Gene Gene information from NCBI Gene database.
Entrez ID 3673
Gene name Integrin subunit alpha 2
Gene symbol ITGA2
Synonyms (NCBI Gene)
BRCD49BFMAIT3GPIaHPA-5VLA-2VLAA2
Chromosome 5
Chromosome location 5q11.2
Summary This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss o
miRNA miRNA information provided by mirtarbase database.
778
miRTarBase ID miRNA Experiments Reference
MIRT005123 hsa-miR-30a-5p pSILAC 18668040
MIRT001449 hsa-miR-16-5p pSILAC 18668040
MIRT017602 hsa-miR-335-5p Microarray 18185580
MIRT027119 hsa-miR-103a-3p Sequencing 20371350
MIRT005123 hsa-miR-30a-5p Proteomics;Other 18668040
Transcription factors Transcription factors information provided by TRRUST V2 database.
2
Transcription factor Regulation Reference
SP1 Unknown 11238113;11313353
SP3 Unknown 11238113
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
85
GO ID Ontology Definition Evidence Reference
GO:0001540 Function Amyloid-beta binding IEA
GO:0001540 Function Amyloid-beta binding ISS
GO:0001618 Function Virus receptor activity IEA
GO:0001666 Process Response to hypoxia IEA
GO:0002687 Process Positive regulation of leukocyte migration IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
192974 6137 ENSG00000164171
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P17301
Protein name Integrin alpha-2 (CD49 antigen-like family member B) (Collagen receptor) (Platelet membrane glycoprotein Ia) (GPIa) (VLA-2 subunit alpha) (CD antigen CD49b)
Protein function Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells
PDB 1AOX , 1DZI , 1V7P , 4BJ3 , 5HJ2 , 5THP , 6ND8 , 6ND9 , 6NDA , 6NDB , 6NDC , 6NDD , 6NDE , 6NDF , 6NDG , 6NDH
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00092 VWA 174 355 von Willebrand factor type A domain Domain
PF01839 FG-GAP 554 589 FG-GAP repeat Repeat
PF08441 Integrin_alpha2 649 1068 Integrin alpha Family
Sequence
MGPERTGAAPLPLLLVLALSQGILNCCLAYNVGLPEAKIFSGPSSEQFGYAVQQFINPKG
NWLLVGSPWSGFPENRMGDVYKCPVDLSTATCEKLNLQTSTSIPNVTEMKTNMSLGLILT
RNMGTGGFLTCGPLWAQQCGNQYYTTGVCSDISPDFQLSASFSPATQPCPSLIDVVVVCD
ESNSIYPWDAVKNFLEKFVQGLDIGPTKTQVGLIQYANNPRVVFNLNTYKTKEEMIVATS
QTSQYGGDLTNTFGAIQYARKYAYSAASGGRRSATKVMVVVTDGESHDGSMLKAVIDQCN
HDNILRFGIAVLGYLNRNALDTKNLIKEIKAIASIPTERYFFNVSDEAALLEKAG
TLGEQ
IFSIEGTVQGGDNFQMEMSQVGFSADYSSQNDILMLGAVGAFGWSGTIVQKTSHGHLIFP
KQAFDQILQDRNHSSYLGYSVAAISTGESTHFVAGAPRANYTGQIVLYSVNENGNITVIQ
AHRGDQIGSYFGSVLCSVDVDKDTITDVLLVGAPMYMSDLKKEEGRVYLFTIKKGILGQH
QFLEGPEGIENTRFGSAIAALSDINMDGFNDVIVGSPLENQNSGAVYIYNGHQGTIRTKY
SQKILGSDGAFRSHLQYFGRSLDGYGDLNGDSITDVSIGAFGQVVQLWSQSIADVAIEAS
FTPEKITLVNKNAQIILKLCFSAKFRPTKQNNQVAIVYNITLDADGFSSRVTSRGLFKEN
NERCLQKNMVVNQAQSCPEHIIYIQEPSDVVNSLDLRVDISLENPGTSPALEAYSETAKV
FSIPFHKDCGEDGLCISDLVLDVRQIPAAQEQPFIVSNQNKRLTFSVTLKNKRESAYNTG
IVVDFSENLFFASFSLPVDGTEVTCQVAASQKSVACDVGYPALKREQQVTFTINFDFNLQ
NLQNQASLSFQALSESQEENKADNLVNLKIPLLYDAEIHLTRSTNINFYEISSDGNVPSI
VHSFEDVGPKFIFSLKVTTGSVPVSMATVIIHIPQYTKEKNPLMYLTGVQTDKAGDISCN
ADINPLKIGQTSSSVSFKSENFRHTKELNCRTASCSNVTCWLKDVHMK
GEYFVNVTTRIW
NGTFASSTFQTVQLTAAAEINTYNPEIYVIEDNTVTIPLMIMKPDEKAEVPTGVIIGSII
AGILLLLALVAILWKLGFFKRKYEKMTKNPDEIDETTELSS
Sequence length 1181
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Virion - Rotavirus
Phagosome
PI3K-Akt signaling pathway
Focal adhesion
ECM-receptor interaction
Platelet activation
Hematopoietic cell lineage
Regulation of actin cytoskeleton
Cytoskeleton in muscle cells
Human papillomavirus infection
Pathways in cancer
Proteoglycans in cancer
Small cell lung cancer
Hypertrophic cardiomyopathy
Arrhythmogenic right ventricular cardiomyopathy
Dilated cardiomyopathy
  Integrin cell surface interactions
Laminin interactions
Syndecan interactions
ECM proteoglycans
MET activates PTK2 signaling
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
212
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Fetal and neonatal alloimmune thrombocytopenia Benign; Likely benign rs199808499 RCV001258314
ITGA2-related disorder Uncertain significance; Benign; Likely benign; Conflicting classifications of pathogenicity rs1744596435, rs1313396530, rs1744961406, rs3212594, rs143262642, rs26675, rs758980432, rs41366951, rs55980302, rs746293859, rs541149162, rs139738925, rs541732593, rs757932706, rs148313613
View all (2 more)
RCV003412398
RCV003402802
RCV003402841
RCV003972485
RCV003932453
RCV003932454
RCV003950254
RCV003902372
RCV003932455
RCV003913848
RCV003941469
RCV003949166
RCV003938520
RCV004753216
RCV003413962
RCV004753218
RCV004753217
Lung cancer Conflicting classifications of pathogenicity rs41441846 RCV005913966
Malignant lymphoma, large B-cell, diffuse Benign rs1363192 RCV005922056
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Acute Aortic Syndrome Associate 33953793
Adenocarcinoma of Lung Associate 37311571
Alcoholism Associate 24890784
Asthma Associate 29769273
beta Thalassemia Associate 26650878
Biliary Atresia Associate 35774294
Blood Platelet Disorders Associate 26367242, 27881421
Brain Diseases Associate 31758065
Breast Neoplasms Associate 22791584, 23875900, 26258411, 26655502, 29121049, 8396565, 9649145
Carcinogenesis Associate 32437034