Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3799
Gene name Gene Name - the full gene name approved by the HGNC.
Kinesin family member 5B
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
KIF5B
Synonyms (NCBI Gene) Gene synonyms aliases
HEL-S-61, KINH, KNS, KNS1, UKHC
Chromosome Chromosome number
10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
10p11.22
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs1114167297 T>C Likely-pathogenic Missense variant, coding sequence variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT021905 hsa-miR-128-3p Sequencing 20371350
MIRT023550 hsa-miR-1-3p Proteomics;Microarray 18668037
MIRT024776 hsa-miR-215-5p Microarray 19074876
MIRT025237 hsa-miR-34a-5p Proteomics 21566225
MIRT025237 hsa-miR-34a-5p Proteomics 21566225
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003777 Function Microtubule motor activity IBA 21873635
GO:0003777 Function Microtubule motor activity IDA 28426968
GO:0003777 Function Microtubule motor activity ISS
GO:0005515 Function Protein binding IPI 15161933, 19164528, 20562859, 21915095, 25855459, 28514442, 32296183
GO:0005524 Function ATP binding IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
602809 6324 ENSG00000170759
Protein
UniProt ID P33176
Protein name Kinesin-1 heavy chain (Conventional kinesin heavy chain) (Ubiquitous kinesin heavy chain) (UKHC)
Protein function Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and n
PDB 1BG2 , 1MKJ , 2P4N , 3J8X , 3J8Y , 4HNA , 4LNU , 5LT0 , 5LT1 , 5LT2 , 5LT3 , 5LT4 , 6OJQ , 7RIK , 8IXA , 8IXB , 8IXD , 8IXE , 8IXF , 8IXG , 8RHB , 8RHH , 8RIK , 8RIZ , 9GNQ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00225 Kinesin 14 325 Kinesin motor domain Domain
Sequence
MADLAECNIKVMCRFRPLNESEVNRGDKYIAKFQGEDTVVIASKPYAFDRVFQSSTSQEQ
VYNDCAKKIVKDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPEGMGIIPRIVQDIFNYIY
SMDENLEFHIKVSYFEIYLDKIRDLLDVSKTNLSVHEDKNRVPYVKGCTERFVCSPDEVM
DTIDEGKSNRHVAVTNMNEHSSRSHSIFLINVKQENTQTEQKLSGKLYLVDLAGSEKVSK
TGAEGAVLDEAKNINKSLSALGNVISALAEGSTYVPYRDSKMTRILQDSLGGNCRTTIVI
CCSPSSYNESETKSTLLFGQRAKTI
KNTVCVNVELTAEQWKKKYEKEKEKNKILRNTIQW
LENELNRWRNGETVPIDEQFDKEKANLEAFTVDKDITLTNDKPATAIGVIGNFTDAERRK
CEEEIAKLYKQLDDKDEEINQQSQLVEKLKTQMLDQEELLASTRRDQDNMQAELNRLQAE
NDASKEEVKEVLQALEELAVNYDQKSQEVEDKTKEYELLSDELNQKSATLASIDAELQKL
KEMTNHQKKRAAEMMASLLKDLAEIGIAVGNNDVKQPEGTGMIDEEFTVARLYISKMKSE
VKTMVKRCKQLESTQTESNKKMEENEKELAACQLRISQHEAKIKSLTEYLQNVEQKKRQL
EESVDALSEELVQLRAQEKVHEMEKEHLNKVQTANEVKQAVEQQIQSHRETHQKQISSLR
DEVEAKAKLITDLQDQNQKMMLEQERLRVEHEKLKATDQEKSRKLHELTVMQDRREQARQ
DLKGLEETVAKELQTLHNLRKLFVQDLATRVKKSAEIDSDDTGGSAAQKQKISFLENNLE
QLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKALESALKEAKENASRDRKRYQQEVD
RIKEAVRSKNMARRGHSAQIAKPIRPGQHPAASPTHPSAIRGGGAFVQNSQPVAVRGGGG
KQV
Sequence length 963
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Endocytosis
Dopaminergic synapse
Motor proteins
Alzheimer disease
Parkinson disease
Amyotrophic lateral sclerosis
Huntington disease
Prion disease
Pathways of neurodegeneration - multiple diseases
Salmonella infection
Non-small cell lung cancer
  MHC class II antigen presentation
RHO GTPases activate KTN1
COPI-dependent Golgi-to-ER retrograde traffic
Kinesins
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Attention deficit hyperactivity disorder Attention deficit hyperactivity disorder rs786205019
Developmental delay Global developmental delay rs28941770, rs199469464, rs281865469, rs143747297, rs398123009, rs587777428, rs786205133, rs606231459, rs797044854, rs797045027, rs864309504, rs878853160, rs886039902, rs886042046, rs886041291
View all (32 more)
Diabetes mellitus Diabetes Mellitus rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237
View all (293 more)
23776493
Lung carcinoma Non-Small Cell Lung Carcinoma rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355
View all (44 more)
21757253
Unknown
Disease term Disease name Evidence References Source
Schizophrenia Schizophrenia GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 21656749, 22194472, 23052255, 23342255, 25567908, 26268359, 33832282
Brain Injuries Traumatic Associate 31038188
Carcinoma Non Small Cell Lung Associate 22194472, 22296236, 25982012, 33832282, 35220468
Carcinoma Renal Cell Associate 36471407
Hirschsprung Disease Associate 33561610
Histiocytoma Malignant Fibrous Associate 35438749
Histiocytosis Associate 30573850, 34727172
Lung Neoplasms Associate 22194472, 23052255, 23342255, 24759083, 29667179, 29912274, 34710947, 36471407
Melanoma Associate 23884313
Multiple Myeloma Associate 35677537