Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3727
Gene name Gene Name - the full gene name approved by the HGNC.
JunD proto-oncogene, AP-1 transcription factor subunit
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
JUND
Synonyms (NCBI Gene) Gene synonyms aliases
AP-1
Chromosome Chromosome number
19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
19p13.11
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. This protein has been proposed to protect cells from p53-dependent senescence and apoptosis. Alternative transla
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT005354 hsa-miR-663a Luciferase reporter assay, Microarray, qRT-PCR, Western blot 20622002
MIRT005354 hsa-miR-663a Luciferase reporter assay, Microarray, qRT-PCR, Western blot 20622002
MIRT017287 hsa-miR-335-5p Microarray 18185580
MIRT045282 hsa-miR-186-5p CLASH 23622248
MIRT650156 hsa-miR-4778-3p HITS-CLIP 23824327
Transcription factors
Transcription factor Regulation Reference
MEN1 Repression 22327296
RBMX Repression 16707624
ZIC1 Activation 20713527
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000785 Component Chromatin ISA
GO:0000976 Function Transcription regulatory region sequence-specific DNA binding IDA 1903194
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA 21873635
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IBA 21873635
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
165162 6206 ENSG00000130522
Protein
UniProt ID P17535
Protein name Transcription factor JunD (Transcription factor AP-1 subunit JunD)
Protein function Transcription factor binding AP-1 sites (PubMed:9989505). Heterodimerizes with proteins of the FOS family to form an AP-1 transcription factor complex, thereby enhancing their DNA binding activity to an AP-1 consensus sequence 3'-TGA[GC]TCA-5' a
PDB 3U86 , 5VPA , 5VPB , 5VPC , 5VPD , 5VPE , 5VPF , 7UCC , 7UCD
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03957 Jun 1 257 Jun-like transcription factor Family
PF00170 bZIP_1 266 329 bZIP transcription factor Coiled-coil
Sequence
Sequence length 347
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  MAPK signaling pathway
Osteoclast differentiation
IL-17 signaling pathway
Parathyroid hormone synthesis, secretion and action
  Estrogen-dependent gene expression
NGF-stimulated transcription
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis, Familial rs267607084, rs312262720, rs312262752, rs121908287, rs121908288, rs29001584, rs28941475, rs121434378, rs386134173, rs386134174, rs80356730, rs80356727, rs4884357, rs80356717, rs80356733
View all (171 more)
11796754
Glomerulonephritis Glomerulonephritis rs778043831 18443593
Lateral sclerosis AMYOTROPHIC LATERAL SCLEROSIS 1, Amyotrophic Lateral Sclerosis, Sporadic rs386134181, rs386134176, rs386134174, rs386134184, rs386134178, rs1693780539, rs1574698048 11796754
Lung cancer Malignant neoplasm of lung rs121913530, rs121913529, rs878855122, rs1057519784, rs770315135 27935865
Unknown
Disease term Disease name Evidence References Source
Systemic lupus erythematosus Systemic lupus erythematosus GWAS
Associations from Text Mining
Disease Name Relationship Type References
Alzheimer Disease Associate 37933012
Arthritis Rheumatoid Associate 23072510
Breast Neoplasms Associate 17166846, 21393445, 22988241, 28212576, 30337371
Cachexia Inhibit 19470832
Carcinogenesis Associate 23496845, 25332240
Carcinoid Tumor Associate 18655788
Carcinoma Hepatocellular Associate 18644981, 24659263, 25522777, 30382079
Carcinoma Pancreatic Ductal Associate 36889906
Carcinoma Squamous Cell Associate 11792626
Cholangiocarcinoma Associate 36400758