Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	3682
Gene name	Integrin subunit alpha E
Gene symbol	ITGAE
Synonyms (NCBI Gene)	CD103HUMINAE
Chromosome	17
Chromosome location	17p13.2
Summary	Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked h

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miRTarBase ID	miRNA	Experiments
MIRT1073749	hsa-miR-129-5p	CLIP-seq
MIRT1073750	hsa-miR-1302	CLIP-seq
MIRT1073751	hsa-miR-1915	CLIP-seq
MIRT1073752	hsa-miR-193a-5p	CLIP-seq
MIRT1073753	hsa-miR-3122	CLIP-seq
MIRT1073754	hsa-miR-3691-3p	CLIP-seq
MIRT1073755	hsa-miR-3913-5p	CLIP-seq
MIRT1073756	hsa-miR-4298	CLIP-seq
MIRT1073757	hsa-miR-450b-5p	CLIP-seq
MIRT1073758	hsa-miR-4726-3p	CLIP-seq
MIRT1073759	hsa-miR-4731-5p	CLIP-seq
MIRT1073760	hsa-miR-507	CLIP-seq
MIRT1073761	hsa-miR-515-5p	CLIP-seq
MIRT1073762	hsa-miR-518a-5p	CLIP-seq
MIRT1073763	hsa-miR-527	CLIP-seq
MIRT1073764	hsa-miR-548ac	CLIP-seq
MIRT1073765	hsa-miR-548ae	CLIP-seq
MIRT1073766	hsa-miR-548aj	CLIP-seq
MIRT1073767	hsa-miR-548am	CLIP-seq
MIRT1073768	hsa-miR-548d-3p	CLIP-seq
MIRT1073769	hsa-miR-548x	CLIP-seq
MIRT1073770	hsa-miR-548z	CLIP-seq
MIRT1073771	hsa-miR-557	CLIP-seq
MIRT1073772	hsa-miR-584	CLIP-seq
MIRT1073749	hsa-miR-129-5p	CLIP-seq
MIRT1073757	hsa-miR-450b-5p	CLIP-seq
MIRT1073760	hsa-miR-507	CLIP-seq
MIRT1073771	hsa-miR-557	CLIP-seq
MIRT2553642	hsa-miR-1252	CLIP-seq
MIRT1073750	hsa-miR-1302	CLIP-seq
MIRT1073751	hsa-miR-1915	CLIP-seq
MIRT1073752	hsa-miR-193a-5p	CLIP-seq
MIRT2553643	hsa-miR-3064-5p	CLIP-seq
MIRT1073753	hsa-miR-3122	CLIP-seq
MIRT2553644	hsa-miR-3129-3p	CLIP-seq
MIRT2553645	hsa-miR-3140-5p	CLIP-seq
MIRT2553646	hsa-miR-3148	CLIP-seq
MIRT2553647	hsa-miR-3169	CLIP-seq
MIRT1073754	hsa-miR-3691-3p	CLIP-seq
MIRT1073755	hsa-miR-3913-5p	CLIP-seq
MIRT1073756	hsa-miR-4298	CLIP-seq
MIRT2553648	hsa-miR-4515	CLIP-seq
MIRT1073758	hsa-miR-4726-3p	CLIP-seq
MIRT1073759	hsa-miR-4731-5p	CLIP-seq
MIRT2553649	hsa-miR-4777-5p	CLIP-seq
MIRT2553650	hsa-miR-4793-5p	CLIP-seq
MIRT1073761	hsa-miR-515-5p	CLIP-seq
MIRT1073762	hsa-miR-518a-5p	CLIP-seq
MIRT1073763	hsa-miR-527	CLIP-seq
MIRT2553651	hsa-miR-548a-5p	CLIP-seq
MIRT2553652	hsa-miR-548ab	CLIP-seq
MIRT1073764	hsa-miR-548ac	CLIP-seq
MIRT1073765	hsa-miR-548ae	CLIP-seq
MIRT1073766	hsa-miR-548aj	CLIP-seq
MIRT2553653	hsa-miR-548ak	CLIP-seq
MIRT1073767	hsa-miR-548am	CLIP-seq
MIRT2553654	hsa-miR-548b-5p	CLIP-seq
MIRT2553655	hsa-miR-548c-5p	CLIP-seq
MIRT1073768	hsa-miR-548d-3p	CLIP-seq
MIRT2553656	hsa-miR-548d-5p	CLIP-seq
MIRT2553657	hsa-miR-548h	CLIP-seq
MIRT2553658	hsa-miR-548i	CLIP-seq
MIRT2553659	hsa-miR-548j	CLIP-seq
MIRT2553660	hsa-miR-548n	CLIP-seq
MIRT2553661	hsa-miR-548w	CLIP-seq
MIRT1073769	hsa-miR-548x	CLIP-seq
MIRT2553662	hsa-miR-548y	CLIP-seq
MIRT1073770	hsa-miR-548z	CLIP-seq
MIRT2553663	hsa-miR-559	CLIP-seq
MIRT1073772	hsa-miR-584	CLIP-seq
MIRT2553664	hsa-miR-892b	CLIP-seq
MIRT2553642	hsa-miR-1252	CLIP-seq
MIRT1073750	hsa-miR-1302	CLIP-seq
MIRT1073751	hsa-miR-1915	CLIP-seq
MIRT1073752	hsa-miR-193a-5p	CLIP-seq
MIRT2553643	hsa-miR-3064-5p	CLIP-seq
MIRT1073753	hsa-miR-3122	CLIP-seq
MIRT2553644	hsa-miR-3129-3p	CLIP-seq
MIRT2553645	hsa-miR-3140-5p	CLIP-seq
MIRT2553646	hsa-miR-3148	CLIP-seq
MIRT2553647	hsa-miR-3169	CLIP-seq
MIRT1073754	hsa-miR-3691-3p	CLIP-seq
MIRT1073755	hsa-miR-3913-5p	CLIP-seq
MIRT1073756	hsa-miR-4298	CLIP-seq
MIRT2553648	hsa-miR-4515	CLIP-seq
MIRT1073758	hsa-miR-4726-3p	CLIP-seq
MIRT1073759	hsa-miR-4731-5p	CLIP-seq
MIRT2553649	hsa-miR-4777-5p	CLIP-seq
MIRT2553650	hsa-miR-4793-5p	CLIP-seq
MIRT1073761	hsa-miR-515-5p	CLIP-seq
MIRT1073762	hsa-miR-518a-5p	CLIP-seq
MIRT1073763	hsa-miR-527	CLIP-seq
MIRT2553651	hsa-miR-548a-5p	CLIP-seq
MIRT2553652	hsa-miR-548ab	CLIP-seq
MIRT1073764	hsa-miR-548ac	CLIP-seq
MIRT1073765	hsa-miR-548ae	CLIP-seq
MIRT1073766	hsa-miR-548aj	CLIP-seq
MIRT2553653	hsa-miR-548ak	CLIP-seq
MIRT1073767	hsa-miR-548am	CLIP-seq
MIRT2553654	hsa-miR-548b-5p	CLIP-seq
MIRT2553655	hsa-miR-548c-5p	CLIP-seq
MIRT1073768	hsa-miR-548d-3p	CLIP-seq
MIRT2553656	hsa-miR-548d-5p	CLIP-seq
MIRT2553657	hsa-miR-548h	CLIP-seq
MIRT2553658	hsa-miR-548i	CLIP-seq
MIRT2553659	hsa-miR-548j	CLIP-seq
MIRT2553660	hsa-miR-548n	CLIP-seq
MIRT2553661	hsa-miR-548w	CLIP-seq
MIRT1073769	hsa-miR-548x	CLIP-seq
MIRT2553662	hsa-miR-548y	CLIP-seq
MIRT1073770	hsa-miR-548z	CLIP-seq
MIRT2553663	hsa-miR-559	CLIP-seq
MIRT1073772	hsa-miR-584	CLIP-seq
MIRT2553664	hsa-miR-892b	CLIP-seq

Show/Hide all (16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0007155	Process	Cell adhesion	IEA
GO:0007160	Process	Cell-matrix adhesion	IBA
GO:0007229	Process	Integrin-mediated signaling pathway	IBA
GO:0007229	Process	Integrin-mediated signaling pathway	IEA
GO:0008305	Component	Integrin complex	IBA
GO:0008305	Component	Integrin complex	IEA
GO:0008305	Component	Integrin complex	TAS	8119947
GO:0009897	Component	External side of plasma membrane	IEA
GO:0009986	Component	Cell surface	IBA
GO:0009986	Component	Cell surface	IEA
GO:0016020	Component	Membrane	IEA
GO:0038023	Function	Signaling receptor activity	IBA
GO:0046872	Function	Metal ion binding	IEA
GO:0098609	Process	Cell-cell adhesion	IBA

MIM	HGNC	e!Ensembl
604682	6147	ENSG00000083457

P38570

Protein name

Integrin alpha-E (HML-1 antigen) (Integrin alpha-IEL) (Mucosal lymphocyte 1 antigen) (CD antigen CD103) [Cleaved into: Integrin alpha-E light chain; Integrin alpha-E heavy chain]

Protein function

Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers.

PDB

8ZJF

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00092	VWA	202 → 381	von Willebrand factor type A domain	Domain
PF01839	FG-GAP	514 → 551	FG-GAP repeat	Repeat
PF01839	FG-GAP	577 → 618	FG-GAP repeat	Repeat
PF08441	Integrin_alpha2	676 → 965	Integrin alpha	Family
PF00357	Integrin_alpha	1148 → 1162	Integrin alpha cytoplasmic region	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed on a subclass of T-lymphocytes known as intra-epithelial lymphocytes which are located between mucosal epithelial cells.

Sequence

MWLFHTLLCIASLALLAAFNVDVARPWLTPKGGAPFVLSSLLHQDPSTNQTWLLVTSPRT
KRTPGPLHRCSLVQDEILCHPVEHVPIPKGRHRGVTVVRSHHGVLICIQVLVRRPHSLSS
ELTGTCSLLGPDLRPQAQANFFDLENLLDPDARVDTGDCYSNKEGGGEDDVNTARQRRAL
EKEEEEDKEEEEDEEEEEAGTEIAIILDGSGSIDPPDFQRAKDFISNMMRNFYEKCFECN
FALVQYGGVIQTEFDLRDSQDVMASLARVQNITQVGSVTKTASAMQHVLDSIFTSSHGSR
RKASKVMVVLTDGGIFEDPLNLTTVINSPKMQGVERFAIGVGEEFKSARTARELNLIASD
PDETHAFKVTNYMALDGLLSKLRYNIISMEGTVGDALHYQLAQIGFSAQILDERQVLLGA
VGAFDWSGGALLYDTRSRRGRFLNQTAAAAADAEAAQYSYLGYAVAVLHKTCSLSYIAGA
PRYKHHGAVFELQKEGREASFLPVLEGEQMGSYFGSELCPVDIDMDGSTDFLLVAAPFYH
VHGEEGRVYVYRLSEQDGSFSLARILSGHPGFTNARFGFAMAAMGDLSQDKLTDVAIGAP
LEGFGADDGASFGSVYIYNGHWDGLSASPSQRIRASTVAPGLQYFGMSMAGGFDISGDGL
ADITVGTLGQAVVFRSRPVVRLKVSMAFTPSALPIGFNGVVNVRLCFEISSVTTASESGL
REALLNFTLDVDVGKQRRRLQCSDVRSCLGCLREWSSGSQLCEDLLLMPTEGELCEEDCF
SNASVKVSYQLQTPEGQTDHPQPILDRYTEPFAIFQLPYEKACKNKLFCVAELQLATTVS
QQELVVGLTKELTLNINLTNSGEDSYMTSMALNYPRNLQLKRMQKPPSPNIQCDDPQPVA
SVLIMNCRIGHPVLKRSSAHVSVVWQLEENAFPNRTADITVTVTNSNERRSLANETHTLQ
FRHGFVAVLSKPSIMYVNTGQGLSHHKEFLFHVHGENLFGAEYQLQICVPTKLRGLQVVA
VKKLTRTQASTVCTWSQERACAYSSVQHVEEWHSVSCVIASDKENVTVAAEISWDHSEEL
LKDVTELQILGEISFNKSLYEGLNAENHRTKITVVFLKDEKYHSLPIIIKGSVGGLLVLI
VILVILFKCGFFKRKYQQLNLESIRKAQLKSENLLEEEN

Sequence length

1179

Interactions

View interactions

	KEGG		Reactome
	Regulation of actin cytoskeleton		Integrin cell surface interactions

ITGAE (integrin subunit alpha E)