Gene Gene information from NCBI Gene database.
Entrez ID 3838
Gene name Karyopherin subunit alpha 2
Gene symbol KPNA2
Synonyms (NCBI Gene)
IPOA1PTAC58QIP2RCH1SRP1-alphaSRP1alpha
Chromosome 17
Chromosome location 17q24.2
Summary The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Im
miRNA miRNA information provided by mirtarbase database.
1338
miRTarBase ID miRNA Experiments Reference
MIRT016443 hsa-miR-193b-3p Proteomics 21512034
MIRT031798 hsa-miR-16-5p Proteomics 18668040
MIRT050744 hsa-miR-17-3p CLASH 23622248
MIRT049112 hsa-miR-92a-3p CLASH 23622248
MIRT048751 hsa-miR-93-5p CLASH 23622248
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
YBX1 Repression 20596676
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
48
GO ID Ontology Definition Evidence Reference
GO:0000018 Process Regulation of DNA recombination TAS 8016130
GO:0000139 Component Golgi membrane IEA
GO:0003723 Function RNA binding HDA 22681889
GO:0005515 Function Protein binding IPI 9168958, 9405152, 9497340, 10353244, 10523667, 10980193, 11024021, 11971900, 12551970, 15507604, 15870280, 15942031, 17324944, 17596301, 19668212, 19883659, 20551905, 20701745, 20965181, 21385873, 21690087, 21988832, 22898364, 24965446, 24981860, 25416956, 25556234, 25609649, 264208
GO:0005634 Component Nucleus IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
600685 6395 ENSG00000182481
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P52292
Protein name Importin subunit alpha-1 (Karyopherin subunit alpha-2) (RAG cohort protein 1) (SRP1-alpha)
Protein function Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1 (PubMed:28991411, PubMed:32130408, PubMed:7604027, PubMed:7754385). Binds specifically and directly to substrates containing either a simple or bipartite NLS mo
PDB 1EFX , 1QGK , 1QGR , 3FEX , 3FEY , 3WPT , 4E4V , 4WV6 , 5H43 , 7CRU , 7N8J , 7N9H , 8FZK , 8GCN
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01749 IBB 13 98 Importin beta binding domain Family
PF00514 Arm 108 149 Armadillo/beta-catenin-like repeat Repeat
PF00514 Arm 151 191 Armadillo/beta-catenin-like repeat Repeat
PF00514 Arm 193 238 Armadillo/beta-catenin-like repeat Repeat
PF00514 Arm 241 280 Armadillo/beta-catenin-like repeat Repeat
PF00514 Arm 282 322 Armadillo/beta-catenin-like repeat Repeat
PF00514 Arm 324 364 Armadillo/beta-catenin-like repeat Repeat
PF00514 Arm 366 406 Armadillo/beta-catenin-like repeat Repeat
PF00514 Arm 409 448 Armadillo/beta-catenin-like repeat Repeat
PF16186 Arm_3 458 509 Atypical Arm repeat Family
Tissue specificity TISSUE SPECIFICITY: Expressed ubiquitously.
Sequence
Sequence length 529
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Nucleocytoplasmic transport
Influenza A
Chemical carcinogenesis - receptor activation
  ISG15 antiviral mechanism
NS1 Mediated Effects on Host Pathways
Sensing of DNA Double Strand Breaks
Estrogen-dependent gene expression
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
10
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ALZHEIMER DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Gastric cancer Uncertain significance ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
INSOMNIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
LUNG DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Adenocarcinoma of Lung Associate 34773335, 36311801, 37060831
★☆☆☆☆
Found in Text Mining only
Bowen's Disease Stimulate 24098495
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Associate 17899179, 25989275, 30732163, 31212646, 31638237, 33962648, 35948941
★☆☆☆☆
Found in Text Mining only
Carcinogenesis Associate 26884852, 33728352
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Associate 25060425, 31046781, 31783876, 32213663, 34112092, 34903711, 35075389, 35915607, 37923899, 38238845
★☆☆☆☆
Found in Text Mining only
Carcinoma Intraductal Noninfiltrating Stimulate 17899179
★☆☆☆☆
Found in Text Mining only
Carcinoma Merkel Cell Stimulate 24098495
★☆☆☆☆
Found in Text Mining only
Carcinoma Non Small Cell Lung Associate 24070213, 27009856
★☆☆☆☆
Found in Text Mining only
Carcinoma Pancreatic Ductal Associate 33728352
★☆☆☆☆
Found in Text Mining only
Carcinoma Squamous Cell Stimulate 24098495
★☆☆☆☆
Found in Text Mining only