Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3839
Gene name Gene Name - the full gene name approved by the HGNC.
Karyopherin subunit alpha 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
KPNA3
Synonyms (NCBI Gene) Gene synonyms aliases
IPOA4, SPG88, SRP1, SRP1gamma, SRP4, hSRP1
Disease Acronyms (UniProt) Disease acronyms from UniProt database
SPG88
Chromosome Chromosome number
13
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
13q14.2
Summary Summary of gene provided in NCBI Entrez Gene.
The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusio
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT001447 hsa-miR-16-5p pSILAC 18668040
MIRT001447 hsa-miR-16-5p Proteomics;Other 18668040
MIRT049397 hsa-miR-92a-3p CLASH 23622248
MIRT068854 hsa-miR-219a-1-3p HITS-CLIP 21572407
MIRT522810 hsa-miR-455-5p HITS-CLIP 21572407
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 10523667, 15057270, 16189514, 17500595, 19412186, 19447967, 21516116, 21988832, 23816991, 25416956, 25910212, 26382858, 26496610, 28611246, 29370303, 30833792, 32296183, 32814053, 33060197
GO:0005634 Component Nucleus IBA 21873635
GO:0005643 Component Nuclear pore TAS 9154134
GO:0005654 Component Nucleoplasm IBA 21873635
GO:0005654 Component Nucleoplasm TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
601892 6396 ENSG00000102753
Protein
UniProt ID O00505
Protein name Importin subunit alpha-4 (Importin alpha Q2) (Qip2) (Karyopherin subunit alpha-3) (SRP1-gamma)
Protein function Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01749 IBB 11 93 Importin beta binding domain Family
PF00514 Arm 103 144 Armadillo/beta-catenin-like repeat Repeat
PF00514 Arm 146 186 Armadillo/beta-catenin-like repeat Repeat
PF00514 Arm 188 229 Armadillo/beta-catenin-like repeat Repeat
PF00514 Arm 232 271 Armadillo/beta-catenin-like repeat Repeat
PF00514 Arm 273 313 Armadillo/beta-catenin-like repeat Repeat
PF00514 Arm 315 355 Armadillo/beta-catenin-like repeat Repeat
PF00514 Arm 357 397 Armadillo/beta-catenin-like repeat Repeat
PF00514 Arm 400 440 Armadillo/beta-catenin-like repeat Repeat
PF16186 Arm_3 447 499 Atypical Arm repeat Family
Tissue specificity TISSUE SPECIFICITY: Ubiquitous. Highest levels in heart and skeletal muscle.
Sequence
Sequence length 521
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Nucleocytoplasmic transport
Salmonella infection
Chemical carcinogenesis - receptor activation
  ISG15 antiviral mechanism
NS1 Mediated Effects on Host Pathways
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Schizophrenia Schizophrenia rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346
View all (12 more)
22960338, 16644122, 15882913
Unknown
Disease term Disease name Evidence References Source
Mental depression Unipolar Depression, Major Depressive Disorder 22960338 ClinVar
Spastic Paraplegia spastic paraplegia 88, autosomal dominant GenCC
Diabetes Diabetes GWAS
Associations from Text Mining
Disease Name Relationship Type References
Alcoholism Associate 22960338
Colorectal Neoplasms Associate 37575080
Depressive Disorder Major Associate 22960338
Glomerulonephritis IGA Associate 24284509
Immunologic Deficiency Syndromes Associate 34987110
Leukemia Lymphocytic Chronic B Cell Associate 12010815
Mental Disorders Associate 22960338
Neoplasm Metastasis Associate 37575080
Opioid Related Disorders Associate 22960338
Schizophrenia Associate 22960338