Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	3680
Gene name	Integrin subunit alpha 9
Gene symbol	ITGA9
Synonyms (NCBI Gene)	ALPHA-RLCITGA4LRLC
Chromosome	3
Chromosome location	3p22.2
Summary	This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane glycoproteins composed of an alpha chain and a beta chain that mediate cell-cell and cell-matrix adhesion. The protein encoded by this gene, when bound to the beta 1 chain,

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miRTarBase ID	miRNA	Experiments	Reference
MIRT005895	hsa-miR-194-5p	Luciferase reporter assayqRT-PCRWestern blot	20979124
MIRT041874	hsa-miR-484	CLASH	23622248
MIRT053450	hsa-miR-452-5p	Microarray	23807165
MIRT573157	hsa-miR-5000-5p	PAR-CLIP	20371350
MIRT573156	hsa-miR-4639-3p	PAR-CLIP	20371350
MIRT573155	hsa-miR-759	PAR-CLIP	20371350
MIRT573154	hsa-miR-519d-5p	PAR-CLIP	20371350
MIRT573153	hsa-miR-5695	PAR-CLIP	20371350
MIRT573152	hsa-miR-302b-5p	PAR-CLIP	20371350
MIRT573151	hsa-miR-302d-5p	PAR-CLIP	20371350
MIRT573150	hsa-miR-6794-3p	PAR-CLIP	20371350
MIRT573149	hsa-miR-452-3p	PAR-CLIP	20371350
MIRT573148	hsa-miR-515-5p	PAR-CLIP	20371350
MIRT573147	hsa-miR-519e-5p	PAR-CLIP	20371350
MIRT736034	hsa-miR-148a-3p	Luciferase reporter assayWestern blottingImmunohistochemistry (IHC)qRT-PCR	31489579
MIRT573157	hsa-miR-5000-5p	PAR-CLIP	20371350
MIRT573156	hsa-miR-4639-3p	PAR-CLIP	20371350
MIRT573155	hsa-miR-759	PAR-CLIP	20371350
MIRT573154	hsa-miR-519d-5p	PAR-CLIP	20371350
MIRT573153	hsa-miR-5695	PAR-CLIP	20371350
MIRT573152	hsa-miR-302b-5p	PAR-CLIP	20371350
MIRT573151	hsa-miR-302d-5p	PAR-CLIP	20371350
MIRT573150	hsa-miR-6794-3p	PAR-CLIP	20371350
MIRT573149	hsa-miR-452-3p	PAR-CLIP	20371350
MIRT573148	hsa-miR-515-5p	PAR-CLIP	20371350
MIRT573147	hsa-miR-519e-5p	PAR-CLIP	20371350
MIRT1073725	hsa-miR-1202	CLIP-seq
MIRT1073726	hsa-miR-134	CLIP-seq
MIRT1073727	hsa-miR-194	CLIP-seq
MIRT1073728	hsa-miR-3118	CLIP-seq
MIRT1073729	hsa-miR-3163	CLIP-seq
MIRT1073730	hsa-miR-3164	CLIP-seq
MIRT1073731	hsa-miR-3165	CLIP-seq
MIRT1073732	hsa-miR-3194-5p	CLIP-seq
MIRT1073733	hsa-miR-331-5p	CLIP-seq
MIRT1073734	hsa-miR-340	CLIP-seq
MIRT1073735	hsa-miR-3607-5p	CLIP-seq
MIRT1073736	hsa-miR-369-5p	CLIP-seq
MIRT1073737	hsa-miR-3972	CLIP-seq
MIRT1073738	hsa-miR-4320	CLIP-seq
MIRT1073739	hsa-miR-4456	CLIP-seq
MIRT1073740	hsa-miR-4501	CLIP-seq
MIRT1073741	hsa-miR-548c-3p	CLIP-seq
MIRT1073742	hsa-miR-767-5p	CLIP-seq
MIRT2018206	hsa-miR-346	CLIP-seq
MIRT2018207	hsa-miR-4288	CLIP-seq
MIRT2018208	hsa-miR-632	CLIP-seq
MIRT2018209	hsa-miR-654-3p	CLIP-seq
MIRT2250087	hsa-miR-132	CLIP-seq
MIRT1073727	hsa-miR-194	CLIP-seq
MIRT2250088	hsa-miR-212	CLIP-seq
MIRT1073733	hsa-miR-331-5p	CLIP-seq
MIRT2250089	hsa-miR-4328	CLIP-seq
MIRT2250090	hsa-miR-4446-5p	CLIP-seq
MIRT2437973	hsa-miR-4659a-3p	CLIP-seq
MIRT2437974	hsa-miR-4659b-3p	CLIP-seq
MIRT2437975	hsa-miR-4666-5p	CLIP-seq
MIRT2437976	hsa-miR-664	CLIP-seq
MIRT1073726	hsa-miR-134	CLIP-seq
MIRT1073728	hsa-miR-3118	CLIP-seq
MIRT1073730	hsa-miR-3164	CLIP-seq
MIRT1073735	hsa-miR-3607-5p	CLIP-seq
MIRT2451994	hsa-miR-3650	CLIP-seq
MIRT2451995	hsa-miR-3688-5p	CLIP-seq
MIRT1073740	hsa-miR-4501	CLIP-seq
MIRT2451996	hsa-miR-4772-5p	CLIP-seq
MIRT2451997	hsa-miR-644	CLIP-seq

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Transcription factor	Regulation	Reference
MEIS1	Unknown	23139255
TBX5	Unknown	23139255

Show/Hide all (27)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	35802072
GO:0005886	Component	Plasma membrane	TAS
GO:0007155	Process	Cell adhesion	IEA
GO:0007155	Process	Cell adhesion	IGI	21060781
GO:0007155	Process	Cell adhesion	TAS	8245132
GO:0007160	Process	Cell-matrix adhesion	IBA
GO:0007160	Process	Cell-matrix adhesion	NAS	19693543
GO:0007229	Process	Integrin-mediated signaling pathway	IBA
GO:0007229	Process	Integrin-mediated signaling pathway	IEA
GO:0007229	Process	Integrin-mediated signaling pathway	NAS	19693543
GO:0008305	Component	Integrin complex	IEA
GO:0008305	Component	Integrin complex	TAS	8245132
GO:0009925	Component	Basal plasma membrane	IEA
GO:0009986	Component	Cell surface	IBA
GO:0016020	Component	Membrane	IEA
GO:0030593	Process	Neutrophil chemotaxis	IEA
GO:0034679	Component	Integrin alpha9-beta1 complex	IBA
GO:0034679	Component	Integrin alpha9-beta1 complex	IEA
GO:0034679	Component	Integrin alpha9-beta1 complex	IPI	25748048
GO:0034679	Component	Integrin alpha9-beta1 complex	ISS
GO:0038023	Function	Signaling receptor activity	IBA
GO:0045906	Process	Negative regulation of vasoconstriction	IEA
GO:0045906	Process	Negative regulation of vasoconstriction	IMP	35802072
GO:0046872	Function	Metal ion binding	IEA
GO:0098609	Process	Cell-cell adhesion	IBA
GO:0098640	Function	Integrin binding involved in cell-matrix adhesion	IEA
GO:0098640	Function	Integrin binding involved in cell-matrix adhesion	ISS

MIM	HGNC	e!Ensembl
603963	6145	ENSG00000144668

Q13797

Protein name

Integrin alpha-9 (Integrin alpha-RLC)

Protein function

Integrin alpha-9/beta-1 (ITGA9:ITGB1) is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. ITGA9:ITGB1 may play a crucial role in SVEP1/polydom-mediated myoblast cell adhesion (By similar

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01839	FG-GAP	304 → 340	FG-GAP repeat	Repeat
PF01839	FG-GAP	364 → 399	FG-GAP repeat	Repeat
PF08441	Integrin_alpha2	459 → 909	Integrin alpha	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in vascular smooth muscle cells (at protein level) (PubMed:35802072). Expressed in the airway epithelium (at protein level) (PubMed:8245132). {ECO:0000269|PubMed:35802072, ECO:0000269|PubMed:8245132}.

Sequence

MGGPAAPRGAGRLRALLLALVVAGIPAGAYNLDPQRPVHFQGPADSFFGYAVLEHFHDNT
RWVLVGAPKADSKYSPSVKSPGAVFKCRVHTNPDRRCTELDMARGKNRGTSCGKTCREDR
DDEWMGVSLARQPKADGRVLACAHRWKNIYYEADHILPHGFCYIIPSNLQAKGRTLIPCY
EEYKKKYGEEHGSCQAGIAGFFTEELVVMGAPGSFYWAGTIKVLNLTDNTYLKLNDEVIM
NRRYTYLGYAVTAGHFSHPSTIDVVGGAPQDKGIGKVYIFRADRRSGTLIKIFQASGKKM
GSYFGSSLCAVDLNGDGLSDLLVGAPMFSEIRDEGQVTVYINRGNGALEEQLALTGDGAY
NAHFGESIASLDDLDNDGFPDVAIGAPKEDDFAGAVYIYHGDAGGIVPQYSMKLSGQKIN
PVLRMFGQSISGGIDMDGNGYPDVTVGAFMSDSVVLLRARPVITVDVSIFLPGSINITAP
QCHDGQQPVNCLNVTTCFSFHGKHVPGEIGLNYVLMADVAKKEKGQMPRVYFVLLGETMG
QVTEKLQLTYMEETCRHYVAHVKRRVQDVISPIVFEAAYSLSEHVTGEEERELPPLTPVL
RWKKGQKIAQKNQTVFERNCRSEDCAADLQLQGKLLLSSMDEKTLYLALGAVKNISLNIS
ISNLGDDAYDANVSFNVSRELFFINMWQKEEMGISCELLESDFLKCSVGFPFMRSKSKYE
FSVIFDTSHLSGEEEVLSFIVTAQSGNTERSESLHDNTLVLMVPLMHEVDTSITGIMSPT
SFVYGESVDAANFIQLDDLECHFQPINITLQVYNTGPSTLPGSSVSISFPNRLSSGGAEM
FHVQEMVVGQEKGNCSFQKNPTPCIIPQEQENIFHTIFAFFTKSGRKVLDCEKPGISCLT
AHCNFSALAKEESRTIDIYMLLNTEILKKDSSSVIQFMSRAKVKVDPALRVVEIAHGNPE
EVTVVFEALHNLEPRGYVVGWIIAISLLVGILIFLLLAVLLWKMGFFRRRYKEIIEAEKN
RKENEDSWDWVQKNQ

Sequence length

1035

Interactions

View interactions

	KEGG		Reactome
	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction Cell adhesion molecules Regulation of actin cytoskeleton Cytoskeleton in muscle cells Human papillomavirus infection Hypertrophic cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy Dilated cardiomyopathy		Integrin cell surface interactions ECM proteoglycans Signal transduction by L1

Show/Hide Unknown Diseases (14)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Acute myeloid leukemia	Benign	rs76424398	RCV005886386
Colon adenocarcinoma	Benign	rs61751189	RCV005929700
Familial cancer of breast	Benign	rs61751189, rs2507940	RCV005929699 RCV005898287
Familial pancreatic carcinoma	Benign	rs61751189	RCV005929702
Gastric cancer	Benign	rs61751189, rs76424398	RCV005929703 RCV005886388
ITGA9-related disorder	Uncertain significance; Benign; Likely benign	rs777228206, rs61751189, rs138705453, rs200735233, rs61751646, rs140716372, rs142025172, rs3733139, rs112785572, rs1118148, rs143960385, rs150482056, rs114129792, rs142961075, rs147528488 View all (10 more)	RCV003414360 RCV003966400 RCV003907183 RCV003909495 RCV003919594 RCV003916780 RCV003916949 RCV003916985 RCV003967318 RCV003982283 RCV003911457 RCV003897377 RCV003929421 RCV003939694 RCV003951680 RCV003914467 RCV003924490 RCV003924726 RCV003954696 RCV003927404 RCV003979026 RCV003972714 RCV003972713 RCV003965740 RCV003920397
Lung cancer	Benign	rs61751189	RCV005929708
Malignant tumor of esophagus	Benign	rs76424398	RCV005886387
Melanoma	Benign	rs61751189	RCV005929707
Ovarian cancer	Benign	rs61751189	RCV005929701
Ovarian serous cystadenocarcinoma	Benign	rs61751189	RCV005929704
Thymoma	Benign	rs61751189	RCV005929705
Thyroid cancer, nonmedullary, 1	Benign	rs61751189	RCV005929706
Uterine corpus endometrial carcinoma	Benign	rs76424398	RCV005886389

Show/Hide Text Mining Associations (27)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Arthritis Rheumatoid	Associate	29038247
Breast Neoplasms	Associate	21975548, 32420379, 33500458
Carcinoma Non Small Cell Lung	Associate	22491060
Carcinoma Ovarian Epithelial	Associate	30945681
Carcinoma Squamous Cell	Associate	22491060, 23478628
Carotid Artery Diseases	Associate	29595698
COVID 19	Associate	33413422
Glioma	Associate	37096960
Head and Neck Neoplasms	Associate	20412120
Heart Diseases	Associate	23343568
Hydrops Fetalis	Associate	36959127
Intracranial Arteriovenous Malformations	Inhibit	36934253
Liver Cirrhosis	Stimulate	31678370
Lung Neoplasms	Associate	9179494
Lymphangioleiomyomatosis	Associate	33863980
Lymphangioma	Associate	17584927
Lymphedema	Associate	22529953
Nasopharyngeal Carcinoma	Associate	26372814, 32985354
Neoplasm Metastasis	Associate	22491060
Neoplasms	Associate	20412120, 26372814, 26491211, 32985354, 33500458
Neoplasms	Inhibit	21975548, 23478628
Primary Myelofibrosis	Associate	31678370
Prostatic Neoplasms	Associate	26491211
Prostatitis	Associate	26491211
Scleroderma Systemic	Associate	28861129
Squamous Cell Carcinoma of Head and Neck	Associate	20412120
Uterine Cervical Neoplasms	Associate	23478628

ITGA9 (integrin subunit alpha 9)