KCNA10 (potassium voltage-gated channel subfamily A member 10)

Gene
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3744
Gene name Gene Name - the full gene name approved by the HGNC.
Potassium voltage-gated channel subfamily A member 10
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
KCNA10
Synonyms (NCBI Gene) Gene synonyms aliases
Kcn1, Kv1.8
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p13.3
Summary Summary of gene provided in NCBI Entrez Gene.
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, e
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(24)
GO ID Ontology Definition Evidence Reference
GO:0001508 Process Action potential IBA
GO:0005216 Function Monoatomic ion channel activity IEA
GO:0005221 Function Intracellularly cyclic nucleotide-activated monoatomic cation channel activity TAS 9177773
GO:0005249 Function Voltage-gated potassium channel activity IDA 10836990
GO:0005249 Function Voltage-gated potassium channel activity IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
602420 6219 ENSG00000143105
Protein
Gene Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q16322
Protein name Potassium voltage-gated channel subfamily A member 10 (Voltage-gated potassium channel subunit Kv1.8)
Protein function Voltage-gated potassium ion channel that mediates K(+) permeability of excitable membranes. When opened in response to the voltage difference across the membrane, KCNA10 channel selectively allows the flow of potassium ions across the membrane d
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02214 BTB_2 88 → 179 BTB/POZ domain Domain
PF00520 Ion_trans 215 → 468 Ion transport protein Family
Tissue specificity TISSUE SPECIFICITY: Detected in kidney, in proximal tubules, glomerular endothelium, in vascular endothelium and in smooth muscle cells. {ECO:0000269|PubMed:12444201}.
Sequence
Sequence length 511
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Voltage gated Potassium channels
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (1)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Metabolic Syndrome Bitter taste perception (phenylthiocarbamide) in obesity with metabolic syndrome N/A N/A GWAS
Show/Hide Text Mining Associations (1)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Squamous Cell Carcinoma of Head and Neck Associate 34051764