Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
375
Gene name Gene Name - the full gene name approved by the HGNC.
ARF GTPase 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ARF1
Synonyms (NCBI Gene) Gene synonyms aliases
PVNH8
Disease Acronyms (UniProt) Disease acronyms from UniProt database
PVNH8
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1q42.13
Summary Summary of gene provided in NCBI Entrez Gene.
ADP-ribosylation factor 1 (ARF1) is a member of the human ARF gene family. The family members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking as
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT049435 hsa-miR-92a-3p CLASH 23622248
MIRT047891 hsa-miR-30c-5p CLASH 23622248
MIRT047891 hsa-miR-30c-5p CLASH 23622248
MIRT046160 hsa-miR-30b-5p CLASH 23622248
MIRT043175 hsa-miR-324-5p CLASH 23622248
Transcription factors
Transcription factor Regulation Reference
ZBTB2 Repression 19380588
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane TAS
GO:0000287 Function Magnesium ion binding IEA
GO:0002090 Process Regulation of receptor internalization ISS
GO:0003723 Function RNA binding HDA 22681889
GO:0003924 Function GTPase activity TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
103180 652 ENSG00000143761
Protein
UniProt ID P84077
Protein name ADP-ribosylation factor 1 (EC 3.6.5.2)
Protein function Small GTPase involved in protein trafficking between different compartments (PubMed:8253837). Modulates vesicle budding and uncoating within the Golgi complex (PubMed:8253837). In its GTP-bound form, triggers the recruitment of coatomer proteins
PDB 1HUR , 1RE0 , 1U81 , 3O47 , 4HMY , 6CM9 , 6CRI , 6D83 , 6D84 , 6DFF , 6FAE , 7DN8 , 7DN9 , 7MGE , 7R4H , 7UX3 , 8D4C , 8D4D , 8D4E , 8D4F , 8D4G , 8D9R , 8D9S , 8D9U , 8D9W , 8SDW , 9C58 , 9C59 , 9C5A , 9C5B
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00025 Arf 3 177 ADP-ribosylation factor family Domain
Sequence
Sequence length 181
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Phospholipase D signaling pathway
Endocytosis
Vibrio cholerae infection
Pathogenic Escherichia coli infection
Shigellosis
Salmonella infection
Legionellosis
  Synthesis of PIPs at the plasma membrane
Synthesis of PIPs at the Golgi membrane
Nef Mediated CD4 Down-regulation
trans-Golgi Network Vesicle Budding
MHC class II antigen presentation
Lysosome Vesicle Biogenesis
Golgi Associated Vesicle Biogenesis
COPI-mediated anterograde transport
COPI-dependent Golgi-to-ER retrograde traffic
Intra-Golgi traffic
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Aortic aneurysm Aortic Aneurysm rs1555554098, rs267606902, rs121434526, rs121434527, rs121434528, rs387906592, rs387906781, rs387906782, rs397516685, rs397514037, rs112901682, rs397515325, rs397515330, rs794728025, rs112602953
View all (29 more)
Attention deficit hyperactivity disorder Attention deficit hyperactivity disorder rs786205019
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
27517156
Breast carcinoma Breast Carcinoma rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451
View all (71 more)
27517156
Unknown
Disease term Disease name Evidence References Source
Periventricular Nodular Heterotopia periventricular nodular heterotopia GenCC
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 32616892
Breast Neoplasms Associate 18990689, 24196838, 26176330, 29614107
Carcinoma Ovarian Epithelial Associate 32558345
Developmental Disabilities Associate 37185208
Diabetes Mellitus Associate 36790478
Epilepsy Associate 40689678
Genetic Diseases Inborn Associate 37185208
Hearing Disorders Associate 37185208
Hyperprolactinemia Associate 25754106
Hypoxia Brain Associate 22962618