Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	3833
Gene name	Kinesin family member C1
Gene symbol	KIFC1
Synonyms (NCBI Gene)	HSETKNSL2
Chromosome	6
Chromosome location	6p21.32

117

Show/Hide all (117)

miRTarBase ID	miRNA	Experiments	Reference
MIRT024729	hsa-miR-215-5p	Microarray	19074876
MIRT051933	hsa-let-7b-5p	CLASH	23622248
MIRT049181	hsa-miR-92a-3p	CLASH	23622248
MIRT037124	hsa-miR-877-3p	CLASH	23622248
MIRT607373	hsa-miR-8485	HITS-CLIP	23313552
MIRT607372	hsa-miR-7845-5p	HITS-CLIP	23313552
MIRT607371	hsa-miR-135a-3p	HITS-CLIP	23313552
MIRT607373	hsa-miR-8485	HITS-CLIP	23824327
MIRT607373	hsa-miR-8485	HITS-CLIP	23824327
MIRT607372	hsa-miR-7845-5p	HITS-CLIP	23824327
MIRT607371	hsa-miR-135a-3p	HITS-CLIP	23824327
MIRT607373	hsa-miR-8485	HITS-CLIP	23824327
MIRT607373	hsa-miR-8485	HITS-CLIP	23824327
MIRT607373	hsa-miR-8485	HITS-CLIP	23824327
MIRT607372	hsa-miR-7845-5p	HITS-CLIP	23824327
MIRT607371	hsa-miR-135a-3p	HITS-CLIP	23824327
MIRT607373	hsa-miR-8485	HITS-CLIP	23824327
MIRT607373	hsa-miR-8485	HITS-CLIP	23824327
MIRT607373	hsa-miR-8485	HITS-CLIP	23824327
MIRT607373	hsa-miR-8485	HITS-CLIP	23824327
MIRT607372	hsa-miR-7845-5p	HITS-CLIP	23824327
MIRT607371	hsa-miR-135a-3p	HITS-CLIP	23824327
MIRT607373	hsa-miR-8485	HITS-CLIP	23824327
MIRT607373	hsa-miR-8485	HITS-CLIP	23824327
MIRT607373	hsa-miR-8485	HITS-CLIP	23824327
MIRT607373	hsa-miR-8485	HITS-CLIP	23824327
MIRT607373	hsa-miR-8485	HITS-CLIP	23824327
MIRT607373	hsa-miR-8485	HITS-CLIP	23824327
MIRT607373	hsa-miR-8485	HITS-CLIP	23824327
MIRT607373	hsa-miR-8485	HITS-CLIP	23824327
MIRT607373	hsa-miR-8485	HITS-CLIP	23824327
MIRT607373	hsa-miR-8485	HITS-CLIP	23824327
MIRT607373	hsa-miR-8485	HITS-CLIP	23824327
MIRT607373	hsa-miR-8485	HITS-CLIP	23824327
MIRT607373	hsa-miR-8485	HITS-CLIP	23824327
MIRT607373	hsa-miR-8485	HITS-CLIP	23824327
MIRT607373	hsa-miR-8485	HITS-CLIP	24906430
MIRT607373	hsa-miR-8485	HITS-CLIP	24906430
MIRT607372	hsa-miR-7845-5p	HITS-CLIP	24906430
MIRT607371	hsa-miR-135a-3p	HITS-CLIP	24906430
MIRT526861	hsa-miR-6835-3p	PAR-CLIP	22012620
MIRT526860	hsa-miR-4422	PAR-CLIP	22012620
MIRT526859	hsa-miR-6871-3p	PAR-CLIP	22012620
MIRT526858	hsa-miR-6865-3p	PAR-CLIP	22012620
MIRT526857	hsa-miR-4530	PAR-CLIP	22012620
MIRT526856	hsa-miR-338-3p	PAR-CLIP	22012620
MIRT526855	hsa-miR-1224-3p	PAR-CLIP	22012620
MIRT526854	hsa-miR-6784-3p	PAR-CLIP	22012620
MIRT526853	hsa-miR-6862-3p	PAR-CLIP	22012620
MIRT526852	hsa-miR-766-3p	PAR-CLIP	22012620
MIRT526851	hsa-miR-532-3p	PAR-CLIP	22012620
MIRT526850	hsa-miR-1260a	PAR-CLIP	22012620
MIRT526849	hsa-miR-1260b	PAR-CLIP	22012620
MIRT607371	hsa-miR-135a-3p	Luciferase reporter assayqRT-PCRWestern blot	27366092
MIRT607371	hsa-miR-135a-3p	Luciferase reporter assayqRT-PCRWestern blot	27366092
MIRT607371	hsa-miR-135a-3p	HITS-CLIP	27418678
MIRT607371	hsa-miR-135a-3p	HITS-CLIP	27418678
MIRT607371	hsa-miR-135a-3p	HITS-CLIP	27418678
MIRT607372	hsa-miR-7845-5p	HITS-CLIP	27418678
MIRT607372	hsa-miR-7845-5p	HITS-CLIP	27418678
MIRT607372	hsa-miR-7845-5p	HITS-CLIP	27418678
MIRT607373	hsa-miR-8485	HITS-CLIP	27418678
MIRT607373	hsa-miR-8485	HITS-CLIP	27418678
MIRT607373	hsa-miR-8485	HITS-CLIP	27418678
MIRT607373	hsa-miR-8485	HITS-CLIP	27418678
MIRT607373	hsa-miR-8485	HITS-CLIP	27418678
MIRT607373	hsa-miR-8485	HITS-CLIP	27418678
MIRT607373	hsa-miR-8485	HITS-CLIP	23313552
MIRT607372	hsa-miR-7845-5p	HITS-CLIP	23313552
MIRT607371	hsa-miR-135a-3p	HITS-CLIP	23313552
MIRT607373	hsa-miR-8485	HITS-CLIP	23824327
MIRT607373	hsa-miR-8485	HITS-CLIP	23824327
MIRT607372	hsa-miR-7845-5p	HITS-CLIP	23824327
MIRT607371	hsa-miR-135a-3p	HITS-CLIP	23824327
MIRT607373	hsa-miR-8485	HITS-CLIP	23824327
MIRT607373	hsa-miR-8485	HITS-CLIP	23824327
MIRT607373	hsa-miR-8485	HITS-CLIP	23824327
MIRT607372	hsa-miR-7845-5p	HITS-CLIP	23824327
MIRT607371	hsa-miR-135a-3p	HITS-CLIP	23824327
MIRT607373	hsa-miR-8485	HITS-CLIP	23824327
MIRT607373	hsa-miR-8485	HITS-CLIP	23824327
MIRT607373	hsa-miR-8485	HITS-CLIP	23824327
MIRT607373	hsa-miR-8485	HITS-CLIP	23824327
MIRT607372	hsa-miR-7845-5p	HITS-CLIP	23824327
MIRT607371	hsa-miR-135a-3p	HITS-CLIP	23824327
MIRT607373	hsa-miR-8485	HITS-CLIP	23824327
MIRT607373	hsa-miR-8485	HITS-CLIP	23824327
MIRT607373	hsa-miR-8485	HITS-CLIP	23824327
MIRT607373	hsa-miR-8485	HITS-CLIP	23824327
MIRT607373	hsa-miR-8485	HITS-CLIP	23824327
MIRT607373	hsa-miR-8485	HITS-CLIP	23824327
MIRT607373	hsa-miR-8485	HITS-CLIP	23824327
MIRT607373	hsa-miR-8485	HITS-CLIP	23824327
MIRT607373	hsa-miR-8485	HITS-CLIP	23824327
MIRT607373	hsa-miR-8485	HITS-CLIP	23824327
MIRT607373	hsa-miR-8485	HITS-CLIP	23824327
MIRT607373	hsa-miR-8485	HITS-CLIP	23824327
MIRT607373	hsa-miR-8485	HITS-CLIP	23824327
MIRT607373	hsa-miR-8485	HITS-CLIP	23824327
MIRT526861	hsa-miR-6835-3p	PAR-CLIP	22012620
MIRT526860	hsa-miR-4422	PAR-CLIP	22012620
MIRT526859	hsa-miR-6871-3p	PAR-CLIP	22012620
MIRT526858	hsa-miR-6865-3p	PAR-CLIP	22012620
MIRT526857	hsa-miR-4530	PAR-CLIP	22012620
MIRT526856	hsa-miR-338-3p	PAR-CLIP	22012620
MIRT526855	hsa-miR-1224-3p	PAR-CLIP	22012620
MIRT526854	hsa-miR-6784-3p	PAR-CLIP	22012620
MIRT526853	hsa-miR-6862-3p	PAR-CLIP	22012620
MIRT526852	hsa-miR-766-3p	PAR-CLIP	22012620
MIRT526851	hsa-miR-532-3p	PAR-CLIP	22012620
MIRT526850	hsa-miR-1260a	PAR-CLIP	22012620
MIRT526849	hsa-miR-1260b	PAR-CLIP	22012620
MIRT1095148	hsa-miR-376c	CLIP-seq
MIRT1095149	hsa-miR-4782-5p	CLIP-seq
MIRT2025506	hsa-miR-1260	CLIP-seq
MIRT2025507	hsa-miR-1280	CLIP-seq
MIRT1095149	hsa-miR-4782-5p	CLIP-seq

Show/Hide all (32)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000070	Process	Mitotic sister chromatid segregation	NAS	8276466
GO:0000166	Function	Nucleotide binding	IEA
GO:0003777	Function	Microtubule motor activity	IBA
GO:0003777	Function	Microtubule motor activity	IEA
GO:0003777	Function	Microtubule motor activity	NAS	8276466
GO:0005524	Function	ATP binding	IEA
GO:0005524	Function	ATP binding	NAS	8276466
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005768	Component	Endosome	IEA
GO:0005769	Component	Early endosome	IEA
GO:0005813	Component	Centrosome	IEA
GO:0005815	Component	Microtubule organizing center	IBA
GO:0005819	Component	Spindle	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005871	Component	Kinesin complex	IBA
GO:0005874	Component	Microtubule	IBA
GO:0005874	Component	Microtubule	IEA
GO:0007018	Process	Microtubule-based movement	IBA
GO:0007018	Process	Microtubule-based movement	IEA
GO:0007080	Process	Mitotic metaphase chromosome alignment	IMP	15843429
GO:0007283	Process	Spermatogenesis	IEA
GO:0008017	Function	Microtubule binding	IBA
GO:0008017	Function	Microtubule binding	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016887	Function	ATP hydrolysis activity	IBA
GO:0051301	Process	Cell division	IEA
GO:0072686	Component	Mitotic spindle	IBA
GO:0090307	Process	Mitotic spindle assembly	IBA
GO:0090307	Process	Mitotic spindle assembly	IMP	15843429

MIM	HGNC	e!Ensembl
603763	6389	ENSG00000237649

Q9BW19

Protein name

Kinesin-like protein KIFC1 (Kinesin-like protein 2) (Kinesin-related protein HSET)

Protein function

Minus end-directed microtubule-dependent motor required for bipolar spindle formation (PubMed:15843429). May contribute to movement of early endocytic vesicles (By similarity). Regulates cilium formation and structure (By similarity). {ECO:00002

PDB

5WDH

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00225	Kinesin	349 → 663	Kinesin motor domain	Domain

Sequence

MDPQRSPLLEVKGNIELKRPLIKAPSQLPLSGSRLKRRPDQMEDGLEPEKKRTRGLGATT
KITTSHPRVPSLTTVPQTQGQTTAQKVSKKTGPRCSTAIATGLKNQKPVPAVPVQKSGTS
GVPPMAGGKKPSKRPAWDLKGQLCDLNAELKRCRERTQTLDQENQQLQDQLRDAQQQVKA
LGTERTTLEGHLAKVQAQAEQGQQELKNLRACVLELEERLSTQEGLVQELQKKQVELQEE
RRGLMSQLEEKERRLQTSEAALSSSQAEVASLRQETVAQAALLTEREERLHGLEMERRRL
HNQLQELKGNIRVFCRVRPVLPGEPTPPPGLLLFPSGPGGPSDPPTRLSLSRSDERRGTL
SGAPAPPTRHDFSFDRVFPPGSGQDEVFEEIAMLVQSALDGYPVCIFAYGQTGSGKTFTM
EGGPGGDPQLEGLIPRALRHLFSVAQELSGQGWTYSFVASYVEIYNETVRDLLATGTRKG
QGGECEIRRAGPGSEELTVTNARYVPVSCEKEVDALLHLARQNRAVARTAQNERSSRSHS
VFQLQISGEHSSRGLQCGAPLSLVDLAGSERLDPGLALGPGERERLRETQAINSSLSTLG
LVIMALSNKESHVPYRNSKLTYLLQNSLGGSAKMLMFVNISPLEENVSESLNSLRFASKV
NQCVIGTAQANRK

Sequence length

673

Interactions

View interactions

	KEGG		Reactome
	Motor proteins		COPI-dependent Golgi-to-ER retrograde traffic Kinesins

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Uterine corpus endometrial carcinoma	Uncertain significance	rs745748227	RCV005932313

Show/Hide Text Mining Associations (31)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma of Lung	Associate	37330525
Breast Neoplasms	Stimulate	25788277
Breast Neoplasms	Associate	26177331, 28218233, 38003261
Calcinosis Cutis	Associate	25028599
Calcinosis Cutis	Stimulate	33760984
Carcinogenesis	Associate	38112634
Carcinoma Hepatocellular	Associate	28901309, 29620256, 34737790, 39596041
Carcinoma Ovarian Epithelial	Stimulate	26992853
Carcinoma Pancreatic Ductal	Associate	36565617
Carcinoma Renal Cell	Associate	37789080
Chromosomal Instability	Associate	27489338
COVID 19	Associate	37278873
Dermatitis Contact	Associate	33318199
Drug Hypersensitivity	Associate	33318199
Esophageal Squamous Cell Carcinoma	Associate	37955677
Glioblastoma	Associate	33588605
Inflammation	Associate	37789080
Lymphoma Non Hodgkin	Associate	36945359
Neoplasm Metastasis	Associate	25028599, 38112634
Neoplasm Metastasis	Stimulate	36990154, 38003261
Neoplasms	Associate	25028599, 25788277, 26177331, 26527623, 26992853, 29620256, 33361741, 33588605, 33760984, 35479190, 36565617, 36990154, 37789080, 37955677, 38112634
Neoplasms	Inhibit	38003261
Osteosarcoma	Associate	35479190
Ovarian Neoplasms	Associate	25028599, 26992853
Ovarian Neoplasms	Stimulate	33361741
Pancreatic Neoplasms	Associate	38112634
Personality Disorders	Associate	26992853, 38003261
Prostatic Neoplasms	Associate	33760984
Silicosis	Associate	37278873
Squamous Cell Carcinoma of Head and Neck	Associate	36990154
Triple Negative Breast Neoplasms	Associate	28218233, 29535384

KIFC1 (kinesin family member C1)