Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3726
Gene name Gene Name - the full gene name approved by the HGNC.
JunB proto-oncogene, AP-1 transcription factor subunit
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
JUNB
Synonyms (NCBI Gene) Gene synonyms aliases
AP-1
Chromosome Chromosome number
19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
19p13.13
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT004391 hsa-miR-199a-5p Microarray, Northern blot 16331254
MIRT000783 hsa-miR-199a-3p Microarray, Northern blot 16331254
MIRT005353 hsa-miR-663a Luciferase reporter assay, Microarray, qRT-PCR, Western blot 20622002
MIRT005353 hsa-miR-663a Luciferase reporter assay, Microarray, qRT-PCR, Western blot 20622002
MIRT005353 hsa-miR-663a Luciferase reporter assay, Microarray, qRT-PCR, Western blot 20622002
Transcription factors
Transcription factor Regulation Reference
ESR1 Activation 11477071
MYC Repression 18838534
NFKB1 Activation 17018379
RBMX Repression 16707624
RELA Activation 17018379
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000785 Component Chromatin ISA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA 21873635
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IBA 21873635
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific ISA
GO:0001228 Function DNA-binding transcription activator activity, RNA polymerase II-specific IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
165161 6205 ENSG00000171223
Protein
UniProt ID P17275
Protein name Transcription factor JunB (Transcription factor AP-1 subunit JunB)
Protein function Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[GC]TCA-3'. Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby en
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03957 Jun 5 257 Jun-like transcription factor Family
PF00170 bZIP_1 266 329 bZIP transcription factor Coiled-coil
Sequence
Sequence length 347
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Osteoclast differentiation
TNF signaling pathway
Growth hormone synthesis, secretion and action
  SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Interleukin-4 and Interleukin-13 signaling
NGF-stimulated transcription
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Lung adenocarcinoma Adenocarcinoma of lung (disorder) rs28934576, rs121913530, rs397516975, rs587776805, rs121913469, rs121913364, rs121913351, rs121913366, rs397516896, rs397516977, rs397516981, rs397517127, rs121913344, rs727504233, rs121913370
View all (5 more)
24366584
Lung cancer Malignant neoplasm of lung rs121913530, rs121913529, rs878855122, rs1057519784, rs770315135 27935865, 16289808
Associations from Text Mining
Disease Name Relationship Type References
Acne Vulgaris Stimulate 15920154
Adenocarcinoma Associate 28859074
Adenomyosis Inhibit 32933042
Anemia Sickle Cell Associate 21175428
Aortic Aneurysm Abdominal Stimulate 20488324
Aortic Valve Stenosis Associate 39766890
Arthritis Associate 17626252
Arthritis Rheumatoid Associate 15142264, 16646028, 39394168
Asthma Associate 34004182, 34591794
Atherosclerosis Associate 15210574