Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	3682
Gene name Gene Name - the full gene name approved by the HGNC.	Integrin subunit alpha E
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ITGAE
Synonyms (NCBI Gene) Gene synonyms aliases	CD103, HUMINAE
Chromosome Chromosome number	17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	17p13.2
Summary Summary of gene provided in NCBI Entrez Gene.	Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked h

Show/Hide all(114)

miRTarBase ID	miRNA	Experiments
MIRT1073749	hsa-miR-129-5p	CLIP-seq
MIRT1073750	hsa-miR-1302	CLIP-seq
MIRT1073751	hsa-miR-1915	CLIP-seq
MIRT1073752	hsa-miR-193a-5p	CLIP-seq
MIRT1073753	hsa-miR-3122	CLIP-seq
MIRT1073754	hsa-miR-3691-3p	CLIP-seq
MIRT1073755	hsa-miR-3913-5p	CLIP-seq
MIRT1073756	hsa-miR-4298	CLIP-seq
MIRT1073757	hsa-miR-450b-5p	CLIP-seq
MIRT1073758	hsa-miR-4726-3p	CLIP-seq
MIRT1073759	hsa-miR-4731-5p	CLIP-seq
MIRT1073760	hsa-miR-507	CLIP-seq
MIRT1073761	hsa-miR-515-5p	CLIP-seq
MIRT1073762	hsa-miR-518a-5p	CLIP-seq
MIRT1073763	hsa-miR-527	CLIP-seq
MIRT1073764	hsa-miR-548ac	CLIP-seq
MIRT1073765	hsa-miR-548ae	CLIP-seq
MIRT1073766	hsa-miR-548aj	CLIP-seq
MIRT1073767	hsa-miR-548am	CLIP-seq
MIRT1073768	hsa-miR-548d-3p	CLIP-seq
MIRT1073769	hsa-miR-548x	CLIP-seq
MIRT1073770	hsa-miR-548z	CLIP-seq
MIRT1073771	hsa-miR-557	CLIP-seq
MIRT1073772	hsa-miR-584	CLIP-seq
MIRT1073749	hsa-miR-129-5p	CLIP-seq
MIRT1073757	hsa-miR-450b-5p	CLIP-seq
MIRT1073760	hsa-miR-507	CLIP-seq
MIRT1073771	hsa-miR-557	CLIP-seq
MIRT2553642	hsa-miR-1252	CLIP-seq
MIRT1073750	hsa-miR-1302	CLIP-seq
MIRT1073751	hsa-miR-1915	CLIP-seq
MIRT1073752	hsa-miR-193a-5p	CLIP-seq
MIRT2553643	hsa-miR-3064-5p	CLIP-seq
MIRT1073753	hsa-miR-3122	CLIP-seq
MIRT2553644	hsa-miR-3129-3p	CLIP-seq
MIRT2553645	hsa-miR-3140-5p	CLIP-seq
MIRT2553646	hsa-miR-3148	CLIP-seq
MIRT2553647	hsa-miR-3169	CLIP-seq
MIRT1073754	hsa-miR-3691-3p	CLIP-seq
MIRT1073755	hsa-miR-3913-5p	CLIP-seq
MIRT1073756	hsa-miR-4298	CLIP-seq
MIRT2553648	hsa-miR-4515	CLIP-seq
MIRT1073758	hsa-miR-4726-3p	CLIP-seq
MIRT1073759	hsa-miR-4731-5p	CLIP-seq
MIRT2553649	hsa-miR-4777-5p	CLIP-seq
MIRT2553650	hsa-miR-4793-5p	CLIP-seq
MIRT1073761	hsa-miR-515-5p	CLIP-seq
MIRT1073762	hsa-miR-518a-5p	CLIP-seq
MIRT1073763	hsa-miR-527	CLIP-seq
MIRT2553651	hsa-miR-548a-5p	CLIP-seq
MIRT2553652	hsa-miR-548ab	CLIP-seq
MIRT1073764	hsa-miR-548ac	CLIP-seq
MIRT1073765	hsa-miR-548ae	CLIP-seq
MIRT1073766	hsa-miR-548aj	CLIP-seq
MIRT2553653	hsa-miR-548ak	CLIP-seq
MIRT1073767	hsa-miR-548am	CLIP-seq
MIRT2553654	hsa-miR-548b-5p	CLIP-seq
MIRT2553655	hsa-miR-548c-5p	CLIP-seq
MIRT1073768	hsa-miR-548d-3p	CLIP-seq
MIRT2553656	hsa-miR-548d-5p	CLIP-seq
MIRT2553657	hsa-miR-548h	CLIP-seq
MIRT2553658	hsa-miR-548i	CLIP-seq
MIRT2553659	hsa-miR-548j	CLIP-seq
MIRT2553660	hsa-miR-548n	CLIP-seq
MIRT2553661	hsa-miR-548w	CLIP-seq
MIRT1073769	hsa-miR-548x	CLIP-seq
MIRT2553662	hsa-miR-548y	CLIP-seq
MIRT1073770	hsa-miR-548z	CLIP-seq
MIRT2553663	hsa-miR-559	CLIP-seq
MIRT1073772	hsa-miR-584	CLIP-seq
MIRT2553664	hsa-miR-892b	CLIP-seq
MIRT2553642	hsa-miR-1252	CLIP-seq
MIRT1073750	hsa-miR-1302	CLIP-seq
MIRT1073751	hsa-miR-1915	CLIP-seq
MIRT1073752	hsa-miR-193a-5p	CLIP-seq
MIRT2553643	hsa-miR-3064-5p	CLIP-seq
MIRT1073753	hsa-miR-3122	CLIP-seq
MIRT2553644	hsa-miR-3129-3p	CLIP-seq
MIRT2553645	hsa-miR-3140-5p	CLIP-seq
MIRT2553646	hsa-miR-3148	CLIP-seq
MIRT2553647	hsa-miR-3169	CLIP-seq
MIRT1073754	hsa-miR-3691-3p	CLIP-seq
MIRT1073755	hsa-miR-3913-5p	CLIP-seq
MIRT1073756	hsa-miR-4298	CLIP-seq
MIRT2553648	hsa-miR-4515	CLIP-seq
MIRT1073758	hsa-miR-4726-3p	CLIP-seq
MIRT1073759	hsa-miR-4731-5p	CLIP-seq
MIRT2553649	hsa-miR-4777-5p	CLIP-seq
MIRT2553650	hsa-miR-4793-5p	CLIP-seq
MIRT1073761	hsa-miR-515-5p	CLIP-seq
MIRT1073762	hsa-miR-518a-5p	CLIP-seq
MIRT1073763	hsa-miR-527	CLIP-seq
MIRT2553651	hsa-miR-548a-5p	CLIP-seq
MIRT2553652	hsa-miR-548ab	CLIP-seq
MIRT1073764	hsa-miR-548ac	CLIP-seq
MIRT1073765	hsa-miR-548ae	CLIP-seq
MIRT1073766	hsa-miR-548aj	CLIP-seq
MIRT2553653	hsa-miR-548ak	CLIP-seq
MIRT1073767	hsa-miR-548am	CLIP-seq
MIRT2553654	hsa-miR-548b-5p	CLIP-seq
MIRT2553655	hsa-miR-548c-5p	CLIP-seq
MIRT1073768	hsa-miR-548d-3p	CLIP-seq
MIRT2553656	hsa-miR-548d-5p	CLIP-seq
MIRT2553657	hsa-miR-548h	CLIP-seq
MIRT2553658	hsa-miR-548i	CLIP-seq
MIRT2553659	hsa-miR-548j	CLIP-seq
MIRT2553660	hsa-miR-548n	CLIP-seq
MIRT2553661	hsa-miR-548w	CLIP-seq
MIRT1073769	hsa-miR-548x	CLIP-seq
MIRT2553662	hsa-miR-548y	CLIP-seq
MIRT1073770	hsa-miR-548z	CLIP-seq
MIRT2553663	hsa-miR-559	CLIP-seq
MIRT1073772	hsa-miR-584	CLIP-seq
MIRT2553664	hsa-miR-892b	CLIP-seq

Show/Hide all(16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0007155	Process	Cell adhesion	IEA
GO:0007160	Process	Cell-matrix adhesion	IBA
GO:0007229	Process	Integrin-mediated signaling pathway	IBA
GO:0007229	Process	Integrin-mediated signaling pathway	IEA
GO:0008305	Component	Integrin complex	IBA
GO:0008305	Component	Integrin complex	IEA
GO:0008305	Component	Integrin complex	TAS	8119947
GO:0009897	Component	External side of plasma membrane	IEA
GO:0009986	Component	Cell surface	IBA
GO:0009986	Component	Cell surface	IEA
GO:0016020	Component	Membrane	IEA
GO:0038023	Function	Signaling receptor activity	IBA
GO:0046872	Function	Metal ion binding	IEA
GO:0098609	Process	Cell-cell adhesion	IBA

MIM	HGNC	e!Ensembl
604682	6147	ENSG00000083457

Protein

UniProt ID

P38570

Protein name

Integrin alpha-E (HML-1 antigen) (Integrin alpha-IEL) (Mucosal lymphocyte 1 antigen) (CD antigen CD103) [Cleaved into: Integrin alpha-E light chain; Integrin alpha-E heavy chain]

Protein function

Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers.

PDB

8ZJF

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00092	VWA	202 → 381	von Willebrand factor type A domain	Domain
PF01839	FG-GAP	514 → 551	FG-GAP repeat	Repeat
PF01839	FG-GAP	577 → 618	FG-GAP repeat	Repeat
PF08441	Integrin_alpha2	676 → 965	Integrin alpha	Family
PF00357	Integrin_alpha	1148 → 1162	Integrin alpha cytoplasmic region	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed on a subclass of T-lymphocytes known as intra-epithelial lymphocytes which are located between mucosal epithelial cells.

Sequence

MWLFHTLLCIASLALLAAFNVDVARPWLTPKGGAPFVLSSLLHQDPSTNQTWLLVTSPRT
KRTPGPLHRCSLVQDEILCHPVEHVPIPKGRHRGVTVVRSHHGVLICIQVLVRRPHSLSS
ELTGTCSLLGPDLRPQAQANFFDLENLLDPDARVDTGDCYSNKEGGGEDDVNTARQRRAL
EKEEEEDKEEEEDEEEEEAGTEIAIILDGSGSIDPPDFQRAKDFISNMMRNFYEKCFECN
FALVQYGGVIQTEFDLRDSQDVMASLARVQNITQVGSVTKTASAMQHVLDSIFTSSHGSR
RKASKVMVVLTDGGIFEDPLNLTTVINSPKMQGVERFAIGVGEEFKSARTARELNLIASD
PDETHAFKVTNYMALDGLLSKLRYNIISMEGTVGDALHYQLAQIGFSAQILDERQVLLGA
VGAFDWSGGALLYDTRSRRGRFLNQTAAAAADAEAAQYSYLGYAVAVLHKTCSLSYIAGA
PRYKHHGAVFELQKEGREASFLPVLEGEQMGSYFGSELCPVDIDMDGSTDFLLVAAPFYH
VHGEEGRVYVYRLSEQDGSFSLARILSGHPGFTNARFGFAMAAMGDLSQDKLTDVAIGAP
LEGFGADDGASFGSVYIYNGHWDGLSASPSQRIRASTVAPGLQYFGMSMAGGFDISGDGL
ADITVGTLGQAVVFRSRPVVRLKVSMAFTPSALPIGFNGVVNVRLCFEISSVTTASESGL
REALLNFTLDVDVGKQRRRLQCSDVRSCLGCLREWSSGSQLCEDLLLMPTEGELCEEDCF
SNASVKVSYQLQTPEGQTDHPQPILDRYTEPFAIFQLPYEKACKNKLFCVAELQLATTVS
QQELVVGLTKELTLNINLTNSGEDSYMTSMALNYPRNLQLKRMQKPPSPNIQCDDPQPVA
SVLIMNCRIGHPVLKRSSAHVSVVWQLEENAFPNRTADITVTVTNSNERRSLANETHTLQ
FRHGFVAVLSKPSIMYVNTGQGLSHHKEFLFHVHGENLFGAEYQLQICVPTKLRGLQVVA
VKKLTRTQASTVCTWSQERACAYSSVQHVEEWHSVSCVIASDKENVTVAAEISWDHSEEL
LKDVTELQILGEISFNKSLYEGLNAENHRTKITVVFLKDEKYHSLPIIIKGSVGGLLVLI
VILVILFKCGFFKRKYQQLNLESIRKAQLKSENLLEEEN

Sequence length

1179

Interactions

View interactions

	KEGG		Reactome
	Regulation of actin cytoskeleton		Integrin cell surface interactions

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Attention Deficit Hyperactivity Disorder	Attention deficit hyperactivity disorder	N/A	N/A	GWAS

Show/Hide Text Mining Associations (94)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adenocarcinoma	Associate	36119930
Adenomatous Polyposis Coli	Inhibit	35297393
Alzheimer Disease	Stimulate	37949669
Ascites	Associate	22104311
Asthma	Associate	12511714, 37271320
Ataxia Telangiectasia	Associate	40607400
Biliary Atresia	Associate	40607400
Breast Neoplasms	Associate	37488535
Bronchiolitis Obliterans Syndrome	Associate	29197137
Carcinoma Non Small Cell Lung	Associate	28099920, 30505306, 31921114, 38183111
Carcinoma Pancreatic Ductal	Associate	35793870
Carcinoma Renal Cell	Associate	34002666
Carcinoma Renal Cell	Stimulate	38031731
Carcinoma Squamous Cell	Associate	28099920, 33479027
Celiac Disease	Associate	33654213, 34495570, 38430190
Clear cell metastatic renal cell carcinoma	Associate	25205170
Colitis Ulcerative	Associate	26080709, 26522261
Colitis Ulcerative	Inhibit	32513301
Colonic Neoplasms	Associate	36119930
Colorectal Neoplasms	Associate	30100393, 36119930, 36792124, 36869093
Conjunctivitis Allergic	Associate	24368924
COVID 19	Associate	35688805
Crohn Disease	Inhibit	32513301
Dermatitis Atopic	Associate	32035984
Diabetes Mellitus Type 1	Associate	28212742
Disease	Associate	29903545
Drug Related Side Effects and Adverse Reactions	Associate	35418483
Dysbiosis	Associate	37099426
Early Onset Glaucoma	Associate	31053597
Endometrial Neoplasms	Associate	32471032, 36581331
Esophageal Neoplasms	Associate	37864146
Fibrous Dysplasia Polyostotic	Associate	30585624
Gastritis	Associate	32974219
Glioblastoma	Associate	37884280, 40498413
Glioma	Associate	37096960
Goiter Multinodular 2	Associate	36420264
Graft vs Host Disease	Inhibit	31402273
Head and Neck Neoplasms	Associate	30006565
Head and Neck Neoplasms	Stimulate	32527931
HIV Infections	Associate	29272532
Hypersensitivity Delayed	Associate	23504637
Infections	Stimulate	12970431
Inflammation	Associate	29873694, 32974219, 34074699
Inflammation	Stimulate	37949669
Inflammatory Bowel Diseases	Inhibit	26080709
Inflammatory Bowel Diseases	Associate	38430190
Influenza Human	Associate	21537083, 34256007, 36912465
Kidney Neoplasms	Associate	34074699
Leukemia	Associate	14656893, 39391310
Leukemia B Cell	Associate	21917686
Leukemia Biphenotypic Acute	Stimulate	36532049
Leukemia Hairy Cell	Associate	11079033, 21917686, 23347903, 24903677, 28418282, 29110361, 34710243, 37530550, 38440808, 8537498
Lung Diseases	Associate	10908151
Lung Diseases Interstitial	Stimulate	12827664
Lung Neoplasms	Associate	24477908, 33205076
Lupus Nephritis	Associate	31402273
Lymphoma	Associate	34166375
Lymphoma Mantle Cell	Associate	22150124
Macular Degeneration	Associate	39547643
Melanoma	Associate	36169985
Memory Disorders	Associate	31400196
Mouth Diseases	Associate	28212742, 36216310
Multiple Sclerosis	Stimulate	37949669
Multiple Sclerosis Chronic Progressive	Associate	17897326
Multiple Sclerosis Relapsing Remitting	Associate	17897326
Neoplasm Metastasis	Associate	33479027, 34435978
Neoplasms	Associate	11737053, 22319577, 23529839, 24477908, 27650547, 28099920, 28628092, 30006565, 30100393, 30505306, 31105699, 31400196, 31481117, 31771983, 31888734 View all (24 more)
Neoplasms	Inhibit	34767045
Neoplasms Squamous Cell	Associate	33479027
Neurodegenerative Diseases	Stimulate	37949669
Neuroinflammatory Diseases	Associate	37949669
Oropharyngeal Neoplasms	Associate	35525376
Ovarian Neoplasms	Associate	27650547
Pancreatic Neoplasms	Associate	12434297, 9566785
Parkinson Disease	Stimulate	37949669
Periodontal Diseases	Associate	31677275
Periodontitis	Stimulate	31677275
Pleural Effusion	Associate	33977110, 35811063
Precursor Cell Lymphoblastic Leukemia Lymphoma	Associate	14656893
Prostatic Neoplasms	Associate	36759726
Pulmonary Disease Chronic Obstructive	Associate	12511714
Renal Insufficiency	Inhibit	32527931
Sarcoidosis	Associate	10908151, 30585624
Sarcoidosis	Inhibit	22537923
Sjogren's Syndrome	Associate	16316423, 34386009, 36881472
Squamous Cell Carcinoma of Head and Neck	Associate	32527931, 35525376
Stomach Neoplasms	Associate	32205862, 33312758, 34767045, 35776160, 36119930
Stroke	Associate	19023099
Thyroid Cancer Papillary	Associate	36420264
Tuberculosis Meningeal	Associate	30219039
Urinary Bladder Neoplasms	Associate	12357319
Uterine Cervical Neoplasms	Associate	38091985, 39206965
Virus Diseases	Associate	21537083
Vitiligo	Associate	28927891

ITGAE (integrin subunit alpha E)