Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	369
Gene name	A-Raf proto-oncogene, serine/threonine kinase
Gene symbol	ARAF
Synonyms (NCBI Gene)	A-RAFARAF1PKS2RAFA1
Chromosome	X
Chromosome location	Xp11.3
Summary	This proto-oncogene belongs to the RAF subfamily of the Ser/Thr protein kinase family, and maybe involved in cell growth and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefS

Show/Hide all (2)

SNP ID	Visualize variation	Clinical significance	Consequence
rs1057519786	C>G,T	Not-provided, likely-pathogenic	Missense variant, coding sequence variant, genic downstream transcript variant
rs1057519876	T>G	Likely-pathogenic	Missense variant, coding sequence variant, genic downstream transcript variant

130

Show/Hide all (130)

miRTarBase ID	miRNA	Experiments	Reference
MIRT004929	hsa-miR-124-3p	Microarray	15685193
MIRT004929	hsa-miR-124-3p	Microarray	18668037
MIRT004929	hsa-miR-124-3p	Microarray	15685193
MIRT043358	hsa-miR-331-3p	CLASH	23622248
MIRT791615	hsa-miR-103a	CLIP-seq
MIRT791616	hsa-miR-107	CLIP-seq
MIRT791617	hsa-miR-1827	CLIP-seq
MIRT791618	hsa-miR-218	CLIP-seq
MIRT791619	hsa-miR-3127-5p	CLIP-seq
MIRT791620	hsa-miR-3185	CLIP-seq
MIRT791621	hsa-miR-3918	CLIP-seq
MIRT791622	hsa-miR-4311	CLIP-seq
MIRT791623	hsa-miR-4436b-3p	CLIP-seq
MIRT791624	hsa-miR-4530	CLIP-seq
MIRT791625	hsa-miR-4649-3p	CLIP-seq
MIRT791626	hsa-miR-4711-5p	CLIP-seq
MIRT791627	hsa-miR-4778-5p	CLIP-seq
MIRT791628	hsa-miR-544b	CLIP-seq
MIRT791629	hsa-miR-636	CLIP-seq
MIRT791630	hsa-miR-922	CLIP-seq
MIRT1933548	hsa-miR-124	CLIP-seq
MIRT1933549	hsa-miR-1270	CLIP-seq
MIRT1933550	hsa-miR-1273f	CLIP-seq
MIRT1933551	hsa-miR-150	CLIP-seq
MIRT1933552	hsa-miR-1825	CLIP-seq
MIRT1933553	hsa-miR-199a-5p	CLIP-seq
MIRT1933554	hsa-miR-199b-5p	CLIP-seq
MIRT1933555	hsa-miR-28-5p	CLIP-seq
MIRT1933556	hsa-miR-3064-3p	CLIP-seq
MIRT1933557	hsa-miR-3139	CLIP-seq
MIRT1933558	hsa-miR-3180-5p	CLIP-seq
MIRT1933559	hsa-miR-3190	CLIP-seq
MIRT1933560	hsa-miR-3202	CLIP-seq
MIRT1933561	hsa-miR-4269	CLIP-seq
MIRT1933562	hsa-miR-4282	CLIP-seq
MIRT1933563	hsa-miR-4303	CLIP-seq
MIRT1933564	hsa-miR-4481	CLIP-seq
MIRT1933565	hsa-miR-4514	CLIP-seq
MIRT1933566	hsa-miR-4531	CLIP-seq
MIRT1933567	hsa-miR-4533	CLIP-seq
MIRT1933568	hsa-miR-4534	CLIP-seq
MIRT1933569	hsa-miR-4682	CLIP-seq
MIRT1933570	hsa-miR-4683	CLIP-seq
MIRT1933571	hsa-miR-4692	CLIP-seq
MIRT1933572	hsa-miR-4719	CLIP-seq
MIRT1933573	hsa-miR-4742-5p	CLIP-seq
MIRT1933574	hsa-miR-4745-5p	CLIP-seq
MIRT1933575	hsa-miR-4758-5p	CLIP-seq
MIRT1933576	hsa-miR-4802-5p	CLIP-seq
MIRT1933577	hsa-miR-506	CLIP-seq
MIRT1933578	hsa-miR-520a-5p	CLIP-seq
MIRT1933579	hsa-miR-525-5p	CLIP-seq
MIRT1933580	hsa-miR-605	CLIP-seq
MIRT1933581	hsa-miR-620	CLIP-seq
MIRT1933582	hsa-miR-708	CLIP-seq
MIRT1933583	hsa-miR-765	CLIP-seq
MIRT791615	hsa-miR-103a	CLIP-seq
MIRT791616	hsa-miR-107	CLIP-seq
MIRT2173641	hsa-miR-1200	CLIP-seq
MIRT1933548	hsa-miR-124	CLIP-seq
MIRT2173642	hsa-miR-1275	CLIP-seq
MIRT1933551	hsa-miR-150	CLIP-seq
MIRT1933552	hsa-miR-1825	CLIP-seq
MIRT791617	hsa-miR-1827	CLIP-seq
MIRT2173643	hsa-miR-1915	CLIP-seq
MIRT1933553	hsa-miR-199a-5p	CLIP-seq
MIRT1933554	hsa-miR-199b-5p	CLIP-seq
MIRT2173644	hsa-miR-2110	CLIP-seq
MIRT1933556	hsa-miR-3064-3p	CLIP-seq
MIRT791619	hsa-miR-3127-5p	CLIP-seq
MIRT1933558	hsa-miR-3180-5p	CLIP-seq
MIRT1933559	hsa-miR-3190	CLIP-seq
MIRT1933560	hsa-miR-3202	CLIP-seq
MIRT791621	hsa-miR-3918	CLIP-seq
MIRT1933561	hsa-miR-4269	CLIP-seq
MIRT2173645	hsa-miR-4271	CLIP-seq
MIRT1933563	hsa-miR-4303	CLIP-seq
MIRT2173646	hsa-miR-4324	CLIP-seq
MIRT791623	hsa-miR-4436b-3p	CLIP-seq
MIRT1933564	hsa-miR-4481	CLIP-seq
MIRT1933565	hsa-miR-4514	CLIP-seq
MIRT2173647	hsa-miR-4525	CLIP-seq
MIRT1933567	hsa-miR-4533	CLIP-seq
MIRT1933568	hsa-miR-4534	CLIP-seq
MIRT791625	hsa-miR-4649-3p	CLIP-seq
MIRT2173648	hsa-miR-4665-5p	CLIP-seq
MIRT2173649	hsa-miR-4668-3p	CLIP-seq
MIRT1933569	hsa-miR-4682	CLIP-seq
MIRT1933571	hsa-miR-4692	CLIP-seq
MIRT791626	hsa-miR-4711-5p	CLIP-seq
MIRT2173650	hsa-miR-4713-3p	CLIP-seq
MIRT2173651	hsa-miR-4713-5p	CLIP-seq
MIRT1933572	hsa-miR-4719	CLIP-seq
MIRT2173652	hsa-miR-4722-3p	CLIP-seq
MIRT2173653	hsa-miR-4723-5p	CLIP-seq
MIRT2173654	hsa-miR-4725-3p	CLIP-seq
MIRT2173655	hsa-miR-4726-3p	CLIP-seq
MIRT1933573	hsa-miR-4742-5p	CLIP-seq
MIRT1933574	hsa-miR-4745-5p	CLIP-seq
MIRT1933575	hsa-miR-4758-5p	CLIP-seq
MIRT1933576	hsa-miR-4802-5p	CLIP-seq
MIRT2173656	hsa-miR-491-5p	CLIP-seq
MIRT1933577	hsa-miR-506	CLIP-seq
MIRT1933578	hsa-miR-520a-5p	CLIP-seq
MIRT1933579	hsa-miR-525-5p	CLIP-seq
MIRT2173657	hsa-miR-532-3p	CLIP-seq
MIRT791628	hsa-miR-544b	CLIP-seq
MIRT1933580	hsa-miR-605	CLIP-seq
MIRT2173658	hsa-miR-625	CLIP-seq
MIRT1933549	hsa-miR-1270	CLIP-seq
MIRT1933550	hsa-miR-1273f	CLIP-seq
MIRT1933551	hsa-miR-150	CLIP-seq
MIRT1933555	hsa-miR-28-5p	CLIP-seq
MIRT1933557	hsa-miR-3139	CLIP-seq
MIRT1933566	hsa-miR-4531	CLIP-seq
MIRT1933568	hsa-miR-4534	CLIP-seq
MIRT1933570	hsa-miR-4683	CLIP-seq
MIRT1933576	hsa-miR-4802-5p	CLIP-seq
MIRT1933581	hsa-miR-620	CLIP-seq
MIRT1933582	hsa-miR-708	CLIP-seq
MIRT1933583	hsa-miR-765	CLIP-seq
MIRT1933549	hsa-miR-1270	CLIP-seq
MIRT1933550	hsa-miR-1273f	CLIP-seq
MIRT1933556	hsa-miR-3064-3p	CLIP-seq
MIRT1933566	hsa-miR-4531	CLIP-seq
MIRT1933568	hsa-miR-4534	CLIP-seq
MIRT1933570	hsa-miR-4683	CLIP-seq
MIRT1933572	hsa-miR-4719	CLIP-seq
MIRT1933580	hsa-miR-605	CLIP-seq
MIRT1933581	hsa-miR-620	CLIP-seq

Show/Hide all (27)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000165	Process	MAPK cascade	IBA
GO:0000166	Function	Nucleotide binding	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004672	Function	Protein kinase activity	TAS	3029685
GO:0004674	Function	Protein serine/threonine kinase activity	IDA	19667065
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004709	Function	MAP kinase kinase kinase activity	IBA
GO:0004709	Function	MAP kinase kinase kinase activity	IEA
GO:0005515	Function	Protein binding	IPI	11909642, 12620389, 15778465, 17979178, 19933840, 20052757, 20130576, 20936779, 21903422, 21988832, 22939624, 24441586, 24746704, 25036637, 25241761, 25852190, 28514442, 31980649, 32707033, 33961781, 34591612, 34591642, 35271311, 35512704, 36241744, 36931259
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	TAS
GO:0007165	Process	Signal transduction	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0032006	Process	Regulation of TOR signaling	IMP	22609986
GO:0032434	Process	Regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP	22609986
GO:0033138	Process	Positive regulation of peptidyl-serine phosphorylation	IDA	19667065
GO:0036211	Process	Protein modification process	TAS	3029685
GO:0043066	Process	Negative regulation of apoptotic process	IDA	19667065
GO:0043066	Process	Negative regulation of apoptotic process	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0106310	Function	Protein serine kinase activity	IEA

MIM	HGNC	e!Ensembl
311010	646	ENSG00000078061

P10398

Protein name

Serine/threonine-protein kinase A-Raf (EC 2.7.11.1) (Proto-oncogene A-Raf) (Proto-oncogene A-Raf-1) (Proto-oncogene Pks)

Protein function

Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade. Phosphorylates PFKFB2 (PubMed:36402789). ; FUNCTION:

PDB

1WXM , 2MSE , 9AXM

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02196	RBD	20 → 89	Raf-like Ras-binding domain	Domain
PF00130	C1_1	99 → 147	Phorbol esters/diacylglycerol binding domain (C1 domain)	Domain
PF07714	PK_Tyr_Ser-Thr	310 → 567	Protein tyrosine and serine/threonine kinase	Domain

Tissue specificity

TISSUE SPECIFICITY: Predominantly in urogenital tissues.

Sequence

MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRQQFYHSVQDLSGGSRQHEAPSNRPLNELL
TPQGPSPRTQHCDPEHFPFPAPANAPLQRIRSTSTPNVHMVSTTAPMDSNLIQLTGQSFS
TDAAGSRGGSDGTPRGSPSPASVSSGRKSPHSKSPAEQRERKSLADDKKKVKNLGYRDSG
YYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRK
TRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYL
HAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRM
QDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPK
AMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLS
AARLVP

Sequence length

606

Interactions

View interactions

	KEGG		Reactome
	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway ErbB signaling pathway FoxO signaling pathway Vascular smooth muscle contraction Natural killer cell mediated cytotoxicity Long-term potentiation Serotonergic synapse Long-term depression Regulation of actin cytoskeleton Insulin signaling pathway Progesterone-mediated oocyte maturation Parathyroid hormone synthesis, secretion and action Alzheimer disease Pathways of neurodegeneration - multiple diseases Alcoholism Hepatitis C Hepatitis B Pathways in cancer Proteoglycans in cancer Chemical carcinogenesis - reactive oxygen species Colorectal cancer Renal cell carcinoma Pancreatic cancer Endometrial cancer Glioma Prostate cancer Melanoma Bladder cancer Chronic myeloid leukemia Acute myeloid leukemia Non-small cell lung cancer Breast cancer Hepatocellular carcinoma Gastric cancer		RAF activation MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
ARAF-related disorder	Uncertain significance	rs143311445	RCV003459008

Show/Hide Text Mining Associations (23)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Abortion Habitual	Inhibit	30206208
Adenocarcinoma of Lung	Associate	24569458, 26486077
Autistic Disorder	Associate	21848643
Breast Neoplasms	Inhibit	26891695
Carcinoma Non Small Cell Lung	Associate	26486077, 33629637
Colorectal Neoplasms	Associate	26222778
Glioblastoma	Associate	25943352
Glioma	Inhibit	27852048
Herpes Simplex	Associate	34308964
Histiocytosis	Associate	26566875
Histiocytosis Langerhans Cell	Associate	34459688
Histiocytosis Non Langerhans Cell	Associate	26566875
Lung Neoplasms	Associate	24189400, 35302851, 35613620
Lymphatic Metastasis	Inhibit	35302851
Neoplasm Metastasis	Inhibit	35302851
Neoplasms	Associate	20145135, 24569458, 26566875, 33629637, 35613620, 36916400
Neoplasms	Inhibit	26891695
Prostatic Neoplasms	Associate	32859632
Pulmonary edema of mountaineers	Associate	24465776
Small Cell Lung Carcinoma	Associate	34741430
Squamous Cell Carcinoma of Head and Neck	Associate	36916400
Urethral Neoplasms	Associate	21533174
Urinary Bladder Neoplasms	Associate	36142409

ARAF (A-Raf proto-oncogene, serine/threonine kinase)