Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	3716
Gene name	Janus kinase 1
Gene symbol	JAK1
Synonyms (NCBI Gene)	AIIDEJAK1AJAK1BJTK3
Chromosome	1
Chromosome location	1p31.3
Summary	This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT

Show/Hide all (3)

SNP ID	Visualize variation	Clinical significance	Consequence
rs151047872	G>A	Likely-pathogenic	Missense variant, coding sequence variant
rs869312953	G>T	Likely-pathogenic	Missense variant, coding sequence variant
rs1057519753	C>A	Likely-pathogenic	Missense variant, coding sequence variant

608

Show/Hide all (608)

miRTarBase ID	miRNA	Experiments	Reference
MIRT000482	hsa-miR-17-5p	Luciferase reporter assayWestern blot	20299512
MIRT020460	hsa-miR-106b-5p	Microarray	17242205
MIRT021877	hsa-miR-128-3p	Microarray	17612493
MIRT046471	hsa-miR-15b-5p	CLASH	23622248
MIRT046312	hsa-miR-23b-3p	CLASH	23622248
MIRT053361	hsa-miR-9-5p	MicroarrayqRT-PCR	23798388
MIRT020460	hsa-miR-106b-5p	Luciferase reporter assayqRT-PCRWestern blot	25307786
MIRT020460	hsa-miR-106b-5p	Luciferase reporter assayqRT-PCRWestern blot	25307786
MIRT054776	hsa-miR-107	Luciferase reporter assayqRT-PCRWestern blotCoimmunoprecipitationChromatin immunoprecipitationImmunofluorescence microscopy	24429361
MIRT020460	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT031081	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT020460	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT000482	hsa-miR-17-5p	HITS-CLIP	22473208
MIRT727412	hsa-miR-20b-5p	HITS-CLIP	22473208
MIRT727411	hsa-miR-93-5p	HITS-CLIP	22473208
MIRT727410	hsa-miR-519d-3p	HITS-CLIP	22473208
MIRT031081	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT727408	hsa-miR-30a-5p	HITS-CLIP	22473208
MIRT727409	hsa-miR-30b-5p	HITS-CLIP	22473208
MIRT727407	hsa-miR-30c-5p	HITS-CLIP	22473208
MIRT727406	hsa-miR-30d-5p	HITS-CLIP	22473208
MIRT727405	hsa-miR-30e-5p	HITS-CLIP	22473208
MIRT731191	hsa-miR-373-3p	ImmunoprecipitaionqRT-PCRLuciferase reporter assayWestern blot	25589644
MIRT731191	hsa-miR-373-3p	ImmunoprecipitaionqRT-PCRLuciferase reporter assayWestern blot	25589644
MIRT727407	hsa-miR-30c-5p	Luciferase reporter assay	26826240
MIRT727407	hsa-miR-30c-5p	Luciferase reporter assay	26826240
MIRT000482	hsa-miR-17-5p	Luciferase reporter assayWestern blottingMicroarrayImmunohistochemistry (IHC)RNA-seqqRT-PCR	32683798
MIRT737307	hsa-miR-126-3p	Luciferase reporter assayWestern blottingImmunofluorescenceqRT-PCR	32554852
MIRT755646	hsa-miR-22-3p	Luciferase reporter assayWestern blottingqRT-PCR	37824732
MIRT727408	hsa-miR-30a-5p	Luciferase reporter assayqRT-PCR	38891028
MIRT1076007	hsa-miR-106a	CLIP-seq
MIRT1076008	hsa-miR-106b	CLIP-seq
MIRT1076009	hsa-miR-1179	CLIP-seq
MIRT1076010	hsa-miR-1245b-3p	CLIP-seq
MIRT1076011	hsa-miR-125a-3p	CLIP-seq
MIRT1076012	hsa-miR-1276	CLIP-seq
MIRT1076013	hsa-miR-1287	CLIP-seq
MIRT1076014	hsa-miR-1323	CLIP-seq
MIRT1076015	hsa-miR-142-5p	CLIP-seq
MIRT1076016	hsa-miR-148a	CLIP-seq
MIRT1076017	hsa-miR-148b	CLIP-seq
MIRT1076018	hsa-miR-152	CLIP-seq
MIRT1076019	hsa-miR-153	CLIP-seq
MIRT1076020	hsa-miR-1587	CLIP-seq
MIRT1076021	hsa-miR-17	CLIP-seq
MIRT1076022	hsa-miR-1825	CLIP-seq
MIRT1076023	hsa-miR-203	CLIP-seq
MIRT1076024	hsa-miR-2054	CLIP-seq
MIRT1076025	hsa-miR-20a	CLIP-seq
MIRT1076026	hsa-miR-20b	CLIP-seq
MIRT1076027	hsa-miR-299-3p	CLIP-seq
MIRT1076028	hsa-miR-30a	CLIP-seq
MIRT1076029	hsa-miR-30b	CLIP-seq
MIRT1076030	hsa-miR-30c	CLIP-seq
MIRT1076031	hsa-miR-30d	CLIP-seq
MIRT1076032	hsa-miR-30e	CLIP-seq
MIRT1076033	hsa-miR-3120-3p	CLIP-seq
MIRT1076034	hsa-miR-3124-3p	CLIP-seq
MIRT1076035	hsa-miR-3135b	CLIP-seq
MIRT1076036	hsa-miR-3149	CLIP-seq
MIRT1076037	hsa-miR-3164	CLIP-seq
MIRT1076038	hsa-miR-3173-3p	CLIP-seq
MIRT1076039	hsa-miR-3189-5p	CLIP-seq
MIRT1076040	hsa-miR-3192	CLIP-seq
MIRT1076041	hsa-miR-323-5p	CLIP-seq
MIRT1076042	hsa-miR-338-5p	CLIP-seq
MIRT1076043	hsa-miR-340	CLIP-seq
MIRT1076044	hsa-miR-3529	CLIP-seq
MIRT1076045	hsa-miR-3677-5p	CLIP-seq
MIRT1076046	hsa-miR-3688-3p	CLIP-seq
MIRT1076047	hsa-miR-3692	CLIP-seq
MIRT1076048	hsa-miR-379	CLIP-seq
MIRT1076049	hsa-miR-3944-5p	CLIP-seq
MIRT1076050	hsa-miR-3976	CLIP-seq
MIRT1076051	hsa-miR-421	CLIP-seq
MIRT1076052	hsa-miR-4261	CLIP-seq
MIRT1076053	hsa-miR-4276	CLIP-seq
MIRT1076054	hsa-miR-4310	CLIP-seq
MIRT1076055	hsa-miR-4311	CLIP-seq
MIRT1076056	hsa-miR-4314	CLIP-seq
MIRT1076057	hsa-miR-4422	CLIP-seq
MIRT1076058	hsa-miR-4437	CLIP-seq
MIRT1076059	hsa-miR-4451	CLIP-seq
MIRT1076060	hsa-miR-4453	CLIP-seq
MIRT1076061	hsa-miR-4457	CLIP-seq
MIRT1076062	hsa-miR-4464	CLIP-seq
MIRT1076063	hsa-miR-448	CLIP-seq
MIRT1076064	hsa-miR-4491	CLIP-seq
MIRT1076065	hsa-miR-4511	CLIP-seq
MIRT1076066	hsa-miR-4520a-3p	CLIP-seq
MIRT1076067	hsa-miR-4520b-3p	CLIP-seq
MIRT1076068	hsa-miR-4529-3p	CLIP-seq
MIRT1076069	hsa-miR-4536	CLIP-seq
MIRT1076070	hsa-miR-4538	CLIP-seq
MIRT1076071	hsa-miR-4646-5p	CLIP-seq
MIRT1076072	hsa-miR-4650-3p	CLIP-seq
MIRT1076073	hsa-miR-4657	CLIP-seq
MIRT1076074	hsa-miR-4674	CLIP-seq
MIRT1076075	hsa-miR-4676-5p	CLIP-seq
MIRT1076076	hsa-miR-4701-5p	CLIP-seq
MIRT1076077	hsa-miR-4709-5p	CLIP-seq
MIRT1076078	hsa-miR-4748	CLIP-seq
MIRT1076079	hsa-miR-4758-3p	CLIP-seq
MIRT1076080	hsa-miR-4773	CLIP-seq
MIRT1076081	hsa-miR-4796-3p	CLIP-seq
MIRT1076082	hsa-miR-495	CLIP-seq
MIRT1076083	hsa-miR-512-3p	CLIP-seq
MIRT1076084	hsa-miR-514	CLIP-seq
MIRT1076085	hsa-miR-514b-3p	CLIP-seq
MIRT1076086	hsa-miR-519a	CLIP-seq
MIRT1076087	hsa-miR-519b-3p	CLIP-seq
MIRT1076088	hsa-miR-519c-3p	CLIP-seq
MIRT1076089	hsa-miR-519d	CLIP-seq
MIRT1076090	hsa-miR-520f	CLIP-seq
MIRT1076091	hsa-miR-520g	CLIP-seq
MIRT1076092	hsa-miR-520h	CLIP-seq
MIRT1076093	hsa-miR-522	CLIP-seq
MIRT1076094	hsa-miR-548a-5p	CLIP-seq
MIRT1076095	hsa-miR-548aa	CLIP-seq
MIRT1076096	hsa-miR-548ab	CLIP-seq
MIRT1076097	hsa-miR-548ak	CLIP-seq
MIRT1076098	hsa-miR-548b-3p	CLIP-seq
MIRT1076099	hsa-miR-548b-5p	CLIP-seq
MIRT1076100	hsa-miR-548c-5p	CLIP-seq
MIRT1076101	hsa-miR-548d-5p	CLIP-seq
MIRT1076102	hsa-miR-548h	CLIP-seq
MIRT1076103	hsa-miR-548i	CLIP-seq
MIRT1076104	hsa-miR-548j	CLIP-seq
MIRT1076105	hsa-miR-548n	CLIP-seq
MIRT1076106	hsa-miR-548o	CLIP-seq
MIRT1076107	hsa-miR-548w	CLIP-seq
MIRT1076108	hsa-miR-548y	CLIP-seq
MIRT1076109	hsa-miR-552	CLIP-seq
MIRT1076110	hsa-miR-559	CLIP-seq
MIRT1076111	hsa-miR-568	CLIP-seq
MIRT1076112	hsa-miR-575	CLIP-seq
MIRT1076113	hsa-miR-583	CLIP-seq
MIRT1076114	hsa-miR-588	CLIP-seq
MIRT1076115	hsa-miR-642b	CLIP-seq
MIRT1076116	hsa-miR-765	CLIP-seq
MIRT1076117	hsa-miR-769-5p	CLIP-seq
MIRT1076118	hsa-miR-802	CLIP-seq
MIRT1076119	hsa-miR-876-3p	CLIP-seq
MIRT1076120	hsa-miR-93	CLIP-seq
MIRT2018893	hsa-miR-103a	CLIP-seq
MIRT1076007	hsa-miR-106a	CLIP-seq
MIRT1076008	hsa-miR-106b	CLIP-seq
MIRT1076011	hsa-miR-125a-3p	CLIP-seq
MIRT2018894	hsa-miR-1263	CLIP-seq
MIRT2018895	hsa-miR-1264	CLIP-seq
MIRT1076012	hsa-miR-1276	CLIP-seq
MIRT2018896	hsa-miR-139-5p	CLIP-seq
MIRT1076015	hsa-miR-142-5p	CLIP-seq
MIRT1076020	hsa-miR-1587	CLIP-seq
MIRT1076021	hsa-miR-17	CLIP-seq
MIRT1076025	hsa-miR-20a	CLIP-seq
MIRT1076026	hsa-miR-20b	CLIP-seq
MIRT2018897	hsa-miR-214	CLIP-seq
MIRT1076027	hsa-miR-299-3p	CLIP-seq
MIRT2018898	hsa-miR-302a	CLIP-seq
MIRT2018899	hsa-miR-302b	CLIP-seq
MIRT2018900	hsa-miR-302c	CLIP-seq
MIRT2018901	hsa-miR-302d	CLIP-seq
MIRT2018902	hsa-miR-302e	CLIP-seq
MIRT1076028	hsa-miR-30a	CLIP-seq
MIRT1076029	hsa-miR-30b	CLIP-seq
MIRT1076030	hsa-miR-30c	CLIP-seq
MIRT1076031	hsa-miR-30d	CLIP-seq
MIRT1076032	hsa-miR-30e	CLIP-seq
MIRT1076033	hsa-miR-3120-3p	CLIP-seq
MIRT1076034	hsa-miR-3124-3p	CLIP-seq
MIRT2018903	hsa-miR-3140-5p	CLIP-seq
MIRT2018904	hsa-miR-3143	CLIP-seq
MIRT1076036	hsa-miR-3149	CLIP-seq
MIRT2018905	hsa-miR-3160-5p	CLIP-seq
MIRT2018906	hsa-miR-3168	CLIP-seq
MIRT2018907	hsa-miR-3171	CLIP-seq
MIRT1076038	hsa-miR-3173-3p	CLIP-seq
MIRT2018908	hsa-miR-323b-5p	CLIP-seq
MIRT1076042	hsa-miR-338-5p	CLIP-seq
MIRT1076043	hsa-miR-340	CLIP-seq
MIRT2018909	hsa-miR-3619-5p	CLIP-seq
MIRT2018910	hsa-miR-3668	CLIP-seq
MIRT2018911	hsa-miR-3671	CLIP-seq
MIRT2018912	hsa-miR-3674	CLIP-seq
MIRT1076045	hsa-miR-3677-5p	CLIP-seq
MIRT1076046	hsa-miR-3688-3p	CLIP-seq
MIRT1076047	hsa-miR-3692	CLIP-seq
MIRT2018913	hsa-miR-372	CLIP-seq
MIRT2018914	hsa-miR-373	CLIP-seq
MIRT2018915	hsa-miR-3935	CLIP-seq
MIRT2018916	hsa-miR-3941	CLIP-seq
MIRT2018917	hsa-miR-3942-3p	CLIP-seq
MIRT1076050	hsa-miR-3976	CLIP-seq
MIRT1076051	hsa-miR-421	CLIP-seq
MIRT2018918	hsa-miR-4252	CLIP-seq
MIRT1076052	hsa-miR-4261	CLIP-seq
MIRT2018919	hsa-miR-4302	CLIP-seq
MIRT1076055	hsa-miR-4311	CLIP-seq
MIRT1076058	hsa-miR-4437	CLIP-seq
MIRT2018920	hsa-miR-4438	CLIP-seq
MIRT1076061	hsa-miR-4457	CLIP-seq
MIRT1076062	hsa-miR-4464	CLIP-seq
MIRT2018921	hsa-miR-4477a	CLIP-seq
MIRT1076063	hsa-miR-448	CLIP-seq
MIRT1076064	hsa-miR-4491	CLIP-seq
MIRT2018922	hsa-miR-4503	CLIP-seq
MIRT2018923	hsa-miR-4528	CLIP-seq
MIRT1076069	hsa-miR-4536	CLIP-seq
MIRT2018924	hsa-miR-4643	CLIP-seq
MIRT1076073	hsa-miR-4657	CLIP-seq
MIRT2018925	hsa-miR-466	CLIP-seq
MIRT2018926	hsa-miR-4668-5p	CLIP-seq
MIRT2018927	hsa-miR-4672	CLIP-seq
MIRT1076074	hsa-miR-4674	CLIP-seq
MIRT2018928	hsa-miR-4680-3p	CLIP-seq
MIRT1076076	hsa-miR-4701-5p	CLIP-seq
MIRT1076077	hsa-miR-4709-5p	CLIP-seq
MIRT2018929	hsa-miR-4720-3p	CLIP-seq
MIRT2018930	hsa-miR-4724-5p	CLIP-seq
MIRT1076078	hsa-miR-4748	CLIP-seq
MIRT2018931	hsa-miR-4774-5p	CLIP-seq
MIRT2018932	hsa-miR-4789-3p	CLIP-seq
MIRT2018933	hsa-miR-4804-3p	CLIP-seq
MIRT1076084	hsa-miR-514	CLIP-seq
MIRT1076085	hsa-miR-514b-3p	CLIP-seq
MIRT1076086	hsa-miR-519a	CLIP-seq
MIRT1076087	hsa-miR-519b-3p	CLIP-seq
MIRT1076088	hsa-miR-519c-3p	CLIP-seq
MIRT1076089	hsa-miR-519d	CLIP-seq
MIRT2018934	hsa-miR-520a-3p	CLIP-seq
MIRT2018935	hsa-miR-520b	CLIP-seq
MIRT2018936	hsa-miR-520c-3p	CLIP-seq
MIRT2018937	hsa-miR-520d-3p	CLIP-seq
MIRT2018938	hsa-miR-520e	CLIP-seq
MIRT1076090	hsa-miR-520f	CLIP-seq
MIRT1076091	hsa-miR-520g	CLIP-seq
MIRT1076092	hsa-miR-520h	CLIP-seq
MIRT1076093	hsa-miR-522	CLIP-seq
MIRT2018939	hsa-miR-526b	CLIP-seq
MIRT2018940	hsa-miR-545	CLIP-seq
MIRT1076109	hsa-miR-552	CLIP-seq
MIRT1076111	hsa-miR-568	CLIP-seq
MIRT2018941	hsa-miR-580	CLIP-seq
MIRT1076113	hsa-miR-583	CLIP-seq
MIRT1076114	hsa-miR-588	CLIP-seq
MIRT2018942	hsa-miR-607	CLIP-seq
MIRT2018943	hsa-miR-616	CLIP-seq
MIRT2018944	hsa-miR-619	CLIP-seq
MIRT1076115	hsa-miR-642b	CLIP-seq
MIRT2018945	hsa-miR-648	CLIP-seq
MIRT2018946	hsa-miR-656	CLIP-seq
MIRT2018947	hsa-miR-659	CLIP-seq
MIRT2018948	hsa-miR-761	CLIP-seq
MIRT1076116	hsa-miR-765	CLIP-seq
MIRT1076117	hsa-miR-769-5p	CLIP-seq
MIRT1076120	hsa-miR-93	CLIP-seq
MIRT2018893	hsa-miR-103a	CLIP-seq
MIRT1076009	hsa-miR-1179	CLIP-seq
MIRT2250763	hsa-miR-1207-3p	CLIP-seq
MIRT1076011	hsa-miR-125a-3p	CLIP-seq
MIRT1076012	hsa-miR-1276	CLIP-seq
MIRT1076014	hsa-miR-1323	CLIP-seq
MIRT1076015	hsa-miR-142-5p	CLIP-seq
MIRT1076016	hsa-miR-148a	CLIP-seq
MIRT1076017	hsa-miR-148b	CLIP-seq
MIRT1076018	hsa-miR-152	CLIP-seq
MIRT1076019	hsa-miR-153	CLIP-seq
MIRT1076020	hsa-miR-1587	CLIP-seq
MIRT2018897	hsa-miR-214	CLIP-seq
MIRT1076027	hsa-miR-299-3p	CLIP-seq
MIRT1076028	hsa-miR-30a	CLIP-seq
MIRT1076029	hsa-miR-30b	CLIP-seq
MIRT1076030	hsa-miR-30c	CLIP-seq
MIRT1076031	hsa-miR-30d	CLIP-seq
MIRT1076032	hsa-miR-30e	CLIP-seq
MIRT1076033	hsa-miR-3120-3p	CLIP-seq
MIRT2250764	hsa-miR-3123	CLIP-seq
MIRT2018903	hsa-miR-3140-5p	CLIP-seq
MIRT2018904	hsa-miR-3143	CLIP-seq
MIRT1076036	hsa-miR-3149	CLIP-seq
MIRT2018906	hsa-miR-3168	CLIP-seq
MIRT2018907	hsa-miR-3171	CLIP-seq
MIRT1076042	hsa-miR-338-5p	CLIP-seq
MIRT1076043	hsa-miR-340	CLIP-seq
MIRT2018909	hsa-miR-3619-5p	CLIP-seq
MIRT2250765	hsa-miR-3681	CLIP-seq
MIRT1076046	hsa-miR-3688-3p	CLIP-seq
MIRT2018917	hsa-miR-3942-3p	CLIP-seq
MIRT1076049	hsa-miR-3944-5p	CLIP-seq
MIRT1076051	hsa-miR-421	CLIP-seq
MIRT1076052	hsa-miR-4261	CLIP-seq
MIRT2250766	hsa-miR-4299	CLIP-seq
MIRT1076054	hsa-miR-4310	CLIP-seq
MIRT1076055	hsa-miR-4311	CLIP-seq
MIRT1076058	hsa-miR-4437	CLIP-seq
MIRT2018920	hsa-miR-4438	CLIP-seq
MIRT2250767	hsa-miR-4463	CLIP-seq
MIRT1076063	hsa-miR-448	CLIP-seq
MIRT1076064	hsa-miR-4491	CLIP-seq
MIRT2250768	hsa-miR-4494	CLIP-seq
MIRT1076065	hsa-miR-4511	CLIP-seq
MIRT1076069	hsa-miR-4536	CLIP-seq
MIRT1076073	hsa-miR-4657	CLIP-seq
MIRT2018926	hsa-miR-4668-5p	CLIP-seq
MIRT1076074	hsa-miR-4674	CLIP-seq
MIRT2018928	hsa-miR-4680-3p	CLIP-seq
MIRT1076077	hsa-miR-4709-5p	CLIP-seq
MIRT2250769	hsa-miR-4710	CLIP-seq
MIRT2018930	hsa-miR-4724-5p	CLIP-seq
MIRT1076080	hsa-miR-4773	CLIP-seq
MIRT2250770	hsa-miR-4792	CLIP-seq
MIRT2250771	hsa-miR-499a-5p	CLIP-seq
MIRT1076091	hsa-miR-520g	CLIP-seq
MIRT1076092	hsa-miR-520h	CLIP-seq
MIRT2018939	hsa-miR-526b	CLIP-seq
MIRT2018940	hsa-miR-545	CLIP-seq
MIRT2250772	hsa-miR-548a-3p	CLIP-seq
MIRT1076094	hsa-miR-548a-5p	CLIP-seq
MIRT1076095	hsa-miR-548aa	CLIP-seq
MIRT1076096	hsa-miR-548ab	CLIP-seq
MIRT1076097	hsa-miR-548ak	CLIP-seq
MIRT1076098	hsa-miR-548b-3p	CLIP-seq
MIRT1076099	hsa-miR-548b-5p	CLIP-seq
MIRT1076100	hsa-miR-548c-5p	CLIP-seq
MIRT1076101	hsa-miR-548d-5p	CLIP-seq
MIRT2250773	hsa-miR-548e	CLIP-seq
MIRT2250774	hsa-miR-548f	CLIP-seq
MIRT2250775	hsa-miR-548g	CLIP-seq
MIRT1076102	hsa-miR-548h	CLIP-seq
MIRT1076103	hsa-miR-548i	CLIP-seq
MIRT1076104	hsa-miR-548j	CLIP-seq
MIRT1076105	hsa-miR-548n	CLIP-seq
MIRT1076106	hsa-miR-548o	CLIP-seq
MIRT1076107	hsa-miR-548w	CLIP-seq
MIRT1076108	hsa-miR-548y	CLIP-seq
MIRT1076109	hsa-miR-552	CLIP-seq
MIRT1076110	hsa-miR-559	CLIP-seq
MIRT1076111	hsa-miR-568	CLIP-seq
MIRT2250776	hsa-miR-570	CLIP-seq
MIRT2018941	hsa-miR-580	CLIP-seq
MIRT1076113	hsa-miR-583	CLIP-seq
MIRT2018946	hsa-miR-656	CLIP-seq
MIRT2018948	hsa-miR-761	CLIP-seq
MIRT1076117	hsa-miR-769-5p	CLIP-seq
MIRT1076118	hsa-miR-802	CLIP-seq
MIRT2250777	hsa-miR-885-3p	CLIP-seq
MIRT2018903	hsa-miR-3140-5p	CLIP-seq
MIRT2018906	hsa-miR-3168	CLIP-seq
MIRT2018907	hsa-miR-3171	CLIP-seq
MIRT2018917	hsa-miR-3942-3p	CLIP-seq
MIRT2018918	hsa-miR-4252	CLIP-seq
MIRT2018920	hsa-miR-4438	CLIP-seq
MIRT2018928	hsa-miR-4680-3p	CLIP-seq
MIRT2018930	hsa-miR-4724-5p	CLIP-seq
MIRT2018939	hsa-miR-526b	CLIP-seq
MIRT2018941	hsa-miR-580	CLIP-seq
MIRT1076115	hsa-miR-642b	CLIP-seq
MIRT1076117	hsa-miR-769-5p	CLIP-seq
MIRT1076012	hsa-miR-1276	CLIP-seq
MIRT2018896	hsa-miR-139-5p	CLIP-seq
MIRT2430178	hsa-miR-3125	CLIP-seq
MIRT1076042	hsa-miR-338-5p	CLIP-seq
MIRT2430179	hsa-miR-3916	CLIP-seq
MIRT2018916	hsa-miR-3941	CLIP-seq
MIRT2018919	hsa-miR-4302	CLIP-seq
MIRT1076055	hsa-miR-4311	CLIP-seq
MIRT2018921	hsa-miR-4477a	CLIP-seq
MIRT2018922	hsa-miR-4503	CLIP-seq
MIRT2018924	hsa-miR-4643	CLIP-seq
MIRT2018925	hsa-miR-466	CLIP-seq
MIRT2430180	hsa-miR-4666-5p	CLIP-seq
MIRT2018927	hsa-miR-4672	CLIP-seq
MIRT2018931	hsa-miR-4774-5p	CLIP-seq
MIRT2018932	hsa-miR-4789-3p	CLIP-seq
MIRT2430181	hsa-miR-4789-5p	CLIP-seq
MIRT2430182	hsa-miR-550a	CLIP-seq
MIRT1076113	hsa-miR-583	CLIP-seq
MIRT2018944	hsa-miR-619	CLIP-seq
MIRT2018945	hsa-miR-648	CLIP-seq
MIRT1076020	hsa-miR-1587	CLIP-seq
MIRT2018903	hsa-miR-3140-5p	CLIP-seq
MIRT2018907	hsa-miR-3171	CLIP-seq
MIRT2018918	hsa-miR-4252	CLIP-seq
MIRT1076058	hsa-miR-4437	CLIP-seq
MIRT1076074	hsa-miR-4674	CLIP-seq
MIRT2018928	hsa-miR-4680-3p	CLIP-seq
MIRT2018930	hsa-miR-4724-5p	CLIP-seq
MIRT1076115	hsa-miR-642b	CLIP-seq
MIRT1076117	hsa-miR-769-5p	CLIP-seq
MIRT2554216	hsa-miR-1202	CLIP-seq
MIRT2554217	hsa-miR-1227	CLIP-seq
MIRT2554218	hsa-miR-1251	CLIP-seq
MIRT1076011	hsa-miR-125a-3p	CLIP-seq
MIRT2018894	hsa-miR-1263	CLIP-seq
MIRT1076012	hsa-miR-1276	CLIP-seq
MIRT2554219	hsa-miR-1297	CLIP-seq
MIRT2554220	hsa-miR-1304	CLIP-seq
MIRT2018896	hsa-miR-139-5p	CLIP-seq
MIRT2554221	hsa-miR-140-3p	CLIP-seq
MIRT1076020	hsa-miR-1587	CLIP-seq
MIRT2554222	hsa-miR-193a-5p	CLIP-seq
MIRT2554223	hsa-miR-23a	CLIP-seq
MIRT2554224	hsa-miR-23b	CLIP-seq
MIRT2554225	hsa-miR-23c	CLIP-seq
MIRT2554226	hsa-miR-26a	CLIP-seq
MIRT2554227	hsa-miR-26b	CLIP-seq
MIRT1076034	hsa-miR-3124-3p	CLIP-seq
MIRT2430178	hsa-miR-3125	CLIP-seq
MIRT2018903	hsa-miR-3140-5p	CLIP-seq
MIRT1076037	hsa-miR-3164	CLIP-seq
MIRT2018907	hsa-miR-3171	CLIP-seq
MIRT1076038	hsa-miR-3173-3p	CLIP-seq
MIRT2554228	hsa-miR-3194-5p	CLIP-seq
MIRT1076042	hsa-miR-338-5p	CLIP-seq
MIRT2554229	hsa-miR-3616-3p	CLIP-seq
MIRT2554230	hsa-miR-3653	CLIP-seq
MIRT2554231	hsa-miR-3658	CLIP-seq
MIRT2018912	hsa-miR-3674	CLIP-seq
MIRT2250765	hsa-miR-3681	CLIP-seq
MIRT2554232	hsa-miR-3682-3p	CLIP-seq
MIRT1076046	hsa-miR-3688-3p	CLIP-seq
MIRT1076047	hsa-miR-3692	CLIP-seq
MIRT2554233	hsa-miR-371-3p	CLIP-seq
MIRT2554234	hsa-miR-371b-3p	CLIP-seq
MIRT2430179	hsa-miR-3916	CLIP-seq
MIRT2018915	hsa-miR-3935	CLIP-seq
MIRT2018916	hsa-miR-3941	CLIP-seq
MIRT2018917	hsa-miR-3942-3p	CLIP-seq
MIRT2554235	hsa-miR-3972	CLIP-seq
MIRT1076051	hsa-miR-421	CLIP-seq
MIRT2018918	hsa-miR-4252	CLIP-seq
MIRT1076052	hsa-miR-4261	CLIP-seq
MIRT1076053	hsa-miR-4276	CLIP-seq
MIRT2018919	hsa-miR-4302	CLIP-seq
MIRT1076055	hsa-miR-4311	CLIP-seq
MIRT2554236	hsa-miR-4317	CLIP-seq
MIRT1076058	hsa-miR-4437	CLIP-seq
MIRT1076061	hsa-miR-4457	CLIP-seq
MIRT2554237	hsa-miR-4465	CLIP-seq
MIRT2018921	hsa-miR-4477a	CLIP-seq
MIRT2250768	hsa-miR-4494	CLIP-seq
MIRT2018922	hsa-miR-4503	CLIP-seq
MIRT1076065	hsa-miR-4511	CLIP-seq
MIRT1076066	hsa-miR-4520a-3p	CLIP-seq
MIRT1076067	hsa-miR-4520b-3p	CLIP-seq
MIRT1076068	hsa-miR-4529-3p	CLIP-seq
MIRT2554238	hsa-miR-455-5p	CLIP-seq
MIRT2018924	hsa-miR-4643	CLIP-seq
MIRT2018925	hsa-miR-466	CLIP-seq
MIRT2430180	hsa-miR-4666-5p	CLIP-seq
MIRT2018927	hsa-miR-4672	CLIP-seq
MIRT1076074	hsa-miR-4674	CLIP-seq
MIRT2018928	hsa-miR-4680-3p	CLIP-seq
MIRT2554239	hsa-miR-4684-3p	CLIP-seq
MIRT2554240	hsa-miR-4694-3p	CLIP-seq
MIRT1076077	hsa-miR-4709-5p	CLIP-seq
MIRT2554241	hsa-miR-4721	CLIP-seq
MIRT2018930	hsa-miR-4724-5p	CLIP-seq
MIRT1076080	hsa-miR-4773	CLIP-seq
MIRT2018931	hsa-miR-4774-5p	CLIP-seq
MIRT2018932	hsa-miR-4789-3p	CLIP-seq
MIRT2430181	hsa-miR-4789-5p	CLIP-seq
MIRT1076082	hsa-miR-495	CLIP-seq
MIRT2554242	hsa-miR-498	CLIP-seq
MIRT2250771	hsa-miR-499a-5p	CLIP-seq
MIRT2554243	hsa-miR-515-3p	CLIP-seq
MIRT2554244	hsa-miR-519e	CLIP-seq
MIRT1076093	hsa-miR-522	CLIP-seq
MIRT2250772	hsa-miR-548a-3p	CLIP-seq
MIRT1076094	hsa-miR-548a-5p	CLIP-seq
MIRT1076096	hsa-miR-548ab	CLIP-seq
MIRT2554245	hsa-miR-548ac	CLIP-seq
MIRT2554246	hsa-miR-548ae	CLIP-seq
MIRT2554247	hsa-miR-548aj	CLIP-seq
MIRT1076097	hsa-miR-548ak	CLIP-seq
MIRT2554248	hsa-miR-548am	CLIP-seq
MIRT1076098	hsa-miR-548b-3p	CLIP-seq
MIRT1076099	hsa-miR-548b-5p	CLIP-seq
MIRT1076100	hsa-miR-548c-5p	CLIP-seq
MIRT2554249	hsa-miR-548d-3p	CLIP-seq
MIRT1076101	hsa-miR-548d-5p	CLIP-seq
MIRT2250773	hsa-miR-548e	CLIP-seq
MIRT2250774	hsa-miR-548f	CLIP-seq
MIRT2250775	hsa-miR-548g	CLIP-seq
MIRT1076102	hsa-miR-548h	CLIP-seq
MIRT1076103	hsa-miR-548i	CLIP-seq
MIRT1076104	hsa-miR-548j	CLIP-seq
MIRT1076105	hsa-miR-548n	CLIP-seq
MIRT2554250	hsa-miR-548u	CLIP-seq
MIRT1076107	hsa-miR-548w	CLIP-seq
MIRT2554251	hsa-miR-548x	CLIP-seq
MIRT1076108	hsa-miR-548y	CLIP-seq
MIRT2554252	hsa-miR-548z	CLIP-seq
MIRT2430182	hsa-miR-550a	CLIP-seq
MIRT1076109	hsa-miR-552	CLIP-seq
MIRT1076110	hsa-miR-559	CLIP-seq
MIRT2250776	hsa-miR-570	CLIP-seq
MIRT1076113	hsa-miR-583	CLIP-seq
MIRT1076115	hsa-miR-642b	CLIP-seq
MIRT2018945	hsa-miR-648	CLIP-seq
MIRT1076116	hsa-miR-765	CLIP-seq
MIRT2554253	hsa-miR-767-5p	CLIP-seq
MIRT1076117	hsa-miR-769-5p	CLIP-seq
MIRT1076118	hsa-miR-802	CLIP-seq
MIRT2554254	hsa-miR-891b	CLIP-seq
MIRT2554218	hsa-miR-1251	CLIP-seq
MIRT1076011	hsa-miR-125a-3p	CLIP-seq
MIRT2018894	hsa-miR-1263	CLIP-seq
MIRT1076012	hsa-miR-1276	CLIP-seq
MIRT2554219	hsa-miR-1297	CLIP-seq
MIRT2018896	hsa-miR-139-5p	CLIP-seq
MIRT2554221	hsa-miR-140-3p	CLIP-seq
MIRT1076020	hsa-miR-1587	CLIP-seq
MIRT2554222	hsa-miR-193a-5p	CLIP-seq
MIRT2554223	hsa-miR-23a	CLIP-seq
MIRT2554224	hsa-miR-23b	CLIP-seq
MIRT2554225	hsa-miR-23c	CLIP-seq
MIRT2554226	hsa-miR-26a	CLIP-seq
MIRT2554227	hsa-miR-26b	CLIP-seq
MIRT1076034	hsa-miR-3124-3p	CLIP-seq
MIRT2430178	hsa-miR-3125	CLIP-seq
MIRT2018903	hsa-miR-3140-5p	CLIP-seq
MIRT1076037	hsa-miR-3164	CLIP-seq
MIRT2018907	hsa-miR-3171	CLIP-seq
MIRT1076038	hsa-miR-3173-3p	CLIP-seq
MIRT1076042	hsa-miR-338-5p	CLIP-seq
MIRT2018912	hsa-miR-3674	CLIP-seq
MIRT2250765	hsa-miR-3681	CLIP-seq
MIRT2554232	hsa-miR-3682-3p	CLIP-seq
MIRT1076046	hsa-miR-3688-3p	CLIP-seq
MIRT1076047	hsa-miR-3692	CLIP-seq
MIRT2554233	hsa-miR-371-3p	CLIP-seq
MIRT2554234	hsa-miR-371b-3p	CLIP-seq
MIRT2430179	hsa-miR-3916	CLIP-seq
MIRT2018915	hsa-miR-3935	CLIP-seq
MIRT2018916	hsa-miR-3941	CLIP-seq
MIRT2018917	hsa-miR-3942-3p	CLIP-seq
MIRT1076051	hsa-miR-421	CLIP-seq
MIRT2018918	hsa-miR-4252	CLIP-seq
MIRT1076052	hsa-miR-4261	CLIP-seq
MIRT1076053	hsa-miR-4276	CLIP-seq
MIRT2018919	hsa-miR-4302	CLIP-seq
MIRT1076055	hsa-miR-4311	CLIP-seq
MIRT2554236	hsa-miR-4317	CLIP-seq
MIRT1076058	hsa-miR-4437	CLIP-seq
MIRT1076061	hsa-miR-4457	CLIP-seq
MIRT2554237	hsa-miR-4465	CLIP-seq
MIRT2018921	hsa-miR-4477a	CLIP-seq
MIRT2250768	hsa-miR-4494	CLIP-seq
MIRT2018922	hsa-miR-4503	CLIP-seq
MIRT1076066	hsa-miR-4520a-3p	CLIP-seq
MIRT1076067	hsa-miR-4520b-3p	CLIP-seq
MIRT1076068	hsa-miR-4529-3p	CLIP-seq
MIRT2018924	hsa-miR-4643	CLIP-seq
MIRT2018925	hsa-miR-466	CLIP-seq
MIRT2430180	hsa-miR-4666-5p	CLIP-seq
MIRT2018927	hsa-miR-4672	CLIP-seq
MIRT1076074	hsa-miR-4674	CLIP-seq
MIRT2018928	hsa-miR-4680-3p	CLIP-seq
MIRT2554239	hsa-miR-4684-3p	CLIP-seq
MIRT2554240	hsa-miR-4694-3p	CLIP-seq
MIRT1076077	hsa-miR-4709-5p	CLIP-seq
MIRT2018930	hsa-miR-4724-5p	CLIP-seq
MIRT2018932	hsa-miR-4789-3p	CLIP-seq
MIRT2430181	hsa-miR-4789-5p	CLIP-seq
MIRT1076082	hsa-miR-495	CLIP-seq
MIRT2554242	hsa-miR-498	CLIP-seq
MIRT2250771	hsa-miR-499a-5p	CLIP-seq
MIRT2554243	hsa-miR-515-3p	CLIP-seq
MIRT2554244	hsa-miR-519e	CLIP-seq
MIRT1076093	hsa-miR-522	CLIP-seq
MIRT2250772	hsa-miR-548a-3p	CLIP-seq
MIRT1076094	hsa-miR-548a-5p	CLIP-seq
MIRT1076096	hsa-miR-548ab	CLIP-seq
MIRT2554245	hsa-miR-548ac	CLIP-seq
MIRT2554246	hsa-miR-548ae	CLIP-seq
MIRT2554247	hsa-miR-548aj	CLIP-seq
MIRT1076097	hsa-miR-548ak	CLIP-seq
MIRT2554248	hsa-miR-548am	CLIP-seq
MIRT1076099	hsa-miR-548b-5p	CLIP-seq
MIRT1076100	hsa-miR-548c-5p	CLIP-seq
MIRT2554249	hsa-miR-548d-3p	CLIP-seq
MIRT1076101	hsa-miR-548d-5p	CLIP-seq
MIRT2250773	hsa-miR-548e	CLIP-seq
MIRT2250774	hsa-miR-548f	CLIP-seq
MIRT2250775	hsa-miR-548g	CLIP-seq
MIRT1076102	hsa-miR-548h	CLIP-seq
MIRT1076103	hsa-miR-548i	CLIP-seq
MIRT1076104	hsa-miR-548j	CLIP-seq
MIRT1076105	hsa-miR-548n	CLIP-seq
MIRT2554250	hsa-miR-548u	CLIP-seq
MIRT1076107	hsa-miR-548w	CLIP-seq
MIRT2554251	hsa-miR-548x	CLIP-seq
MIRT1076108	hsa-miR-548y	CLIP-seq
MIRT2554252	hsa-miR-548z	CLIP-seq
MIRT2430182	hsa-miR-550a	CLIP-seq
MIRT1076109	hsa-miR-552	CLIP-seq
MIRT1076110	hsa-miR-559	CLIP-seq
MIRT2250776	hsa-miR-570	CLIP-seq
MIRT1076113	hsa-miR-583	CLIP-seq
MIRT1076115	hsa-miR-642b	CLIP-seq
MIRT2018945	hsa-miR-648	CLIP-seq
MIRT1076116	hsa-miR-765	CLIP-seq
MIRT2554253	hsa-miR-767-5p	CLIP-seq
MIRT1076117	hsa-miR-769-5p	CLIP-seq
MIRT1076118	hsa-miR-802	CLIP-seq
MIRT2554254	hsa-miR-891b	CLIP-seq

Show/Hide all (1)

Transcription factor	Regulation	Reference
BRCA1	Unknown	11163768

Show/Hide all (96)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004713	Function	Protein tyrosine kinase activity	EXP	1386289, 9446616, 10825200, 31892268
GO:0004713	Function	Protein tyrosine kinase activity	IC	7543512
GO:0004713	Function	Protein tyrosine kinase activity	IDA	7532278, 7929391, 7973659, 8272873, 8756628, 10702271, 15226449
GO:0004713	Function	Protein tyrosine kinase activity	IEA
GO:0004713	Function	Protein tyrosine kinase activity	TAS	1848670
GO:0004715	Function	Non-membrane spanning protein tyrosine kinase activity	IBA
GO:0004715	Function	Non-membrane spanning protein tyrosine kinase activity	IDA	7657660, 8232552
GO:0004715	Function	Non-membrane spanning protein tyrosine kinase activity	IEA
GO:0004715	Function	Non-membrane spanning protein tyrosine kinase activity	TAS	8232552, 34813358
GO:0005131	Function	Growth hormone receptor binding	IBA
GO:0005131	Function	Growth hormone receptor binding	IEA
GO:0005131	Function	Growth hormone receptor binding	ISS	10502458
GO:0005515	Function	Protein binding	IPI	7759950, 16273093, 16710296, 21220115, 21679692, 25065853, 26175413, 28514442, 32953130, 33961781, 34950606, 35512704
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IDA	10502458
GO:0005737	Component	Cytoplasm	IC	7532278
GO:0005737	Component	Cytoplasm	IDA	10502458
GO:0005768	Component	Endosome	IEA
GO:0005768	Component	Endosome	TAS
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IC	10702271
GO:0005886	Component	Plasma membrane	TAS	34813358
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IDA	9020188, 28753426
GO:0006468	Process	Protein phosphorylation	IMP	28111307, 32750333
GO:0006468	Process	Protein phosphorylation	TAS	1848670
GO:0007259	Process	Cell surface receptor signaling pathway via JAK-STAT	IBA
GO:0007259	Process	Cell surface receptor signaling pathway via JAK-STAT	IDA	7526154, 7657660, 7759950, 8272873, 8605876, 23139419, 28753426
GO:0007259	Process	Cell surface receptor signaling pathway via JAK-STAT	IDA	7657660, 8232552, 8272873
GO:0007259	Process	Cell surface receptor signaling pathway via JAK-STAT	IEA
GO:0007259	Process	Cell surface receptor signaling pathway via JAK-STAT	IMP	28111307, 32750333
GO:0007259	Process	Cell surface receptor signaling pathway via JAK-STAT	NAS	12574355
GO:0007259	Process	Cell surface receptor signaling pathway via JAK-STAT	TAS	8232552
GO:0009898	Component	Cytoplasmic side of plasma membrane	IDA	8272873
GO:0012505	Component	Endomembrane system	IEA
GO:0016020	Component	Membrane	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0019221	Process	Cytokine-mediated signaling pathway	IBA
GO:0019221	Process	Cytokine-mediated signaling pathway	IEA
GO:0019221	Process	Cytokine-mediated signaling pathway	TAS
GO:0019903	Function	Protein phosphatase binding	IPI	11909529
GO:0022407	Process	Regulation of cell-cell adhesion	IEA
GO:0030154	Process	Cell differentiation	IBA
GO:0030154	Process	Cell differentiation	IDA	28781374
GO:0031234	Component	Extrinsic component of cytoplasmic side of plasma membrane	IC	7543512, 7929391, 7973659, 8272873, 8756628
GO:0031234	Component	Extrinsic component of cytoplasmic side of plasma membrane	IDA	7973659
GO:0031234	Component	Extrinsic component of cytoplasmic side of plasma membrane	IEA
GO:0031625	Function	Ubiquitin protein ligase binding	IPI	24882218
GO:0031730	Function	CCR5 chemokine receptor binding	IEA
GO:0034112	Process	Positive regulation of homotypic cell-cell adhesion	IMP	21679692
GO:0035556	Process	Intracellular signal transduction	IBA
GO:0035556	Process	Intracellular signal transduction	IEA
GO:0035556	Process	Intracellular signal transduction	TAS	8232552
GO:0035723	Process	Interleukin-15-mediated signaling pathway	IDA	7568001
GO:0035723	Process	Interleukin-15-mediated signaling pathway	IDA	7568001
GO:0035771	Process	Interleukin-4-mediated signaling pathway	IDA	7760829
GO:0035771	Process	Interleukin-4-mediated signaling pathway	IDA	7929391
GO:0035771	Process	Interleukin-4-mediated signaling pathway	NAS	12574355
GO:0038110	Process	Interleukin-2-mediated signaling pathway	IDA	7568005
GO:0038110	Process	Interleukin-2-mediated signaling pathway	IDA	7973659, 11909529
GO:0038110	Process	Interleukin-2-mediated signaling pathway	TAS
GO:0038111	Process	Interleukin-7-mediated signaling pathway	IC	20974963
GO:0038111	Process	Interleukin-7-mediated signaling pathway	IDA	29202461
GO:0038113	Process	Interleukin-9-mediated signaling pathway	IDA	9535918
GO:0038113	Process	Interleukin-9-mediated signaling pathway	IDA	8756628
GO:0038154	Process	Interleukin-11-mediated signaling pathway	IDA	28781374
GO:0038154	Process	Interleukin-11-mediated signaling pathway	IDA	8272872
GO:0038196	Process	Type III interferon-mediated signaling pathway	NAS	30936491
GO:0043235	Component	Receptor complex	IPI	21854986
GO:0046677	Process	Response to antibiotic	IDA	16280321
GO:0046872	Function	Metal ion binding	IEA
GO:0051239	Process	Regulation of multicellular organismal process	IEA
GO:0060333	Process	Type II interferon-mediated signaling pathway	IDA	8232552
GO:0060333	Process	Type II interferon-mediated signaling pathway	NAS	15864272
GO:0060333	Process	Type II interferon-mediated signaling pathway	TAS
GO:0060337	Process	Type I interferon-mediated signaling pathway	IDA	7532278, 8232552
GO:0060337	Process	Type I interferon-mediated signaling pathway	IMP	23391734
GO:0060337	Process	Type I interferon-mediated signaling pathway	NAS	30936491
GO:0060337	Process	Type I interferon-mediated signaling pathway	TAS
GO:0060397	Process	Growth hormone receptor signaling pathway via JAK-STAT	IBA
GO:0070102	Process	Interleukin-6-mediated signaling pathway	IDA	8272873
GO:0070102	Process	Interleukin-6-mediated signaling pathway	TAS
GO:0072540	Process	T-helper 17 cell lineage commitment	TAS	27893700
GO:0072540	Process	T-helper 17 cell lineage commitment	TAS	27893700
GO:0098586	Process	Cellular response to virus	NAS	15864272, 30936491
GO:0098761	Process	Cellular response to interleukin-7	IEA
GO:0140105	Process	Interleukin-10-mediated signaling pathway	IDA	7543512
GO:0140105	Process	Interleukin-10-mediated signaling pathway	IDA	7543512
GO:0150105	Process	Protein localization to cell-cell junction	IMP	21679692
GO:1900182	Process	Positive regulation of protein localization to nucleus	IDA	8605876, 26479788
GO:1900182	Process	Positive regulation of protein localization to nucleus	IDA	26479788
GO:1903672	Process	Positive regulation of sprouting angiogenesis	IGI	20299512

MIM	HGNC	e!Ensembl
147795	6190	ENSG00000162434

P23458

Protein name

Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1)

Protein function

Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway (PubMed:16239216, PubMed:28111307, PubMed:32750333, PubMed:7615558, PubMed:8232552). Kinase partner for the interleukin (IL)-2 receptor (PubMed:1190952

PDB

3EYG , 3EYH , 4E4L , 4E4N , 4E5W , 4EHZ , 4EI4 , 4FK6 , 4GS0 , 4I5C , 4IVB , 4IVC , 4IVD , 4K6Z , 4K77 , 4L00 , 4L01 , 5E1E , 5HX8 , 5IXD , 5IXI , 5KHW , 5KHX , 5L04 , 5WO4 , 6AAH , 6BBU , 6C7Y , 6DBN , 6ELR , 6GGH , 6HZU , 6N77 , 6N78 , 6N79 , 6N7A , 6N7B , 6N7C , 6N7D , 6RSB , 6RSC , 6RSD , 6RSE , 6RSH , 6SM8 , 6SMB , 6TPE , 6TPF , 6W8L , 8EXJ , 8S85

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF18379	FERM_F1	36 → 129	FERM F1 ubiquitin-like domain	Domain
PF18377	FERM_F2	147 → 277	FERM F2 acyl-CoA binding protein-like domain	Domain
PF17887	Jak1_Phl	284 → 421	Jak1 pleckstrin homology-like domain	Domain
PF07714	PK_Tyr_Ser-Thr	583 → 845	Protein tyrosine and serine/threonine kinase	Domain
PF07714	PK_Tyr_Ser-Thr	875 → 1149	Protein tyrosine and serine/threonine kinase	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue. {ECO:0000269|PubMed:7896447}.

Sequence

MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEEL
CIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTN
DNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQ
DGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRI
NNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMN
WFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIR
EEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAH
HYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVT
CFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFML
KRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSG
TLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRD
VENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNL
LLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFG
TTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRA
IMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDN
TGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLP
SGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIG
DFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDS
DSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRT
SFQNLIEGFEALLK

Sequence length

1154

Interactions

View interactions

	KEGG		Reactome
	EGFR tyrosine kinase inhibitor resistance PI3K-Akt signaling pathway Necroptosis Osteoclast differentiation Signaling pathways regulating pluripotency of stem cells Toll-like receptor signaling pathway NOD-like receptor signaling pathway JAK-STAT signaling pathway Th1 and Th2 cell differentiation Th17 cell differentiation Leishmaniasis Toxoplasmosis Tuberculosis Hepatitis C Hepatitis B Measles Human cytomegalovirus infection Influenza A Human papillomavirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Coronavirus disease - COVID-19 Pathways in cancer Viral carcinogenesis Pancreatic cancer PD-L1 expression and PD-1 checkpoint pathway in cancer		Interleukin-6 signaling MAPK3 (ERK1) activation MAPK1 (ERK2) activation ISG15 antiviral mechanism Interleukin-7 signaling Other interleukin signaling RAF/MAP kinase cascade Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling IL-6-type cytokine receptor ligand interactions Interferon gamma signaling Regulation of IFNG signaling Interleukin-20 family signaling Interleukin-15 signaling Interleukin-35 Signalling Interleukin-9 signaling Interleukin-2 signaling Interleukin-12 signaling Interleukin-27 signaling Interleukin-21 signaling Interferon alpha/beta signaling Interleukin receptor SHC signaling Regulation of IFNA signaling

Show/Hide Causal Diseases (2)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Acute megakaryoblastic leukemia in down syndrome	Likely pathogenic	rs1655079234	RCV001293764
Autoinflammation, immune dysregulation, and eosinophilia	Pathogenic; Likely pathogenic	rs2524099521, rs869312953, rs1655173102	RCV002280062 RCV001255134 RCV001255135

Show/Hide Unknown Diseases (18)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
-	no classification for the single variant	rs760807400	-
Acute myeloid leukemia	Uncertain significance	rs764565978	RCV005924326
Adrenocortical carcinoma, hereditary	Benign	rs3737139	RCV005914309
Autosomal recessive mendelian susceptibility to mycobacterial diseases due to partial jak1 deficiency	Uncertain significance	rs779408869	RCV005429067
Cholangiocarcinoma	Benign	rs3737139, rs2230587	RCV005914314 RCV005909571
Colon adenocarcinoma	Benign	rs3737139	RCV005914307
Colorectal cancer	Benign	rs3737139	RCV005914311
Gastric cancer	Benign	rs201443299	RCV005914087
Hepatocellular carcinoma	Benign	rs2254002	RCV005927807
Inflammatory myofibroblastic tumor	-	rs1057519753	RCV006255007
JAK1-related disorder	Likely benign; Benign; Conflicting classifications of pathogenicity; Uncertain significance	rs371739901, rs3737139, rs2230587, rs17127063, rs2230586, rs201443299, rs140703760, rs11585932, rs758758044, rs187043211, rs373142876, rs770735783, rs553794700, rs544541009, rs565648053 View all (15 more)	RCV003938810 RCV003980531 RCV003983951 RCV003966129 RCV003980532 RCV003948504 RCV003908861 RCV003983934 RCV003941247 RCV003925194 RCV004752113 RCV003416519 RCV003893225 RCV003978572 RCV003933422 RCV003933423 RCV003926671 RCV003943432 RCV004750764 RCV003963511 RCV003399797 RCV003412049 RCV003427959 RCV003399854 RCV003892248 RCV003962194 RCV003915812 RCV003948341 RCV003923239 RCV003973194
Malignant lymphoma, large B-cell, diffuse	Benign	rs3737139, rs2230587, rs2254002, rs1129739	RCV005914310 RCV005909570 RCV005927808 RCV005903041
Malignant tumor of esophagus	Benign	rs149442739, rs1129739	RCV005935054 RCV005903040
Nonpapillary renal cell carcinoma	Benign; Likely benign	rs3737139, rs762097420	RCV005914308 RCV005926728
Sarcoma	Benign	rs3737139	RCV005914312
Thymoma	Benign	rs3737139	RCV005914313
Thyroid cancer, nonmedullary, 1	Benign	rs1129739	RCV005903042
Uterine corpus endometrial carcinoma	Benign; Uncertain significance	rs3737139, rs1655869190	RCV005914315 RCV005926820

Show/Hide Text Mining Associations (157)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Acute erythroleukemia	Associate	37565053
Adenocarcinoma of Lung	Associate	26840709, 34587898, 37640192
Adenocarcinoma of Lung	Inhibit	33323549
Adenoma Pleomorphic	Associate	27286739
Aicardi Goutieres syndrome	Associate	37171742
Allergic Fungal Sinusitis	Stimulate	30657646
Anemia	Inhibit	27789678
Anemia Aplastic	Associate	35590143
Anophthalmia with pulmonary hypoplasia	Associate	26586478
Arthralgia	Associate	37343845
Arthritis	Associate	29530480
Arthritis Juvenile	Associate	29530480
Arthritis Rheumatoid	Associate	23968543, 25398374, 31181818, 33950229, 34521259, 38272919, 39724808
Asthma	Associate	40604958
Astrocytoma	Stimulate	20052595
Ataxia Telangiectasia	Associate	21551237, 27602765
Atherosclerosis	Associate	28334721
Autoimmune Diseases	Associate	16239216, 34745118, 34845259
Axial Spondyloarthritis	Associate	33950229
Behcet Syndrome	Associate	25410656
Bipolar Disorder	Associate	37713898
Breast Neoplasms	Associate	25104439, 29436642, 31790361, 34572592, 35441810, 35575798, 37779428
Carcinogenesis	Associate	33323549, 36376931
Carcinoma Hepatocellular	Associate	22930530, 23788652, 29628508, 29805309, 31560893, 31852247, 32705212, 35504805, 35710093
Carcinoma Non Small Cell Lung	Associate	10612755, 22319590, 28729401, 37838086
Carcinoma Renal Cell	Associate	17573897, 26911335, 36775874
Castleman Disease	Associate	28241173
Cerebral Infarction	Associate	32960689
Chemical and Drug Induced Liver Injury	Associate	32054011
Colonic Neoplasms	Associate	8530527
Colorectal Neoplasms	Associate	18320073, 27546461, 27903500, 28539123, 29641532, 30670049, 31783811, 35343934, 38001065, 39456850
COVID 19	Associate	32513989, 35842705, 36693535
Coxa Magna	Associate	38204239
Dermatitis Atopic	Stimulate	27711196
Dermatitis Atopic	Associate	37343845
Diabetes Mellitus Type 2	Associate	34589546
Diabetic Nephropathies	Associate	32096183
Diarrhea	Associate	37343845
Disease	Associate	33579790, 40496858
Disease Progression	Associate	35698045
Down Syndrome	Associate	27472900
Drug Hypersensitivity	Associate	27007833, 37343845
Dyslipidemias	Inhibit	28316372
Endometrial Neoplasms	Associate	24154688, 27213585, 29121062, 30816518, 35262923, 35849120
Endometrial Neoplasms	Inhibit	36376931
Enteropathy Associated T Cell Lymphoma	Associate	33579790
Eosinophilia	Associate	34496019, 37343845, 38563187
Fasciitis	Associate	34381187
Fibrosarcoma	Associate	15883164, 16237089, 7537214, 9794795
Fibrosis	Associate	32096183, 35288649
Gastrointestinal Diseases	Associate	37343845
Genital Neoplasms Female	Associate	24154688
Glioblastoma	Associate	32629176
Glucosephosphate Dehydrogenase Deficiency	Associate	27213585, 36376931
Glycosuria Renal	Associate	32096183
Hematologic Neoplasms	Associate	36669486
Hepatitis C Chronic	Associate	28704535
Hereditary Autoinflammatory Diseases	Associate	29649002, 32750333, 37343845
Hereditary Breast and Ovarian Cancer Syndrome	Associate	12032322, 33331925
Hodgkin Disease	Associate	29650799
Hypereosinophilic Syndrome	Associate	38563187
Hypersensitivity Immediate	Stimulate	20052595
Hypertrophy	Associate	16920889
Hypoxia	Associate	29459227, 29693186
Ichthyosis	Associate	37343845
Ige Responsiveness Atopic	Associate	37343845
Immune Dysregulation Polyendocrinopathy Enteropathy X Linked Syndrome	Associate	33864888
Immunoglobulin G4 Related Disease	Associate	32733444
Immunologic Deficiency Syndromes	Associate	28008925
Infections	Associate	31552026
Inflammation	Associate	28334721, 29530480, 30571852, 33297736, 33495298, 33950229, 34155623, 34286840, 34324169, 35908591, 36418348, 36918905, 37342057, 37343845
Inflammation	Stimulate	33902571
Inflammatory Bowel Diseases	Associate	34042156, 36437465
Keloid	Associate	33662027
Leukemia	Associate	23733339, 34324169, 36418348
Leukemia B Cell	Associate	27799566
Leukemia Myelogenous Chronic BCR ABL Positive	Associate	27793879
Leukemia Myeloid Acute	Associate	18270328, 27903959, 34324169
Leukemia Prolymphocytic T Cell	Associate	24825865
Leukemia T Cell	Associate	24013208
Lichen Planus	Associate	27711196
Lung Neoplasms	Associate	24833526
Lupus Erythematosus Systemic	Associate	22859983, 34745118
Lupus Nephritis	Associate	34745118
Lymphoma B Cell	Associate	31292115, 33994432
Lymphoma Large B Cell Diffuse	Associate	27799566, 28031410, 29295936, 29895903
Lymphoma T Cell	Associate	32767332
Lymphoma T Cell Cutaneous	Associate	24523507
Lymphoma T Cell Peripheral	Associate	34653242
Lymphoproliferative Disorders	Associate	31655559
Mastocytosis Systemic	Associate	37171742
Medulloblastoma	Stimulate	35159191
Melanoma	Associate	16741510, 27903500, 28561041
Melanoma Cutaneous Malignant	Associate	29641532
Mental Disorders	Associate	37713898
Microcystic adnexal carcinoma	Associate	31857679
Microsatellite Instability	Associate	28539123, 37838086
Multi centric Castleman's Disease	Associate	32206779
Multiple Myeloma	Associate	11986233
Multiple Sclerosis	Associate	28892075
Mycobacterium Infections Nontuberculous	Associate	28008925
Myeloproliferative Syndrome Transient	Associate	23733339
Nasopharyngeal Carcinoma	Associate	30849642, 36213586
Neoplasm Metastasis	Associate	36213586
Neoplasms	Associate	16239216, 17021139, 17603634, 18025156, 18320073, 22084247, 22684105, 24154688, 24293293, 24833526, 25824483, 26491227, 27213585, 27433843, 27903500 View all (28 more)
Neoplasms	Inhibit	36376931
Nephrotic Syndrome	Associate	27997540
Neural Tube Defects	Associate	38563187
Neuritis Autoimmune Experimental	Associate	37713206
Neuroendocrine Tumors	Associate	36307579
Non alcoholic Fatty Liver Disease	Associate	37861538
Non Muscle Invasive Bladder Neoplasms	Associate	39986350
Obesity	Inhibit	29737494
Osteoarthritis	Associate	33297736
Ovarian Diseases	Associate	16815388
Ovarian Neoplasms	Associate	34626802, 35820543, 37151134, 38143770
Pancreatic Neoplasms	Associate	24293293, 26586478
Pancreatitis	Associate	26215634
Papillomavirus Infections	Associate	37461056
Paroxysmal ventricular fibrillation	Associate	35271300
Pdgfra Associated Chronic Eosinophilic Leukemia	Associate	34496019
Plasmablastic Lymphoma	Associate	33225311
Pneumocephalus	Associate	29895903
Polycythemia Vera	Associate	16239216, 28674362, 38563187
Precancerous Conditions	Associate	36213586
Precursor Cell Lymphoblastic Leukemia Lymphoma	Associate	27997540, 28245838, 28408464
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	20868368, 21551237, 21880637, 22237106, 27602765
Primary Immunodeficiency Diseases	Associate	31552026
Primary Myelofibrosis	Associate	27789678, 34324169
Prostatic Neoplasms	Associate	10514409, 10660600, 27366948, 29641532, 32592689, 34322995
Prostatic Neoplasms Castration Resistant	Associate	29693186
Prostatitis	Associate	10660600, 27366948
Psoriasis	Associate	27711196, 31972249
Pyoderma Gangrenosum	Stimulate	27711196
Renal Insufficiency	Associate	36546418
Rhinitis Allergic	Associate	27007833
Scleroderma Localized	Associate	37471168
Severe Acute Respiratory Syndrome	Stimulate	33902571
Sezary Syndrome	Associate	26415585
Smoke Inhalation Injury	Associate	37011378
Specific Language Disorder	Inhibit	31940699
Splenomegaly	Inhibit	27789678
Squamous Cell Carcinoma of Head and Neck	Associate	28236344
Stomach Neoplasms	Associate	27049718, 29121062, 37511629
Stomach Neoplasms	Stimulate	27049718
Tertiary Lymphoid Structures	Associate	31790361
Thrombocytopenia	Stimulate	27789678
Thyroid Cancer Papillary	Associate	30278442
Thyroid Carcinoma Anaplastic	Associate	32554601
Thyroid Neoplasms	Associate	37897947, 38275291
Turcot syndrome	Associate	37838086
Urinary Bladder Neoplasms	Associate	28008925, 28770966, 31552026, 39986350
Uveitis	Associate	29530480, 37713206
Vasculitis Leukocytoclastic Cutaneous	Associate	37171742
Weight Loss	Stimulate	29737494
Wells syndrome	Associate	37342057
X Linked Combined Immunodeficiency Diseases	Associate	8605323, 9054429

JAK1 (Janus kinase 1)