Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID	3727
Gene name	JunD proto-oncogene, AP-1 transcription factor subunit
Gene symbol	JUND
Synonyms (NCBI Gene)	AP-1
Chromosome	19
Chromosome location	19p13.11
Summary	The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. This protein has been proposed to protect cells from p53-dependent senescence and apoptosis. Alternative transla

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miRTarBase ID	miRNA	Experiments	Reference
MIRT005354	hsa-miR-663a	Luciferase reporter assayMicroarrayqRT-PCRWestern blot	20622002
MIRT005354	hsa-miR-663a	Luciferase reporter assayMicroarrayqRT-PCRWestern blot	20622002
MIRT017287	hsa-miR-335-5p	Microarray	18185580
MIRT045282	hsa-miR-186-5p	CLASH	23622248
MIRT650156	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT650155	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT491193	hsa-miR-3173-3p	PAR-CLIP	20371350
MIRT491191	hsa-miR-6891-5p	PAR-CLIP	20371350
MIRT570207	hsa-miR-4695-5p	PAR-CLIP	20371350
MIRT570208	hsa-miR-4707-5p	PAR-CLIP	20371350
MIRT491190	hsa-miR-3185	PAR-CLIP	20371350
MIRT491189	hsa-miR-4755-3p	PAR-CLIP	20371350
MIRT491188	hsa-miR-1908-5p	PAR-CLIP	20371350
MIRT005354	hsa-miR-663a	PAR-CLIP	20371350
MIRT491187	hsa-miR-6787-5p	PAR-CLIP	20371350
MIRT491186	hsa-miR-4271	PAR-CLIP	20371350
MIRT491185	hsa-miR-4725-3p	PAR-CLIP	20371350
MIRT491183	hsa-miR-6780b-5p	PAR-CLIP	20371350
MIRT570206	hsa-miR-625-5p	PAR-CLIP	20371350
MIRT491193	hsa-miR-3173-3p	PAR-CLIP	23592263
MIRT491191	hsa-miR-6891-5p	PAR-CLIP	23592263
MIRT491190	hsa-miR-3185	PAR-CLIP	23592263
MIRT491189	hsa-miR-4755-3p	PAR-CLIP	23592263
MIRT491188	hsa-miR-1908-5p	PAR-CLIP	23592263
MIRT005354	hsa-miR-663a	PAR-CLIP	23592263
MIRT491187	hsa-miR-6787-5p	PAR-CLIP	23592263
MIRT491186	hsa-miR-4271	PAR-CLIP	23592263
MIRT491185	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT491183	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT005354	hsa-miR-663a	Luciferase reporter assayWestern blot	27184257
MIRT005354	hsa-miR-663a	Luciferase reporter assayWestern blot	27184257
MIRT491188	hsa-miR-1908-5p	PAR-CLIP	26701625
MIRT570206	hsa-miR-625-5p	PAR-CLIP	26701625
MIRT005354	hsa-miR-663a	PAR-CLIP	26701625
MIRT491187	hsa-miR-6787-5p	PAR-CLIP	26701625
MIRT650156	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT650155	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT491193	hsa-miR-3173-3p	PAR-CLIP	20371350
MIRT491191	hsa-miR-6891-5p	PAR-CLIP	20371350
MIRT570207	hsa-miR-4695-5p	PAR-CLIP	20371350
MIRT570208	hsa-miR-4707-5p	PAR-CLIP	20371350
MIRT491190	hsa-miR-3185	PAR-CLIP	20371350
MIRT491189	hsa-miR-4755-3p	PAR-CLIP	20371350
MIRT491188	hsa-miR-1908-5p	PAR-CLIP	20371350
MIRT005354	hsa-miR-663a	PAR-CLIP	20371350
MIRT491187	hsa-miR-6787-5p	PAR-CLIP	20371350
MIRT491186	hsa-miR-4271	PAR-CLIP	20371350
MIRT491185	hsa-miR-4725-3p	PAR-CLIP	20371350
MIRT491183	hsa-miR-6780b-5p	PAR-CLIP	20371350
MIRT570206	hsa-miR-625-5p	PAR-CLIP	20371350
MIRT491193	hsa-miR-3173-3p	PAR-CLIP	23592263
MIRT491191	hsa-miR-6891-5p	PAR-CLIP	23592263
MIRT491190	hsa-miR-3185	PAR-CLIP	23592263
MIRT491189	hsa-miR-4755-3p	PAR-CLIP	23592263
MIRT491188	hsa-miR-1908-5p	PAR-CLIP	23592263
MIRT005354	hsa-miR-663a	PAR-CLIP	23592263
MIRT491187	hsa-miR-6787-5p	PAR-CLIP	23592263
MIRT491186	hsa-miR-4271	PAR-CLIP	23592263
MIRT491185	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT491183	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT1078219	hsa-miR-1	CLIP-seq
MIRT1078220	hsa-miR-1321	CLIP-seq
MIRT1078221	hsa-miR-139-3p	CLIP-seq
MIRT1078222	hsa-miR-19a	CLIP-seq
MIRT1078223	hsa-miR-19b	CLIP-seq
MIRT1078224	hsa-miR-206	CLIP-seq
MIRT1078225	hsa-miR-2110	CLIP-seq
MIRT1078226	hsa-miR-2113	CLIP-seq
MIRT1078227	hsa-miR-2116	CLIP-seq
MIRT1078228	hsa-miR-3121-3p	CLIP-seq
MIRT1078229	hsa-miR-3133	CLIP-seq
MIRT1078230	hsa-miR-3138	CLIP-seq
MIRT1078231	hsa-miR-3144-5p	CLIP-seq
MIRT1078232	hsa-miR-3150a-3p	CLIP-seq
MIRT1078233	hsa-miR-3159	CLIP-seq
MIRT1078234	hsa-miR-3175	CLIP-seq
MIRT1078235	hsa-miR-3177-5p	CLIP-seq
MIRT1078236	hsa-miR-3183	CLIP-seq
MIRT1078237	hsa-miR-3189-3p	CLIP-seq
MIRT1078238	hsa-miR-3664-5p	CLIP-seq
MIRT1078239	hsa-miR-375	CLIP-seq
MIRT1078240	hsa-miR-3921	CLIP-seq
MIRT1078241	hsa-miR-4436b-3p	CLIP-seq
MIRT1078242	hsa-miR-4487	CLIP-seq
MIRT1078243	hsa-miR-4491	CLIP-seq
MIRT1078244	hsa-miR-4532	CLIP-seq
MIRT1078245	hsa-miR-4653-5p	CLIP-seq
MIRT1078246	hsa-miR-4657	CLIP-seq
MIRT1078247	hsa-miR-4659a-3p	CLIP-seq
MIRT1078248	hsa-miR-4659b-3p	CLIP-seq
MIRT1078249	hsa-miR-4677-5p	CLIP-seq
MIRT1078250	hsa-miR-4682	CLIP-seq
MIRT1078251	hsa-miR-4688	CLIP-seq
MIRT1078252	hsa-miR-4707-3p	CLIP-seq
MIRT1078253	hsa-miR-4723-3p	CLIP-seq
MIRT1078254	hsa-miR-4724-5p	CLIP-seq
MIRT1078255	hsa-miR-4728-5p	CLIP-seq
MIRT1078256	hsa-miR-4731-3p	CLIP-seq
MIRT1078257	hsa-miR-4739	CLIP-seq
MIRT1078258	hsa-miR-4740-3p	CLIP-seq
MIRT1078259	hsa-miR-4756-5p	CLIP-seq
MIRT1078260	hsa-miR-4761-3p	CLIP-seq
MIRT1078261	hsa-miR-4787-3p	CLIP-seq
MIRT1078262	hsa-miR-4800-5p	CLIP-seq
MIRT1078263	hsa-miR-4801	CLIP-seq
MIRT1078264	hsa-miR-4803	CLIP-seq
MIRT1078265	hsa-miR-486-3p	CLIP-seq
MIRT1078266	hsa-miR-494	CLIP-seq
MIRT1078267	hsa-miR-520d-5p	CLIP-seq
MIRT1078268	hsa-miR-524-5p	CLIP-seq
MIRT1078269	hsa-miR-548aa	CLIP-seq
MIRT1078270	hsa-miR-548ac	CLIP-seq
MIRT1078271	hsa-miR-548b-3p	CLIP-seq
MIRT1078272	hsa-miR-548d-3p	CLIP-seq
MIRT1078273	hsa-miR-548p	CLIP-seq
MIRT1078274	hsa-miR-548z	CLIP-seq
MIRT1078275	hsa-miR-570	CLIP-seq
MIRT1078276	hsa-miR-602	CLIP-seq
MIRT1078277	hsa-miR-613	CLIP-seq
MIRT1078278	hsa-miR-939	CLIP-seq
MIRT1078219	hsa-miR-1	CLIP-seq
MIRT1078221	hsa-miR-139-3p	CLIP-seq
MIRT2019494	hsa-miR-1908	CLIP-seq
MIRT2019495	hsa-miR-1909	CLIP-seq
MIRT1078222	hsa-miR-19a	CLIP-seq
MIRT1078223	hsa-miR-19b	CLIP-seq
MIRT1078224	hsa-miR-206	CLIP-seq
MIRT1078226	hsa-miR-2113	CLIP-seq
MIRT1078230	hsa-miR-3138	CLIP-seq
MIRT1078233	hsa-miR-3159	CLIP-seq
MIRT1078235	hsa-miR-3177-5p	CLIP-seq
MIRT2019496	hsa-miR-3180	CLIP-seq
MIRT2019497	hsa-miR-3180-3p	CLIP-seq
MIRT2019498	hsa-miR-3196	CLIP-seq
MIRT2019499	hsa-miR-3655	CLIP-seq
MIRT2019500	hsa-miR-4267	CLIP-seq
MIRT1078243	hsa-miR-4491	CLIP-seq
MIRT1078246	hsa-miR-4657	CLIP-seq
MIRT1078247	hsa-miR-4659a-3p	CLIP-seq
MIRT1078248	hsa-miR-4659b-3p	CLIP-seq
MIRT1078251	hsa-miR-4688	CLIP-seq
MIRT2019501	hsa-miR-4787-5p	CLIP-seq
MIRT1078262	hsa-miR-4800-5p	CLIP-seq
MIRT1078265	hsa-miR-486-3p	CLIP-seq
MIRT1078267	hsa-miR-520d-5p	CLIP-seq
MIRT1078268	hsa-miR-524-5p	CLIP-seq
MIRT1078270	hsa-miR-548ac	CLIP-seq
MIRT1078272	hsa-miR-548d-3p	CLIP-seq
MIRT1078274	hsa-miR-548z	CLIP-seq
MIRT1078275	hsa-miR-570	CLIP-seq
MIRT1078276	hsa-miR-602	CLIP-seq
MIRT1078277	hsa-miR-613	CLIP-seq
MIRT2019502	hsa-miR-615-5p	CLIP-seq
MIRT2019503	hsa-miR-625	CLIP-seq
MIRT2019504	hsa-miR-663	CLIP-seq
MIRT2019505	hsa-miR-937	CLIP-seq
MIRT1078219	hsa-miR-1	CLIP-seq
MIRT2251331	hsa-miR-1236	CLIP-seq
MIRT2019494	hsa-miR-1908	CLIP-seq
MIRT1078222	hsa-miR-19a	CLIP-seq
MIRT1078223	hsa-miR-19b	CLIP-seq
MIRT1078224	hsa-miR-206	CLIP-seq
MIRT1078226	hsa-miR-2113	CLIP-seq
MIRT1078227	hsa-miR-2116	CLIP-seq
MIRT1078228	hsa-miR-3121-3p	CLIP-seq
MIRT1078233	hsa-miR-3159	CLIP-seq
MIRT2019496	hsa-miR-3180	CLIP-seq
MIRT2019497	hsa-miR-3180-3p	CLIP-seq
MIRT2019498	hsa-miR-3196	CLIP-seq
MIRT1078238	hsa-miR-3664-5p	CLIP-seq
MIRT1078239	hsa-miR-375	CLIP-seq
MIRT2019500	hsa-miR-4267	CLIP-seq
MIRT1078241	hsa-miR-4436b-3p	CLIP-seq
MIRT1078247	hsa-miR-4659a-3p	CLIP-seq
MIRT1078248	hsa-miR-4659b-3p	CLIP-seq
MIRT1078249	hsa-miR-4677-5p	CLIP-seq
MIRT1078254	hsa-miR-4724-5p	CLIP-seq
MIRT1078258	hsa-miR-4740-3p	CLIP-seq
MIRT1078260	hsa-miR-4761-3p	CLIP-seq
MIRT2251332	hsa-miR-4768-5p	CLIP-seq
MIRT1078264	hsa-miR-4803	CLIP-seq
MIRT1078267	hsa-miR-520d-5p	CLIP-seq
MIRT1078268	hsa-miR-524-5p	CLIP-seq
MIRT1078275	hsa-miR-570	CLIP-seq
MIRT1078276	hsa-miR-602	CLIP-seq
MIRT1078277	hsa-miR-613	CLIP-seq
MIRT2019502	hsa-miR-615-5p	CLIP-seq
MIRT2019503	hsa-miR-625	CLIP-seq
MIRT2019504	hsa-miR-663	CLIP-seq
MIRT2251333	hsa-miR-942	CLIP-seq
MIRT2389576	hsa-miR-1285	CLIP-seq
MIRT2389577	hsa-miR-1343	CLIP-seq
MIRT1078222	hsa-miR-19a	CLIP-seq
MIRT1078223	hsa-miR-19b	CLIP-seq
MIRT1078226	hsa-miR-2113	CLIP-seq
MIRT2389578	hsa-miR-3187-5p	CLIP-seq
MIRT2019499	hsa-miR-3655	CLIP-seq
MIRT2389579	hsa-miR-612	CLIP-seq
MIRT1078219	hsa-miR-1	CLIP-seq
MIRT1078220	hsa-miR-1321	CLIP-seq
MIRT2554640	hsa-miR-151-5p	CLIP-seq
MIRT2554641	hsa-miR-151b	CLIP-seq
MIRT1078224	hsa-miR-206	CLIP-seq
MIRT1078228	hsa-miR-3121-3p	CLIP-seq
MIRT2554642	hsa-miR-3131	CLIP-seq
MIRT1078229	hsa-miR-3133	CLIP-seq
MIRT1078230	hsa-miR-3138	CLIP-seq
MIRT1078231	hsa-miR-3144-5p	CLIP-seq
MIRT1078233	hsa-miR-3159	CLIP-seq
MIRT2554643	hsa-miR-3179	CLIP-seq
MIRT2019496	hsa-miR-3180	CLIP-seq
MIRT2019497	hsa-miR-3180-3p	CLIP-seq
MIRT2019498	hsa-miR-3196	CLIP-seq
MIRT2554644	hsa-miR-3613-3p	CLIP-seq
MIRT1078241	hsa-miR-4436b-3p	CLIP-seq
MIRT1078243	hsa-miR-4491	CLIP-seq
MIRT1078246	hsa-miR-4657	CLIP-seq
MIRT2554645	hsa-miR-4723-5p	CLIP-seq
MIRT1078255	hsa-miR-4728-5p	CLIP-seq
MIRT1078257	hsa-miR-4739	CLIP-seq
MIRT1078258	hsa-miR-4740-3p	CLIP-seq
MIRT1078259	hsa-miR-4756-5p	CLIP-seq
MIRT1078260	hsa-miR-4761-3p	CLIP-seq
MIRT1078262	hsa-miR-4800-5p	CLIP-seq
MIRT1078264	hsa-miR-4803	CLIP-seq
MIRT1078266	hsa-miR-494	CLIP-seq
MIRT1078267	hsa-miR-520d-5p	CLIP-seq
MIRT1078268	hsa-miR-524-5p	CLIP-seq
MIRT1078271	hsa-miR-548b-3p	CLIP-seq
MIRT1078273	hsa-miR-548p	CLIP-seq
MIRT1078275	hsa-miR-570	CLIP-seq
MIRT2554646	hsa-miR-611	CLIP-seq
MIRT1078277	hsa-miR-613	CLIP-seq
MIRT1078278	hsa-miR-939	CLIP-seq
MIRT1078219	hsa-miR-1	CLIP-seq
MIRT1078220	hsa-miR-1321	CLIP-seq
MIRT1078224	hsa-miR-206	CLIP-seq
MIRT1078229	hsa-miR-3133	CLIP-seq
MIRT1078230	hsa-miR-3138	CLIP-seq
MIRT1078231	hsa-miR-3144-5p	CLIP-seq
MIRT1078233	hsa-miR-3159	CLIP-seq
MIRT2554643	hsa-miR-3179	CLIP-seq
MIRT2554644	hsa-miR-3613-3p	CLIP-seq
MIRT1078243	hsa-miR-4491	CLIP-seq
MIRT1078246	hsa-miR-4657	CLIP-seq
MIRT2554645	hsa-miR-4723-5p	CLIP-seq
MIRT1078255	hsa-miR-4728-5p	CLIP-seq
MIRT1078257	hsa-miR-4739	CLIP-seq
MIRT1078259	hsa-miR-4756-5p	CLIP-seq
MIRT1078262	hsa-miR-4800-5p	CLIP-seq
MIRT1078267	hsa-miR-520d-5p	CLIP-seq
MIRT1078268	hsa-miR-524-5p	CLIP-seq
MIRT1078271	hsa-miR-548b-3p	CLIP-seq
MIRT1078273	hsa-miR-548p	CLIP-seq
MIRT1078275	hsa-miR-570	CLIP-seq
MIRT1078277	hsa-miR-613	CLIP-seq
MIRT1078278	hsa-miR-939	CLIP-seq

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Transcription factor	Regulation	Reference
MEN1	Repression	22327296
RBMX	Repression	16707624
ZIC1	Activation	20713527

Show/Hide all (56)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IDA	22327296
GO:0000785	Component	Chromatin	ISA
GO:0000785	Component	Chromatin	TAS	1903194
GO:0000976	Function	Transcription cis-regulatory region binding	IDA	1903194
GO:0000976	Function	Transcription cis-regulatory region binding	IEA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001221	Function	Transcription coregulator binding	IEA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IEA
GO:0002076	Process	Osteoblast development	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003690	Function	Double-stranded DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IEA
GO:0003713	Function	Transcription coactivator activity	IEA
GO:0005515	Function	Protein binding	IPI	9989505, 17577209, 20102225, 20195357, 22327296, 23784080, 24029232, 25609649, 26496610, 28514442, 30833792, 32814053, 33961781, 35140242
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	NAS	20102225
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005667	Component	Transcription regulator complex	IBA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	NAS	20102225
GO:0006357	Process	Regulation of transcription by RNA polymerase II	TAS	1903194
GO:0006366	Process	Transcription by RNA polymerase II	IEA
GO:0007623	Process	Circadian rhythm	IEA
GO:0009416	Process	Response to light stimulus	IEA
GO:0009612	Process	Response to mechanical stimulus	IEA
GO:0010467	Process	Gene expression	IEA
GO:0016922	Function	Nuclear receptor binding	IEA
GO:0017053	Component	Transcription repressor complex	IPI	22327296
GO:0019899	Function	Enzyme binding	IPI	23382074
GO:0032496	Process	Response to lipopolysaccharide	IEA
GO:0032991	Component	Protein-containing complex	IEA
GO:0032993	Component	Protein-DNA complex	IEA
GO:0035360	Process	Positive regulation of peroxisome proliferator activated receptor signaling pathway	IEA
GO:0035976	Component	Transcription factor AP-1 complex	IDA	10508860
GO:0035976	Component	Transcription factor AP-1 complex	IEA
GO:0042127	Process	Regulation of cell population proliferation	IBA
GO:0043032	Process	Positive regulation of macrophage activation	IEA
GO:0043434	Process	Response to peptide hormone	IEA
GO:0043565	Function	Sequence-specific DNA binding	IEA
GO:0045669	Process	Positive regulation of osteoblast differentiation	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IBA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	10508860
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0048545	Process	Response to steroid hormone	IBA
GO:0051726	Process	Regulation of cell cycle	IBA
GO:0071277	Process	Cellular response to calcium ion	IEA
GO:0071398	Process	Cellular response to fatty acid	IEA
GO:0071456	Process	Cellular response to hypoxia	IEA
GO:0090575	Component	RNA polymerase II transcription regulator complex	IPI	20102225
GO:1904321	Process	Response to forskolin	IEA
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

MIM	HGNC	e!Ensembl
165162	6206	ENSG00000130522

P17535

Protein name

Transcription factor JunD (Transcription factor AP-1 subunit JunD)

Protein function

Transcription factor binding AP-1 sites (PubMed:9989505). Heterodimerizes with proteins of the FOS family to form an AP-1 transcription factor complex, thereby enhancing their DNA binding activity to an AP-1 consensus sequence 3'-TGA[GC]TCA-5' a

PDB

3U86 , 5VPA , 5VPB , 5VPC , 5VPD , 5VPE , 5VPF , 7UCC , 7UCD

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03957	Jun	1 → 257	Jun-like transcription factor	Family
PF00170	bZIP_1	266 → 329	bZIP transcription factor	Coiled-coil

Sequence

METPFYGDEALSGLGGGASGSGGSFASPGRLFPGAPPTAAAGSMMKKDALTLSLSEQVAA
ALKPAAAPPPTPLRADGAPSAAPPDGLLASPDLGLLKLASPELERLIIQSNGLVTTTPTS
SQFLYPKVAASEEQEFAEGFVKALEDLHKQNQLGAGAAAAAAAAAAGGPSGTATGSAPPG
ELAPAAAAPEAPVYANLSSYAGGAGGAGGAATVAFAAEPVPFPPPPPPGALGPPRLAALK
DEPQTVPDVPSFGESPPLSPIDMDTQERIKAERKRLRNRIAASKCRKRKLERISRLEEKV
KTLKSQNTELASTASLLREQVAQLKQKVLSHVNSGCQLLPQHQVPAY

Sequence length

347

Interactions

View interactions

	KEGG		Reactome
	MAPK signaling pathway Osteoclast differentiation IL-17 signaling pathway Parathyroid hormone synthesis, secretion and action		Estrogen-dependent gene expression NGF-stimulated transcription

JUND (JunD proto-oncogene, AP-1 transcription factor subunit)