Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3688
Gene name Gene Name - the full gene name approved by the HGNC.
Integrin subunit beta 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ITGB1
Synonyms (NCBI Gene) Gene synonyms aliases
CD29, FNRB, GPIIA, MDF2, MSK12, VLA-BETA, VLAB
Chromosome Chromosome number
10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
10p11.22
Summary Summary of gene provided in NCBI Entrez Gene.
Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of process
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs1565818580 ->T Risk-factor Frameshift variant, coding sequence variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT004015 hsa-miR-183-5p Immunoblot, Immunocytochemistry, Luciferase reporter assay, qRT-PCR 19940135
MIRT002731 hsa-miR-124-3p Microarray 15685193
MIRT002731 hsa-miR-124-3p Immunoblot, Immunohistochemistry, qRT-PCR, Western blot 21196113
MIRT002731 hsa-miR-124-3p Immunoblot, Immunohistochemistry, qRT-PCR, Western blot 21196113
MIRT002731 hsa-miR-124-3p Luciferase reporter assay 21112327
Transcription factors
Transcription factor Regulation Reference
FOXF2 Repression 19562724
HOXD1 Unknown 21501586
HOXD3 Unknown 14610084
PAX6 Unknown 10954416
TWIST1 Activation 17487558
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000132 Process Establishment of mitotic spindle orientation IMP 30992345
GO:0001618 Function Virus receptor activity IEA
GO:0001726 Component Ruffle TAS 11919189
GO:0001968 Function Fibronectin binding IBA 21873635
GO:0001968 Function Fibronectin binding IDA 26763945
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
135630 6153 ENSG00000150093
Protein
UniProt ID P05556
Protein name Integrin beta-1 (Fibronectin receptor subunit beta) (Glycoprotein IIa) (GPIIA) (VLA-4 subunit beta) (CD antigen CD29)
Protein function Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1,
PDB 3G9W , 3T9K , 3VI3 , 3VI4 , 4DX9 , 4WJK , 4WK0 , 4WK2 , 4WK4 , 7CEB , 7CEC , 7NWL , 7NXD , 8RPQ , 8W30 , 9B9J , 9B9K , 9CKV
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF17205 PSI_integrin 25 76 Integrin plexin domain Domain
PF00362 Integrin_beta 138 382 Integrin beta chain VWA domain Domain
PF18372 I-EGF_1 466 495 Integrin beta epidermal growth factor like domain 1 Domain
PF07974 EGF_2 599 630 EGF-like domain Domain
PF07965 Integrin_B_tail 640 728 Integrin beta tail domain Domain
PF08725 Integrin_b_cyt 752 796 Integrin beta cytoplasmic domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in vascular smooth muscle cells (at protein level). {ECO:0000269|PubMed:35802072}.; TISSUE SPECIFICITY: [Isoform 1]: Expressed in placenta (at protein level) (PubMed:33962943). Widely expressed, other isoforms are generally c
Sequence
Sequence length 798
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Virion - Rotavirus
Rap1 signaling pathway
Phagosome
PI3K-Akt signaling pathway
Axon guidance
Focal adhesion
ECM-receptor interaction
Cell adhesion molecules
Tight junction
Platelet activation
Leukocyte transendothelial migration
Regulation of actin cytoskeleton
Cytoskeleton in muscle cells
Bacterial invasion of epithelial cells
Pathogenic Escherichia coli infection
Shigellosis
Pertussis
Yersinia infection
Leishmaniasis
Toxoplasmosis
Human papillomavirus infection
Pathways in cancer
Proteoglycans in cancer
Small cell lung cancer
Hypertrophic cardiomyopathy
Arrhythmogenic right ventricular cardiomyopathy
Dilated cardiomyopathy
  Elastic fibre formation
Fibronectin matrix formation
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Cell surface interactions at the vascular wall
Basigin interactions
Molecules associated with elastic fibres
Integrin cell surface interactions
Laminin interactions
Syndecan interactions
ECM proteoglycans
Signal transduction by L1
Localization of the PINCH-ILK-PARVIN complex to focal adhesions
RHO GTPases Activate Formins
Interleukin-4 and Interleukin-13 signaling
MET activates PTK2 signaling
MET interacts with TNS proteins
HCMV Early Events
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Carcinoma Squamous cell carcinoma rs121912654, rs555607708, rs786202962, rs1564055259 21401805
Cardiomyopathy Cardiomyopathy, Dilated, Cardiomyopathies, Primary, Cardiomyopathies, Cardiomyopathy, Familial Idiopathic rs267607003, rs267607002, rs267607004, rs63750743, rs121908333, rs121908334, rs104894655, rs121434420, rs121434421, rs193922674, rs111517471, rs121908987, rs193922384, rs121909374, rs121909377
View all (900 more)
11884376, 18340010
Lung carcinoma Non-Small Cell Lung Carcinoma rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355
View all (44 more)
21478906
Tumoral calcinosis Tumoral calcinosis rs104894343, rs104894344, rs745655924, rs137853086, rs375879489, rs761396172, rs137853087, rs137853091, rs137853088, rs137853089, rs137853090, rs766750282, rs760830864, rs786205250, rs267606841
View all (4 more)
18340010
Unknown
Disease term Disease name Evidence References Source
Congestive heart failure Congestive heart failure 11884376 ClinVar
Endometriosis Endometriosis 21063030 ClinVar, GWAS
Heart failure Heart failure, Left-Sided Heart Failure, Heart Failure, Right-Sided 11884376 ClinVar
Myocardial infarction Myocardial Failure 11884376 ClinVar
Associations from Text Mining
Disease Name Relationship Type References
Achlorhydria Associate 24009701
Acute Disease Stimulate 26283883
Acute Lung Injury Associate 37855260
Adenocarcinoma Associate 16732726, 36456612
Adenocarcinoma of Lung Associate 15221867, 25066397, 30106131, 32549766, 33134373, 35017116, 36178365
Adenoma Associate 26722470
Adenomatous Polyposis Coli Associate 26722470
Alzheimer Disease Associate 21272192, 30918899, 34556089, 35029059, 39657893
Amniotic Band Syndrome Associate 37027338
Anti N Methyl D Aspartate Receptor Encephalitis Stimulate 38063052