Gene Gene information from NCBI Gene database.
Entrez ID 3817
Gene name Kallikrein related peptidase 2
Gene symbol KLK2
Synonyms (NCBI Gene)
KLK2A2hGK-1hK2
Chromosome 19
Chromosome location 19q13.33
Summary This gene encodes a member of the grandular kallikrein protein family. Kallikreins are a subgroup of serine proteases that are clustered on chromosome 19. Members of this family are involved in a diverse array of biological functions. The protein encoded
miRNA miRNA information provided by mirtarbase database.
388
miRTarBase ID miRNA Experiments Reference
MIRT722828 hsa-miR-21-5p HITS-CLIP 19536157
MIRT722827 hsa-miR-590-5p HITS-CLIP 19536157
MIRT722826 hsa-miR-1245a HITS-CLIP 19536157
MIRT722825 hsa-miR-8079 HITS-CLIP 19536157
MIRT722824 hsa-miR-5190 HITS-CLIP 19536157
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
AR Unknown 11532861;16751804;20688158;9241247
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
14
GO ID Ontology Definition Evidence Reference
GO:0003073 Process Regulation of systemic arterial blood pressure IBA
GO:0004252 Function Serine-type endopeptidase activity IBA
GO:0004252 Function Serine-type endopeptidase activity IDA 9042371
GO:0004252 Function Serine-type endopeptidase activity IEA
GO:0004252 Function Serine-type endopeptidase activity TAS 10463585
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
147960 6363 ENSG00000167751
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P20151
Protein name Kallikrein-2 (EC 3.4.21.35) (Glandular kallikrein-1) (hGK-1) (Tissue kallikrein-2)
Protein function Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.
PDB 4NFE , 4NFF
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00089 Trypsin 25 253 Trypsin Domain
Sequence
Sequence length 261
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Renin-angiotensin system
Endocrine and other factor-regulated calcium reabsorption
  Activation of Matrix Metalloproteinases
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
1
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Acute myeloid leukemia Benign rs198977 RCV003315277
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Adenoma Pleomorphic Associate 30120721
Breast Neoplasms Stimulate 27058005
Hyperlipidemia Familial Combined Associate 23877856
Lung Neoplasms Stimulate 19170196
Neoplasm Metastasis Associate 27497761
Neoplasms Associate 20424135, 23391636, 29614347, 29670000, 30307468, 31500625
Personality Disorders Associate 23683475
Prostatic Neoplasms Associate 11486050, 11834722, 19318432, 20424135, 20460480, 21178268, 21372204, 25847286, 25969144, 28802831, 30307468, 30334974, 33596994, 34254325
Prostatic Neoplasms Castration Resistant Associate 25189356, 27497761
Prostatitis Associate 24065644