Gene Gene information from NCBI Gene database.
Entrez ID 3837
Gene name Karyopherin subunit beta 1
Gene symbol KPNB1
Synonyms (NCBI Gene)
IMB1IPO1IPOBImpnbNTF97
Chromosome 17
Chromosome location 17q21.32
Summary Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a het
miRNA miRNA information provided by mirtarbase database.
609
miRTarBase ID miRNA Experiments Reference
MIRT049219 hsa-miR-92a-3p CLASH 23622248
MIRT047765 hsa-miR-7-5p CLASH 23622248
MIRT047236 hsa-miR-181b-5p CLASH 23622248
MIRT046618 hsa-miR-222-3p CLASH 23622248
MIRT046618 hsa-miR-222-3p CLASH 23622248
Transcription factors Transcription factors information provided by TRRUST V2 database.
2
Transcription factor Regulation Reference
EZH2 Activation 24132643
SRF Unknown 21131446
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
67
GO ID Ontology Definition Evidence Reference
GO:0003723 Function RNA binding HDA 22681889
GO:0005515 Function Protein binding IPI 9405152, 10353244, 10523667, 11024021, 11311162, 11971900, 12372823, 15282309, 15494309, 15507604, 15870280, 16314522, 17209048, 17596301, 19668212, 19680228, 20701745, 20818336, 21072240, 21858095, 22084111, 22500989, 24169621, 26195665, 26496610, 28514442, 29734393, 30833792, 3396
GO:0005576 Component Extracellular region TAS
GO:0005634 Component Nucleus IBA
GO:0005634 Component Nucleus IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
602738 6400 ENSG00000108424
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q14974
Protein name Importin subunit beta-1 (Importin-90) (Karyopherin subunit beta-1) (Nuclear factor p97) (Pore targeting complex 97 kDa subunit) (PTAC97)
Protein function Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor (Pub
PDB 1F59 , 1IBR , 1M5N , 1O6O , 1O6P , 1QGK , 1QGR , 2P8Q , 2Q5D , 2QNA , 3LWW , 3W5K , 6N88 , 6N89 , 8GCN
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03810 IBN_N 21 101 Importin-beta N-terminal domain Family
PF00514 Arm 399 437 Armadillo/beta-catenin-like repeat Repeat
Sequence
MELITILEKTVSPDRLELEAAQKFLERAAVENLPTFLVELSRVLANPGNSQVARVAAGLQ
IKNSLTSKDPDIKAQYQQRWLAIDANARREVKNYVLQTLGT
ETYRPSSASQCVAGIACAE
IPVNQWPELIPQLVANVTNPNSTEHMKESTLEAIGYICQDIDPEQLQDKSNEILTAIIQG
MRKEEPSNNVKLAATNALLNSLEFTKANFDKESERHFIMQVVCEATQCPDTRVRVAALQN
LVKIMSLYYQYMETYMGPALFAITIEAMKSDIDEVALQGIEFWSNVCDEEMDLAIEASEA
AEQGRPPEHTSKFYAKGALQYLVPILTQTLTKQDENDDDDDWNPCKAAGVCLMLLATCCE
DDIVPHVLPFIKEHIKNPDWRYRDAAVMAFGCILEGPEPSQLKPLVIQAMPTLIELMKDP
SVVVRDTAAWTVGRICE
LLPEAAINDVYLAPLLQCLIEGLSAEPRVASNVCWAFSSLAEA
AYEAADVADDQEEPATYCLSSSFELIVQKLLETTDRPDGHQNNLRSSAYESLMEIVKNSA
KDCYPAVQKTTLVIMERLQQVLQMESHIQSTSDRIQFNDLQSLLCATLQNVLRKVQHQDA
LQISDVVMASLLRMFQSTAGSGGVQEDALMAVSTLVEVLGGEFLKYMEAFKPFLGIGLKN
YAEYQVCLAAVGLVGDLCRALQSNIIPFCDEVMQLLLENLGNENVHRSVKPQILSVFGDI
ALAIGGEFKKYLEVVLNTLQQASQAQVDKSDYDMVDYLNELRESCLEAYTGIVQGLKGDQ
ENVHPDVMLVQPRVEFILSFIDHIAGDEDHTDGVVACAAGLIGDLCTAFGKDVLKLVEAR
PMIHELLTEGRRSKTNKAKTLATWATKELRKLKNQA
Sequence length 876
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Nucleocytoplasmic transport
Chemical carcinogenesis - receptor activation
  ISG15 antiviral mechanism
Apoptosis induced DNA fragmentation
Regulation of cholesterol biosynthesis by SREBP (SREBF)
Transport of Ribonucleoproteins into the Host Nucleus
NS1 Mediated Effects on Host Pathways
Nuclear import of Rev protein
Initiation of Nuclear Envelope (NE) Reformation
Neutrophil degranulation
Inhibition of nitric oxide production