ITGA1 (integrin subunit alpha 1)
| Gene | |
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
3672 |
|
Gene name
Gene Name - the full gene name approved by the HGNC.
|
Integrin subunit alpha 1 |
|
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
|
ITGA1 |
|
Synonyms (NCBI Gene)
Gene synonyms aliases
|
CD49a, VLA1 |
|
Chromosome
Chromosome number
|
5 |
|
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
5q11.2 |
|
Summary
Summary of gene provided in NCBI Entrez Gene.
|
This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in |
|
miRNA
miRNA information provided by mirtarbase database.
|
|||||||||||||||||||||||||
|
|||||||||||||||||||||||||
|
Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
|
|||||||||||||||||||||||||||||||
|
|||||||||||||||||||||||||||||||
|
Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
|
|||||||
|
|||||||
| Protein | ||||||||||||||||||||||||||
| UniProt ID | P56199 | |||||||||||||||||||||||||
| Protein name | Integrin alpha-1 (CD49 antigen-like family member A) (Laminin and collagen receptor) (VLA-1) (CD antigen CD49a) | |||||||||||||||||||||||||
| Protein function | Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth. {ECO:0000269|PubMed:1559 | |||||||||||||||||||||||||
| PDB | 1PT6 , 1QC5 , 1QCY , 2L8S , 2M32 , 4A0Q , 5HGJ | |||||||||||||||||||||||||
| Family and domains |
Pfam
|
|||||||||||||||||||||||||
| Sequence | ||||||||||||||||||||||||||
| Sequence length | 1179 | |||||||||||||||||||||||||
| Interactions | View interactions | |||||||||||||||||||||||||
|
Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
|
|
|
Associated diseases
Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
|
|||||||||||||||||||||||||||||||||||||
|
|||||||||||||||||||||||||||||||||||||
|
|||||||||||||||||||||||||||||||||||||