ITGB8 (integrin subunit beta 8)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 3696 |
| Gene name | Integrin subunit beta 8 |
| Gene symbol | ITGB8 |
| Synonyms (NCBI Gene) |
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| Chromosome | 7 |
| Chromosome location | 7p21.1 |
| Summary | This gene is a member of the integrin beta chain family and encodes a single-pass type I membrane protein with a VWFA domain and four cysteine-rich repeats. This protein noncovalently binds to an alpha subunit to form a heterodimeric integrin complex. In |
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miRNA
miRNA information provided by mirtarbase database.
893
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Transcription factors
Transcription factors information provided by TRRUST V2 database.
2
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
39
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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P26012 | ||||||||||||||||||||
| Protein name | Integrin beta-8 | ||||||||||||||||||||
| Protein function | Integrin alpha-V:beta-8 (ITGAV:ITGB8) is a receptor for fibronectin (PubMed:1918072). It recognizes the sequence R-G-D in its ligands (PubMed:1918072). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth | ||||||||||||||||||||
| PDB | 6DJP , 6OM1 , 6OM2 , 6UJA , 6UJB , 6UJC , 7Y1T , 8TCF , 8VS6 , 8VSD , 9IND | ||||||||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Placenta, kidney, brain, ovary, uterus and in several transformed cells. Transiently expressed in 293 human embryonic kidney cells. {ECO:0000269|PubMed:1918072}. | ||||||||||||||||||||
| Sequence |
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| Sequence length | 769 | ||||||||||||||||||||
| Interactions | View interactions | ||||||||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
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