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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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P17301 |
| Protein name |
Integrin alpha-2 (CD49 antigen-like family member B) (Collagen receptor) (Platelet membrane glycoprotein Ia) (GPIa) (VLA-2 subunit alpha) (CD antigen CD49b) |
| Protein function |
Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells |
| PDB |
1AOX
, 1DZI
, 1V7P
, 4BJ3
, 5HJ2
, 5THP
, 6ND8
, 6ND9
, 6NDA
, 6NDB
, 6NDC
, 6NDD
, 6NDE
, 6NDF
, 6NDG
, 6NDH
|
| Family and domains |
Pfam
| Accession |
ID |
Position in sequence |
Description |
Type |
| PF00092 |
VWA |
174 → 355 |
von Willebrand factor type A domain |
Domain |
| PF01839 |
FG-GAP |
554 → 589 |
FG-GAP repeat |
Repeat |
| PF08441 |
Integrin_alpha2 |
649 → 1068 |
Integrin alpha |
Family |
|
| Sequence |
|
| Sequence length |
1181 |
| Interactions |
View interactions |
| Phenotype Name |
Clinical Significance |
dbSNP ID |
RCV Accession |
| Fetal and neonatal alloimmune thrombocytopenia |
Benign; Likely benign |
rs199808499 |
RCV001258314 |
| ITGA2-related disorder |
Uncertain significance; Benign; Likely benign; Conflicting classifications of pathogenicity |
rs1744596435, rs1313396530, rs1744961406, rs3212594, rs143262642, rs26675, rs758980432, rs41366951, rs55980302, rs746293859, rs541149162, rs139738925, rs541732593, rs757932706, rs148313613, rs144334272, rs41272305 View all (2 more) |
RCV003412398 RCV003402802 RCV003402841 RCV003972485 RCV003932453 RCV003932454 RCV003950254 RCV003902372 RCV003932455 RCV003913848 RCV003941469 RCV003949166 RCV003938520 RCV004753216 RCV003413962 RCV004753218 RCV004753217 |
| Lung cancer |
Conflicting classifications of pathogenicity |
rs41441846 |
RCV005913966 |
| Malignant lymphoma, large B-cell, diffuse |
Benign |
rs1363192 |
RCV005922056 |
| Nonpapillary renal cell carcinoma |
- |
rs774131464 |
RCV005973206 |
| Platelet-type bleeding disorder 9 |
Benign; Likely benign; Uncertain significance; Conflicting classifications of pathogenicity |
rs3212385, rs143667535, rs559975113, rs3212523, rs570925083, rs2303127, rs201610232, rs3212555, rs118190231, rs761499417, rs3212327, rs116473481, rs3212594, rs3212645, rs200155411, rs886060663, rs531102187, rs9292006, rs561106268, rs533206560, rs79488788, rs886060683, rs886060685, rs886060686, rs886060688, rs886060690, rs566829678, rs181976027, rs55973669, rs1421933, rs202058704, rs1062535, rs140178479, rs1801106, rs748826809, rs2303122, rs113222066, rs3212647, rs886060666, rs182541283, rs752068879, rs886060671, rs1042323, rs369001095, rs10076541, rs35863692, rs886060681, rs557257907, rs57674800, rs143236463, rs143262642, rs188816090, rs886060657, rs26675, rs373539496, rs1126643, rs1139484, rs3212521, rs545988273, rs199602142, rs146370217, rs886060660, rs530127630, rs3212583, rs773985586, rs2287870, rs886060661, rs150997093, rs13173706, rs202180218, rs190842751, rs886060668, rs886060670, rs570965140, rs188770677, rs76840527, rs886060676, rs149715267, rs145580223, rs547012254, rs886060687, rs139102895, rs530007169, rs879585300, rs886060656, rs758980432, rs61737774, rs41272301, rs767342253, rs199808499, rs41366951, rs191616009, rs79932422, rs3213805, rs80331976, rs55980302, rs772014693, rs886060667, rs537086711, rs771530392, rs548494960, rs543100435, rs886060674, rs540698536, rs886060677, rs886060678, rs886060680, rs886060682, rs886060684, rs6149022, rs115863238, rs552507591, rs542924934, rs546009701, rs886060692, rs528320695, rs200476815, rs2287871, rs543948644, rs768692399, rs140852048, rs780441074, rs190131248, rs773789837, rs41377544, rs577503636, rs541732593, rs144998443, rs377150294, rs1744884286, rs757932706, rs267606593, rs41441846, rs148313613, rs372372566, rs1745609993, rs768656331, rs144334272, rs199575892, rs1437160437, rs1184111868, rs1740392086, rs1021854035, rs1034269446, rs1740405266, rs3212650, rs191591133, rs1740412814, rs1740416494, rs965526283, rs1055904276, rs910292856, rs1740450196, rs192927707, rs79223114, rs140728831, rs1740479829, rs1740480277, rs1388184739, rs1223966045, rs201170451, rs1026813584, rs200790251, rs1001186003, rs775163275, rs1740529330, rs1740558620, rs140380471, rs137861998, rs1183806468, rs893708736, rs72760448, rs191917189, rs974919174, rs752392366, rs534251174, rs41272305 View all (162 more) |
RCV000323846 RCV000279267 RCV000337125 RCV000281281 RCV000320005 RCV000344873 RCV000401675 RCV000407562 RCV000272876 RCV000382459 RCV000333884 RCV000348555 RCV000280572 RCV000271507 RCV000307975 RCV000332392 RCV000268632 RCV000383700 RCV000289317 RCV000354291 RCV000320360 RCV000386977 RCV000334984 RCV000268904 RCV000276893 RCV000343318 RCV000315117 RCV000357250 RCV000391672 RCV000362482 RCV000322047 RCV000268212 RCV000386245 RCV000295674 RCV000297737 RCV000302029 RCV000277395 RCV000373185 RCV000278715 RCV000324583 RCV000399271 RCV000392474 RCV000310987 RCV000262655 RCV000354027 RCV000401880 RCV000277171 RCV000386551 RCV000285078 RCV000300121 RCV000292703 RCV000349935 RCV000314751 RCV000391667 RCV000309269 RCV000264523 RCV000360617 RCV000316451 RCV000350631 RCV000301417 RCV000337750 RCV000361882 RCV000267357 RCV000358207 RCV000388488 RCV000335586 RCV000398950 RCV000407606 RCV000362413 RCV000263412 RCV000318640 RCV000339777 RCV000314509 RCV000329069 RCV000295289 RCV000402381 RCV000407113 RCV000292601 RCV000338269 RCV000308867 RCV000307586 RCV000329592 RCV000306856 RCV000275450 RCV000371467 RCV000401294 RCV000366240 RCV000373389 RCV000289940 RCV000380765 RCV000303731 RCV000327832 RCV000269427 RCV000294171 RCV000375221 RCV000305172 RCV000366041 RCV000386879 RCV000284734 RCV000390384 RCV000317851 RCV000323656 RCV000283776 RCV000350249 RCV000299450 RCV000305267 RCV000359889 RCV000365646 RCV000332513 RCV000374403 RCV000279805 RCV000365836 RCV000261663 RCV000373667 RCV000286047 RCV000377188 RCV000400644 RCV000367484 RCV001153730 RCV000987524 RCV001152457 RCV001152458 RCV001152459 RCV001153729 RCV001153732 RCV001156345 RCV001158024 RCV001158025 RCV001152546 RCV001152547 RCV001152548 RCV001152549 RCV001152550 RCV001156464 RCV001158125 RCV001158127 RCV001152656 RCV001152658 RCV001152659 RCV001152660 RCV001153939 RCV001154794 RCV001154795 RCV001154796 RCV001158243 RCV001158244 RCV001158245 RCV001158246 RCV001158247 RCV001152765 RCV001152766 RCV001154037 RCV001154038 RCV001154039 RCV001154040 RCV001154883 RCV001154884 RCV001154885 RCV001156555 RCV001156556 RCV001156557 RCV001156558 RCV001156559 RCV001152877 RCV001152878 RCV001154158 RCV001154998 RCV001154999 RCV001151199 RCV001151200 RCV001151201 RCV001154269 RCV001154270 RCV001154271 RCV001154272 RCV001155110 RCV001153731 RCV001158126 RCV001152657 |
| See cases |
Uncertain significance |
rs1745457945 |
RCV001197587 |
|
| Disease Name |
Relationship Type |
References |
| Acute Aortic Syndrome |
Associate |
33953793 |
| Adenocarcinoma of Lung |
Associate |
37311571 |
| Alcoholism |
Associate |
24890784 |
| Asthma |
Associate |
29769273 |
| beta Thalassemia |
Associate |
26650878 |
| Biliary Atresia |
Associate |
35774294 |
| Blood Platelet Disorders |
Associate |
26367242, 27881421 |
| Brain Diseases |
Associate |
31758065 |
| Breast Neoplasms |
Associate |
22791584, 23875900, 26258411, 26655502, 29121049, 8396565, 9649145 |
| Carcinogenesis |
Associate |
32437034 |
| Carcinoma Hepatocellular |
Associate |
27765911, 29658607, 30515639, 32557953, 7684197 |
| Carcinoma Pancreatic Ductal |
Associate |
24500968, 31926587, 32899691, 34007003, 35998796, 37907515 |
| Carcinoma Squamous Cell |
Associate |
35147120 |
| Carotid Artery Diseases |
Associate |
37137812 |
| Carotid Stenosis |
Associate |
21393601 |
| Cerebral Infarction |
Associate |
17534386 |
| Cerebrovascular Disorders |
Associate |
27881421 |
| Cholangiocarcinoma |
Associate |
32116234, 36575207, 7684197 |
| Colorectal Neoplasms |
Associate |
12657625, 15304500, 25549357, 28902367, 29843204, 34860147 |
| Colorectal Neoplasms |
Stimulate |
35147120 |
| Coronary Artery Disease |
Associate |
27881421, 33557870 |
| Coronary Artery Disease Autosomal Dominant 1 |
Associate |
10828008 |
| Diabetes Mellitus |
Associate |
36295578 |
| Diabetes Mellitus Type 2 |
Associate |
36295578 |
| DNA Virus Infections |
Associate |
35998796 |
| Endometrial Neoplasms |
Associate |
37737665 |
| Eosinophilic Esophagitis |
Associate |
32426497 |
| Epidermolysis Bullosa |
Associate |
1694890 |
| Epstein Barr Virus Infections |
Stimulate |
25041527 |
| Gastroschisis |
Associate |
31075877 |
| Graves Disease |
Stimulate |
9218832 |
| Hashimoto Disease |
Stimulate |
9218832 |
| Heart Diseases |
Associate |
10828008 |
| Hemangiosarcoma |
Associate |
7682756 |
| Hemorrhage |
Associate |
15226188, 15978109, 16409463, 25901734 |
| Hereditary Breast and Ovarian Cancer Syndrome |
Associate |
35149005 |
| Immunoglobulin G4 Related Disease |
Associate |
8421065 |
| Inflammation |
Associate |
36042612 |
| Leiomyoma |
Associate |
25658015, 28324020 |
| Leiomyosarcoma |
Inhibit |
7682756 |
| Leukemia Myeloid Acute |
Associate |
30484958, 30545930 |
| Leukoplakia Hairy |
Associate |
10918561 |
| Lung Neoplasms |
Associate |
2022922, 35147120, 8080732 |
| Lupus Erythematosus Systemic |
Associate |
2646323 |
| Lymphatic Metastasis |
Associate |
26258411 |
| Melanoma |
Associate |
1991990, 36091936 |
| Melanoma |
Stimulate |
32426497 |
| Meningeal Carcinomatosis |
Associate |
9649145 |
| Mesothelioma Malignant |
Associate |
34768883 |
| Mucocutaneous Lymph Node Syndrome |
Associate |
33557870 |
| Myelodysplastic Syndromes |
Associate |
30484958 |
| Myocardial Infarction |
Associate |
11835340, 30143348 |
| Nasopharyngeal Carcinoma |
Associate |
29121049 |
| Neoplasm Metastasis |
Associate |
32202508 |
| Neoplasms |
Associate |
10906100, 16461767, 18830231, 19650860, 2000944, 2022922, 22500976, 25422375, 25658015, 26567111, 27125458, 27225591, 28587194, 28962550, 29104488, 29121049, 29843204, 30515639, 30718673, 32202508, 34127544, 35147120, 36091936, 36311789, 37881431, 7682756, 9649145 View all (12 more) |
| Neoplasms |
Inhibit |
26258411 |
| Neurilemmoma |
Associate |
7682756 |
| Neuroblastoma |
Associate |
31432180 |
| Neurofibrosarcoma |
Inhibit |
7682756 |
| Niemann Pick Disease Type C |
Associate |
29912899 |
| Osteoarthritis |
Associate |
33303888 |
| Osteoporosis |
Associate |
23638215 |
| Osteoporotic Fractures |
Inhibit |
23638215 |
| Osteosarcoma |
Associate |
26700675 |
| Ovarian Neoplasms |
Associate |
17179151, 32878513, 36766725, 37527178 |
| Ovarian Neoplasms |
Stimulate |
32202508 |
| Pancreatic Intraductal Neoplasms |
Associate |
37907515 |
| Pancreatic Neoplasms |
Associate |
30428899, 32235821, 34007003, 35998796, 36311789, 37881431 |
| Paroxysmal ventricular fibrillation |
Associate |
27759448 |
| Platelet Disorder Familial with Associated Myeloid Malignancy |
Associate |
30545930 |
| Polycystic Ovary Syndrome |
Associate |
37737665 |
| Prostate cancer familial |
Associate |
18830231 |
| Prostatic Neoplasms |
Associate |
18830231, 22782340, 24175814, 31682594 |
| Prostatic Neoplasms |
Stimulate |
35147120 |
| Small Cell Lung Carcinoma |
Associate |
35147120 |
| Squamous Cell Carcinoma of Head and Neck |
Stimulate |
32437034 |
| Stomach Neoplasms |
Associate |
21734795 |
| Stomach Neoplasms |
Stimulate |
35147120 |
| Stroke |
Associate |
17534386 |
| Synesthesia |
Associate |
29507195 |
| Takayasu Arteritis |
Associate |
34523592 |
| Thrombocytopenia Neonatal Alloimmune |
Associate |
11370330, 23865077 |
| Thrombosis |
Associate |
11835340 |
| Thyroid Cancer Papillary |
Associate |
30414611 |
| Thyroid Neoplasms |
Associate |
32337286 |
| Transfusion Reaction |
Associate |
23865077 |
| Uterine Diseases |
Associate |
36552753 |
| Uveal melanoma |
Associate |
10906100 |
| Vascular Diseases |
Associate |
15978109 |
| Vascular System Injuries |
Associate |
11835340 |
| von Willebrand Disease Type 1 |
Associate |
10339461 |
| von Willebrand Disease Type 2 |
Associate |
16409463 |
|