KRT7 (keratin 7)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3855
Gene name Gene Name - the full gene name approved by the HGNC.
Keratin 7
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
KRT7
Synonyms (NCBI Gene) Gene synonyms aliases
CK7, K2C7, K7, SCL
Chromosome Chromosome number
12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
12q13.13
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified ep
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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miRTarBase ID miRNA Experiments Reference
MIRT000331 hsa-miR-133a-3p Review 20026422
MIRT003324 hsa-miR-199a-3p Review 20026422
MIRT004939 hsa-miR-30a-3p Immunoblot, qRT-PCR 19378336
MIRT000331 hsa-miR-133a-3p Immunoblot, qRT-PCR 19378336
MIRT003324 hsa-miR-199a-3p Immunoblot, qRT-PCR 19378336
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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Transcription factor Regulation Reference
FOXA1 Activation 20043065
TAL1 Unknown 20140202
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 11169732, 21149639, 29721183, 31694235
GO:0005634 Component Nucleus HDA 21630459
GO:0005737 Component Cytoplasm IDA 2459129
GO:0005829 Component Cytosol TAS
GO:0005882 Component Intermediate filament NAS 2415537
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
148059 6445 ENSG00000135480
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P08729
Protein name Keratin, type II cytoskeletal 7 (Cytokeratin-7) (CK-7) (Keratin-7) (K7) (Sarcolectin) (Type-II keratin Kb7)
Protein function Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7).
PDB 4XIF
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF16208 Keratin_2_head 48 → 87 Keratin type II head Family
PF00038 Filament 90 → 402 Intermediate filament protein Coiled-coil
Tissue specificity TISSUE SPECIFICITY: Expressed in cultured epidermal, bronchial and mesothelial cells but absent in colon, ectocervix and liver. Observed throughout the glandular cells in the junction between stomach and esophagus but is absent in the esophagus. {ECO:0000
Sequence
Sequence length 469
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Keratinization
Formation of the cornified envelope
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (3)
Causal
Disease term Disease name dbSNP ID References
Oxyphilic adenoma Oxyphilic Adenoma rs869312882 16927643
Papillary renal carcinoma Papillary Renal Cell Carcinoma rs5030823, rs2137087134, rs121913668, rs121913669, rs121913670, rs121913671, rs121913673, rs121913243, rs786202724 16927643, 15108329
Renal carcinoma Renal Cell Carcinoma, Conventional (Clear Cell) Renal Cell Carcinoma, Sarcomatoid Renal Cell Carcinoma, Collecting Duct Carcinoma of the Kidney rs121913668, rs121913670, rs121913243, rs786202724 15108329, 16927643
Show/Hide Unknown Diseases (2)
Unknown
Disease term Disease name Evidence References Source
Asthma Asthma 25918132 ClinVar
Chromophobe carcinoma Chromophobe Renal Cell Carcinoma 16927643, 15108329 ClinVar
Show/Hide Text Mining Associations (172)
Associations from Text Mining
Disease Name Relationship Type References
AA amyloidosis Associate 32861330
Adenocarcinoma Associate 11857318, 14631371, 14632574, 15333652, 16570563, 1690512, 17922593, 20563874, 22623086, 23348905, 23469219, 24338588, 25690258, 25997063, 26603157
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Adenocarcinoma Bronchiolo Alveolar Associate 22117833
Adenocarcinoma in Situ Associate 25612672
Adenocarcinoma Mucinous Associate 16822880, 21699710, 22117833, 29698701
Adenocarcinoma Of Esophagus Associate 11141476
Adenocarcinoma of Lung Associate 12192603, 16570563, 17606426, 2414994, 25117316, 25982999, 30539871, 32930112, 36820582, 38608841
Adenocarcinoma Papillary Stimulate 15333652
Adenolymphoma Associate 22990554
Adenoma Associate 22623086, 24474301, 26248896