PNPLA7 (patatin like domain 7, lysophospholipase)

Gene

• Entrez ID: 375775
• Gene name: Patatin like domain 7, lysophospholipase
• Gene symbol: PNPLA7
• Synonyms (NCBI Gene): C9orf111, NTE-R1, NTEL1
• Chromosome: 9
• Chromosome location: 9q34.3
• Summary: Human patatin-like phospholipases, such as PNPLA7, have been implicated in regulation of adipocyte differentiation and have been induced by metabolic stimuli (Wilson et al., 2006 [PubMed 16799181]).[supplied by OMIM, Jun 2008]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1245496	hsa-miR-103a	CLIP-seq
MIRT1245497	hsa-miR-107	CLIP-seq
MIRT1245498	hsa-miR-188-3p	CLIP-seq
MIRT1245499	hsa-miR-3127-5p	CLIP-seq
MIRT1245500	hsa-miR-3918	CLIP-seq
MIRT1245501	hsa-miR-4711-5p	CLIP-seq
MIRT1245502	hsa-miR-532-3p	CLIP-seq
MIRT2299836	hsa-miR-1228	CLIP-seq
MIRT1245498	hsa-miR-188-3p	CLIP-seq
MIRT2299837	hsa-miR-214	CLIP-seq
MIRT2299838	hsa-miR-2682	CLIP-seq
MIRT2299839	hsa-miR-27a	CLIP-seq
MIRT2299840	hsa-miR-27b	CLIP-seq
MIRT1245499	hsa-miR-3127-5p	CLIP-seq
MIRT2299841	hsa-miR-3619-5p	CLIP-seq
MIRT1245500	hsa-miR-3918	CLIP-seq
MIRT2299842	hsa-miR-4436a	CLIP-seq
MIRT2299843	hsa-miR-4436b-3p	CLIP-seq
MIRT2299844	hsa-miR-449c	CLIP-seq
MIRT2299845	hsa-miR-4514	CLIP-seq
MIRT2299846	hsa-miR-4690-5p	CLIP-seq
MIRT2299847	hsa-miR-4692	CLIP-seq
MIRT2299848	hsa-miR-4700-3p	CLIP-seq
MIRT2299849	hsa-miR-513a-5p	CLIP-seq
MIRT1245502	hsa-miR-532-3p	CLIP-seq
MIRT2299850	hsa-miR-761	CLIP-seq
MIRT2456795	hsa-miR-2115	CLIP-seq
MIRT2299837	hsa-miR-214	CLIP-seq
MIRT2299839	hsa-miR-27a	CLIP-seq
MIRT2299840	hsa-miR-27b	CLIP-seq
MIRT1245499	hsa-miR-3127-5p	CLIP-seq
MIRT2456796	hsa-miR-3158-3p	CLIP-seq
MIRT2456797	hsa-miR-338-3p	CLIP-seq
MIRT2299841	hsa-miR-3619-5p	CLIP-seq
MIRT1245500	hsa-miR-3918	CLIP-seq
MIRT2299843	hsa-miR-4436b-3p	CLIP-seq
MIRT2456798	hsa-miR-4530	CLIP-seq
MIRT2299849	hsa-miR-513a-5p	CLIP-seq
MIRT2299850	hsa-miR-761	CLIP-seq
MIRT2299839	hsa-miR-27a	CLIP-seq
MIRT2299840	hsa-miR-27b	CLIP-seq
MIRT1245499	hsa-miR-3127-5p	CLIP-seq
MIRT2299849	hsa-miR-513a-5p	CLIP-seq
MIRT2299839	hsa-miR-27a	CLIP-seq
MIRT2299840	hsa-miR-27b	CLIP-seq
MIRT1245499	hsa-miR-3127-5p	CLIP-seq
MIRT2299849	hsa-miR-513a-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004622	Function	Phosphatidylcholine lysophospholipase activity	IBA
GO:0004622	Function	Phosphatidylcholine lysophospholipase activity	IEA
GO:0005783	Component	Endoplasmic reticulum	IBA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005811	Component	Lipid droplet	IEA
GO:0006629	Process	Lipid metabolic process	IEA
GO:0016020	Component	Membrane	IEA
GO:0016042	Process	Lipid catabolic process	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0034638	Process	Phosphatidylcholine catabolic process	IEA

Other IDs

• MIM: 612122
• HGNC: 24768
• e!Ensembl: ENSG00000130653

Protein

• UniProt ID: Q6ZV29
• Protein name: Patatin-like phospholipase domain-containing protein 7 (EC 3.1.1.-) (EC 3.1.1.5)
• Protein function: Lysophospholipase which preferentially deacylates unsaturated lysophosphatidylcholine (C18:1), generating glycerophosphocholine. Also can deacylate, to a lesser extent, lysophosphatidylethanolamine (C18:1), lysophosphatidyl-L-serine (C18:1) and
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00027	cNMP_binding	163 → 258	Cyclic nucleotide-binding domain	Domain
  PF00027	cNMP_binding	477 → 566	Cyclic nucleotide-binding domain	Domain
  PF00027	cNMP_binding	594 → 682	Cyclic nucleotide-binding domain	Domain
  PF01734	Patatin	928 → 1094	Patatin-like phospholipase	Family

• Sequence:

  MEEEKDDSPQLTGIAVGALLALALVGVLILFMFRRLRQFRQAQPTPQYRFRKRDKVMFYG
  RKIMRKVTTLPNTLVENTALPRQRARKRTKVLSLAKRILRFKKEYPALQPKEPPPSLLEA
  DLTEFDVKNSHLPSEVLYMLKNVRVLGHFEKPLFLELCKHIVFVQLQEGEHVFQPREPDP
  SICVVQDGRLEVCIQDTDGTEVVVKEVLAGDSVHSLLSILDIITGHAAPYKTVSVRAAIP
  STILRLPAAAFHGVFEKYPETLVRVVQIIMVRLQRVTFLALHNYLGLTTELFNAESQAIP
  LVSVASVAAGKAKKQVFYGEEERLKKPPRLQESCDSDHGGGRPAAAGPLLKRSHSVPAPS
  IRKQILEELEKPGAGDPDPSAPQGGPGSATSDLGMACDRARVFLHSDEHPGSSVASKSRK
  SVMVAEIPSTVSQHSESHTDETLASRKSDAIFRAAKKDLLTLMKLEDSSLLDGRVALLHV
  PAGTVVSRQGDQDASILFVVSGLLHVYQRKIGSQEDTCLFLTRPGEMVGQLAVLTGEPLI
  FTVKANRDCSFLSISKAHFYEIMRKQPTVVLGVAHTVVKRMSSFVRQIDFALDWVEVEAG
  RAIYRQGDKSDCTYIMLSGRLRSVIRKDDGKKRLAGEYGRGDLVGVVETLTHQARATTVH
  AVRDSELAKLPAGALTSIKRRYPQVVTRLIHLLGEKILGSLQQGPVTGHQLGLPTEGSKW
  DLGNPAVNLSTVAVMPVSEEVPLTAFALELEHALSAIGPTLLLTSDNIKRRLGSAALDSV
  HEYRLSSWLGQQEDTHRIVLYQADGTLTPWTQRCVRQADCILIVGLGDQEPTVGELERML
  ESTAVRAQKQLILLHREEGPAPARTVEWLNMRSWCSGHLHLCCPRRVFSRRSLPKLVEMY
  KHVFQRPPDRHSDFSRLARVLTGNAIALVLGGGGARGCAQVGVLKALAECGIPVDMVGGT
  SIGAFVGALYSEERNYSQMRIRAKQWAEGMTSLMKAALDLTYPITSMFSGAGFNSSIFSV
  FKDQQIEDLWIPYFAITTDITASAMRVHTDGSLWWYVRASMSLSGYMPPLCDPKDGHLLM
  DGGYINNLPADVARSMGAKVVIAIDVGSRDETDLTNYGDALSGWWLLWKRWNPLATKVKV
  LNMAEIQTRLAYVCCVRQLEVVKSSDYCEYLRPPIDSYSTLDFGKFNEICEVGYQHGRTV
  FDIWGRSGVLEKMLRDQQGPSKKPASAVLTCPNASFTDLAEIVSRIEPAKPAMVDDESDY
  QTEYEEELLDVPRDAYADFQSTSAQQGSDLEDESSLRHRHPSLAFPKLSEGSSDQDG

• Sequence length: 1317

Pathways

KEGG:

Glycerophospholipid metabolism

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Associated diseases

Unknown
Disease merge term	Disease name	Evidence	References	Source
premature ovarian failure	Premature ovarian failure	N/A	N/A	ClinVar

Associations from Text Mining
Disease Name	Relationship Type	References
Carcinoma Hepatocellular	Associate	37861523
Colorectal Neoplasms	Associate	37861523
Hypertension	Associate	29996846
Inflammation	Associate	36499308
Osteoporosis	Associate	32496000
Rectal Neoplasms	Associate	37861523