ASPG (asparaginase)

Gene

• Entrez ID: 374569
• Gene name: Asparaginase
• Gene symbol: ASPG
• Synonyms (NCBI Gene): C14orf76, GPA/WT, LYSOLP, hASNase1
• Chromosome: 14
• Chromosome location: 14q32.33

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018153	hsa-miR-335-5p	Microarray	18185580

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003847	Function	1-alkyl-2-acetylglycerophosphocholine esterase activity	IEA
GO:0004067	Function	Asparaginase activity	IBA
GO:0004067	Function	Asparaginase activity	IEA
GO:0004067	Function	Asparaginase activity	TAS
GO:0004622	Function	Phosphatidylcholine lysophospholipase activity	IEA
GO:0004622	Function	Phosphatidylcholine lysophospholipase activity	ISS
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005829	Component	Cytosol	TAS
GO:0006520	Process	Amino acid metabolic process	IEA
GO:0006629	Process	Lipid metabolic process	IEA
GO:0009066	Process	Aspartate family amino acid metabolic process	IEA
GO:0009066	Process	Aspartate family amino acid metabolic process	TAS
GO:0016042	Process	Lipid catabolic process	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016746	Function	Acyltransferase activity	IEA
GO:0016747	Function	Acyltransferase activity, transferring groups other than amino-acyl groups	ISS
GO:0016787	Function	Hydrolase activity	IEA

Other IDs

• MIM: 618472
• HGNC: 20123
• e!Ensembl: ENSG00000166183

Protein

• UniProt ID: Q86U10
• Protein name: 60 kDa lysophospholipase (LysoLP) (EC 3.1.1.5) (Lysophospholipase-transacylase) [Includes: L-asparaginase (EC 3.5.1.1) (L-asparagine amidohydrolase); 1-alkyl-2-acetylglycerophosphocholine esterase (EC 3.1.1.47) (Platelet-activating factor acetylhydrolase)
• Protein function: Exhibits lysophospholipase, transacylase, PAF acetylhydrolase and asparaginase activities (By similarity). Can catalyze three types of transacylation reactions: (1) acyl transfer from 1-acyl-sn-glycero-3-phosphocholine (1-acyl-GPC) to the sn-1(3
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00710	Asparaginase	10 → 220	Asparaginase, N-terminal	Domain
  PF17763	Asparaginase_C	237 → 352	Glutaminase/Asparaginase C-terminal domain	Domain
  PF12796	Ank_2	404 → 497	Ankyrin repeats (3 copies)	Repeat

• Sequence:

  MARAVGPERRLLAVYTGGTIGMRSELGVLVPGTGLAAILRTLPMFHDEEHARARGLSEDT
  LVLPPASRNQRILYTVLECQPLFDSSDMTIAEWVCLAQTIKRHYEQYHGFVVIHGTDTMA
  FAASMLSFMLENLQKTVILTGAQVPIHALWSDGRENLLGALLMAGQYVIPEVCLFFQNQL
  FRGNRATKVDARRFAAFCSPNLLPLATVGADITINRELVRKVDGKAGLVVHSSMEQDVGL
  LRLYPGIPAALVRAFLQPPLKGVVMETFGSGNGPTKPDLLQELRVATERGLVIVNCTHCL
  QGAVTTDYAAGMAMAGAGVISGFDMTSEAALAKLSYVLGQPGLSLDVRKELLTKDLRGEM
  TPPSVEERRPSLQGNTLGGGVSWLLSLSGSQEADALRNALVPSLACAAAHAGDVEALQAL
  VELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHP
  GVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADLGQPGYDGHSALHV
  AEAAGNLAVVAFLQSLEGAVGAQAPCPEVLPGV

• Sequence length: 573

Pathways

Reactome:

Aspartate and asparagine metabolism