Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3707
Gene name Gene Name - the full gene name approved by the HGNC.
Inositol-trisphosphate 3-kinase B
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ITPKB
Synonyms (NCBI Gene) Gene synonyms aliases
IP3-3KB, IP3K, IP3K-B, IP3KB, PIG37
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1q42.12
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this protein regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of this encoded protein is responsible for regulating the levels of a large num
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT047075 hsa-miR-183-5p CLASH 23622248
MIRT045004 hsa-miR-186-5p CLASH 23622248
MIRT719365 hsa-miR-941 HITS-CLIP 19536157
MIRT719364 hsa-miR-3914 HITS-CLIP 19536157
MIRT719363 hsa-miR-873-5p HITS-CLIP 19536157
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000165 Process MAPK cascade IEA
GO:0000828 Function Inositol hexakisphosphate kinase activity IBA 21873635
GO:0001932 Process Regulation of protein phosphorylation IEA
GO:0002262 Process Myeloid cell homeostasis IEA
GO:0005515 Function Protein binding IPI 21516116, 23060452, 25416956, 32296183
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
147522 6179 ENSG00000143772
Protein
UniProt ID P27987
Protein name Inositol-trisphosphate 3-kinase B (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase B) (IP3 3-kinase B) (IP3K B) (InsP 3-kinase B)
Protein function Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis. {ECO:0000269|PubMed:11846419, ECO:0000269|PubMed:12747803, ECO
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03770 IPK 726 937 Inositol polyphosphate kinase Family
Sequence
MAVYCYALNSLVIMNSANEMKSGGGPGPSGSETPPPPRRAVLSPGSVFSPGRGASFLFPP
AESLSPEEPRSPGGWRSGRRRLNSSSGSGSGSSGSSVSSPSWAGRLRGDRQQVVAAGTLS
PPGPEEAKRKLRILQRELQNVQVNQKVGMFEAHIQAQSSAIQAPRSPRLGRARSPSPCPF
RSSSQPPGRVLVQGARSEERRTKSWGEQCPETSGTDSGRKGGPSLCSSQVKKGMPPLPGR
AAPTGSEAQGPSAFVRMEKGIPASPRCGSPTAMEIDKRGSPTPGTRSCLAPSLGLFGASL
TMATEVAARVTSTGPHRPQDLALTEPSGRARELEDLQPPEALVERQGQFLGSETSPAPER
GGPRDGEPPGKMGKGYLPCGMPGSGEPEVGKRPEETTVSVQSAESSDSLSWSRLPRALAS
VGPEEARSGAPVGGGRWQLSDRVEGGSPTLGLLGGSPSAQPGTGNVEAGIPSGRMLEPLP
CWDAAKDLKEPQCPPGDRVGVQPGNSRVWQGTMEKAGLAWTRGTGVQSEGTWESQRQDSD
ALPSPELLPQDPDKPFLRKACSPSNIPAVIITDMGTQEDGALEETQGSPRGNLPLRKLSS
SSASSTGFSSSYEDSEEDISSDPERTLDPNSAFLHTLDQQKPRVSKSWRKIKNMVHWSPF
VMSFKKKYPWIQLAGHAGSFKAAANGRILKKHCESEQRCLDRLMVDVLRPFVPAYHGDVV
KDGERYNQMDDLLADFDSPCVMDCKMGIRTYLEEELTKARKKPSLRKDMYQKMIEVDPEA
PTEEEKAQRAVTKPRYMQWRETISSTATLGFRIEGIKKEDGTVNRDFKKTKTREQVTEAF
REFTKGNHNILIAYRDRLKAIRTTLEVSPFFKCHEVIGSSLLFIHDKKEQAKVWMIDFGK
TTPLPEGQTLQHDVPWQEGNREDGYLSGLNNLVDILT
EMSQDAPLA
Sequence length 946
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Inositol phosphate metabolism
Metabolic pathways
Calcium signaling pathway
Phosphatidylinositol signaling system
  Synthesis of IP3 and IP4 in the cytosol
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Parkinson disease Parkinson Disease rs33939927, rs35801418, rs34805604, rs35870237, rs34995376, rs74315355, rs28940284, rs74315356, rs74315357, rs28940285, rs730880302, rs750664040, rs74315359, rs74315360, rs45539432
View all (84 more)
28892059
Unknown
Disease term Disease name Evidence References Source
Parkinson Disease Parkinson Disease GWAS
Hyperopia Hyperopia GWAS
Asthma Asthma GWAS
Dental caries Dental caries GWAS
Associations from Text Mining
Disease Name Relationship Type References
Autism Spectrum Disorder Associate 37407249
Carcinoma Renal Cell Associate 34598322
Carcinoma Small Cell Associate 26642205
Drug Related Side Effects and Adverse Reactions Associate 36768321
Hereditary Breast and Ovarian Cancer Syndrome Associate 35937947
Hodgkin Disease Associate 29650799, 31822802, 32079702
Lupus Erythematosus Systemic Associate 34084162
Lymphoma Associate 36306325
Lymphoma B Cell Associate 26819451
Lymphoma Large B Cell Diffuse Associate 33684939