Gene Gene information from NCBI Gene database.
Entrez ID 3843
Gene name Importin 5
Gene symbol IPO5
Synonyms (NCBI Gene)
IMB3KPNB3Pse1RANBP5imp5
Chromosome 13
Chromosome location 13q32.2
Summary Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a het
miRNA miRNA information provided by mirtarbase database.
504
miRTarBase ID miRNA Experiments Reference
MIRT051154 hsa-miR-16-5p CLASH 23622248
MIRT049490 hsa-miR-92a-3p CLASH 23622248
MIRT048827 hsa-miR-93-5p CLASH 23622248
MIRT048251 hsa-miR-196a-5p CLASH 23622248
MIRT046603 hsa-miR-222-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
42
GO ID Ontology Definition Evidence Reference
GO:0002753 Process Cytoplasmic pattern recognition receptor signaling pathway IDA 8524823
GO:0002753 Process Cytoplasmic pattern recognition receptor signaling pathway IDA 31340999
GO:0003723 Function RNA binding HDA 22681889
GO:0005095 Function GTPase inhibitor activity TAS 9271386
GO:0005515 Function Protein binding IPI 10799599, 15282309, 20562859, 20828572, 21044950, 22730302, 29475951, 32814053, 33961781
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
602008 6402 ENSG00000065150
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O00410
Protein name Importin-5 (Imp5) (Importin subunit beta-3) (Karyopherin beta-3) (Ran-binding protein 5) (RanBP5)
Protein function Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) t
PDB 6XTE , 6XU2 , 9IM6
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF18808 Importin_rep_4 268 357 Importin repeat Repeat
PF02985 HEAT 400 430 HEAT repeat Repeat
PF18829 Importin_rep_6 765 874 Importin repeat 6 Repeat
PF02985 HEAT 906 936 HEAT repeat Repeat
PF18816 Importin_rep_5 1005 1061 Importin repeat Repeat
Sequence
MAAAAAEQQQFYLLLGNLLSPDNVVRKQAEETYENIPGQSKITFLLQAIRNTTAAEEARQ
MAAVLLRRLLSSAFDEVYPALPSDVQTAIKSELLMIIQMETQSSMRKKVCDIAAELARNL
IDEDGNNQWPEGLKFLFDSVSSQNVGLREAALHIFWNFPGIFGNQQQHYLDVIKRMLVQC
MQDQEHPSIRTLSARATAAFILANEHNVALFKHFADLLPGFLQAVNDSCYQNDDSVLKSL
VEIADTVPKYLRPHLEATLQLSLKLCGDTSLNNMQRQLALEVIVTLSETAAAMLRKHTNI
VAQTIPQMLAMMVDLEEDEDWANADELEDDDFDSNAVAGESALDRMACGLGGKLVLP
MIK
EHIMQMLQNPDWKYRHAGLMALSAIGEGCHQQMEGILNEIVNFVLLFLQDPHPRVRYAAC
NAVGQMATDF
APGFQKKFHEKVIAALLQTMEDQGNQRVQAHAAAALINFTEDCPKSLLIP
YLDNLVKHLHSIMVLKLQELIQKGTKLVLEQVVTSIASVADTAEEKFVPYYDLFMPSLKH
IVENAVQKELRLLRGKTIECISLIGLAVGKEKFMQDASDVMQLLLKTQTDFNDMEDDDPQ
ISYMISAWARMCKILGKEFQQYLPVVMGPLMKTASIKPEVALLDTQDMENMSDDDGWEFV
NLGDQQSFGIKTAGLEEKSTACQMLVCYAKELKEGFVEYTEQVVKLMVPLLKFYFHDGVR
VAAAESMPLLLECARVRGPEYLTQMWHFMCDALIKAIGTEPDSDVLSEIMHSFAKCIEVM
GDGCLNNEHFEELGGILKAKLEEHFKNQELRQVKRQDEDYDEQVEESLQDEDDNDVYILT
KVSDILHSIFSSYKEKVLPWFEQLLPLIVNLICP
HRPWPDRQWGLCIFDDVIEHCSPASF
KYAEYFLRPMLQYVCDNSPEVRQAAAYGLGVMAQYGGDNYRPFCTEALPLLVRVIQSADS
KTKENVNATENCISAVGKIMKFKPDCVNVEEVLPHWLSWLPLHEDKEEAVQTFNYLCDLI
ESNHPIVLGPNNTNLPKIFSIIAEGEMHEAIKHEDPCAKRL
ANVVRQVQTSGGLWTECIA
QLSPEQQAAIQELLNSA
Sequence length 1097
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Nucleocytoplasmic transport   vRNP Assembly
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
1
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Acute myeloid leukemia Uncertain significance rs144227305 RCV005932298
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Cardiomyopathy Dilated Associate 25137373
Esophageal Neoplasms Associate 32373960
Keratoconus Associate 28159702
Lung Neoplasms Associate 36380607
Neoplasms Associate 32373960
Peripheral Arterial Disease Associate 26488411