ISLR (immunoglobulin superfamily containing leucine rich repeat)

Gene

• Entrez ID: 3671
• Gene name: Immunoglobulin superfamily containing leucine rich repeat
• Gene symbol: ISLR
• Synonyms (NCBI Gene): HsT17563, Meflin
• Chromosome: 15
• Chromosome location: 15q24.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1072756	hsa-miR-1224-5p	CLIP-seq
MIRT1072757	hsa-miR-1245b-3p	CLIP-seq
MIRT1072758	hsa-miR-4330	CLIP-seq
MIRT1072759	hsa-miR-4475	CLIP-seq
MIRT1072760	hsa-miR-4751	CLIP-seq
MIRT1550228	hsa-let-7a	CLIP-seq
MIRT1550229	hsa-let-7b	CLIP-seq
MIRT1550230	hsa-let-7c	CLIP-seq
MIRT1550231	hsa-let-7d	CLIP-seq
MIRT1550232	hsa-let-7e	CLIP-seq
MIRT1550233	hsa-let-7f	CLIP-seq
MIRT1550234	hsa-let-7g	CLIP-seq
MIRT1550235	hsa-let-7i	CLIP-seq
MIRT1550236	hsa-miR-224	CLIP-seq
MIRT1550237	hsa-miR-3154	CLIP-seq
MIRT1550238	hsa-miR-3611	CLIP-seq
MIRT1550239	hsa-miR-4428	CLIP-seq
MIRT1550240	hsa-miR-4458	CLIP-seq
MIRT1550241	hsa-miR-4496	CLIP-seq
MIRT1550242	hsa-miR-4500	CLIP-seq
MIRT1550243	hsa-miR-98	CLIP-seq
MIRT2249709	hsa-miR-320e	CLIP-seq
MIRT2249710	hsa-miR-2110	CLIP-seq
MIRT2249711	hsa-miR-3150a-3p	CLIP-seq
MIRT2249709	hsa-miR-320e	CLIP-seq
MIRT2249712	hsa-miR-3665	CLIP-seq
MIRT2249713	hsa-miR-3907	CLIP-seq
MIRT2249714	hsa-miR-4450	CLIP-seq
MIRT2249715	hsa-miR-4690-5p	CLIP-seq
MIRT2249716	hsa-miR-764	CLIP-seq
MIRT2451962	hsa-miR-28-5p	CLIP-seq
MIRT2451963	hsa-miR-3120-3p	CLIP-seq
MIRT2451964	hsa-miR-3139	CLIP-seq
MIRT2451965	hsa-miR-4459	CLIP-seq
MIRT2451966	hsa-miR-4722-5p	CLIP-seq
MIRT2451967	hsa-miR-708	CLIP-seq
MIRT2451968	hsa-miR-765	CLIP-seq
MIRT2553202	hsa-miR-1181	CLIP-seq
MIRT2553203	hsa-miR-1254	CLIP-seq
MIRT2553204	hsa-miR-125a-5p	CLIP-seq
MIRT2553205	hsa-miR-125b	CLIP-seq
MIRT2553206	hsa-miR-128	CLIP-seq
MIRT2553207	hsa-miR-1324	CLIP-seq
MIRT2553208	hsa-miR-150	CLIP-seq
MIRT2553209	hsa-miR-15a	CLIP-seq
MIRT2553210	hsa-miR-15b	CLIP-seq
MIRT2553211	hsa-miR-16	CLIP-seq
MIRT2553212	hsa-miR-1913	CLIP-seq
MIRT2553213	hsa-miR-195	CLIP-seq
MIRT2553214	hsa-miR-2467-5p	CLIP-seq
MIRT2553215	hsa-miR-27a	CLIP-seq
MIRT2553216	hsa-miR-27b	CLIP-seq
MIRT2553217	hsa-miR-3116	CLIP-seq
MIRT2553218	hsa-miR-3117-3p	CLIP-seq
MIRT2553219	hsa-miR-3150b-3p	CLIP-seq
MIRT2553220	hsa-miR-3166	CLIP-seq
MIRT2553221	hsa-miR-3174	CLIP-seq
MIRT2553222	hsa-miR-3188	CLIP-seq
MIRT2553223	hsa-miR-324-3p	CLIP-seq
MIRT2553224	hsa-miR-3663-3p	CLIP-seq
MIRT2553225	hsa-miR-3908	CLIP-seq
MIRT2553226	hsa-miR-3975	CLIP-seq
MIRT2553227	hsa-miR-424	CLIP-seq
MIRT2553228	hsa-miR-4278	CLIP-seq
MIRT2553229	hsa-miR-4319	CLIP-seq
MIRT2553230	hsa-miR-4324	CLIP-seq
MIRT2553231	hsa-miR-4424	CLIP-seq
MIRT2553232	hsa-miR-4524	CLIP-seq
MIRT2553233	hsa-miR-4649-3p	CLIP-seq
MIRT2553234	hsa-miR-4713-5p	CLIP-seq
MIRT2553235	hsa-miR-4742-5p	CLIP-seq
MIRT2553236	hsa-miR-4749-3p	CLIP-seq
MIRT2553237	hsa-miR-4784	CLIP-seq
MIRT2553238	hsa-miR-485-5p	CLIP-seq
MIRT2553239	hsa-miR-497	CLIP-seq
MIRT2553240	hsa-miR-503	CLIP-seq
MIRT2553241	hsa-miR-515-3p	CLIP-seq
MIRT2553242	hsa-miR-519e	CLIP-seq
MIRT2553243	hsa-miR-532-3p	CLIP-seq
MIRT2553244	hsa-miR-550a	CLIP-seq
MIRT2553245	hsa-miR-646	CLIP-seq
MIRT2553246	hsa-miR-661	CLIP-seq
MIRT2553202	hsa-miR-1181	CLIP-seq
MIRT2553203	hsa-miR-1254	CLIP-seq
MIRT2553204	hsa-miR-125a-5p	CLIP-seq
MIRT2553205	hsa-miR-125b	CLIP-seq
MIRT2553206	hsa-miR-128	CLIP-seq
MIRT2553207	hsa-miR-1324	CLIP-seq
MIRT2553208	hsa-miR-150	CLIP-seq
MIRT2553209	hsa-miR-15a	CLIP-seq
MIRT2553210	hsa-miR-15b	CLIP-seq
MIRT2553211	hsa-miR-16	CLIP-seq
MIRT2553212	hsa-miR-1913	CLIP-seq
MIRT2553213	hsa-miR-195	CLIP-seq
MIRT2553214	hsa-miR-2467-5p	CLIP-seq
MIRT2553215	hsa-miR-27a	CLIP-seq
MIRT2553216	hsa-miR-27b	CLIP-seq
MIRT2553217	hsa-miR-3116	CLIP-seq
MIRT2553218	hsa-miR-3117-3p	CLIP-seq
MIRT2553219	hsa-miR-3150b-3p	CLIP-seq
MIRT2553220	hsa-miR-3166	CLIP-seq
MIRT2553221	hsa-miR-3174	CLIP-seq
MIRT2553222	hsa-miR-3188	CLIP-seq
MIRT2553223	hsa-miR-324-3p	CLIP-seq
MIRT2553224	hsa-miR-3663-3p	CLIP-seq
MIRT2553225	hsa-miR-3908	CLIP-seq
MIRT2553226	hsa-miR-3975	CLIP-seq
MIRT2553227	hsa-miR-424	CLIP-seq
MIRT2553229	hsa-miR-4319	CLIP-seq
MIRT2553230	hsa-miR-4324	CLIP-seq
MIRT2553231	hsa-miR-4424	CLIP-seq
MIRT2553232	hsa-miR-4524	CLIP-seq
MIRT2553233	hsa-miR-4649-3p	CLIP-seq
MIRT2553234	hsa-miR-4713-5p	CLIP-seq
MIRT2553235	hsa-miR-4742-5p	CLIP-seq
MIRT2553236	hsa-miR-4749-3p	CLIP-seq
MIRT2553237	hsa-miR-4784	CLIP-seq
MIRT2553238	hsa-miR-485-5p	CLIP-seq
MIRT2553239	hsa-miR-497	CLIP-seq
MIRT2553240	hsa-miR-503	CLIP-seq
MIRT2553241	hsa-miR-515-3p	CLIP-seq
MIRT2553242	hsa-miR-519e	CLIP-seq
MIRT2553243	hsa-miR-532-3p	CLIP-seq
MIRT2553244	hsa-miR-550a	CLIP-seq
MIRT2553245	hsa-miR-646	CLIP-seq
MIRT2553246	hsa-miR-661	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0007155	Process	Cell adhesion	TAS	9325048
GO:0031093	Component	Platelet alpha granule lumen	TAS
GO:0070062	Component	Extracellular exosome	HDA	23533145

Other IDs

• MIM: 602059
• HGNC: 6133
• e!Ensembl: ENSG00000129009

Protein

• UniProt ID: O14498
• Protein name: Immunoglobulin superfamily containing leucine-rich repeat protein
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13855	LRR_8	50 → 110	Leucine rich repeat	Repeat
  PF13855	LRR_8	81 → 134	Leucine rich repeat	Repeat
  PF13855	LRR_8	122 → 182	Leucine rich repeat	Repeat
  PF07679	I-set	237 → 344	Immunoglobulin I-set domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in various tissues including retina, heart, skeletal muscle, prostate, ovary, small intestine, thyroid, adrenal cortex, testis, stomach and spinal cord. {ECO:0000269|PubMed:10512678, ECO:0000269|PubMed:9325048}.
• Sequence:

  MQELHLLWWALLLGLAQACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSAN
  RLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHN
  LSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINEN
  PFDCTCGIVWLKTWALTTAVSIPEQDNIACTSPHVLKGTPLSRLPPLPCSAPSVQLSYQP
  SQDGAELRPGFVLALHCDVDGQPAPQLHWHIQIPSGIVEITSPNVGTDGRALPGTPVASS
  QPRFQAFANGSLLIPDFGKLEEGTYSCLATNELGSAESSVDVALATPGEGGEDTLGRRFH
  GKAVEGKGCYTVDNEVQPSGPEDNVVIIYLSRAGNPEAAVAEGVPGQLPPGLLLLGQSLL
  LFFFLTSF

• Sequence length: 428

Pathways

Reactome:

Platelet degranulation