ISG20 (interferon stimulated exonuclease gene 20)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3669
Gene name Gene Name - the full gene name approved by the HGNC.
Interferon stimulated exonuclease gene 20
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ISG20
Synonyms (NCBI Gene) Gene synonyms aliases
CD25, HEM45
Chromosome Chromosome number
15
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
15q26.1
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(6)
miRTarBase ID miRNA Experiments Reference
MIRT018907 hsa-miR-335-5p Microarray 18185580
MIRT024004 hsa-miR-1-3p Microarray 18668037
MIRT737487 hsa-miR-486-5p Luciferase reporter assay, Western blotting, Immunoprecipitaion (IP), Immunohistochemistry (IHC), qRT-PCR 33939247
MIRT1072604 hsa-miR-3123 CLIP-seq
MIRT1072605 hsa-miR-3925-5p CLIP-seq
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(2)
Transcription factor Regulation Reference
SP1 Unknown 10871365
USF1 Unknown 10871365
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(41)
GO ID Ontology Definition Evidence Reference
GO:0000175 Function 3'-5'-RNA exonuclease activity IDA 11401564
GO:0000932 Component P-body IEA
GO:0002376 Process Immune system process IEA
GO:0003676 Function Nucleic acid binding IEA
GO:0003723 Function RNA binding IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
604533 6130 ENSG00000172183
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q96AZ6
Protein name Interferon-stimulated gene 20 kDa protein (EC 3.1.13.1) (Estrogen-regulated transcript 45 protein) (Promyelocytic leukemia nuclear body-associated protein ISG20)
Protein function Interferon-induced antiviral exoribonuclease that acts mainly on single-stranded RNA (PubMed:11401564, PubMed:12594219, PubMed:16033969). Exhibits antiviral activity against RNA viruses including hepatitis C virus (HCV), hepatitis A virus (HAV)
PDB 1WLJ , 7UGB
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00929 RNase_T 8 → 162 Exonuclease Family
Tissue specificity TISSUE SPECIFICITY: Highly expressed in peripheral blood leukocytes, spleen, thymus, colon and lung. Up regulated by E2 in estrogen receptor-positive breast cancer lines. {ECO:0000269|PubMed:9235947, ECO:0000269|PubMed:9569007}.
Sequence
Sequence length 181
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Interferon alpha/beta signaling
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (1)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Metabolic Syndrome Serum total polyunsaturated fatty acid concentration in metabolic syndrome, Serum omega-6 polyunsaturated fatty acid concentration in metabolic syndrome N/A N/A GWAS
Show/Hide Text Mining Associations (93)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Acute Coronary Syndrome Associate 27999237
Acute On Chronic Liver Failure Associate 22978653
Age Related Hearing Impairment 1 Associate 27764096
Anemia Aplastic Associate 22797698
Arthritis Juvenile Associate 21702013
Arthritis Reactive Associate 9613339
Arthritis Rheumatoid Stimulate 1347492
Arthritis Rheumatoid Associate 24397353, 24742142, 28358698
Arthritis Rheumatoid Inhibit 33916798
Asthma Associate 18250971