Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	3671
Gene name Gene Name - the full gene name approved by the HGNC.	Immunoglobulin superfamily containing leucine rich repeat
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ISLR
Synonyms (NCBI Gene) Gene synonyms aliases	HsT17563, Meflin
Chromosome Chromosome number	15
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	15q24.1

Show/Hide all(126)

miRTarBase ID	miRNA	Experiments
MIRT1072756	hsa-miR-1224-5p	CLIP-seq
MIRT1072757	hsa-miR-1245b-3p	CLIP-seq
MIRT1072758	hsa-miR-4330	CLIP-seq
MIRT1072759	hsa-miR-4475	CLIP-seq
MIRT1072760	hsa-miR-4751	CLIP-seq
MIRT1550228	hsa-let-7a	CLIP-seq
MIRT1550229	hsa-let-7b	CLIP-seq
MIRT1550230	hsa-let-7c	CLIP-seq
MIRT1550231	hsa-let-7d	CLIP-seq
MIRT1550232	hsa-let-7e	CLIP-seq
MIRT1550233	hsa-let-7f	CLIP-seq
MIRT1550234	hsa-let-7g	CLIP-seq
MIRT1550235	hsa-let-7i	CLIP-seq
MIRT1550236	hsa-miR-224	CLIP-seq
MIRT1550237	hsa-miR-3154	CLIP-seq
MIRT1550238	hsa-miR-3611	CLIP-seq
MIRT1550239	hsa-miR-4428	CLIP-seq
MIRT1550240	hsa-miR-4458	CLIP-seq
MIRT1550241	hsa-miR-4496	CLIP-seq
MIRT1550242	hsa-miR-4500	CLIP-seq
MIRT1550243	hsa-miR-98	CLIP-seq
MIRT2249709	hsa-miR-320e	CLIP-seq
MIRT2249710	hsa-miR-2110	CLIP-seq
MIRT2249711	hsa-miR-3150a-3p	CLIP-seq
MIRT2249709	hsa-miR-320e	CLIP-seq
MIRT2249712	hsa-miR-3665	CLIP-seq
MIRT2249713	hsa-miR-3907	CLIP-seq
MIRT2249714	hsa-miR-4450	CLIP-seq
MIRT2249715	hsa-miR-4690-5p	CLIP-seq
MIRT2249716	hsa-miR-764	CLIP-seq
MIRT2451962	hsa-miR-28-5p	CLIP-seq
MIRT2451963	hsa-miR-3120-3p	CLIP-seq
MIRT2451964	hsa-miR-3139	CLIP-seq
MIRT2451965	hsa-miR-4459	CLIP-seq
MIRT2451966	hsa-miR-4722-5p	CLIP-seq
MIRT2451967	hsa-miR-708	CLIP-seq
MIRT2451968	hsa-miR-765	CLIP-seq
MIRT2553202	hsa-miR-1181	CLIP-seq
MIRT2553203	hsa-miR-1254	CLIP-seq
MIRT2553204	hsa-miR-125a-5p	CLIP-seq
MIRT2553205	hsa-miR-125b	CLIP-seq
MIRT2553206	hsa-miR-128	CLIP-seq
MIRT2553207	hsa-miR-1324	CLIP-seq
MIRT2553208	hsa-miR-150	CLIP-seq
MIRT2553209	hsa-miR-15a	CLIP-seq
MIRT2553210	hsa-miR-15b	CLIP-seq
MIRT2553211	hsa-miR-16	CLIP-seq
MIRT2553212	hsa-miR-1913	CLIP-seq
MIRT2553213	hsa-miR-195	CLIP-seq
MIRT2553214	hsa-miR-2467-5p	CLIP-seq
MIRT2553215	hsa-miR-27a	CLIP-seq
MIRT2553216	hsa-miR-27b	CLIP-seq
MIRT2553217	hsa-miR-3116	CLIP-seq
MIRT2553218	hsa-miR-3117-3p	CLIP-seq
MIRT2553219	hsa-miR-3150b-3p	CLIP-seq
MIRT2553220	hsa-miR-3166	CLIP-seq
MIRT2553221	hsa-miR-3174	CLIP-seq
MIRT2553222	hsa-miR-3188	CLIP-seq
MIRT2553223	hsa-miR-324-3p	CLIP-seq
MIRT2553224	hsa-miR-3663-3p	CLIP-seq
MIRT2553225	hsa-miR-3908	CLIP-seq
MIRT2553226	hsa-miR-3975	CLIP-seq
MIRT2553227	hsa-miR-424	CLIP-seq
MIRT2553228	hsa-miR-4278	CLIP-seq
MIRT2553229	hsa-miR-4319	CLIP-seq
MIRT2553230	hsa-miR-4324	CLIP-seq
MIRT2553231	hsa-miR-4424	CLIP-seq
MIRT2553232	hsa-miR-4524	CLIP-seq
MIRT2553233	hsa-miR-4649-3p	CLIP-seq
MIRT2553234	hsa-miR-4713-5p	CLIP-seq
MIRT2553235	hsa-miR-4742-5p	CLIP-seq
MIRT2553236	hsa-miR-4749-3p	CLIP-seq
MIRT2553237	hsa-miR-4784	CLIP-seq
MIRT2553238	hsa-miR-485-5p	CLIP-seq
MIRT2553239	hsa-miR-497	CLIP-seq
MIRT2553240	hsa-miR-503	CLIP-seq
MIRT2553241	hsa-miR-515-3p	CLIP-seq
MIRT2553242	hsa-miR-519e	CLIP-seq
MIRT2553243	hsa-miR-532-3p	CLIP-seq
MIRT2553244	hsa-miR-550a	CLIP-seq
MIRT2553245	hsa-miR-646	CLIP-seq
MIRT2553246	hsa-miR-661	CLIP-seq
MIRT2553202	hsa-miR-1181	CLIP-seq
MIRT2553203	hsa-miR-1254	CLIP-seq
MIRT2553204	hsa-miR-125a-5p	CLIP-seq
MIRT2553205	hsa-miR-125b	CLIP-seq
MIRT2553206	hsa-miR-128	CLIP-seq
MIRT2553207	hsa-miR-1324	CLIP-seq
MIRT2553208	hsa-miR-150	CLIP-seq
MIRT2553209	hsa-miR-15a	CLIP-seq
MIRT2553210	hsa-miR-15b	CLIP-seq
MIRT2553211	hsa-miR-16	CLIP-seq
MIRT2553212	hsa-miR-1913	CLIP-seq
MIRT2553213	hsa-miR-195	CLIP-seq
MIRT2553214	hsa-miR-2467-5p	CLIP-seq
MIRT2553215	hsa-miR-27a	CLIP-seq
MIRT2553216	hsa-miR-27b	CLIP-seq
MIRT2553217	hsa-miR-3116	CLIP-seq
MIRT2553218	hsa-miR-3117-3p	CLIP-seq
MIRT2553219	hsa-miR-3150b-3p	CLIP-seq
MIRT2553220	hsa-miR-3166	CLIP-seq
MIRT2553221	hsa-miR-3174	CLIP-seq
MIRT2553222	hsa-miR-3188	CLIP-seq
MIRT2553223	hsa-miR-324-3p	CLIP-seq
MIRT2553224	hsa-miR-3663-3p	CLIP-seq
MIRT2553225	hsa-miR-3908	CLIP-seq
MIRT2553226	hsa-miR-3975	CLIP-seq
MIRT2553227	hsa-miR-424	CLIP-seq
MIRT2553229	hsa-miR-4319	CLIP-seq
MIRT2553230	hsa-miR-4324	CLIP-seq
MIRT2553231	hsa-miR-4424	CLIP-seq
MIRT2553232	hsa-miR-4524	CLIP-seq
MIRT2553233	hsa-miR-4649-3p	CLIP-seq
MIRT2553234	hsa-miR-4713-5p	CLIP-seq
MIRT2553235	hsa-miR-4742-5p	CLIP-seq
MIRT2553236	hsa-miR-4749-3p	CLIP-seq
MIRT2553237	hsa-miR-4784	CLIP-seq
MIRT2553238	hsa-miR-485-5p	CLIP-seq
MIRT2553239	hsa-miR-497	CLIP-seq
MIRT2553240	hsa-miR-503	CLIP-seq
MIRT2553241	hsa-miR-515-3p	CLIP-seq
MIRT2553242	hsa-miR-519e	CLIP-seq
MIRT2553243	hsa-miR-532-3p	CLIP-seq
MIRT2553244	hsa-miR-550a	CLIP-seq
MIRT2553245	hsa-miR-646	CLIP-seq
MIRT2553246	hsa-miR-661	CLIP-seq

Show/Hide all(5)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002576	Process	Platelet degranulation	TAS
GO:0005576	Component	Extracellular region	TAS
GO:0007155	Process	Cell adhesion	TAS	9325048
GO:0031093	Component	Platelet alpha granule lumen	TAS
GO:0070062	Component	Extracellular exosome	HDA	23533145

MIM	HGNC	e!Ensembl
602059	6133	ENSG00000129009

Protein

UniProt ID

O14498

Protein name

Immunoglobulin superfamily containing leucine-rich repeat protein

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13855	LRR_8	50 → 110	Leucine rich repeat	Repeat
PF13855	LRR_8	81 → 134	Leucine rich repeat	Repeat
PF13855	LRR_8	122 → 182	Leucine rich repeat	Repeat
PF07679	I-set	237 → 344	Immunoglobulin I-set domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in various tissues including retina, heart, skeletal muscle, prostate, ovary, small intestine, thyroid, adrenal cortex, testis, stomach and spinal cord. {ECO:0000269|PubMed:10512678, ECO:0000269|PubMed:9325048}.

Sequence

MQELHLLWWALLLGLAQACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSAN
RLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHN
LSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINEN
PFDCTCGIVWLKTWALTTAVSIPEQDNIACTSPHVLKGTPLSRLPPLPCSAPSVQLSYQP
SQDGAELRPGFVLALHCDVDGQPAPQLHWHIQIPSGIVEITSPNVGTDGRALPGTPVASS
QPRFQAFANGSLLIPDFGKLEEGTYSCLATNELGSAESSVDVALATPGEGGEDTLGRRFH
GKAVEGKGCYTVDNEVQPSGPEDNVVIIYLSRAGNPEAAVAEGVPGQLPPGLLLLGQSLL
LFFFLTSF

Sequence length

428

Interactions

View interactions

	Reactome
			Platelet degranulation

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Colorectal cancer	Colorectal Carcinoma	rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800 View all (467 more)

Show/Hide Text Mining Associations (10)

Disease Name	Relationship Type	References
Associations from Text Mining
Carcinoma Non Small Cell Lung	Stimulate	34713300
Carcinoma Pancreatic Ductal	Associate	33048956
Colorectal Neoplasms	Associate	34520435
Desmoplastic Small Round Cell Tumor	Associate	28415643
Gaucher Disease	Associate	30988500
Inflammation	Associate	39216827
Lymphatic Metastasis	Associate	35653801
Neoplasm Metastasis	Stimulate	35653801
Neoplasms	Associate	28415643, 32705221, 34713300, 35653801
Stomach Neoplasms	Associate	35653801

ISLR (immunoglobulin superfamily containing leucine rich repeat)