Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3842
Gene name Gene Name - the full gene name approved by the HGNC.
Transportin 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
TNPO1
Synonyms (NCBI Gene) Gene synonyms aliases
IPO2, KPNB2, MIP, MIP1, TRN
Chromosome Chromosome number
5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
5q13.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes the beta subunit of the karyopherin receptor complex which interacts with nuclear localization signals to target nuclear proteins to the nucleus. The karyopherin receptor complex is a heterodimer of an alpha subunit which recognizes the
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT003172 hsa-miR-210-3p immunoprecipitaion, Microarray, qRT-PCR 19826008
MIRT003172 hsa-miR-210-3p immunoprecipitaion, Microarray, qRT-PCR 19826008
MIRT021043 hsa-miR-155-5p Proteomics 21310411
MIRT023181 hsa-miR-124-3p Microarray 18668037
MIRT025575 hsa-miR-34a-5p Sequencing 20371350
Transcription factors
Transcription factor Regulation Reference
IRF3 Unknown 20483755
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003723 Function RNA binding HDA 22658674, 22681889
GO:0005515 Function Protein binding IPI 17435768, 17474147, 19124606
GO:0005634 Component Nucleus IBA 21873635
GO:0005737 Component Cytoplasm IBA 21873635
GO:0005829 Component Cytosol TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
602901 6401 ENSG00000083312
Protein
UniProt ID Q92973
Protein name Transportin-1 (Importin beta-2) (Karyopherin beta-2) (M9 region interaction protein) (MIP)
Protein function Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates (PubMed:24753571). May mediate docking of the importin/substrate complex to the nuclear pore complex
PDB 1QBK , 2H4M , 2OT8 , 2QMR , 2Z5J , 2Z5K , 2Z5M , 2Z5N , 2Z5O , 4FDD , 4FQ3 , 4JLQ , 4OO6 , 5J3V , 5TQC , 5YVG , 5YVH , 5YVI , 7CYL , 7VPW , 8SGH
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03810 IBN_N 41 109 Importin-beta N-terminal domain Family
PF13513 HEAT_EZ 419 473 Repeat
Sequence
MVWDRQTKMEYEWKPDEQGLQQILQLLKESQSPDTTIQRTVQQKLEQLNQYPDFNNYLIF
VLTKLKSEDEPTRSLSGLILKNNVKAHFQNFPNGVTDFIKSECLNNIGD
SSPLIRATVGI
LITTIASKGELQNWPDLLPKLCSLLDSEDYNTCEGAFGALQKICEDSAEILDSDVLDRPL
NIMIPKFLQFFKHSSPKIRSHAVACVNQFIISRTQALMLHIDSFIENLFALAGDEEPEVR
KNVCRALVMLLEVRMDRLLPHMHNIVEYMLQRTQDQDENVALEACEFWLTLAEQPICKDV
LVRHLPKLIPVLVNGMKYSDIDIILLKGDVEEDETIPDSEQDIRPRFHRSRTVAQQHDED
GIEEEDDDDDEIDDDDTISDWNLRKCSAAALDVLANVYRDELLPHILPLLKELLFHHEWV
VKESGILVLGAIAEGCMQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRY
AHWVVSQ
PPDTYLKPLMTELLKRILDSNKRVQEAACSAFATLEEEACTELVPYLAYILDTLVFAFSK
YQHKNLLILYDAIGTLADSVGHHLNKPEYIQMLMPPLIQKWNMLKDEDKDLFPLLECLSS
VATALQSGFLPYCEPVYQRCVNLVQKTLAQAMLNNAQPDQYEAPDKDFMIVALDLLSGLA
EGLGGNIEQLVARSNILTLMYQCMQDKMPEVRQSSFALLGDLTKACFQHVKPCIADFMPI
LGTNLNPEFISVCNNATWAIGEISIQMGIEMQPYIPMVLHQLVEIINRPNTPKTLLENTA
ITIGRLGYVCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICTMISVNPSGVIQDF
IFFCDAVASWINPKDDLRDMFCKILHGFKNQVGDENWRRFSDQFPLPLKERLAAFYGV
Sequence length 898
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Nucleocytoplasmic transport   Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
Intraflagellar transport
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Chronic obstructive pulmonary disease Chronic Obstructive Airway Disease 30804561 ClinVar
Asthma Asthma GWAS
Diabetes Diabetes GWAS
Insomnia Insomnia GWAS
Associations from Text Mining
Disease Name Relationship Type References
Arthritis Stimulate 22035391
Atherosclerosis Associate 35388333
Breast Neoplasms Associate 35982039
Frontotemporal Lobar Degeneration Associate 22968170, 24899704
Glioblastoma Associate 26056081
Inflammation Stimulate 35412793
Melanoma Cutaneous Malignant Associate 40191195
Meningitis Bacterial Associate 21473761
Motor Neuron Disease Associate 33580145
Progeria Associate 29970603