ASPG (asparaginase)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
374569
Gene name Gene Name - the full gene name approved by the HGNC.
Asparaginase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ASPG
Synonyms (NCBI Gene) Gene synonyms aliases
C14orf76, GPA/WT, LYSOLP, hASNase1
Chromosome Chromosome number
14
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
14q32.33
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(1)
miRTarBase ID miRNA Experiments Reference
MIRT018153 hsa-miR-335-5p Microarray 18185580
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(10)
GO ID Ontology Definition Evidence Reference
GO:0003847 Function 1-alkyl-2-acetylglycerophosphocholine esterase activity IEA
GO:0004067 Function Asparaginase activity IBA 21873635
GO:0004067 Function Asparaginase activity TAS
GO:0004622 Function Lysophospholipase activity ISS
GO:0005515 Function Protein binding IPI 32296183
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
618472 20123 ENSG00000166183
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q86U10
Protein name 60 kDa lysophospholipase (LysoLP) (EC 3.1.1.5) (Lysophospholipase-transacylase) [Includes: L-asparaginase (EC 3.5.1.1) (L-asparagine amidohydrolase); 1-alkyl-2-acetylglycerophosphocholine esterase (EC 3.1.1.47) (Platelet-activating factor acetylhydrolase)
Protein function Exhibits lysophospholipase, transacylase, PAF acetylhydrolase and asparaginase activities (By similarity). Can catalyze three types of transacylation reactions: (1) acyl transfer from 1-acyl-sn-glycero-3-phosphocholine (1-acyl-GPC) to the sn-1(3
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00710 Asparaginase 10 → 220 Asparaginase, N-terminal Domain
PF17763 Asparaginase_C 237 → 352 Glutaminase/Asparaginase C-terminal domain Domain
PF12796 Ank_2 404 → 497 Ankyrin repeats (3 copies) Repeat
Sequence
Sequence length 573
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Aspartate and asparagine metabolism
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (3)
Causal
Disease term Disease name dbSNP ID References
Anemia Anemia rs118204044, rs118204045, rs118204046, rs121918330, rs869320719, rs869312029, rs121918332, rs869320724, rs767094129, rs786205058, rs786205059, rs137853119, rs137853120, rs137853121, rs1384933966
View all (89 more)		 2187653
Cholelithiasis Cholelithiasis rs121918440, rs72552778, rs387906528, rs759202962, rs377160065, rs1051861187, rs757693457, rs752563752 12902918
Kidney disease Chronic Kidney Diseases rs74315342, rs749740335, rs757649673, rs112417755, rs35138315 29545352
Show/Hide Unknown Diseases (1)
Unknown
Disease term Disease name Evidence References Source
Schizophrenia Schizophrenia GWAS
Show/Hide Text Mining Associations (22)
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 31391525
Burkitt Lymphoma Inhibit 30578463
Colonic Neoplasms Associate 35712285
Drug Hypersensitivity Associate 24907114
Drug Hypersensitivity Stimulate 24970932, 27019981, 30450575, 33217039, 33278328, 34310867, 34717720
Drug Related Side Effects and Adverse Reactions Stimulate 24907114, 31943292, 35658244
Drug Related Side Effects and Adverse Reactions Associate 31391525
Head and Neck Neoplasms Inhibit 31943292
Leukemia Inhibit 24970932, 28542249
Leukemia Biphenotypic Acute Inhibit 37839090