Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	3855
Gene name Gene Name - the full gene name approved by the HGNC.	Keratin 7
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	KRT7
Synonyms (NCBI Gene) Gene synonyms aliases	CK7, K2C7, K7, SCL
Chromosome Chromosome number	12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	12q13.13
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified ep

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miRTarBase ID	miRNA	Experiments	Reference
MIRT000331	hsa-miR-133a-3p	Review	20026422
MIRT003324	hsa-miR-199a-3p	Review	20026422
MIRT004939	hsa-miR-30a-3p	Immunoblot, qRT-PCR	19378336
MIRT000331	hsa-miR-133a-3p	Immunoblot, qRT-PCR	19378336
MIRT003324	hsa-miR-199a-3p	Immunoblot, qRT-PCR	19378336
MIRT004938	hsa-miR-145-5p	Immunoblot, qRT-PCR	19378336
MIRT004937	hsa-miR-195-5p	Immunoblot, qRT-PCR	19378336
MIRT004936	hsa-miR-125b-5p	Immunoblot, qRT-PCR	19378336
MIRT025743	hsa-miR-7-5p	Microarray	19073608
MIRT1101438	hsa-miR-1207-5p	CLIP-seq
MIRT1101439	hsa-miR-1827	CLIP-seq
MIRT1101440	hsa-miR-1909	CLIP-seq
MIRT1101441	hsa-miR-3612	CLIP-seq
MIRT1101442	hsa-miR-3622b-5p	CLIP-seq
MIRT1101443	hsa-miR-3689a-3p	CLIP-seq
MIRT1101444	hsa-miR-3689c	CLIP-seq
MIRT1101445	hsa-miR-4645-5p	CLIP-seq
MIRT1101446	hsa-miR-4651	CLIP-seq
MIRT1101447	hsa-miR-4673	CLIP-seq
MIRT1101448	hsa-miR-4728-5p	CLIP-seq
MIRT1101449	hsa-miR-4763-3p	CLIP-seq
MIRT1101450	hsa-miR-608	CLIP-seq
MIRT1101451	hsa-miR-650	CLIP-seq
MIRT1101452	hsa-miR-940	CLIP-seq
MIRT1101438	hsa-miR-1207-5p	CLIP-seq
MIRT2258903	hsa-miR-1208	CLIP-seq
MIRT2258904	hsa-miR-122	CLIP-seq
MIRT2258905	hsa-miR-1293	CLIP-seq
MIRT2258906	hsa-miR-1302	CLIP-seq
MIRT1101439	hsa-miR-1827	CLIP-seq
MIRT1101440	hsa-miR-1909	CLIP-seq
MIRT2258907	hsa-miR-1972	CLIP-seq
MIRT2258908	hsa-miR-219-5p	CLIP-seq
MIRT2258909	hsa-miR-2467-5p	CLIP-seq
MIRT2258910	hsa-miR-3122	CLIP-seq
MIRT2258911	hsa-miR-3135b	CLIP-seq
MIRT2258912	hsa-miR-3180-5p	CLIP-seq
MIRT2258913	hsa-miR-3188	CLIP-seq
MIRT1101441	hsa-miR-3612	CLIP-seq
MIRT1101442	hsa-miR-3622b-5p	CLIP-seq
MIRT2258914	hsa-miR-3649	CLIP-seq
MIRT2258915	hsa-miR-3652	CLIP-seq
MIRT1101443	hsa-miR-3689a-3p	CLIP-seq
MIRT1101444	hsa-miR-3689c	CLIP-seq
MIRT2258916	hsa-miR-3913-5p	CLIP-seq
MIRT2258917	hsa-miR-3975	CLIP-seq
MIRT2258918	hsa-miR-4265	CLIP-seq
MIRT2258919	hsa-miR-4296	CLIP-seq
MIRT2258920	hsa-miR-4298	CLIP-seq
MIRT2258921	hsa-miR-431	CLIP-seq
MIRT2258922	hsa-miR-4322	CLIP-seq
MIRT2258923	hsa-miR-4430	CLIP-seq
MIRT2258924	hsa-miR-4445	CLIP-seq
MIRT2258925	hsa-miR-4483	CLIP-seq
MIRT2258926	hsa-miR-4494	CLIP-seq
MIRT2258927	hsa-miR-4505	CLIP-seq
MIRT1101445	hsa-miR-4645-5p	CLIP-seq
MIRT2258928	hsa-miR-4650-5p	CLIP-seq
MIRT1101446	hsa-miR-4651	CLIP-seq
MIRT1101447	hsa-miR-4673	CLIP-seq
MIRT1101448	hsa-miR-4728-5p	CLIP-seq
MIRT1101449	hsa-miR-4763-3p	CLIP-seq
MIRT2258929	hsa-miR-4778-3p	CLIP-seq
MIRT2258930	hsa-miR-4778-5p	CLIP-seq
MIRT2258931	hsa-miR-4782-3p	CLIP-seq
MIRT2258932	hsa-miR-485-5p	CLIP-seq
MIRT2258933	hsa-miR-508-3p	CLIP-seq
MIRT2258934	hsa-miR-510	CLIP-seq
MIRT2258935	hsa-miR-520a-5p	CLIP-seq
MIRT2258936	hsa-miR-525-5p	CLIP-seq
MIRT2258937	hsa-miR-541	CLIP-seq
MIRT2258938	hsa-miR-578	CLIP-seq
MIRT2258939	hsa-miR-581	CLIP-seq
MIRT1101450	hsa-miR-608	CLIP-seq
MIRT2258940	hsa-miR-635	CLIP-seq
MIRT1101451	hsa-miR-650	CLIP-seq
MIRT2258941	hsa-miR-654-5p	CLIP-seq
MIRT2258942	hsa-miR-671-5p	CLIP-seq
MIRT2258943	hsa-miR-765	CLIP-seq
MIRT1101452	hsa-miR-940	CLIP-seq
MIRT2258903	hsa-miR-1208	CLIP-seq
MIRT2258906	hsa-miR-1302	CLIP-seq
MIRT1101439	hsa-miR-1827	CLIP-seq
MIRT2258910	hsa-miR-3122	CLIP-seq
MIRT1101441	hsa-miR-3612	CLIP-seq
MIRT1101442	hsa-miR-3622b-5p	CLIP-seq
MIRT2258914	hsa-miR-3649	CLIP-seq
MIRT1101443	hsa-miR-3689a-3p	CLIP-seq
MIRT1101444	hsa-miR-3689c	CLIP-seq
MIRT2258916	hsa-miR-3913-5p	CLIP-seq
MIRT2258920	hsa-miR-4298	CLIP-seq
MIRT2258921	hsa-miR-431	CLIP-seq
MIRT1101445	hsa-miR-4645-5p	CLIP-seq
MIRT1101447	hsa-miR-4673	CLIP-seq
MIRT1101448	hsa-miR-4728-5p	CLIP-seq
MIRT2258940	hsa-miR-635	CLIP-seq
MIRT1101451	hsa-miR-650	CLIP-seq
MIRT1101452	hsa-miR-940	CLIP-seq

Transcription factors

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Transcription factor	Regulation	Reference
FOXA1	Activation	20043065
TAL1	Unknown	20140202

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	11169732, 21149639, 29721183, 31694235, 32867128
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005737	Component	Cytoplasm	IDA	2459129
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005882	Component	Intermediate filament	IEA
GO:0005882	Component	Intermediate filament	NAS	2415537
GO:0030280	Function	Structural constituent of skin epidermis	IBA
GO:0031424	Process	Keratinization	IBA
GO:0045095	Component	Keratin filament	IBA
GO:0045095	Component	Keratin filament	IEA
GO:0045109	Process	Intermediate filament organization	IBA
GO:0045111	Component	Intermediate filament cytoskeleton	IDA
GO:0070062	Component	Extracellular exosome	HDA	23533145

MIM	HGNC	e!Ensembl
148059	6445	ENSG00000135480

Protein

UniProt ID

P08729

Protein name

Keratin, type II cytoskeletal 7 (Cytokeratin-7) (CK-7) (Keratin-7) (K7) (Sarcolectin) (Type-II keratin Kb7)

Protein function

Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7).

PDB

4XIF

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF16208	Keratin_2_head	48 → 87	Keratin type II head	Family
PF00038	Filament	90 → 402	Intermediate filament protein	Coiled-coil

Tissue specificity

TISSUE SPECIFICITY: Expressed in cultured epidermal, bronchial and mesothelial cells but absent in colon, ectocervix and liver. Observed throughout the glandular cells in the junction between stomach and esophagus but is absent in the esophagus. {ECO:0000

Sequence

MSIHFSSPVFTSRSAAFSGRGAQVRLSSARPGGLGSSSLYGLGASRPRVAVRSAYGGPVG
AGIREVTINQSLLAPLRLDADPSLQRVRQEESEQIKTLNNKFASFIDKVRFLEQQNKLLE
TKWTLLQEQKSAKSSRLPDIFEAQIAGLRGQLEALQVDGGRLEAELRSMQDVVEDFKNKY
EDEINHRTAAENEFVVLKKDVDAAYMSKVELEAKVDALNDEINFLRTLNETELTELQSQI
SDTSVVLSMDNSRSLDLDGIIAEVKAQYEEMAKCSRAEAEAWYQTKFETLQAQAGKHGDD
LRNTRNEISEMNRAIQRLQAEIDNIKNQRAKLEAAIAEAEERGELALKDARAKQEELEAA
LQRGKQDMARQLREYQELMSVKLALDIEIATYRKLLEGEESRLAGDGVGAVNISVMNSTG
GSSSGGGIGLTLGGTMGSNALSFSSSAGPGLLKAYSIRTASASRRSARD

Sequence length

469

Interactions

View interactions

	Reactome
			Keratinization Formation of the cornified envelope

KRT7 (keratin 7)