Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3838
Gene name Gene Name - the full gene name approved by the HGNC.
Karyopherin subunit alpha 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
KPNA2
Synonyms (NCBI Gene) Gene synonyms aliases
IPOA1, PTAC58, QIP2, RCH1, SRP1-alpha, SRP1alpha
Chromosome Chromosome number
17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17q24.2
Summary Summary of gene provided in NCBI Entrez Gene.
The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Im
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT016443 hsa-miR-193b-3p Proteomics 21512034
MIRT031798 hsa-miR-16-5p Proteomics 18668040
MIRT050744 hsa-miR-17-3p CLASH 23622248
MIRT049112 hsa-miR-92a-3p CLASH 23622248
MIRT048751 hsa-miR-93-5p CLASH 23622248
Transcription factors
Transcription factor Regulation Reference
YBX1 Repression 20596676
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000018 Process Regulation of DNA recombination TAS 8016130
GO:0000139 Component Golgi membrane IEA
GO:0003723 Function RNA binding HDA 22681889
GO:0005515 Function Protein binding IPI 9168958, 9405152, 9497340, 10353244, 10523667, 10980193, 11024021, 11971900, 12551970, 15507604, 15870280, 15942031, 17324944, 17596301, 19668212, 19883659, 20551905, 20701745, 20965181, 21385873, 21988832, 24965446, 25416956, 25556234, 25609649, 26420826, 26496610, 28514442, 290425
GO:0005634 Component Nucleus IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
600685 6395 ENSG00000182481
Protein
UniProt ID P52292
Protein name Importin subunit alpha-1 (Karyopherin subunit alpha-2) (RAG cohort protein 1) (SRP1-alpha)
Protein function Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1 (PubMed:28991411, PubMed:32130408, PubMed:7604027, PubMed:7754385). Binds specifically and directly to substrates containing either a simple or bipartite NLS mo
PDB 1EFX , 1QGK , 1QGR , 3FEX , 3FEY , 3WPT , 4E4V , 4WV6 , 5H43 , 7CRU , 7N8J , 7N9H , 8FZK , 8GCN
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01749 IBB 13 98 Importin beta binding domain Family
PF00514 Arm 108 149 Armadillo/beta-catenin-like repeat Repeat
PF00514 Arm 151 191 Armadillo/beta-catenin-like repeat Repeat
PF00514 Arm 193 238 Armadillo/beta-catenin-like repeat Repeat
PF00514 Arm 241 280 Armadillo/beta-catenin-like repeat Repeat
PF00514 Arm 282 322 Armadillo/beta-catenin-like repeat Repeat
PF00514 Arm 324 364 Armadillo/beta-catenin-like repeat Repeat
PF00514 Arm 366 406 Armadillo/beta-catenin-like repeat Repeat
PF00514 Arm 409 448 Armadillo/beta-catenin-like repeat Repeat
PF16186 Arm_3 458 509 Atypical Arm repeat Family
Tissue specificity TISSUE SPECIFICITY: Expressed ubiquitously.
Sequence
Sequence length 529
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Nucleocytoplasmic transport
Influenza A
Chemical carcinogenesis - receptor activation
  ISG15 antiviral mechanism
NS1 Mediated Effects on Host Pathways
Sensing of DNA Double Strand Breaks
Estrogen-dependent gene expression
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Lung adenocarcinoma Adenocarcinoma of lung (disorder) rs28934576, rs121913530, rs397516975, rs587776805, rs121913469, rs121913364, rs121913351, rs121913366, rs397516896, rs397516977, rs397516981, rs397517127, rs121913344, rs727504233, rs121913370
View all (5 more)
27602772
Unknown
Disease term Disease name Evidence References Source
Prostate cancer Prostate cancer Together, these results show that PRRX2 is an oncogene and might play a role in the aggressiveness of PC within the DNPC population. GWAS, CBGDA
Insomnia Insomnia GWAS
Alzheimer disease Alzheimer disease GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 34773335, 36311801, 37060831
Bowen's Disease Stimulate 24098495
Breast Neoplasms Associate 17899179, 25989275, 30732163, 31212646, 31638237, 33962648, 35948941
Carcinogenesis Associate 26884852, 33728352
Carcinoma Hepatocellular Associate 25060425, 31046781, 31783876, 32213663, 34112092, 34903711, 35075389, 35915607, 37923899, 38238845
Carcinoma Intraductal Noninfiltrating Stimulate 17899179
Carcinoma Merkel Cell Stimulate 24098495
Carcinoma Non Small Cell Lung Associate 24070213, 27009856
Carcinoma Pancreatic Ductal Associate 33728352
Carcinoma Squamous Cell Stimulate 24098495