Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	375616
Gene name	Kielin cysteine rich BMP regulator
Gene symbol	KCP
Synonyms (NCBI Gene)	CRIM2KCP1NET67
Chromosome	7
Chromosome location	7q32.1

Show/Hide all (58)

miRTarBase ID	miRNA	Experiments
MIRT1082526	hsa-miR-1183	CLIP-seq
MIRT1082527	hsa-miR-1203	CLIP-seq
MIRT1082528	hsa-miR-1208	CLIP-seq
MIRT1082529	hsa-miR-1224-3p	CLIP-seq
MIRT1082530	hsa-miR-1260	CLIP-seq
MIRT1082531	hsa-miR-1260b	CLIP-seq
MIRT1082532	hsa-miR-1280	CLIP-seq
MIRT1082533	hsa-miR-1285	CLIP-seq
MIRT1082534	hsa-miR-1343	CLIP-seq
MIRT1082535	hsa-miR-3137	CLIP-seq
MIRT1082536	hsa-miR-3187-5p	CLIP-seq
MIRT1082537	hsa-miR-371-5p	CLIP-seq
MIRT1082538	hsa-miR-4420	CLIP-seq
MIRT1082539	hsa-miR-532-3p	CLIP-seq
MIRT1082540	hsa-miR-612	CLIP-seq
MIRT2020534	hsa-miR-1245	CLIP-seq
MIRT1082534	hsa-miR-1343	CLIP-seq
MIRT2020535	hsa-miR-1976	CLIP-seq
MIRT2020536	hsa-miR-3545-3p	CLIP-seq
MIRT2020537	hsa-miR-3663-5p	CLIP-seq
MIRT2020538	hsa-miR-378g	CLIP-seq
MIRT2020539	hsa-miR-4423-5p	CLIP-seq
MIRT2020540	hsa-miR-4437	CLIP-seq
MIRT2020541	hsa-miR-4635	CLIP-seq
MIRT2020542	hsa-miR-4674	CLIP-seq
MIRT2020543	hsa-miR-4680-5p	CLIP-seq
MIRT2020544	hsa-miR-4722-3p	CLIP-seq
MIRT2020545	hsa-miR-4781-3p	CLIP-seq
MIRT2020546	hsa-miR-570	CLIP-seq
MIRT1082526	hsa-miR-1183	CLIP-seq
MIRT1082528	hsa-miR-1208	CLIP-seq
MIRT2020534	hsa-miR-1245	CLIP-seq
MIRT1082534	hsa-miR-1343	CLIP-seq
MIRT2252261	hsa-miR-150	CLIP-seq
MIRT2020535	hsa-miR-1976	CLIP-seq
MIRT1082535	hsa-miR-3137	CLIP-seq
MIRT2020536	hsa-miR-3545-3p	CLIP-seq
MIRT1082537	hsa-miR-371-5p	CLIP-seq
MIRT2020538	hsa-miR-378g	CLIP-seq
MIRT1082538	hsa-miR-4420	CLIP-seq
MIRT2020540	hsa-miR-4437	CLIP-seq
MIRT2020541	hsa-miR-4635	CLIP-seq
MIRT2020542	hsa-miR-4674	CLIP-seq
MIRT2020543	hsa-miR-4680-5p	CLIP-seq
MIRT2020544	hsa-miR-4722-3p	CLIP-seq
MIRT2020534	hsa-miR-1245	CLIP-seq
MIRT1082534	hsa-miR-1343	CLIP-seq
MIRT2020535	hsa-miR-1976	CLIP-seq
MIRT2020536	hsa-miR-3545-3p	CLIP-seq
MIRT2020538	hsa-miR-378g	CLIP-seq
MIRT2020540	hsa-miR-4437	CLIP-seq
MIRT2020541	hsa-miR-4635	CLIP-seq
MIRT2020542	hsa-miR-4674	CLIP-seq
MIRT2020543	hsa-miR-4680-5p	CLIP-seq
MIRT2020544	hsa-miR-4722-3p	CLIP-seq
MIRT2452300	hsa-miR-3664-5p	CLIP-seq
MIRT2452301	hsa-miR-4639-3p	CLIP-seq
MIRT2452302	hsa-miR-624	CLIP-seq

Show/Hide all (3)

GO ID	Ontology	Definition	Evidence
GO:0005576	Component	Extracellular region	IBA
GO:0005576	Component	Extracellular region	IEA
GO:0030513	Process	Positive regulation of BMP signaling pathway	IBA

MIM	HGNC	e!Ensembl
609344	17585	ENSG00000135253

Q6ZWJ8

Protein name

Kielin/chordin-like protein (Cysteine-rich BMP regulator 2) (Cysteine-rich motor neuron 2 protein) (CRIM-2) (Kielin/chordin-like protein 1) (KCP-1)

Protein function

Enhances bone morphogenetic protein (BMP) signaling in a paracrine manner. In contrast, it inhibits both the activin-A and TGFB1-mediated signaling pathways (By similarity).

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00093	VWC	138 → 192	von Willebrand factor type C domain	Family
PF00093	VWC	196 → 252	von Willebrand factor type C domain	Family
PF00093	VWC	255 → 311	von Willebrand factor type C domain	Family
PF00093	VWC	314 → 369	von Willebrand factor type C domain	Family
PF00093	VWC	428 → 484	von Willebrand factor type C domain	Family
PF00093	VWC	487 → 543	von Willebrand factor type C domain	Family
PF00093	VWC	604 → 660	von Willebrand factor type C domain	Family
PF00093	VWC	902 → 958	von Willebrand factor type C domain	Family
PF00093	VWC	1151 → 1208	von Willebrand factor type C domain	Family
PF00094	VWD	1215 → 1364	von Willebrand factor type D domain	Family

Sequence

MAGVGAAALSLLLHLGALALAAGAEGGAVPREPPGQQTTAHSSVLAGNSQEQWHPLREWL
GRLEAAVMELREQNKDLQTRVRQLESCECHPASPQCWGLGRAWPEGARWEPDACTACVCQ
DGAAHCGPQAHLPHCRGCSQNGQTYGNGETFSPDACTTCRCLTGAVQCQGPSCSELNCLE
SCTPPGECCPICRPGCDYEGQLYEEGVTFLSSSNPCLQCTCLRSRVRCMALKCPPSPCPE
PVLRPGHCCPTCQGCTEGGSHWEHGQEWTTPGDPCRICRCLEGHIQCRQRECASLCPYPA
RPLPGTCCPVCDGCFLNGREHRSGEPVGSGDPCSHCRCANGSVQCEPLPCPPVPCRHPGK
IPGQCCPVCDGCEYQGHQYQSQETFRLQERGLCVRCSCQAGEVSCEEQECPVTPCALPAS
GRQLCPACELDGEEFAEGVQWEPDGRPCTACVCQDGVPKCGAVLCPPAPCQHPTQPPGAC
CPSCDSCTYHSQVYANGQNFTDADSPCHACHCQDGTVTCSLVDCPPTTCARPQSGPGQCC
PRCPDCILEEEVFVDGESFSHPRDPCQECRCQEGHAHCQPRPCPRAPCAHPLPGTCCPND
CSGCAFGGKEYPSGADFPHPSDPCRLCRCLSGNVQCLARRCVPLPCPEPVLLPGECCPQC
PAAPAPAGCPRPGAAHARHQEYFSPPGDPCRRCLCLDGSVSCQRLPCPPAPCAHPRQGPC
CPSCDGCLYQGKEFASGERFPSPTAACHLCLCWEGSVSCEPKACAPALCPFPARGDCCPD
CDGCEYLGESYLSNQEFPDPREPCNLCTCLGGFVTCGRRPCEPPGCSHPLIPSGHCCPTC
QGCRYHGVTTASGETLPDPLDPTCSLCTCQEGSMRCQKKPCPPALCPHPSPGPCFCPVCH
SCLSQGREHQDGEEFEGPAGSCEWCRCQAGQVSCVRLQCPPLPCKLQVTERGSCCPRCRG
CLAHGEEHPEGSRWVPPDSACSSCVCHEGVVTCARIQCISSCAQPRQGPHDCCPQCSDCE
HEGRKYEPGESFQPGADPCEVCICEPQPEGPPSLRCHRRQCPSLVGCPPSQLLPPGPQHC
CPTCAEALSNCSEGLLGSELAPPDPCYTCQCQDLTWLCIHQACPELSCPLSERHTPPGSC
CPVCRAPTQSCVHQGREVASGERWTVDTCTSCSCMAGTVRCQSQRCSPLSCGPDKAPALS
PGSCCPRCLPRPASCMAFGDPHYRTFDGRLLHFQGSCSYVLAKDCHSGDFSVHVTNDDRG
RSGVAWTQEVAVLLGDMAVRLLQDGAVTVDGHPVALPFLQEPLLYVELRGHTVILHAQPG
LQVLWDGQSQVEVSVPGSYQGRTCGLCGNFNGFAQDDLQGPEGLLLPSEAAFGNSWQVSE
GLWPGRPCSAGREVDPCRAAGYRARREANARCGVLKSSPFSRCHAVVPPEPFFAACVYDL
CACGPGSSADACLCDALEAYASHCRQAGVTPTWRGPTLCVVGCPLERGFVFDECGPPCPR
TCFNQHIPLGELAAHCVRPCVPGCQCPAGLVEHEAHCIPPEACPQVLLTGDQPLGARPSP
SREPQETP

Sequence length

1568

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (8)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
AUTOIMMUNE DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GOUT	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTROPHIC CARDIOMYOPATHY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSORIASIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RHEUMATOID ARTHRITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SJOGREN SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SYSTEMIC LUPUS ERYTHEMATOSUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SYSTEMIC SCLERODERMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (3)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Anaphylaxis	Associate	12645526	★★★★★ ★☆☆☆☆ Found in Text Mining only
Kidney Diseases	Inhibit	30602563	★★★★★ ★☆☆☆☆ Found in Text Mining only
Renal Insufficiency Chronic	Inhibit	30602563	★★★★★ ★☆☆☆☆ Found in Text Mining only

KCP (kielin cysteine rich BMP regulator)