Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3817
Gene name Gene Name - the full gene name approved by the HGNC.
Kallikrein related peptidase 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
KLK2
Synonyms (NCBI Gene) Gene synonyms aliases
KLK2A2, hGK-1, hK2
Chromosome Chromosome number
19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
19q13.33
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the grandular kallikrein protein family. Kallikreins are a subgroup of serine proteases that are clustered on chromosome 19. Members of this family are involved in a diverse array of biological functions. The protein encoded
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT722828 hsa-miR-21-5p HITS-CLIP 19536157
MIRT722827 hsa-miR-590-5p HITS-CLIP 19536157
MIRT722826 hsa-miR-1245a HITS-CLIP 19536157
MIRT722825 hsa-miR-8079 HITS-CLIP 19536157
MIRT722824 hsa-miR-5190 HITS-CLIP 19536157
Transcription factors
Transcription factor Regulation Reference
AR Unknown 11532861;16751804;20688158;9241247
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003073 Process Regulation of systemic arterial blood pressure IBA 21873635
GO:0004252 Function Serine-type endopeptidase activity IDA 9042371
GO:0005576 Component Extracellular region TAS
GO:0022617 Process Extracellular matrix disassembly TAS
GO:0030141 Component Secretory granule IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
147960 6363 ENSG00000167751
Protein
UniProt ID P20151
Protein name Kallikrein-2 (EC 3.4.21.35) (Glandular kallikrein-1) (hGK-1) (Tissue kallikrein-2)
Protein function Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.
PDB 4NFE , 4NFF
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00089 Trypsin 25 253 Trypsin Domain
Sequence
Sequence length 261
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Renin-angiotensin system
Endocrine and other factor-regulated calcium reabsorption
  Activation of Matrix Metalloproteinases
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Prostate cancer Malignant neoplasm of prostate rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 17085659, 15643194
Unknown
Disease term Disease name Evidence References Source
Celiac disease Celiac disease GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenoma Pleomorphic Associate 30120721
Breast Neoplasms Stimulate 27058005
Hyperlipidemia Familial Combined Associate 23877856
Lung Neoplasms Stimulate 19170196
Neoplasm Metastasis Associate 27497761
Neoplasms Associate 20424135, 23391636, 29614347, 29670000, 30307468, 31500625
Personality Disorders Associate 23683475
Prostatic Neoplasms Associate 11486050, 11834722, 19318432, 20424135, 20460480, 21178268, 21372204, 25847286, 25969144, 28802831, 30307468, 30334974, 33596994, 34254325
Prostatic Neoplasms Castration Resistant Associate 25189356, 27497761
Prostatitis Associate 24065644