ITGAM (integrin subunit alpha M)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3684
Gene name Gene Name - the full gene name approved by the HGNC.
Integrin subunit alpha M
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ITGAM
Synonyms (NCBI Gene) Gene synonyms aliases
CD11B, CR3A, MAC-1, MAC1A, MO1A, SLEB6
Chromosome Chromosome number
16
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
16p11.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific i
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(23)
miRTarBase ID miRNA Experiments Reference
MIRT1073816 hsa-miR-203 CLIP-seq
MIRT1073817 hsa-miR-224 CLIP-seq
MIRT1073818 hsa-miR-23a CLIP-seq
MIRT1073819 hsa-miR-23b CLIP-seq
MIRT1073820 hsa-miR-23c CLIP-seq
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(1)
Transcription factor Regulation Reference
SPI1 Activation 15163413;8095266;9295016
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(64)
GO ID Ontology Definition Evidence Reference
GO:0001540 Function Amyloid-beta binding IC
GO:0001774 Process Microglial cell activation ISS
GO:0001851 Function Complement component C3b binding ISS
GO:0002376 Process Immune system process IEA
GO:0002430 Process Complement receptor mediated signaling pathway ISS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
120980 6149 ENSG00000169896
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P11215
Protein name Integrin alpha-M (CD11 antigen-like family member B) (CR-3 alpha chain) (Cell surface glycoprotein MAC-1 subunit alpha) (Leukocyte adhesion receptor MO1) (Neutrophil adherence receptor) (CD antigen CD11b)
Protein function Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens (PubMed:20008295, PubMed:9558116). It is identical wit
PDB 1BHO , 1BHQ , 1IDN , 1IDO , 1JLM , 1M1U , 1MF7 , 1N9Z , 1NA5 , 2LKE , 2LKJ , 3Q3G , 3QA3 , 4M76 , 4XW2 , 6RHW , 7AKK , 7P2D , 7USL , 7USM , 8CE6 , 8CE9 , 8VOH , 8VOI
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00092 VWA 150 → 327 von Willebrand factor type A domain Domain
PF01839 FG-GAP 520 → 555 FG-GAP repeat Repeat
PF08441 Integrin_alpha2 614 → 1005 Integrin alpha Family
PF00357 Integrin_alpha 1129 → 1143 Integrin alpha cytoplasmic region Family
Tissue specificity TISSUE SPECIFICITY: Predominantly expressed in monocytes and granulocytes (PubMed:1346576). Expressed in neutrophils (at protein level) (PubMed:21193407). {ECO:0000269|PubMed:1346576, ECO:0000269|PubMed:21193407}.
Sequence 
MALRVLLLTALTLCHGFNLDTENAMTFQENARGFGQSVVQLQGSRVVVGAPQEIVAANQR
GSLYQCDYSTGSCEPIRLQVPVEAVNMSLGLSLAATTSPPQLLACGPTVHQTCSENTYVK
GLCFLFGSNLRQQPQKFPEALRGCPQEDSDIAFLIDGSGSIIPHDFRRMKEFVSTVMEQL
KKSKTLFSLMQYSEEFRIHFTFKEFQNNPNPRSLVKPITQLLGRTHTATGIRKVVRELFN
ITNGARKNAFKILVVITDGEKFGDPLGYEDVIPEADREGVIRYVIGVGDAFRSEKSRQEL
NTIASKPPRDHVFQVNNFEALKTIQNQLREKIFAIEGTQTGSSSSFEHEMSQEGFSAAIT
SNGPLLSTVGSYDWAGGVFLYTSKEKSTFINMTRVDSDMNDAYLGYAAAIILRNRVQSLV
LGAPRYQHIGLVAMFRQNTGMWESNANVKGTQIGAYFGASLCSVDVDSNGSTDLVLIGAP
HYYEQTRGGQVSVCPLPRGRARWQCDAVLYGEQGQPWGRFGAALTVLGDVNGDKLTDVAI
GAPGEEDNRGAVYLFHGTSGSGISPSHSQRIAGSKLSPRLQYFGQSLSGGQDLTMDGLVD
LTVGAQGHVLLLRSQPVLRVKAIMEFNPREVARNVFECNDQVVKGKEAGEVRVCLHVQKS
TRDRLREGQIQSVVTYDLALDSGRPHSRAVFNETKNSTRRQTQVLGLTQTCETLKLQLPN
CIEDPVSPIVLRLNFSLVGTPLSAFGNLRPVLAEDAQRLFTALFPFEKNCGNDNICQDDL
SITFSFMSLDCLVVGGPREFNVTVTVRNDGEDSYRTQVTFFFPLDLSYRKVSTLQNQRSQ
RSWRLACESASSTEVSGALKSTSCSINHPIFPENSEVTFNITFDVDSKASLGNKLLLKAN
VTSENNMPRTNKTEFQLELPVKYAVYMVVTSHGVSTKYLNFTASENTSRVMQHQYQVSNL
GQRSLPISLVFLVPVRLNQTVIWDRPQVTFSENLSSTCHTKERLPSHSDFLAELRKAPVV
NCSIAVCQRIQCDIPFFGIQEEFNATLKGNLSFDWYIKTSHNHLLIVSTAEILFNDSVFT
LLPGQGAFVRSQTETKVEPFEVPNPLPLIVGSSVGGLLLLALITAALYKLGFFKRQYKDM
MSEGGPPGAEPQ
Sequence length 1152
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Rap1 signaling pathway
Phagosome
Cell adhesion molecules
Complement and coagulation cascades
Neutrophil extracellular trap formation
Hematopoietic cell lineage
Leukocyte transendothelial migration
Regulation of actin cytoskeleton
Pertussis
Legionellosis
Leishmaniasis
Amoebiasis
Staphylococcus aureus infection
Tuberculosis
Transcriptional misregulation in cancer
Acute myeloid leukemia 		  Toll Like Receptor 4 (TLR4) Cascade
Cell surface interactions at the vascular wall
Integrin cell surface interactions
Interleukin-4 and Interleukin-13 signaling
Neutrophil degranulation
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (1)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Systemic lupus erythematosus systemic lupus erythematosus, Systemic lupus erythematosus N/A N/A GenCC, GWAS
Show/Hide Text Mining Associations (286)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Accessory Nerve Injuries Associate 35892263
Acute Coronary Syndrome Stimulate 11132167
Acute Lung Injury Associate 33949285
Acute On Chronic Liver Failure Associate 28592438
Adenocarcinoma Associate 32509861
Adenocarcinoma of Lung Associate 35291954
Agranulocytosis Associate 1372668
Albuminuria Associate 31023084
Alzheimer Disease Associate 23134465, 40465637
Amyotrophic Lateral Sclerosis Associate 35328793