ITGA1 (integrin subunit alpha 1)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 3672 |
| Gene name | Integrin subunit alpha 1 |
| Gene symbol | ITGA1 |
| Synonyms (NCBI Gene) |
CD49aVLA1
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| Chromosome | 5 |
| Chromosome location | 5q11.2 |
| Summary | This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in |
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miRNA
miRNA information provided by mirtarbase database.
505
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
48
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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P56199 | |||||||||||||||||||||||||
| Protein name | Integrin alpha-1 (CD49 antigen-like family member A) (Laminin and collagen receptor) (VLA-1) (CD antigen CD49a) | |||||||||||||||||||||||||
| Protein function | Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth. {ECO:0000269|PubMed:1559 | |||||||||||||||||||||||||
| PDB | 1PT6 , 1QC5 , 1QCY , 2L8S , 2M32 , 4A0Q , 5HGJ | |||||||||||||||||||||||||
| Family and domains |
Pfam
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| Sequence | ||||||||||||||||||||||||||
| Sequence length | 1179 | |||||||||||||||||||||||||
| Interactions | View interactions | |||||||||||||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
1
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