ITGA4 (integrin subunit alpha 4)

Gene

• Entrez ID: 3676
• Gene name: Integrin subunit alpha 4
• Gene symbol: ITGA4
• Synonyms (NCBI Gene): CD49D, IA4
• Chromosome: 2
• Chromosome location: 2q31.3
• Summary: The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT007135	hsa-miR-30c-5p	qRT-PCR	23418453
MIRT1073585	hsa-miR-186	CLIP-seq
MIRT1073586	hsa-miR-3171	CLIP-seq
MIRT1073587	hsa-miR-4659a-3p	CLIP-seq
MIRT1073588	hsa-miR-4659b-3p	CLIP-seq
MIRT1073589	hsa-miR-4716-5p	CLIP-seq
MIRT1073590	hsa-miR-495	CLIP-seq
MIRT1073591	hsa-miR-587	CLIP-seq
MIRT2018180	hsa-miR-450b-5p	CLIP-seq
MIRT2018181	hsa-miR-4711-3p	CLIP-seq
MIRT2018182	hsa-miR-511	CLIP-seq
MIRT2018183	hsa-miR-513a-3p	CLIP-seq
MIRT2018184	hsa-miR-548ae	CLIP-seq
MIRT2018185	hsa-miR-548aj	CLIP-seq
MIRT2018186	hsa-miR-548am	CLIP-seq
MIRT2018187	hsa-miR-548x	CLIP-seq
MIRT2250056	hsa-miR-106a	CLIP-seq
MIRT2250057	hsa-miR-106b	CLIP-seq
MIRT2250058	hsa-miR-130a	CLIP-seq
MIRT2250059	hsa-miR-130b	CLIP-seq
MIRT2250060	hsa-miR-17	CLIP-seq
MIRT2250061	hsa-miR-20a	CLIP-seq
MIRT2250062	hsa-miR-20b	CLIP-seq
MIRT2250063	hsa-miR-301a	CLIP-seq
MIRT2250064	hsa-miR-301b	CLIP-seq
MIRT2250065	hsa-miR-3609	CLIP-seq
MIRT2250066	hsa-miR-3666	CLIP-seq
MIRT2250067	hsa-miR-3670	CLIP-seq
MIRT2250068	hsa-miR-4275	CLIP-seq
MIRT2250069	hsa-miR-4295	CLIP-seq
MIRT2250070	hsa-miR-454	CLIP-seq
MIRT2250071	hsa-miR-4796-3p	CLIP-seq
MIRT2250072	hsa-miR-519a	CLIP-seq
MIRT2250073	hsa-miR-519b-3p	CLIP-seq
MIRT2250074	hsa-miR-519c-3p	CLIP-seq
MIRT2250075	hsa-miR-519d	CLIP-seq
MIRT2250076	hsa-miR-548ah	CLIP-seq
MIRT2250077	hsa-miR-93	CLIP-seq
MIRT2018184	hsa-miR-548ae	CLIP-seq
MIRT2018185	hsa-miR-548aj	CLIP-seq
MIRT2018186	hsa-miR-548am	CLIP-seq
MIRT2018187	hsa-miR-548x	CLIP-seq
MIRT2430127	hsa-miR-3942-3p	CLIP-seq
MIRT2430128	hsa-miR-410	CLIP-seq
MIRT2430129	hsa-miR-4313	CLIP-seq
MIRT2430130	hsa-miR-4747-3p	CLIP-seq
MIRT2430131	hsa-miR-507	CLIP-seq
MIRT2430132	hsa-miR-557	CLIP-seq
MIRT2553557	hsa-miR-1208	CLIP-seq
MIRT2553558	hsa-miR-1278	CLIP-seq
MIRT2553559	hsa-miR-1285	CLIP-seq
MIRT2553560	hsa-miR-1297	CLIP-seq
MIRT2553561	hsa-miR-1827	CLIP-seq
MIRT2553562	hsa-miR-26a	CLIP-seq
MIRT2553563	hsa-miR-26b	CLIP-seq
MIRT2553564	hsa-miR-300	CLIP-seq
MIRT2553565	hsa-miR-30a	CLIP-seq
MIRT2553566	hsa-miR-30b	CLIP-seq
MIRT2553567	hsa-miR-30c	CLIP-seq
MIRT2553568	hsa-miR-30d	CLIP-seq
MIRT2553569	hsa-miR-30e	CLIP-seq
MIRT2553570	hsa-miR-3127-3p	CLIP-seq
MIRT2553571	hsa-miR-3160-5p	CLIP-seq
MIRT2553572	hsa-miR-3161	CLIP-seq
MIRT2553573	hsa-miR-3187-5p	CLIP-seq
MIRT2553574	hsa-miR-3200-5p	CLIP-seq
MIRT2553575	hsa-miR-3545-3p	CLIP-seq
MIRT2553576	hsa-miR-3664-5p	CLIP-seq
MIRT2553577	hsa-miR-380	CLIP-seq
MIRT2553578	hsa-miR-381	CLIP-seq
MIRT2553579	hsa-miR-382	CLIP-seq
MIRT2553580	hsa-miR-3973	CLIP-seq
MIRT2553581	hsa-miR-4251	CLIP-seq
MIRT2553582	hsa-miR-4329	CLIP-seq
MIRT2553583	hsa-miR-4420	CLIP-seq
MIRT2553584	hsa-miR-4432	CLIP-seq
MIRT2553585	hsa-miR-4457	CLIP-seq
MIRT2553586	hsa-miR-4465	CLIP-seq
MIRT2553587	hsa-miR-4495	CLIP-seq
MIRT2553588	hsa-miR-4520a-3p	CLIP-seq
MIRT2553589	hsa-miR-4520b-3p	CLIP-seq
MIRT2018181	hsa-miR-4711-3p	CLIP-seq
MIRT2553590	hsa-miR-4714-5p	CLIP-seq
MIRT2553591	hsa-miR-4760-3p	CLIP-seq
MIRT1073590	hsa-miR-495	CLIP-seq
MIRT2553592	hsa-miR-498	CLIP-seq
MIRT2553593	hsa-miR-499-5p	CLIP-seq
MIRT2018182	hsa-miR-511	CLIP-seq
MIRT2553594	hsa-miR-513b	CLIP-seq
MIRT2553595	hsa-miR-548a-5p	CLIP-seq
MIRT2553596	hsa-miR-548ab	CLIP-seq
MIRT2553597	hsa-miR-548ak	CLIP-seq
MIRT2553598	hsa-miR-548b-5p	CLIP-seq
MIRT2553599	hsa-miR-548c-5p	CLIP-seq
MIRT2553600	hsa-miR-548d-5p	CLIP-seq
MIRT2553601	hsa-miR-548h	CLIP-seq
MIRT2553602	hsa-miR-548i	CLIP-seq
MIRT2553603	hsa-miR-548j	CLIP-seq
MIRT2553604	hsa-miR-548w	CLIP-seq
MIRT2553605	hsa-miR-548y	CLIP-seq
MIRT2553606	hsa-miR-559	CLIP-seq
MIRT2553607	hsa-miR-562	CLIP-seq
MIRT2553608	hsa-miR-578	CLIP-seq
MIRT2553609	hsa-miR-579	CLIP-seq
MIRT2553610	hsa-miR-612	CLIP-seq
MIRT2553611	hsa-miR-643	CLIP-seq
MIRT2553612	hsa-miR-664	CLIP-seq
MIRT2553613	hsa-miR-802	CLIP-seq
MIRT2553558	hsa-miR-1278	CLIP-seq
MIRT2553559	hsa-miR-1285	CLIP-seq
MIRT2553560	hsa-miR-1297	CLIP-seq
MIRT2553561	hsa-miR-1827	CLIP-seq
MIRT2553562	hsa-miR-26a	CLIP-seq
MIRT2553563	hsa-miR-26b	CLIP-seq
MIRT2553564	hsa-miR-300	CLIP-seq
MIRT2553570	hsa-miR-3127-3p	CLIP-seq
MIRT2553572	hsa-miR-3161	CLIP-seq
MIRT2553573	hsa-miR-3187-5p	CLIP-seq
MIRT2553574	hsa-miR-3200-5p	CLIP-seq
MIRT2553575	hsa-miR-3545-3p	CLIP-seq
MIRT2553576	hsa-miR-3664-5p	CLIP-seq
MIRT2553577	hsa-miR-380	CLIP-seq
MIRT2553578	hsa-miR-381	CLIP-seq
MIRT2553579	hsa-miR-382	CLIP-seq
MIRT2553580	hsa-miR-3973	CLIP-seq
MIRT2553581	hsa-miR-4251	CLIP-seq
MIRT2553582	hsa-miR-4329	CLIP-seq
MIRT2553585	hsa-miR-4457	CLIP-seq
MIRT2553586	hsa-miR-4465	CLIP-seq
MIRT2553587	hsa-miR-4495	CLIP-seq
MIRT2553588	hsa-miR-4520a-3p	CLIP-seq
MIRT2553589	hsa-miR-4520b-3p	CLIP-seq
MIRT2553590	hsa-miR-4714-5p	CLIP-seq
MIRT2553591	hsa-miR-4760-3p	CLIP-seq
MIRT1073590	hsa-miR-495	CLIP-seq
MIRT2553592	hsa-miR-498	CLIP-seq
MIRT2553594	hsa-miR-513b	CLIP-seq
MIRT2553595	hsa-miR-548a-5p	CLIP-seq
MIRT2553596	hsa-miR-548ab	CLIP-seq
MIRT2553597	hsa-miR-548ak	CLIP-seq
MIRT2553598	hsa-miR-548b-5p	CLIP-seq
MIRT2553599	hsa-miR-548c-5p	CLIP-seq
MIRT2553600	hsa-miR-548d-5p	CLIP-seq
MIRT2553601	hsa-miR-548h	CLIP-seq
MIRT2553602	hsa-miR-548i	CLIP-seq
MIRT2553603	hsa-miR-548j	CLIP-seq
MIRT2553604	hsa-miR-548w	CLIP-seq
MIRT2553605	hsa-miR-548y	CLIP-seq
MIRT2553606	hsa-miR-559	CLIP-seq
MIRT2553607	hsa-miR-562	CLIP-seq
MIRT2553608	hsa-miR-578	CLIP-seq
MIRT2553609	hsa-miR-579	CLIP-seq
MIRT2553610	hsa-miR-612	CLIP-seq
MIRT2553611	hsa-miR-643	CLIP-seq
MIRT2553612	hsa-miR-664	CLIP-seq
MIRT2553613	hsa-miR-802	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001968	Function	Fibronectin binding	IEA
GO:0002387	Process	Immune response in gut-associated lymphoid tissue	NAS	7687523
GO:0002687	Process	Positive regulation of leukocyte migration	IEA
GO:0003366	Process	Cell-matrix adhesion involved in ameboidal cell migration	IMP	23986478
GO:0003823	Function	Antigen binding	IEA
GO:0005178	Function	Integrin binding	TAS	8020569
GO:0005515	Function	Protein binding	IPI	1542691, 9079671, 10604475, 14681217, 15466886, 20159608, 21173240, 22232704, 26779610, 35802072, 37184585
GO:0005886	Component	Plasma membrane	IDA	12869515
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0007155	Process	Cell adhesion	IEA
GO:0007159	Process	Leukocyte cell-cell adhesion	IDA	1715889
GO:0007159	Process	Leukocyte cell-cell adhesion	IEA
GO:0007159	Process	Leukocyte cell-cell adhesion	NAS	30819933
GO:0007160	Process	Cell-matrix adhesion	IBA
GO:0007160	Process	Cell-matrix adhesion	IDA	22232704
GO:0007160	Process	Cell-matrix adhesion	IEA
GO:0007160	Process	Cell-matrix adhesion	IMP	18308860, 23986478
GO:0007160	Process	Cell-matrix adhesion	NAS	30819933
GO:0007229	Process	Integrin-mediated signaling pathway	IBA
GO:0007229	Process	Integrin-mediated signaling pathway	IEA
GO:0007229	Process	Integrin-mediated signaling pathway	NAS	22232704, 30819933
GO:0008305	Component	Integrin complex	IEA
GO:0009888	Process	Tissue development	IEA
GO:0009986	Component	Cell surface	IBA
GO:0009986	Component	Cell surface	IDA	1715889, 18308860, 20563599, 23986478
GO:0009986	Component	Cell surface	IEA
GO:0015026	Function	Coreceptor activity	TAS	23125415
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0019960	Function	C-X3-C chemokine binding	IDA	23125415
GO:0030183	Process	B cell differentiation	IC	1715889
GO:0030426	Component	Growth cone	IEA
GO:0033631	Process	Cell-cell adhesion mediated by integrin	IGI	11078691
GO:0034113	Process	Heterotypic cell-cell adhesion	IGI	11078691
GO:0034113	Process	Heterotypic cell-cell adhesion	IMP	18308860
GO:0034446	Process	Substrate adhesion-dependent cell spreading	IMP	23986478
GO:0034668	Component	Integrin alpha4-beta1 complex	IBA
GO:0034668	Component	Integrin alpha4-beta1 complex	IPI	1542691
GO:0034668	Component	Integrin alpha4-beta1 complex	TAS	8020569
GO:0034669	Component	Integrin alpha4-beta7 complex	IBA
GO:0034669	Component	Integrin alpha4-beta7 complex	IDA	18308860, 23986478
GO:0034669	Component	Integrin alpha4-beta7 complex	IPI	22232704
GO:0035987	Process	Endodermal cell differentiation	IEP	23154389
GO:0038023	Function	Signaling receptor activity	IBA
GO:0043025	Component	Neuronal cell body	IEA
GO:0043113	Process	Receptor clustering	IMP	23986478
GO:0045906	Process	Negative regulation of vasoconstriction	IEA
GO:0045906	Process	Negative regulation of vasoconstriction	IMP	35802072
GO:0046872	Function	Metal ion binding	IEA
GO:0048598	Process	Embryonic morphogenesis	IEA
GO:0050839	Function	Cell adhesion molecule binding	IEA
GO:0050839	Function	Cell adhesion molecule binding	IMP	23986478
GO:0050839	Function	Cell adhesion molecule binding	IPI	12869515
GO:0050900	Process	Leukocyte migration	IEA
GO:0050901	Process	Leukocyte tethering or rolling	IMP	18308860
GO:0050904	Process	Diapedesis	IEA
GO:0060385	Process	Axonogenesis involved in innervation	IEA
GO:0070062	Component	Extracellular exosome	HDA	12519789, 20458337
GO:0071345	Process	Cellular response to cytokine stimulus	IEA
GO:0090074	Process	Negative regulation of protein homodimerization activity	IDA	12869515
GO:0098609	Process	Cell-cell adhesion	IBA
GO:0098657	Process	Import into cell	IEA
GO:1903039	Process	Positive regulation of leukocyte cell-cell adhesion	IEA
GO:1903238	Process	Positive regulation of leukocyte tethering or rolling	IEA
GO:1904646	Process	Cellular response to amyloid-beta	IGI	11078691
GO:1905564	Process	Positive regulation of vascular endothelial cell proliferation	IMP	27464494
GO:1990138	Process	Neuron projection extension	IEA
GO:1990405	Function	Protein antigen binding	IEA
GO:1990771	Process	Clathrin-dependent extracellular exosome endocytosis	IEA
GO:2000353	Process	Positive regulation of endothelial cell apoptotic process	IMP	27464494
GO:2000406	Process	Positive regulation of T cell migration	IEA

Other IDs

• MIM: 192975
• HGNC: 6140
• e!Ensembl: ENSG00000115232

Protein

• UniProt ID: P13612
• Protein name: Integrin alpha-4 (CD49 antigen-like family member D) (Integrin alpha-IV) (VLA-4 subunit alpha) (CD antigen CD49d)
• Protein function: Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta
• PDB: 3V4P, 3V4V, 4HKC, 5C7Z, 5FPI
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01839	FG-GAP	306 → 342	FG-GAP repeat	Repeat
  PF01839	FG-GAP	369 → 403	FG-GAP repeat	Repeat
  PF08441	Integrin_alpha2	463 → 905	Integrin alpha	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in vascular smooth muscle cells (at protein level). {ECO:0000269|PubMed:35802072}.
• Sequence:

  MAWEARREPGPRRAAVRETVMLLLCLGVPTGRPYNVDTESALLYQGPHNTLFGYSVVLHS
  HGANRWLLVGAPTANWLANASVINPGAIYRCRIGKNPGQTCEQLQLGSPNGEPCGKTCLE
  ERDNQWLGVTLSRQPGENGSIVTCGHRWKNIFYIKNENKLPTGGCYGVPPDLRTELSKRI
  APCYQDYVKKFGENFASCQAGISSFYTKDLIVMGAPGSSYWTGSLFVYNITTNKYKAFLD
  KQNQVKFGSYLGYSVGAGHFRSQHTTEVVGGAPQHEQIGKAYIFSIDEKELNILHEMKGK
  KLGSYFGASVCAVDLNADGFSDLLVGAPMQSTIREEGRVFVYINSGSGAVMNAMETNLVG
  SDKYAARFGESIVNLGDIDNDGFEDVAIGAPQEDDLQGAIYIYNGRADGISSTFSQRIEG
  LQISKSLSMFGQSISGQIDADNNGYVDVAVGAFRSDSAVLLRTRPVVIVDASLSHPESVN
  RTKFDCVENGWPSVCIDLTLCFSYKGKEVPGYIVLFYNMSLDVNRKAESPPRFYFSSNGT
  SDVITGSIQVSSREANCRTHQAFMRKDVRDILTPIQIEAAYHLGPHVISKRSTEEFPPLQ
  PILQQKKEKDIMKKTINFARFCAHENCSADLQVSAKIGFLKPHENKTYLAVGSMKTLMLN
  VSLFNAGDDAYETTLHVKLPVGLYFIKILELEEKQINCEVTDNSGVVQLDCSIGYIYVDH
  LSRIDISFLLDVSSLSRAEEDLSITVHATCENEEEMDNLKHSRVTVAIPLKYEVKLTVHG
  FVNPTSFVYGSNDENEPETCMVEKMNLTFHVINTGNSMAPNVSVEIMVPNSFSPQTDKLF
  NILDVQTTTGECHFENYQRVCALEQQKSAMQTLKGIVRFLSKTDKRLLYCIKADPHCLNF
  LCNFGKMESGKEASVHIQLEGRPSILEMDETSALKFEIRATGFPEPNPRVIELNKDENVA
  HVLLEGLHHQRPKRYFTIVIISSSLLLGLIVLLLISYVMWKAGFFKRQYKSILQEENRRD
  SWSYINSKSNDD

• Sequence length: 1032

Pathways

KEGG:

PI3K-Akt signaling pathway
Focal adhesion
ECM-receptor interaction
Cell adhesion molecules
Hematopoietic cell lineage
Leukocyte transendothelial migration
Intestinal immune network for IgA production
Regulation of actin cytoskeleton
Cytoskeleton in muscle cells
Yersinia infection
Leishmaniasis
Human papillomavirus infection
Hypertrophic cardiomyopathy
Arrhythmogenic right ventricular cardiomyopathy
Dilated cardiomyopathy

Reactome:

Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Cell surface interactions at the vascular wall
Integrin cell surface interactions
RUNX3 Regulates Immune Response and Cell Migration

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Acute myeloid leukemia	Benign	rs35322532	RCV005902456
Clear cell carcinoma of kidney	Benign	rs35322532	RCV005902459
Familial cancer of breast	Benign	rs188125632	RCV005907655
Familial pancreatic carcinoma	Likely benign	rs201929112	RCV005904741
Gastric cancer	Benign	rs35322532	RCV005902461
Hepatocellular carcinoma	Benign	rs35322532	RCV005902457
ITGA4-related disorder	Conflicting classifications of pathogenicity; Likely benign; Uncertain significance; Benign	rs1143675, rs200957447, rs2468596980, rs2468544989, rs200722520, rs181661156, rs35021228, rs201433950, rs35322532, rs188125632	RCV003917824 RCV003980914 RCV003893860 RCV003904357 RCV003974267 RCV003941952 RCV003939617 RCV003971392 RCV003920511 RCV003923064
Lung cancer	Benign	rs35322532	RCV005902462
Malignant tumor of esophagus	Benign	rs35322532	RCV005902458
Ovarian serous cystadenocarcinoma	Uncertain significance	rs199618280	RCV005929035
Sarcoma	Benign	rs35322532	RCV005902460
Uterine corpus endometrial carcinoma	Benign	rs35322532, rs188125632	RCV005902463 RCV005907656

Associations from Text Mining
Disease Name	Relationship Type	References
Adenocarcinoma	Associate	30720096
Adenoma	Associate	25759530
Agammaglobulinemia	Stimulate	25931291
Alzheimer Disease	Associate	29769839
Anemia Diamond Blackfan	Associate	31157955
Asthma	Associate	23160057, 29956778
Breast Neoplasms	Associate	24756760, 33500458
Cap Myopathy	Associate	19470770
Carcinoma Squamous Cell	Associate	28886030
Celiac Disease	Associate	19648293
Chagas Disease	Associate	11309161
Cholangiocarcinoma	Inhibit	19655168
Chromosome 12 12p trisomy	Stimulate	24068493
Chromosome 12 12p trisomy	Associate	24829201
Colorectal Neoplasms	Associate	25759530, 26917449, 27111221, 28982739, 29068474, 32531444, 33892797
COVID 19	Associate	33413422
Crohn Disease	Stimulate	29027377
Death	Inhibit	20663947
Death	Associate	34689222
Deltaretrovirus Infections	Associate	7545080
Diabetes Mellitus	Associate	38241313
Diabetes Mellitus Type 1	Inhibit	25793768
Diabetes Mellitus Type 1	Associate	30942443
Diffuse panbronchiolitis	Associate	9030883
Disease	Associate	33446885
Ectrodactyly cardiopathy dysmorphism	Associate	11309161
Eosinophilia	Associate	37548395
Fluorosis Dental	Associate	29317700
Gastrointestinal Stromal Tumors	Associate	29377440
Glaucoma	Associate	31680442
Glioblastoma	Associate	30375429, 35464424
Hypoxia	Stimulate	38172514
Inflammation	Associate	27111221, 28487530, 9030883
Inflammatory Bowel Diseases	Associate	39273699
Intervertebral Disc Degeneration	Associate	28586059
Kashin Beck Disease	Associate	29317700
Latent Autoimmune Diabetes in Adults	Associate	33391182
Leukemia	Associate	11399509, 29955944, 7678062
Leukemia B Cell	Associate	11160154, 20839337, 21617698
Leukemia Lymphocytic Chronic B Cell	Associate	17053842, 17959854, 18641015, 19383907, 20809501, 21569005, 21617698, 24068493, 24421328, 24516016, 24637360, 24829201, 26559905, 26873628, 27221715, 27252234, 27697994, 29301866, 29955944, 31157955, 32006000, 35871396, 37227160
Leukemia Lymphocytic Chronic B Cell	Stimulate	21865343, 25544766
Leukemia Myelogenous Chronic BCR ABL Positive	Associate	19543515
Leukemia Myeloid Acute	Associate	11264180, 15183897, 15493582, 19543515, 30484958, 36266324
Leukemia Myelomonocytic Acute	Associate	7678062
Leukemia Prolymphocytic T Cell	Associate	18275431, 21569005, 26559905, 29978459, 35776688
Leukemia T Cell	Associate	21569005
Leukoplakia	Associate	39748722
Liver Cirrhosis	Associate	17036394
Lung Neoplasms	Associate	37888615, 8080732
Lupus Erythematosus Systemic	Associate	32317002
Lymphatic Diseases	Associate	26873628
Lymphatic Metastasis	Associate	24756760, 26917449
Lymphocytosis	Inhibit	29301866
Lymphocytosis	Associate	37227160
Lymphoma B Cell	Associate	17053842
Lymphoma Mantle Cell	Associate	17053842, 19228923
Multiple Myeloma	Associate	10848782, 23178378, 23450831, 28670693, 39493694
Multiple Sclerosis	Stimulate	25814153, 8697624
Multiple Sclerosis	Associate	28487530, 33589541
Multiple Sclerosis Chronic Progressive	Associate	17897326
Multiple Sclerosis Relapsing Remitting	Associate	17897326
Multiple Sclerosis Relapsing Remitting	Inhibit	39675643
Myelodysplastic Syndromes	Associate	30484958, 31157955
Nasopharyngeal Carcinoma	Associate	28716111, 32324312
Neoplasm Metastasis	Associate	19655168, 26917449, 29377440
Neoplasms	Associate	19655168, 25743258, 28982739, 30720096, 32324312, 33500458, 34689222, 39748722
Neoplasms	Inhibit	36803573
Neoplasms	Stimulate	37888615
Nervous System Diseases	Associate	27486658
Neuroinflammatory Diseases	Associate	33504893
Neuroma Acoustic	Associate	23354516
Obesity	Associate	38172514
Ovarian Neoplasms	Associate	20796276, 34689222
Pancreatic Neoplasms	Associate	32272917
Parkinson Disease	Associate	33504893
Personality Disorders	Associate	30285776
Pituitary Neoplasms	Associate	24198235
Polycystic Ovary Syndrome	Associate	35551681
Precancerous Conditions	Associate	32531444
Prostatic Hyperplasia	Associate	28836852
Prostatic Neoplasms	Associate	25743258
Prostatic Neoplasms Castration Resistant	Associate	28836852
Prostatitis	Associate	25743258
Respiratory Distress Syndrome	Associate	39684262
Sarcoidosis	Associate	35075176
Sleep Apnea Obstructive	Associate	38172514
Squamous Cell Carcinoma of Head and Neck	Associate	28814981, 32937734, 39748722
Stomach Neoplasms	Associate	40416795
Uterine Cervical Neoplasms	Associate	15989693, 24647315, 36803573
Wiskott Aldrich Syndrome	Stimulate	8918565