Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3725
Gene name Gene Name - the full gene name approved by the HGNC.
Jun proto-oncogene, AP-1 transcription factor subunit
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
JUN
Synonyms (NCBI Gene) Gene synonyms aliases
AP-1, AP1, c-Jun, cJUN, p39
Disease Acronyms (UniProt) Disease acronyms from UniProt database
AP1
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p32.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT000868 hsa-miR-15a-5p Microarray 18362358
MIRT000867 hsa-miR-16-5p Microarray 18362358
MIRT005128 hsa-miR-30a-5p pSILAC 18668040
MIRT006208 hsa-miR-155-5p Luciferase reporter assay, qRT-PCR, Western blot 22508041
MIRT006208 hsa-miR-155-5p Luciferase reporter assay, qRT-PCR, Western blot 22508041
Transcription factors
Transcription factor Regulation Reference
ABL1 Activation 15145216
ABL1 Repression 19357699
AR Activation 20148354
ARNT Repression 21544813
ATF2 Activation 9502786
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IDA 2833704
GO:0000228 Component Nuclear chromosome TAS 10918580
GO:0000785 Component Chromatin ISA
GO:0000791 Component Euchromatin IDA 19861239
GO:0000976 Function Transcription regulatory region sequence-specific DNA binding IDA 2833704, 9732876, 14645924, 21113145, 22083952, 24623306
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
165160 6204 ENSG00000177606
Protein
UniProt ID P05412
Protein name Transcription factor Jun (Activator protein 1) (AP1) (Proto-oncogene c-Jun) (Transcription factor AP-1 subunit Jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39)
Protein function Transcription factor that recognizes and binds to the AP-1 consensus motif 5'-TGA[GC]TCA-3' (PubMed:10995748, PubMed:22083952). Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA bind
PDB 1A02 , 1FOS , 1JNM , 1JUN , 1S9K , 1T2K , 5FV8 , 5T01 , 6Y3V , 8SOS
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03957 Jun 5 241 Jun-like transcription factor Family
PF00170 bZIP_1 250 313 bZIP transcription factor Coiled-coil
Tissue specificity TISSUE SPECIFICITY: Expressed in the developing and adult prostate and prostate cancer cells. {ECO:0000269|PubMed:24263171, ECO:0000269|PubMed:24559171}.
Sequence
Sequence length 331
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Endocrine resistance
MAPK signaling pathway
ErbB signaling pathway
cAMP signaling pathway
Mitophagy - animal
Apoptosis
Wnt signaling pathway
Osteoclast differentiation
Focal adhesion
Tight junction
Toll-like receptor signaling pathway
NOD-like receptor signaling pathway
C-type lectin receptor signaling pathway
IL-17 signaling pathway
Th1 and Th2 cell differentiation
Th17 cell differentiation
T cell receptor signaling pathway
B cell receptor signaling pathway
TNF signaling pathway
Neurotrophin signaling pathway
GnRH signaling pathway
Estrogen signaling pathway
Oxytocin signaling pathway
Relaxin signaling pathway
Non-alcoholic fatty liver disease
AGE-RAGE signaling pathway in diabetic complications
Cocaine addiction
Amphetamine addiction
Epithelial cell signaling in Helicobacter pylori infection
Pathogenic Escherichia coli infection
Shigellosis
Salmonella infection
Pertussis
Yersinia infection
Leishmaniasis
Chagas disease
Hepatitis B
Measles
Human T-cell leukemia virus 1 infection
Kaposi sarcoma-associated herpesvirus infection
Epstein-Barr virus infection
Human immunodeficiency virus 1 infection
Coronavirus disease - COVID-19
Pathways in cancer
Viral carcinogenesis
Chemical carcinogenesis - receptor activation
Chemical carcinogenesis - reactive oxygen species
Colorectal cancer
Renal cell carcinoma
Breast cancer
Choline metabolism in cancer
PD-L1 expression and PD-1 checkpoint pathway in cancer
Inflammatory bowel disease
Rheumatoid arthritis
Lipid and atherosclerosis
Fluid shear stress and atherosclerosis
  Pre-NOTCH Transcription and Translation
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
FCERI mediated MAPK activation
Activation of the AP-1 family of transcription factors
MAPK6/MAPK4 signaling
TP53 Regulates Transcription of DNA Repair Genes
Regulation of PTEN gene transcription
Estrogen-dependent gene expression
WNT5:FZD7-mediated leishmania damping
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Arthritis Juvenile arthritis rs1594890601, rs1594882933, rs184370809, rs776489319, rs1594883470 19565504
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
16298037
Breast carcinoma Breast Carcinoma rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451
View all (71 more)
16298037
Cholestasis Cholestasis, Extrahepatic rs121909103, rs751511532, rs376368459, rs762702807, rs1578490102, rs1578499691, rs1578504946, rs1317656688, rs199791850, rs1452792080, rs1578491039 28789951
Unknown
Disease term Disease name Evidence References Source
Hemangiosarcoma Hemangiosarcoma 17569031 ClinVar
Coronary artery disease Coronary artery disease GWAS
Insomnia Insomnia GWAS
Associations from Text Mining
Disease Name Relationship Type References
Acidemia isovaleric Associate 27391542
Acne Vulgaris Associate 30148860
Acrocephalosyndactylia Stimulate 23404329
Adenocarcinoma Associate 18992165
Adenocarcinoma of Lung Associate 33299528, 7529661
Adenoma Stimulate 18992165
Alzheimer Disease Stimulate 17712163, 8774439
Alzheimer Disease Associate 19162185, 24346217, 32437347, 38049398, 40363838, 8063812, 9880041
Amyotrophic Lateral Sclerosis Associate 28366453, 37488208
Anodontia Stimulate 33318474