLIP-seq
MIRT1101103	hsa-miR-578	CLIP-seq
MIRT1101104	hsa-miR-587	CLIP-seq
MIRT2027545	hsa-miR-618	CLIP-seq
MIRT1101107	hsa-miR-633	CLIP-seq
MIRT1101109	hsa-miR-93	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
HOXA7	Activation	11435435

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001533	Component	Cornified envelope	IDA	7543090
GO:0002009	Process	Morphogenesis of an epithelium	IBA
GO:0005198	Function	Structural molecule activity	IEA
GO:0005515	Function	Protein binding	IPI	19627498, 24940650, 27595935
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	HDA	23580065
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005737	Component	Cytoplasm	IDA	22170488, 32179842
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IBA
GO:0005882	Component	Intermediate filament	IEA
GO:0005882	Component	Intermediate filament	NAS	2459124
GO:0009986	Component	Cell surface	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0018149	Process	Peptide cross-linking	IDA	7543090
GO:0030216	Process	Keratinocyte differentiation	IBA
GO:0030216	Process	Keratinocyte differentiation	IEP	22170488
GO:0030280	Function	Structural constituent of skin epidermis	IBA
GO:0030280	Function	Structural constituent of skin epidermis	IDA	7543090
GO:0030280	Function	Structural constituent of skin epidermis	NAS	2459124
GO:0045095	Component	Keratin filament	IBA
GO:0045095	Component	Keratin filament	IPI	27595935
GO:0045109	Process	Intermediate filament organization	IBA
GO:0045684	Process	Positive regulation of epidermis development	ISS
GO:0046982	Function	Protein heterodimerization activity	IDA	27595935
GO:0051290	Process	Protein heterotetramerization	IDA	27595935
GO:0070062	Component	Extracellular exosome	HDA	11487543, 19199708, 23533145

Other IDs

• MIM: 148080
• HGNC: 6413
• e!Ensembl: ENSG00000186395

Protein

• UniProt ID: P13645
• Protein name: Keratin, type I cytoskeletal 10 (Cytokeratin-10) (CK-10) (Keratin-10) (K10)
• Protein function: Plays a role in the establishment of the epidermal barrier on plantar skin (By similarity). Involved in the maintenance of cell layer development and keratin filament bundles in suprabasal cells of the epithelium (By similarity). {ECO:0000250|Un
• PDB: 3ASW, 4F1Z, 4ZRY, 6E2J, 6EC0, 6UUI
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00038	Filament	145 → 459	Intermediate filament protein	Coiled-coil

• Tissue specificity: TISSUE SPECIFICITY: Seen in all suprabasal cell layers including stratum corneum. Expressed on the surface of lung cell lines (PubMed:19627498). Localized on the surface of desquamated nasal epithelial cells (at protein level) (PubMed:12427098). {ECO:0000
• Sequence:

  MSVRYSSSKHYSSSRSGGGGGGGGCGGGGGVSSLRISSSKGSLGGGFSSGGFSGGSFSRG
  SSGGGCFGGSSGGYGGLGGFGGGSFRGSYGSSSFGGSYGGIFGGGSFGGGSFGGGSFGGG
  GFGGGGFGGGFGGGFGGDGGLLSGNEKVTMQNLNDRLASYLDKVRALEESNYELEGKIKE
  WYEKHGNSHQGEPRDYSKYYKTIDDLKNQILNLTTDNANILLQIDNARLAADDFRLKYEN
  EVALRQSVEADINGLRRVLDELTLTKADLEMQIESLTEELAYLKKNHEEEMKDLRNVSTG
  DVNVEMNAAPGVDLTQLLNNMRSQYEQLAEQNRKDAEAWFNEKSKELTTEIDNNIEQISS
  YKSEITELRRNVQALEIELQSQLALKQSLEASLAETEGRYCVQLSQIQAQISALEEQLQQ
  IRAETECQNTEYQQLLDIKIRLENEIQTYRSLLEGEGSSGGGGRGGGSFGGGYGGGSSGG
  GSSGGGHGGGHGGSSGGGYGGGSSGGGSSGGGYGGGSSSGGHGGSSSGGYGGGSSGGGGG
  GYGGGSSGGGSSSGGGYGGGSSSGGHKSSSSGSVGESSSKGPRY

• Sequence length: 584

Pathways

KEGG:

Estrogen signaling pathway
Staphylococcus aureus infection

Reactome:

Keratinization
Formation of the cornified envelope

Associated diseases

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Annular epidermolytic ichthyosis	Likely pathogenic; Pathogenic	rs2143150768, rs59075499	RCV002283888 RCV000015681
Congenital reticular ichthyosiform erythroderma	Pathogenic; Likely pathogenic	rs2143131560, rs2143133654, rs2143130756, rs2143150768, rs587776815, rs587776816, rs587776817, rs267607384	RCV001619783 RCV001619784 RCV001619785 RCV001730093 RCV003140427 RCV000015682 RCV000015683 RCV000015684 RCV000015685
Epidermolytic hyperkeratosis 1	Pathogenic	rs58075662, rs61434181	RCV004786265 RCV004593969
Epidermolytic hyperkeratosis 2A, autosomal dominant	Likely pathogenic; Pathogenic	rs2143131560, rs60118264, rs57784225, rs58414354, rs58075662, rs58026994, rs58901407	RCV003988887 RCV004593963 RCV004593964 RCV004593965 RCV004562211 RCV004593966 RCV004593968 RCV004593970
Epidermolytic hyperkeratosis 2B, autosomal recessive	Pathogenic	rs60035576, rs387906640, rs267607381, rs267607379	RCV004593975 RCV004593976 RCV004593982 RCV004593983
Epidermolytic ichthyosis	Likely pathogenic; Pathogenic	rs1597822243, rs58075662	RCV003227577 RCV000015674
Ichthyosis and erythrokeratoderma	Pathogenic	rs58075662	RCV006275856
Ichthyosis, annular epidermolytic 1	Pathogenic	rs62651994	RCV004595904
KRT10-related disorder	Pathogenic	rs58075662, rs267607384	RCV004755736 RCV006270338

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Cervical cancer	Benign; Likely benign	rs150048434	RCV005911377
Clear cell carcinoma of kidney	Benign; Likely benign	rs150048434, rs71371451	RCV005911378 RCV005923589
Ichthyosis hystrix gravior	Uncertain significance; Likely benign; Conflicting classifications of pathogenicity	rs1491197463, rs373397541, rs752563839	RCV005398242 RCV005406650 RCV005394603
Lung cancer	Benign	rs71371451	RCV005923592
Ovarian serous cystadenocarcinoma	Benign	rs71371451	RCV005923591
Sarcoma	Benign	rs71371451, rs770578877	RCV005923590 RCV005927992
Thyroid cancer, nonmedullary, 1	Benign; Likely benign	rs150048434	RCV005911379
Uterine carcinosarcoma	Benign	rs1799874, rs6503559	RCV005917333 RCV005920073

Associations from Text Mining
Disease Name	Relationship Type	References
AA amyloidosis	Associate	32861330
Acanthoma	Associate	32045015
Acanthosis Nigricans	Associate	29784039
Adenocarcinoma	Associate	9930073
Alopecia	Associate	34851365
Arthritis Psoriatic	Associate	29784039
Asthma	Associate	37146352
Basal Cell Nevus Syndrome	Associate	11558869
Blister	Associate	26176760, 30859768
Breast Neoplasms	Associate	32618487
Carcinogenesis	Associate	18986660
Carcinoma Basal Cell	Associate	16415791
Carcinoma Non Small Cell Lung	Associate	23613495
Carcinoma Squamous Cell	Associate	10343611, 1379783, 36029589, 9930073
Carcinoma Squamous Cell	Stimulate	16415791
Cholesteatoma	Associate	30021014
Cholesteatoma	Inhibit	8703383
Cholesteatoma Congenital	Associate	26335306
Diabetes Mellitus	Inhibit	28403359
Disease	Associate	23613495
Edema	Associate	7510721
Epidermal Cyst	Associate	2458356
Epidermal Nevus	Associate	17255957, 7526210
Epidermolysis Bullosa Simplex	Associate	1721080
Epithelial Squamous Dysplasia Keratinizing Desquamative of Urinary Tract	Associate	7529318
Erythema	Associate	30859768
Genetic Diseases Inborn	Associate	25774499
Glioblastoma	Associate	22952576
Glomerulonephritis IGA	Associate	36793719
Glutamate Monosodium Sensitivity	Associate	29520099
Hearing Loss	Associate	34851365
Heat Stress Disorders	Associate	29520099
Hereditary Breast and Ovarian Cancer Syndrome	Associate	32618487
HID Syndrome	Associate	29689068
Hyperkeratosis Epidermolytic	Associate	10201536, 11558869, 14594577, 14708600, 17255957, 18219278, 22133519, 22504942, 22930352, 24346896, 26176760, 26581228, 27617465, 28121638, 29689068, 30859768, 32045015, 33081034, 33818988, 34387055, 7507150, 7507151, 7507152, 7508181, 7512983, 7513736, 7526210, 7532198, 7678607, 8077693, 8648165, 9036939, 9347802, 9833037, 9856845
Ichthyosis	Associate	11558869, 20798280, 26581228, 34387055, 34851365
Ichthyosis Cyclic with Epidermolytic Hyperkeratosis	Associate	14594577, 9036939, 9856845
Ichthyosis hystrix Curth Macklin type	Associate	29689068
Infections	Associate	22090118
Keratoderma Palmoplantar	Associate	11558869, 14708600
Leukemia Myeloid Acute	Associate	2461420
Lichen Planus Oral	Associate	19776502
Lupus Erythematosus Systemic	Associate	19089296
Melanoma	Inhibit	25560632, 36123693
Mouth Diseases	Associate	19776502
Myasthenia Gravis	Associate	35802752
Neoplasms	Inhibit	15140235
Neoplasms	Associate	22073364, 32618487, 34360875, 36029589, 7678716
Neoplasms Glandular and Epithelial	Associate	23264211
Nevus	Associate	33081034, 34199056, 7526210
Nevus Sebaceous of Jadassohn	Associate	35853659
Odontogenic Cysts	Associate	26666851
Pachyonychia Congenita	Associate	7529318
Peeling skin syndrome acral type	Associate	22622422
Periapical Diseases	Associate	23264211
Periodontitis	Associate	36793719
Pre Eclampsia	Stimulate	24296084
Prostatic Neoplasms	Associate	34360875
Psoriasis	Associate	29784039
Retinal Dysplasia	Inhibit	9420282
Sarcoma Kaposi	Associate	33276600
Skin Diseases	Associate	29563344, 30859768
Skin Diseases Genetic	Associate	8648165
Squamous Cell Carcinoma of Head and Neck	Associate	27584795
Thymoma	Associate	35802752
Trichilemmal Cyst 1	Associate	17091763
Tubular Sweat Gland Adenomas	Associate	16222893
Ulcer	Inhibit	18373736
Uterine Cervical Neoplasms	Associate	10343611, 18986660
Warts	Associate	10195031