Gene Gene information from NCBI Gene database.
Entrez ID 3842
Gene name Transportin 1
Gene symbol TNPO1
Synonyms (NCBI Gene)
IPO2KPNB2MIPMIP1TRN
Chromosome 5
Chromosome location 5q13.2
Summary This gene encodes the beta subunit of the karyopherin receptor complex which interacts with nuclear localization signals to target nuclear proteins to the nucleus. The karyopherin receptor complex is a heterodimer of an alpha subunit which recognizes the
miRNA miRNA information provided by mirtarbase database.
1737
miRTarBase ID miRNA Experiments Reference
MIRT003172 hsa-miR-210-3p immunoprecipitaionMicroarrayqRT-PCR 19826008
MIRT003172 hsa-miR-210-3p immunoprecipitaionMicroarrayqRT-PCR 19826008
MIRT021043 hsa-miR-155-5p Proteomics 21310411
MIRT023181 hsa-miR-124-3p Microarray 18668037
MIRT025575 hsa-miR-34a-5p Sequencing 20371350
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
IRF3 Unknown 20483755
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
23
GO ID Ontology Definition Evidence Reference
GO:0003723 Function RNA binding HDA 22658674, 22681889
GO:0005515 Function Protein binding IPI 10353245, 17435768, 17474147, 19124606, 22778397, 35271311
GO:0005634 Component Nucleus IBA
GO:0005634 Component Nucleus IEA
GO:0005634 Component Nucleus TAS 9144189
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
602901 6401 ENSG00000083312
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q92973
Protein name Transportin-1 (Importin beta-2) (Karyopherin beta-2) (M9 region interaction protein) (MIP)
Protein function Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates (PubMed:24753571). May mediate docking of the importin/substrate complex to the nuclear pore complex
PDB 1QBK , 2H4M , 2OT8 , 2QMR , 2Z5J , 2Z5K , 2Z5M , 2Z5N , 2Z5O , 4FDD , 4FQ3 , 4JLQ , 4OO6 , 5J3V , 5TQC , 5YVG , 5YVH , 5YVI , 7CYL , 7VPW , 8SGH
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03810 IBN_N 41 109 Importin-beta N-terminal domain Family
PF13513 HEAT_EZ 419 473 Repeat
Sequence
MVWDRQTKMEYEWKPDEQGLQQILQLLKESQSPDTTIQRTVQQKLEQLNQYPDFNNYLIF
VLTKLKSEDEPTRSLSGLILKNNVKAHFQNFPNGVTDFIKSECLNNIGD
SSPLIRATVGI
LITTIASKGELQNWPDLLPKLCSLLDSEDYNTCEGAFGALQKICEDSAEILDSDVLDRPL
NIMIPKFLQFFKHSSPKIRSHAVACVNQFIISRTQALMLHIDSFIENLFALAGDEEPEVR
KNVCRALVMLLEVRMDRLLPHMHNIVEYMLQRTQDQDENVALEACEFWLTLAEQPICKDV
LVRHLPKLIPVLVNGMKYSDIDIILLKGDVEEDETIPDSEQDIRPRFHRSRTVAQQHDED
GIEEEDDDDDEIDDDDTISDWNLRKCSAAALDVLANVYRDELLPHILPLLKELLFHHEWV
VKESGILVLGAIAEGCMQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRY
AHWVVSQ
PPDTYLKPLMTELLKRILDSNKRVQEAACSAFATLEEEACTELVPYLAYILDTLVFAFSK
YQHKNLLILYDAIGTLADSVGHHLNKPEYIQMLMPPLIQKWNMLKDEDKDLFPLLECLSS
VATALQSGFLPYCEPVYQRCVNLVQKTLAQAMLNNAQPDQYEAPDKDFMIVALDLLSGLA
EGLGGNIEQLVARSNILTLMYQCMQDKMPEVRQSSFALLGDLTKACFQHVKPCIADFMPI
LGTNLNPEFISVCNNATWAIGEISIQMGIEMQPYIPMVLHQLVEIINRPNTPKTLLENTA
ITIGRLGYVCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICTMISVNPSGVIQDF
IFFCDAVASWINPKDDLRDMFCKILHGFKNQVGDENWRRFSDQFPLPLKERLAAFYGV
Sequence length 898
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Nucleocytoplasmic transport   Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
Intraflagellar transport
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
13
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
TNPO1-related disorder Uncertain significance; Likely benign; Benign rs753376038, rs776822870, rs191625222, rs61749606, rs116204058, rs2479187686, rs2479270486, rs149437731, rs200584417, rs192419761, rs777229547, rs766283408, rs768294052 RCV003399738
RCV003904631
RCV003903954
RCV003973959
RCV003909651
RCV003911859
RCV003933981
RCV003927165
RCV003941475
RCV003939356
RCV003921936
RCV003921958
RCV003954471
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Arthritis Stimulate 22035391
Atherosclerosis Associate 35388333
Breast Neoplasms Associate 35982039
Frontotemporal Lobar Degeneration Associate 22968170, 24899704
Glioblastoma Associate 26056081
Inflammation Stimulate 35412793
Melanoma Cutaneous Malignant Associate 40191195
Meningitis Bacterial Associate 21473761
Motor Neuron Disease Associate 33580145
Progeria Associate 29970603