Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	374986
Gene name	Mitoguardin 1
Gene symbol	MIGA1
Synonyms (NCBI Gene)	FAM73A
Chromosome	1
Chromosome location	1p31.1

Show/Hide all (51)

miRTarBase ID	miRNA	Experiments	Reference
MIRT682920	hsa-miR-508-5p	HITS-CLIP	23706177
MIRT682919	hsa-miR-6849-3p	HITS-CLIP	23706177
MIRT682918	hsa-miR-939-3p	HITS-CLIP	23706177
MIRT682917	hsa-miR-766-3p	HITS-CLIP	23706177
MIRT682916	hsa-miR-4793-3p	HITS-CLIP	23706177
MIRT682915	hsa-miR-1285-3p	HITS-CLIP	23706177
MIRT682914	hsa-miR-3187-5p	HITS-CLIP	23706177
MIRT682913	hsa-miR-5189-5p	HITS-CLIP	23706177
MIRT682912	hsa-miR-612	HITS-CLIP	23706177
MIRT682911	hsa-miR-6860	HITS-CLIP	23706177
MIRT682910	hsa-miR-8064	HITS-CLIP	23706177
MIRT682909	hsa-miR-661	HITS-CLIP	23706177
MIRT682908	hsa-miR-585-5p	HITS-CLIP	23706177
MIRT682907	hsa-miR-6512-3p	HITS-CLIP	23706177
MIRT682906	hsa-miR-6720-5p	HITS-CLIP	23706177
MIRT682905	hsa-miR-7703	HITS-CLIP	23706177
MIRT682904	hsa-miR-1273g-3p	HITS-CLIP	23706177
MIRT674716	hsa-miR-6819-3p	HITS-CLIP	23824327
MIRT674715	hsa-miR-6877-3p	HITS-CLIP	23824327
MIRT674714	hsa-miR-1247-3p	HITS-CLIP	23824327
MIRT674713	hsa-miR-4532	HITS-CLIP	23824327
MIRT674712	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT674711	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT674710	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT674709	hsa-miR-1281	HITS-CLIP	23824327
MIRT674708	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT674707	hsa-miR-1976	HITS-CLIP	23824327
MIRT674706	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT674705	hsa-miR-4279	HITS-CLIP	23824327
MIRT674704	hsa-miR-516a-5p	HITS-CLIP	23824327
MIRT674703	hsa-miR-498	HITS-CLIP	23824327
MIRT557939	hsa-miR-96-5p	PAR-CLIP	21572407
MIRT557938	hsa-miR-1271-5p	PAR-CLIP	21572407
MIRT557937	hsa-miR-182-5p	PAR-CLIP	21572407
MIRT557936	hsa-miR-5002-5p	PAR-CLIP	21572407
MIRT557935	hsa-miR-6884-3p	PAR-CLIP	21572407
MIRT557934	hsa-miR-34a-5p	PAR-CLIP	21572407
MIRT557933	hsa-miR-34c-5p	PAR-CLIP	21572407
MIRT557932	hsa-miR-449a	PAR-CLIP	21572407
MIRT557931	hsa-miR-449b-5p	PAR-CLIP	21572407
MIRT557930	hsa-miR-548au-3p	PAR-CLIP	21572407
MIRT557929	hsa-miR-374c-5p	PAR-CLIP	21572407
MIRT557928	hsa-miR-655-3p	PAR-CLIP	21572407
MIRT557927	hsa-miR-633	PAR-CLIP	21572407
MIRT557926	hsa-miR-7150	PAR-CLIP	21572407
MIRT727701	hsa-miR-15a-5p	HITS-CLIP	22473208
MIRT727700	hsa-miR-15b-5p	HITS-CLIP	22473208
MIRT727699	hsa-miR-16-5p	HITS-CLIP	22473208
MIRT727698	hsa-miR-195-5p	HITS-CLIP	22473208
MIRT727697	hsa-miR-19a-3p	HITS-CLIP	22473208
MIRT727696	hsa-miR-19b-3p	HITS-CLIP	22473208

Show/Hide all (12)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	26711011
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IDA
GO:0005739	Component	Mitochondrion	IEA
GO:0005741	Component	Mitochondrial outer membrane	IEA
GO:0005886	Component	Plasma membrane	IDA	26711011
GO:0008053	Process	Mitochondrial fusion	IBA
GO:0008053	Process	Mitochondrial fusion	IDA	26711011
GO:0008053	Process	Mitochondrial fusion	IEA
GO:0016020	Component	Membrane	IEA
GO:0042803	Function	Protein homodimerization activity	IDA	26711011
GO:0046982	Function	Protein heterodimerization activity	IDA	26711011

MIM	HGNC	e!Ensembl
616773	24741	ENSG00000180488

Q8NAN2

Protein name

Mitoguardin 1 (Protein FAM73A)

Protein function

Regulator of mitochondrial fusion: acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers. May act by regulating phospholipid metabolism via PLD6/MitoPLD. {ECO:0000269|Pub

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF10265	Miga	59 → 603	Mitoguardin	Family

Sequence

MSDCCSAPGISWEAGVGRPAVPGLELQIRRGAMSEETVSESQFSLKTAALRVFDLPLTWY
YSLSQIKFSPVAKKLFVVTAVSAISVIFLAHHFKRKRGKKKGKILPWEPEHLILEYTKRA
ASDKGSSCSSSRQNLTLSLSSTKDKGSQVCNYANGGLFSKYSGSAQSLASVQSVNSCHSC
ACGNSNSWDKADEDDIKLVNIPVTTPENLYLMGMELFEEALRRWEQALTFRNRQAEDEAC
GSIKLGAGDAIAEENVDDIISTEFIHKLEALLQRAYRLQEEFEATLGASDPNSLADDIDK
DTDITMKGNVEDFGLRDTLSIASTDSFASAAELAEHREVRHTYSLESLCHCPFYEEAMHL
VEEGKIYSRVLRTEMLECLGDSDFLAKLHCIRQAFQVILSESANRIFLAESGRKILSALI
VKARKNPKKFEDVFDEMIYFLEQTDHWGSTEMELAARGVKNLNFYDVVLDFILMDSFEDL
ENPPTSIQNVVNNRWLNSSFKETAVASSCWSVLKQKRQQMKIPDGFFAHFYAICEHISPV
LAWGFLGPRNSLYDLCCFFKNQVLLFLKDIFDFEKVRYSSTETLAEDLMQLLIRRTELLM
AYLEADALRHTSSCLSSHGHVMSTGLLEAKVQ

Sequence length

632

Interactions

View interactions

	Reactome
			Synthesis of PA

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (6)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CHRONIC OBSTRUCTIVE PULMONARY DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG ADENOCARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RHEUMATOID ARTHRITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SQUAMOUS CELL CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

MIGA1 (mitoguardin 1)