KCNC4 (potassium voltage-gated channel subfamily C member 4)

Gene

• Entrez ID: 3749
• Gene name: Potassium voltage-gated channel subfamily C member 4
• Gene symbol: KCNC4
• Synonyms (NCBI Gene): C1orf30, HKSHIIIC, KSHIIIC, KV3.4
• Chromosome: 1
• Chromosome location: 1p13.3
• Summary: The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to the Shaw subfamily. The protein encoded by this gene belongs to the del

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT022478	hsa-miR-124-3p	Microarray	18668037
MIRT027123	hsa-miR-103a-3p	Sequencing	20371350
MIRT031651	hsa-miR-16-5p	Sequencing	20371350
MIRT052053	hsa-let-7b-5p	CLASH	23622248
MIRT031651	hsa-miR-16-5p	CLASH	23622248
MIRT264524	hsa-miR-4517	PAR-CLIP	20371350
MIRT264525	hsa-miR-5583-3p	PAR-CLIP	20371350
MIRT567035	hsa-miR-4731-3p	PAR-CLIP	20371350
MIRT567034	hsa-miR-4801	PAR-CLIP	20371350
MIRT567033	hsa-miR-8485	PAR-CLIP	20371350
MIRT567032	hsa-miR-329-3p	PAR-CLIP	20371350
MIRT567031	hsa-miR-362-3p	PAR-CLIP	20371350
MIRT567030	hsa-miR-603	PAR-CLIP	20371350
MIRT567029	hsa-miR-625-3p	PAR-CLIP	20371350
MIRT264519	hsa-miR-369-3p	PAR-CLIP	20371350
MIRT264528	hsa-miR-5692b	PAR-CLIP	20371350
MIRT264527	hsa-miR-5692c	PAR-CLIP	20371350
MIRT567028	hsa-miR-3941	PAR-CLIP	20371350
MIRT264520	hsa-miR-374a-5p	PAR-CLIP	20371350
MIRT264522	hsa-miR-374b-5p	PAR-CLIP	20371350
MIRT264523	hsa-miR-3924	PAR-CLIP	20371350
MIRT264524	hsa-miR-4517	PAR-CLIP	20371350
MIRT264525	hsa-miR-5583-3p	PAR-CLIP	20371350
MIRT567035	hsa-miR-4731-3p	PAR-CLIP	20371350
MIRT567034	hsa-miR-4801	PAR-CLIP	20371350
MIRT567033	hsa-miR-8485	PAR-CLIP	20371350
MIRT567032	hsa-miR-329-3p	PAR-CLIP	20371350
MIRT567031	hsa-miR-362-3p	PAR-CLIP	20371350
MIRT567030	hsa-miR-603	PAR-CLIP	20371350
MIRT567029	hsa-miR-625-3p	PAR-CLIP	20371350
MIRT264519	hsa-miR-369-3p	PAR-CLIP	20371350
MIRT264528	hsa-miR-5692b	PAR-CLIP	20371350
MIRT264527	hsa-miR-5692c	PAR-CLIP	20371350
MIRT567028	hsa-miR-3941	PAR-CLIP	20371350
MIRT264520	hsa-miR-374a-5p	PAR-CLIP	20371350
MIRT264522	hsa-miR-374b-5p	PAR-CLIP	20371350
MIRT264523	hsa-miR-3924	PAR-CLIP	20371350
MIRT1080619	hsa-let-7a	CLIP-seq
MIRT1080620	hsa-let-7b	CLIP-seq
MIRT1080621	hsa-let-7c	CLIP-seq
MIRT1080622	hsa-let-7d	CLIP-seq
MIRT1080623	hsa-let-7e	CLIP-seq
MIRT1080624	hsa-let-7f	CLIP-seq
MIRT1080625	hsa-let-7g	CLIP-seq
MIRT1080626	hsa-let-7i	CLIP-seq
MIRT1080627	hsa-miR-224	CLIP-seq
MIRT1080628	hsa-miR-3151	CLIP-seq
MIRT1080629	hsa-miR-3180-5p	CLIP-seq
MIRT1080630	hsa-miR-3191	CLIP-seq
MIRT1080631	hsa-miR-342-5p	CLIP-seq
MIRT1080632	hsa-miR-3689a-3p	CLIP-seq
MIRT1080633	hsa-miR-3689c	CLIP-seq
MIRT1080634	hsa-miR-376c	CLIP-seq
MIRT1080635	hsa-miR-3927	CLIP-seq
MIRT1080636	hsa-miR-4276	CLIP-seq
MIRT1080637	hsa-miR-4446-5p	CLIP-seq
MIRT1080638	hsa-miR-4447	CLIP-seq
MIRT1080639	hsa-miR-4458	CLIP-seq
MIRT1080640	hsa-miR-4472	CLIP-seq
MIRT1080641	hsa-miR-4500	CLIP-seq
MIRT1080642	hsa-miR-4650-3p	CLIP-seq
MIRT1080643	hsa-miR-4651	CLIP-seq
MIRT1080644	hsa-miR-4664-5p	CLIP-seq
MIRT1080645	hsa-miR-4681	CLIP-seq
MIRT1080646	hsa-miR-4728-5p	CLIP-seq
MIRT1080647	hsa-miR-4755-5p	CLIP-seq
MIRT1080648	hsa-miR-491-5p	CLIP-seq
MIRT1080649	hsa-miR-520a-5p	CLIP-seq
MIRT1080650	hsa-miR-525-5p	CLIP-seq
MIRT1080651	hsa-miR-608	CLIP-seq
MIRT1080652	hsa-miR-98	CLIP-seq
MIRT1080653	hsa-miR-1200	CLIP-seq
MIRT1080654	hsa-miR-1285	CLIP-seq
MIRT1080655	hsa-miR-1827	CLIP-seq
MIRT1080656	hsa-miR-2110	CLIP-seq
MIRT1080657	hsa-miR-2682	CLIP-seq
MIRT1080658	hsa-miR-3153	CLIP-seq
MIRT1080659	hsa-miR-3187-5p	CLIP-seq
MIRT1080660	hsa-miR-3189-5p	CLIP-seq
MIRT1080661	hsa-miR-34a	CLIP-seq
MIRT1080662	hsa-miR-34c-5p	CLIP-seq
MIRT1080663	hsa-miR-3612	CLIP-seq
MIRT1080664	hsa-miR-3918	CLIP-seq
MIRT1080665	hsa-miR-3945	CLIP-seq
MIRT1080666	hsa-miR-4253	CLIP-seq
MIRT1080667	hsa-miR-4271	CLIP-seq
MIRT1080668	hsa-miR-4443	CLIP-seq
MIRT1080669	hsa-miR-449a	CLIP-seq
MIRT1080670	hsa-miR-449b	CLIP-seq
MIRT1080671	hsa-miR-449c	CLIP-seq
MIRT1080672	hsa-miR-4725-3p	CLIP-seq
MIRT1080673	hsa-miR-4758-3p	CLIP-seq
MIRT1080648	hsa-miR-491-5p	CLIP-seq
MIRT1080674	hsa-miR-612	CLIP-seq
MIRT1080675	hsa-miR-650	CLIP-seq
MIRT1080676	hsa-miR-661	CLIP-seq
MIRT2020001	hsa-miR-125a-3p	CLIP-seq
MIRT2020002	hsa-miR-3934	CLIP-seq
MIRT2020003	hsa-miR-4299	CLIP-seq
MIRT2020004	hsa-miR-4456	CLIP-seq
MIRT2020005	hsa-miR-510	CLIP-seq
MIRT2020006	hsa-miR-548q	CLIP-seq
MIRT2020007	hsa-miR-764	CLIP-seq
MIRT1080628	hsa-miR-3151	CLIP-seq
MIRT2251869	hsa-miR-486-3p	CLIP-seq
MIRT2389623	hsa-miR-1321	CLIP-seq
MIRT2389624	hsa-miR-4739	CLIP-seq
MIRT2389625	hsa-miR-4756-5p	CLIP-seq
MIRT2452170	hsa-miR-4291	CLIP-seq
MIRT2452171	hsa-miR-545	CLIP-seq
MIRT2452172	hsa-miR-548p	CLIP-seq
MIRT2555111	hsa-miR-101	CLIP-seq
MIRT2389623	hsa-miR-1321	CLIP-seq
MIRT2555112	hsa-miR-144	CLIP-seq
MIRT2555113	hsa-miR-204	CLIP-seq
MIRT2555114	hsa-miR-211	CLIP-seq
MIRT2555115	hsa-miR-2467-3p	CLIP-seq
MIRT2555116	hsa-miR-25	CLIP-seq
MIRT2555117	hsa-miR-3184	CLIP-seq
MIRT2555118	hsa-miR-32	CLIP-seq
MIRT2555119	hsa-miR-3591-3p	CLIP-seq
MIRT2555120	hsa-miR-363	CLIP-seq
MIRT2555121	hsa-miR-3663-5p	CLIP-seq
MIRT2555122	hsa-miR-367	CLIP-seq
MIRT2555123	hsa-miR-3917	CLIP-seq
MIRT2555124	hsa-miR-3929	CLIP-seq
MIRT2555125	hsa-miR-423-5p	CLIP-seq
MIRT2555126	hsa-miR-4270	CLIP-seq
MIRT2555127	hsa-miR-4279	CLIP-seq
MIRT2555128	hsa-miR-4419a	CLIP-seq
MIRT2555129	hsa-miR-4419b	CLIP-seq
MIRT2555130	hsa-miR-4441	CLIP-seq
MIRT2555131	hsa-miR-4478	CLIP-seq
MIRT2555132	hsa-miR-4510	CLIP-seq
MIRT2555133	hsa-miR-4688	CLIP-seq
MIRT1080646	hsa-miR-4728-5p	CLIP-seq
MIRT2555134	hsa-miR-4733-3p	CLIP-seq
MIRT2389624	hsa-miR-4739	CLIP-seq
MIRT1080647	hsa-miR-4755-5p	CLIP-seq
MIRT2389625	hsa-miR-4756-5p	CLIP-seq
MIRT2251869	hsa-miR-486-3p	CLIP-seq
MIRT2555135	hsa-miR-582-3p	CLIP-seq
MIRT2555136	hsa-miR-623	CLIP-seq
MIRT2555137	hsa-miR-765	CLIP-seq
MIRT2555138	hsa-miR-891b	CLIP-seq
MIRT2555139	hsa-miR-92a	CLIP-seq
MIRT2555140	hsa-miR-92b	CLIP-seq
MIRT2555111	hsa-miR-101	CLIP-seq
MIRT2389623	hsa-miR-1321	CLIP-seq
MIRT2555112	hsa-miR-144	CLIP-seq
MIRT2555115	hsa-miR-2467-3p	CLIP-seq
MIRT2555116	hsa-miR-25	CLIP-seq
MIRT2555117	hsa-miR-3184	CLIP-seq
MIRT2555118	hsa-miR-32	CLIP-seq
MIRT2555120	hsa-miR-363	CLIP-seq
MIRT2555121	hsa-miR-3663-5p	CLIP-seq
MIRT2555122	hsa-miR-367	CLIP-seq
MIRT2555124	hsa-miR-3929	CLIP-seq
MIRT2555125	hsa-miR-423-5p	CLIP-seq
MIRT2555127	hsa-miR-4279	CLIP-seq
MIRT2555129	hsa-miR-4419b	CLIP-seq
MIRT2555131	hsa-miR-4478	CLIP-seq
MIRT2555133	hsa-miR-4688	CLIP-seq
MIRT1080646	hsa-miR-4728-5p	CLIP-seq
MIRT2389624	hsa-miR-4739	CLIP-seq
MIRT2389625	hsa-miR-4756-5p	CLIP-seq
MIRT2251869	hsa-miR-486-3p	CLIP-seq
MIRT2555135	hsa-miR-582-3p	CLIP-seq
MIRT2555138	hsa-miR-891b	CLIP-seq
MIRT2555139	hsa-miR-92a	CLIP-seq
MIRT2555140	hsa-miR-92b	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001508	Process	Action potential	IBA
GO:0005216	Function	Monoatomic ion channel activity	IEA
GO:0005249	Function	Voltage-gated potassium channel activity	IDA	7993631, 9649584
GO:0005249	Function	Voltage-gated potassium channel activity	IEA
GO:0005249	Function	Voltage-gated potassium channel activity	TAS	1920536
GO:0005251	Function	Delayed rectifier potassium channel activity	IBA
GO:0005267	Function	Potassium channel activity	IEA
GO:0005267	Function	Potassium channel activity	TAS	1740329
GO:0005515	Function	Protein binding	IPI	29507146
GO:0005886	Component	Plasma membrane	TAS
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006813	Process	Potassium ion transport	IEA
GO:0006813	Process	Potassium ion transport	TAS	1920536
GO:0007268	Process	Chemical synaptic transmission	TAS
GO:0008076	Component	Voltage-gated potassium channel complex	IBA
GO:0008076	Component	Voltage-gated potassium channel complex	IEA
GO:0008076	Component	Voltage-gated potassium channel complex	TAS	1920536
GO:0016020	Component	Membrane	IEA
GO:0022836	Function	Gated channel activity	IEA
GO:0032590	Component	Dendrite membrane	IBA
GO:0032809	Component	Neuronal cell body membrane	IBA
GO:0034220	Process	Monoatomic ion transmembrane transport	IEA
GO:0034702	Component	Monoatomic ion channel complex	IEA
GO:0042734	Component	Presynaptic membrane	IBA
GO:0043679	Component	Axon terminus	IBA
GO:0045211	Component	Postsynaptic membrane	IBA
GO:0046872	Function	Metal ion binding	IEA
GO:0051260	Process	Protein homooligomerization	IEA
GO:0055085	Process	Transmembrane transport	IEA
GO:0071805	Process	Potassium ion transmembrane transport	IBA
GO:0071805	Process	Potassium ion transmembrane transport	IEA

Other IDs

• MIM: 176265
• HGNC: 6236
• e!Ensembl: ENSG00000116396

Protein

• UniProt ID: Q03721
• Protein name: Voltage-gated potassium channel KCNC4 (KSHIIIC) (Potassium voltage-gated channel subfamily C member 4) (Voltage-gated potassium channel subunit Kv3.4)
• Protein function: Voltage-gated potassium channel that opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient (PubMed:7993631). The
• PDB: 1B4G, 1B4I, 1ZTN
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF11404	Potassium_chann	1 → 29	Potassium voltage-gated channel	Family
  PF02214	BTB_2	38 → 143	BTB/POZ domain	Domain
  PF00520	Ion_trans	225 → 483	Ion transport protein	Family

• Sequence:

  MISSVCVSSYRGRKSGNKPPSKTCLKEEMAKGEASEKIIINVGGTRHETYRSTLRTLPGT
  RLAWLADPDGGGRPETDGGGVGSSGSSGGGGCEFFFDRHPGVFAYVLNYYRTGKLHCPAD
  VCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEEALDIFESPDGGGSGAGPSDEAGDD
  ERELALQRLGPHEGGAGHGAGSGGCRGWQPRMWALFEDPYSSRAARVVAFASLFFILVSI
  TTFCLETHEAFNIDRNVTEILRVGNITSVHFRREVETEPILTYIEGVCVLWFTLEFLVRI
  VCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLSSKAARDVLGFLRVVRFVRILRIFKL
  TRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGARPSDPRGNDHTDF
  KNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYS
  LAMAKQKLPKKRKKHVPRPAQLESPMYCKSEETSPRDSTCSDTSPPAREEGMIERKRADS
  KQNGDANAVLSDEEGAGLTQPLASSPTPEERRALRRSTTRDRNKKAAACFLLSTGDYACA
  DGSVRKGTFVLRDLPLQHSPEAACPPTAGTLFLPH

• Sequence length: 635

Pathways

Reactome:

Voltage gated Potassium channels