MIGA1 (mitoguardin 1)

Gene

• Entrez ID: 374986
• Gene name: Mitoguardin 1
• Gene symbol: MIGA1
• Synonyms (NCBI Gene): FAM73A
• Chromosome: 1
• Chromosome location: 1p31.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT682920	hsa-miR-508-5p	HITS-CLIP	23706177
MIRT682919	hsa-miR-6849-3p	HITS-CLIP	23706177
MIRT682918	hsa-miR-939-3p	HITS-CLIP	23706177
MIRT682917	hsa-miR-766-3p	HITS-CLIP	23706177
MIRT682916	hsa-miR-4793-3p	HITS-CLIP	23706177
MIRT682915	hsa-miR-1285-3p	HITS-CLIP	23706177
MIRT682914	hsa-miR-3187-5p	HITS-CLIP	23706177
MIRT682913	hsa-miR-5189-5p	HITS-CLIP	23706177
MIRT682912	hsa-miR-612	HITS-CLIP	23706177
MIRT682911	hsa-miR-6860	HITS-CLIP	23706177
MIRT682910	hsa-miR-8064	HITS-CLIP	23706177
MIRT682909	hsa-miR-661	HITS-CLIP	23706177
MIRT682908	hsa-miR-585-5p	HITS-CLIP	23706177
MIRT682907	hsa-miR-6512-3p	HITS-CLIP	23706177
MIRT682906	hsa-miR-6720-5p	HITS-CLIP	23706177
MIRT682905	hsa-miR-7703	HITS-CLIP	23706177
MIRT682904	hsa-miR-1273g-3p	HITS-CLIP	23706177
MIRT674716	hsa-miR-6819-3p	HITS-CLIP	23824327
MIRT674715	hsa-miR-6877-3p	HITS-CLIP	23824327
MIRT674714	hsa-miR-1247-3p	HITS-CLIP	23824327
MIRT674713	hsa-miR-4532	HITS-CLIP	23824327
MIRT674712	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT674711	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT674710	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT674709	hsa-miR-1281	HITS-CLIP	23824327
MIRT674708	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT674707	hsa-miR-1976	HITS-CLIP	23824327
MIRT674706	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT674705	hsa-miR-4279	HITS-CLIP	23824327
MIRT674704	hsa-miR-516a-5p	HITS-CLIP	23824327
MIRT674703	hsa-miR-498	HITS-CLIP	23824327
MIRT557939	hsa-miR-96-5p	PAR-CLIP	21572407
MIRT557938	hsa-miR-1271-5p	PAR-CLIP	21572407
MIRT557937	hsa-miR-182-5p	PAR-CLIP	21572407
MIRT557936	hsa-miR-5002-5p	PAR-CLIP	21572407
MIRT557935	hsa-miR-6884-3p	PAR-CLIP	21572407
MIRT557934	hsa-miR-34a-5p	PAR-CLIP	21572407
MIRT557933	hsa-miR-34c-5p	PAR-CLIP	21572407
MIRT557932	hsa-miR-449a	PAR-CLIP	21572407
MIRT557931	hsa-miR-449b-5p	PAR-CLIP	21572407
MIRT557930	hsa-miR-548au-3p	PAR-CLIP	21572407
MIRT557929	hsa-miR-374c-5p	PAR-CLIP	21572407
MIRT557928	hsa-miR-655-3p	PAR-CLIP	21572407
MIRT557927	hsa-miR-633	PAR-CLIP	21572407
MIRT557926	hsa-miR-7150	PAR-CLIP	21572407
MIRT727701	hsa-miR-15a-5p	HITS-CLIP	22473208
MIRT727700	hsa-miR-15b-5p	HITS-CLIP	22473208
MIRT727699	hsa-miR-16-5p	HITS-CLIP	22473208
MIRT727698	hsa-miR-195-5p	HITS-CLIP	22473208
MIRT727697	hsa-miR-19a-3p	HITS-CLIP	22473208
MIRT727696	hsa-miR-19b-3p	HITS-CLIP	22473208

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	26711011
GO:0005739	Component	Mitochondrion	IDA
GO:0005741	Component	Mitochondrial outer membrane	IEA
GO:0005887	Component	Integral component of plasma membrane	IDA	26711011
GO:0008053	Process	Mitochondrial fusion	IBA	21873635
GO:0008053	Process	Mitochondrial fusion	IDA	26711011
GO:0042803	Function	Protein homodimerization activity	IDA	26711011
GO:0046982	Function	Protein heterodimerization activity	IDA	26711011

Other IDs

• MIM: 616773
• HGNC: 24741
• e!Ensembl: ENSG00000180488

Protein

• UniProt ID: Q8NAN2
• Protein name: Mitoguardin 1 (Protein FAM73A)
• Protein function: Regulator of mitochondrial fusion: acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers. May act by regulating phospholipid metabolism via PLD6/MitoPLD. {ECO:0000269|Pub
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF10265	Miga	59 → 603	Mitoguardin	Family

• Sequence:

  MSDCCSAPGISWEAGVGRPAVPGLELQIRRGAMSEETVSESQFSLKTAALRVFDLPLTWY
  YSLSQIKFSPVAKKLFVVTAVSAISVIFLAHHFKRKRGKKKGKILPWEPEHLILEYTKRA
  ASDKGSSCSSSRQNLTLSLSSTKDKGSQVCNYANGGLFSKYSGSAQSLASVQSVNSCHSC
  ACGNSNSWDKADEDDIKLVNIPVTTPENLYLMGMELFEEALRRWEQALTFRNRQAEDEAC
  GSIKLGAGDAIAEENVDDIISTEFIHKLEALLQRAYRLQEEFEATLGASDPNSLADDIDK
  DTDITMKGNVEDFGLRDTLSIASTDSFASAAELAEHREVRHTYSLESLCHCPFYEEAMHL
  VEEGKIYSRVLRTEMLECLGDSDFLAKLHCIRQAFQVILSESANRIFLAESGRKILSALI
  VKARKNPKKFEDVFDEMIYFLEQTDHWGSTEMELAARGVKNLNFYDVVLDFILMDSFEDL
  ENPPTSIQNVVNNRWLNSSFKETAVASSCWSVLKQKRQQMKIPDGFFAHFYAICEHISPV
  LAWGFLGPRNSLYDLCCFFKNQVLLFLKDIFDFEKVRYSSTETLAEDLMQLLIRRTELLM
  AYLEADALRHTSSCLSSHGHVMSTGLLEAKVQ

• Sequence length: 632

Pathways

Reactome:

Synthesis of PA

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Lung adenocarcinoma	Adenocarcinoma of lung (disorder)	rs28934576, rs121913530, rs397516975, rs587776805, rs121913469, rs121913364, rs121913351, rs121913366, rs397516896, rs397516977, rs397516981, rs397517127, rs121913344, rs727504233, rs121913370, rs760043106, rs1057519788, rs1131692238, rs1131692237, rs1554350382	28604730