Gene Gene information from NCBI Gene database.
Entrez ID 3836
Gene name Karyopherin subunit alpha 1
Gene symbol KPNA1
Synonyms (NCBI Gene)
IPOA5NPI-1RCH2SRP1
Chromosome 3
Chromosome location 3q21.1
Summary The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusio
miRNA miRNA information provided by mirtarbase database.
1209
miRTarBase ID miRNA Experiments Reference
MIRT025234 hsa-miR-34a-5p Proteomics 21566225
MIRT025234 hsa-miR-34a-5p Proteomics 21566225
MIRT027097 hsa-miR-103a-3p Sequencing 20371350
MIRT028495 hsa-miR-30a-5p Proteomics 18668040
MIRT031732 hsa-miR-16-5p Sequencing 20371350
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
SRF Unknown 21131446
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
40
GO ID Ontology Definition Evidence Reference
GO:0000018 Process Regulation of DNA recombination TAS 8052633
GO:0005515 Function Protein binding IPI 10523667, 12011095, 15942031, 16713569, 17310249, 17596301, 18985028, 19084525, 19412186, 21385873, 21988832, 21994455, 22500989, 25416956, 25599645, 26420826, 26496610, 26966684, 29370303, 31515488, 32296183, 33060197, 33961781, 35271311
GO:0005634 Component Nucleus IBA
GO:0005634 Component Nucleus IEA
GO:0005634 Component Nucleus ISS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
600686 6394 ENSG00000114030
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P52294
Protein name Importin subunit alpha-5 (Karyopherin subunit alpha-1) (Nucleoprotein interactor 1) (NPI-1) (RAG cohort protein 2) (SRP1-beta) [Cleaved into: Importin subunit alpha-5, N-terminally processed]
Protein function Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1 (PubMed:27713473, PubMed:7892216, PubMed:8692858). Binds specifically and directly to substrates containing either a simple or bipartite NLS motif (PubMed:27713
PDB 2JDQ , 3TJ3 , 4B18 , 6WX9
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01749 IBB 10 104 Importin beta binding domain Family
PF00514 Arm 114 156 Armadillo/beta-catenin-like repeat Repeat
PF00514 Arm 158 198 Armadillo/beta-catenin-like repeat Repeat
PF00514 Arm 200 241 Armadillo/beta-catenin-like repeat Repeat
PF00514 Arm 243 283 Armadillo/beta-catenin-like repeat Repeat
PF00514 Arm 285 325 Armadillo/beta-catenin-like repeat Repeat
PF00514 Arm 327 367 Armadillo/beta-catenin-like repeat Repeat
PF00514 Arm 369 409 Armadillo/beta-catenin-like repeat Repeat
PF00514 Arm 412 452 Armadillo/beta-catenin-like repeat Repeat
PF16186 Arm_3 466 517 Atypical Arm repeat Family
Tissue specificity TISSUE SPECIFICITY: Expressed ubiquitously. {ECO:0000269|PubMed:7892216}.
Sequence
Sequence length 538
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Nucleocytoplasmic transport
Salmonella infection
Influenza A
Chemical carcinogenesis - receptor activation
  ISG15 antiviral mechanism
Apoptosis induced DNA fragmentation
Integration of provirus
Transport of Ribonucleoproteins into the Host Nucleus
NS1 Mediated Effects on Host Pathways
Vpr-mediated nuclear import of PICs
Inhibition of nitric oxide production