Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	374
Gene name Gene Name - the full gene name approved by the HGNC.	Amphiregulin
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	AREG
Synonyms (NCBI Gene) Gene synonyms aliases	AR, AREGB, CRDGF, SDGF
Chromosome Chromosome number	4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	4q13.3
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth

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miRTarBase ID	miRNA	Experiments	Reference
MIRT018541	hsa-miR-335-5p	Microarray	18185580
MIRT437742	hsa-miR-34a-5p	Microarray, qRT-PCR	22815788
MIRT437873	hsa-miR-200a-3p	ELISA, Immunohistochemistry, Immunoprecipitaion, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	24762440
MIRT437873	hsa-miR-200a-3p	ELISA, Immunohistochemistry, Immunoprecipitaion, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	24762440
MIRT2435438	hsa-miR-135a	CLIP-seq
MIRT2435439	hsa-miR-135b	CLIP-seq
MIRT2435440	hsa-miR-34a	CLIP-seq
MIRT2435441	hsa-miR-34c-5p	CLIP-seq
MIRT2435442	hsa-miR-449a	CLIP-seq
MIRT2435443	hsa-miR-449b	CLIP-seq
MIRT2435444	hsa-miR-4729	CLIP-seq

Transcription factors

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Transcription factor	Regulation	Reference
BRCA1	Repression	20103632
NFIL3	Unknown	1620116
SP1	Unknown	14742435

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005125	Function	Cytokine activity	IEA
GO:0005154	Function	Epidermal growth factor receptor binding	IBA
GO:0005154	Function	Epidermal growth factor receptor binding	IEA
GO:0005515	Function	Protein binding	IPI	19740107, 30083275, 32296183
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IDA	8702723
GO:0005615	Component	Extracellular space	IDA	12743035, 22184114
GO:0005615	Component	Extracellular space	IEA
GO:0005615	Component	Extracellular space	IEA
GO:0005615	Component	Extracellular space	TAS	3413110
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0007173	Process	Epidermal growth factor receptor signaling pathway	IBA
GO:0007173	Process	Epidermal growth factor receptor signaling pathway	IDA	12743035
GO:0007173	Process	Epidermal growth factor receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IDA	12743035
GO:0007267	Process	Cell-cell signaling	TAS	2466334
GO:0008083	Function	Growth factor activity	IBA
GO:0008083	Function	Growth factor activity	IEA
GO:0008083	Function	Growth factor activity	TAS	2466334
GO:0008284	Process	Positive regulation of cell population proliferation	IBA
GO:0008284	Process	Positive regulation of cell population proliferation	IEA
GO:0008284	Process	Positive regulation of cell population proliferation	IEA
GO:0008284	Process	Positive regulation of cell population proliferation	IMP	12743035
GO:0009986	Component	Cell surface	IDA	12743035
GO:0010838	Process	Positive regulation of keratinocyte proliferation	TAS	2466334
GO:0012507	Component	ER to Golgi transport vesicle membrane	TAS
GO:0014009	Process	Glial cell proliferation	IEA
GO:0016020	Component	Membrane	IEA
GO:0030297	Function	Transmembrane receptor protein tyrosine kinase activator activity	IDA	8702723
GO:0030297	Function	Transmembrane receptor protein tyrosine kinase activator activity	IEA
GO:0030669	Component	Clathrin-coated endocytic vesicle membrane	IEA
GO:0030669	Component	Clathrin-coated endocytic vesicle membrane	TAS
GO:0031175	Process	Neuron projection development	IEA
GO:0032355	Process	Response to estradiol	IEA
GO:0033116	Component	Endoplasmic reticulum-Golgi intermediate compartment membrane	TAS
GO:0038134	Process	ERBB2-EGFR signaling pathway	IDA	8702723
GO:0042327	Process	Positive regulation of phosphorylation	IEA
GO:0042542	Process	Response to hydrogen peroxide	IEA
GO:0043434	Process	Response to peptide hormone	IEA
GO:0045668	Process	Negative regulation of osteoblast differentiation	IEA
GO:0048018	Function	Receptor ligand activity	IDA	8702723
GO:0048018	Function	Receptor ligand activity	IEA
GO:0051384	Process	Response to glucocorticoid	IEA
GO:0051591	Process	Response to cAMP	IEA
GO:0060598	Process	Dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis	IEA
GO:0060744	Process	Mammary gland branching involved in thelarche	IEA
GO:0060749	Process	Mammary gland alveolus development	IEA
GO:0060750	Process	Epithelial cell proliferation involved in mammary gland duct elongation	IEA

MIM	HGNC	e!Ensembl
104640	651	ENSG00000109321

Protein

UniProt ID

P15514

Protein name

Amphiregulin (AR) (Colorectum cell-derived growth factor) (CRDGF)

Protein function

Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts.

PDB

2RNL

Family and domains

Sequence

MRAPLLPPAPVVLSLLILGSGHYAAGLDLNDTYSGKREPFSGDHSADGFEVTSRSEMSSG
SEISPVSEMPSSSEPSSGADYDYSEEYDNEPQIPGYIVDDSVRVEQVVKPPQNKTESENT
SDKPKRKKKGGKNGKNRRNRKKKNPCNAEFQNFCIHGECKYIEHLEAVTCKCQQEYFGER
CGEKSMKTHSMIDSSLSKIALAAIAAFMSAVILTAVAVITVQLRRQYVRKYEGEAEERKK
LRQENGNVHAIA

Sequence length

252

Interactions

View interactions

	KEGG		Reactome
	MAPK signaling pathway ErbB signaling pathway PI3K-Akt signaling pathway Hippo signaling pathway Colorectal cancer		PIP3 activates AKT signaling Signaling by EGFR GRB2 events in EGFR signaling GAB1 signalosome SHC1 events in EGFR signaling EGFR downregulation COPII-mediated vesicle transport EGFR interacts with phospholipase C-gamma Constitutive Signaling by Aberrant PI3K in Cancer Inhibition of Signaling by Overexpressed EGFR RAF/MAP kinase cascade Cargo concentration in the ER PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Extra-nuclear estrogen signaling Estrogen-dependent nuclear events downstream of ESR-membrane signaling

AREG (amphiregulin)