Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	375775
Gene name Gene Name - the full gene name approved by the HGNC.	Patatin like domain 7, lysophospholipase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PNPLA7
Synonyms (NCBI Gene) Gene synonyms aliases	C9orf111, NTE-R1, NTEL1
Chromosome Chromosome number	9
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	9q34.3
Summary Summary of gene provided in NCBI Entrez Gene.	Human patatin-like phospholipases, such as PNPLA7, have been implicated in regulation of adipocyte differentiation and have been induced by metabolic stimuli (Wilson et al., 2006 [PubMed 16799181]).[supplied by OMIM, Jun 2008]

Show/Hide all(47)

miRTarBase ID	miRNA	Experiments
MIRT1245496	hsa-miR-103a	CLIP-seq
MIRT1245497	hsa-miR-107	CLIP-seq
MIRT1245498	hsa-miR-188-3p	CLIP-seq
MIRT1245499	hsa-miR-3127-5p	CLIP-seq
MIRT1245500	hsa-miR-3918	CLIP-seq
MIRT1245501	hsa-miR-4711-5p	CLIP-seq
MIRT1245502	hsa-miR-532-3p	CLIP-seq
MIRT2299836	hsa-miR-1228	CLIP-seq
MIRT1245498	hsa-miR-188-3p	CLIP-seq
MIRT2299837	hsa-miR-214	CLIP-seq
MIRT2299838	hsa-miR-2682	CLIP-seq
MIRT2299839	hsa-miR-27a	CLIP-seq
MIRT2299840	hsa-miR-27b	CLIP-seq
MIRT1245499	hsa-miR-3127-5p	CLIP-seq
MIRT2299841	hsa-miR-3619-5p	CLIP-seq
MIRT1245500	hsa-miR-3918	CLIP-seq
MIRT2299842	hsa-miR-4436a	CLIP-seq
MIRT2299843	hsa-miR-4436b-3p	CLIP-seq
MIRT2299844	hsa-miR-449c	CLIP-seq
MIRT2299845	hsa-miR-4514	CLIP-seq
MIRT2299846	hsa-miR-4690-5p	CLIP-seq
MIRT2299847	hsa-miR-4692	CLIP-seq
MIRT2299848	hsa-miR-4700-3p	CLIP-seq
MIRT2299849	hsa-miR-513a-5p	CLIP-seq
MIRT1245502	hsa-miR-532-3p	CLIP-seq
MIRT2299850	hsa-miR-761	CLIP-seq
MIRT2456795	hsa-miR-2115	CLIP-seq
MIRT2299837	hsa-miR-214	CLIP-seq
MIRT2299839	hsa-miR-27a	CLIP-seq
MIRT2299840	hsa-miR-27b	CLIP-seq
MIRT1245499	hsa-miR-3127-5p	CLIP-seq
MIRT2456796	hsa-miR-3158-3p	CLIP-seq
MIRT2456797	hsa-miR-338-3p	CLIP-seq
MIRT2299841	hsa-miR-3619-5p	CLIP-seq
MIRT1245500	hsa-miR-3918	CLIP-seq
MIRT2299843	hsa-miR-4436b-3p	CLIP-seq
MIRT2456798	hsa-miR-4530	CLIP-seq
MIRT2299849	hsa-miR-513a-5p	CLIP-seq
MIRT2299850	hsa-miR-761	CLIP-seq
MIRT2299839	hsa-miR-27a	CLIP-seq
MIRT2299840	hsa-miR-27b	CLIP-seq
MIRT1245499	hsa-miR-3127-5p	CLIP-seq
MIRT2299849	hsa-miR-513a-5p	CLIP-seq
MIRT2299839	hsa-miR-27a	CLIP-seq
MIRT2299840	hsa-miR-27b	CLIP-seq
MIRT1245499	hsa-miR-3127-5p	CLIP-seq
MIRT2299849	hsa-miR-513a-5p	CLIP-seq

Show/Hide all(7)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004622	Function	Lysophospholipase activity	IBA	21873635
GO:0005783	Component	Endoplasmic reticulum	IBA	21873635
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005811	Component	Lipid droplet	IEA
GO:0016021	Component	Integral component of membrane	IEA
GO:0034638	Process	Phosphatidylcholine catabolic process	IEA
GO:0102545	Function	Phosphatidyl phospholipase B activity	IEA

MIM	HGNC	e!Ensembl
612122	24768	ENSG00000130653

Protein

UniProt ID

Q6ZV29

Protein name

Patatin-like phospholipase domain-containing protein 7 (EC 3.1.1.-) (EC 3.1.1.5)

Protein function

Lysophospholipase which preferentially deacylates unsaturated lysophosphatidylcholine (C18:1), generating glycerophosphocholine. Also can deacylate, to a lesser extent, lysophosphatidylethanolamine (C18:1), lysophosphatidyl-L-serine (C18:1) and

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00027	cNMP_binding	163 → 258	Cyclic nucleotide-binding domain	Domain
PF00027	cNMP_binding	477 → 566	Cyclic nucleotide-binding domain	Domain
PF00027	cNMP_binding	594 → 682	Cyclic nucleotide-binding domain	Domain
PF01734	Patatin	928 → 1094	Patatin-like phospholipase	Family

Sequence

MEEEKDDSPQLTGIAVGALLALALVGVLILFMFRRLRQFRQAQPTPQYRFRKRDKVMFYG
RKIMRKVTTLPNTLVENTALPRQRARKRTKVLSLAKRILRFKKEYPALQPKEPPPSLLEA
DLTEFDVKNSHLPSEVLYMLKNVRVLGHFEKPLFLELCKHIVFVQLQEGEHVFQPREPDP
SICVVQDGRLEVCIQDTDGTEVVVKEVLAGDSVHSLLSILDIITGHAAPYKTVSVRAAIP
STILRLPAAAFHGVFEKYPETLVRVVQIIMVRLQRVTFLALHNYLGLTTELFNAESQAIP
LVSVASVAAGKAKKQVFYGEEERLKKPPRLQESCDSDHGGGRPAAAGPLLKRSHSVPAPS
IRKQILEELEKPGAGDPDPSAPQGGPGSATSDLGMACDRARVFLHSDEHPGSSVASKSRK
SVMVAEIPSTVSQHSESHTDETLASRKSDAIFRAAKKDLLTLMKLEDSSLLDGRVALLHV
PAGTVVSRQGDQDASILFVVSGLLHVYQRKIGSQEDTCLFLTRPGEMVGQLAVLTGEPLI
FTVKANRDCSFLSISKAHFYEIMRKQPTVVLGVAHTVVKRMSSFVRQIDFALDWVEVEAG
RAIYRQGDKSDCTYIMLSGRLRSVIRKDDGKKRLAGEYGRGDLVGVVETLTHQARATTVH
AVRDSELAKLPAGALTSIKRRYPQVVTRLIHLLGEKILGSLQQGPVTGHQLGLPTEGSKW
DLGNPAVNLSTVAVMPVSEEVPLTAFALELEHALSAIGPTLLLTSDNIKRRLGSAALDSV
HEYRLSSWLGQQEDTHRIVLYQADGTLTPWTQRCVRQADCILIVGLGDQEPTVGELERML
ESTAVRAQKQLILLHREEGPAPARTVEWLNMRSWCSGHLHLCCPRRVFSRRSLPKLVEMY
KHVFQRPPDRHSDFSRLARVLTGNAIALVLGGGGARGCAQVGVLKALAECGIPVDMVGGT
SIGAFVGALYSEERNYSQMRIRAKQWAEGMTSLMKAALDLTYPITSMFSGAGFNSSIFSV
FKDQQIEDLWIPYFAITTDITASAMRVHTDGSLWWYVRASMSLSGYMPPLCDPKDGHLLM
DGGYINNLPADVARSMGAKVVIAIDVGSRDETDLTNYGDALSGWWLLWKRWNPLATKVKV
LNMAEIQTRLAYVCCVRQLEVVKSSDYCEYLRPPIDSYSTLDFGKFNEICEVGYQHGRTV
FDIWGRSGVLEKMLRDQQGPSKKPASAVLTCPNASFTDLAEIVSRIEPAKPAMVDDESDY
QTEYEEELLDVPRDAYADFQSTSAQQGSDLEDESSLRHRHPSLAFPKLSEGSSDQDG

Sequence length

1317

Interactions

View interactions

	KEGG
	Glycerophospholipid metabolism

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Alzheimer disease	Alzheimer`s Disease	rs63750215, rs28936379, rs63749851, rs63749884, rs28936380, rs63750048, rs63750579, rs63750264, rs63749964, rs63750671, rs281865161, rs63750066, rs63750399, rs63750734, rs63751039 View all (65 more)	26830138

Show/Hide Text Mining Associations (6)

Disease Name	Relationship Type	References
Associations from Text Mining
Carcinoma Hepatocellular	Associate	37861523
Colorectal Neoplasms	Associate	37861523
Hypertension	Associate	29996846
Inflammation	Associate	36499308
Osteoporosis	Associate	32496000
Rectal Neoplasms	Associate	37861523

PNPLA7 (patatin like domain 7, lysophospholipase)