Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3779
Gene name Gene Name - the full gene name approved by the HGNC.
Potassium calcium-activated channel subfamily M regulatory beta subunit 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
KCNMB1
Synonyms (NCBI Gene) Gene synonyms aliases
BKbeta1, K(VCA)beta, SLO-BETA, hbeta1, hslo-beta, k(VCA)beta-1, slo-beta-1
Chromosome Chromosome number
5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
5q35.1
Summary Summary of gene provided in NCBI Entrez Gene.
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT724289 hsa-miR-4677-3p HITS-CLIP 19536157
MIRT724288 hsa-miR-4679 HITS-CLIP 19536157
MIRT724287 hsa-miR-1180-5p HITS-CLIP 19536157
MIRT724286 hsa-miR-7114-3p HITS-CLIP 19536157
MIRT724285 hsa-miR-4316 HITS-CLIP 19536157
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005513 Process Detection of calcium ion IBA 21873635
GO:0005886 Component Plasma membrane TAS
GO:0006813 Process Potassium ion transport TAS 8799178
GO:0007268 Process Chemical synaptic transmission TAS 8799178
GO:0007568 Process Aging IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
603951 6285 ENSG00000145936
Protein
UniProt ID Q16558
Protein name Calcium-activated potassium channel subunit beta-1 (BK channel subunit beta-1) (BKbeta) (BKbeta1) (Hbeta1) (Calcium-activated potassium channel, subfamily M subunit beta-1) (Calcium-activated potassium channel subunit beta) (Charybdotoxin receptor subunit
Protein function Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03185 CaKB 7 190 Calcium-activated potassium channel, beta subunit Family
Tissue specificity TISSUE SPECIFICITY: Abundantly expressed in smooth muscle. Low levels of expression in most other tissues. Within the brain, relatively high levels found in hippocampus and corpus callosum.
Sequence
Sequence length 191
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  cGMP-PKG signaling pathway
Vascular smooth muscle contraction
Insulin secretion
  Ca2+ activated K+ channels
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Hypertension Hypertensive disease, Hypertension, Diastolic, Resistance to rs13306026 17700361
Associations from Text Mining
Disease Name Relationship Type References
Airway Obstruction Associate 18535015
Alzheimer Disease Associate 16371011
Asthma Associate 18535015
Cardiovascular Diseases Associate 16293791
Diabetes Mellitus Inhibit 20966391
Diabetes Mellitus Associate 20966391
Diabetes Mellitus Type 2 Inhibit 29850792
Disease Progression Associate 20861615
Endometrial Neoplasms Associate 25884434
Hypertension Associate 17496725, 17700361, 18418400, 20861615